MX2022005615A - Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceutica y uso del mismo. - Google Patents

Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceutica y uso del mismo.

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Publication number
MX2022005615A
MX2022005615A MX2022005615A MX2022005615A MX2022005615A MX 2022005615 A MX2022005615 A MX 2022005615A MX 2022005615 A MX2022005615 A MX 2022005615A MX 2022005615 A MX2022005615 A MX 2022005615A MX 2022005615 A MX2022005615 A MX 2022005615A
Authority
MX
Mexico
Prior art keywords
preparation
pharmaceutical composition
method therefor
dihydroimidazopyrimidone
tricyclic
Prior art date
Application number
MX2022005615A
Other languages
English (en)
Inventor
Yun Jin
Yong Sun
Jinhua Wu
Jun Peng
Original Assignee
Shanghai Simr Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Simr Biotechnology Co Ltd filed Critical Shanghai Simr Biotechnology Co Ltd
Publication of MX2022005615A publication Critical patent/MX2022005615A/es

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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
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    • C07D491/20—Spiro-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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Abstract

Se desvelan un compuesto representado por la fórmula general (I), un isómero cis-trans del mismo, un enantiómero del mismo, un diastereómero del mismo, un racemato del mismo, un solvato del mismo, un hidrato del mismo, o una sal farmacéuticamente aceptable del mismo o un profármaco del mismo, un método de preparación para el mismo, una composición farmacéutica que comprende el compuesto y el uso del compuesto como inhibidor de Lp-PLA2. (ver Fórmula).
MX2022005615A 2019-11-09 2020-11-09 Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceutica y uso del mismo. MX2022005615A (es)

Applications Claiming Priority (2)

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CN201911104067 2019-11-09
PCT/CN2020/127426 WO2021089032A1 (zh) 2019-11-09 2020-11-09 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途

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US (1) US20230044787A1 (es)
EP (1) EP4056571A4 (es)
JP (1) JP2023500710A (es)
KR (1) KR20220102628A (es)
CN (2) CN114805389B (es)
AU (1) AU2020379796B2 (es)
BR (1) BR112022008786A2 (es)
CA (1) CA3156783A1 (es)
CO (1) CO2022008171A2 (es)
IL (1) IL292668A (es)
MX (1) MX2022005615A (es)
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WO (1) WO2021089032A1 (es)

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CN112574221B (zh) * 2019-09-30 2022-03-04 上海纽思克生物科技有限公司 四环嘧啶酮类化合物、其制备方法、其组合物和用途
CN115304620A (zh) * 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途
CN114057740B (zh) * 2021-12-15 2024-04-02 上海赛默罗生物科技有限公司 螺环嘧啶酮衍生物、其制备方法、药物组合物和用途
WO2024027116A1 (en) * 2022-08-04 2024-02-08 4B Technologies (Beijing) Co., Limited Dihydroimidazo-pyrimidinone compounds as lp-pla2 inhibitors and use thereof
CN116008443B (zh) * 2023-03-28 2023-06-30 上海赛默罗生物科技有限公司 α5-GABAA受体调节剂类药物中有关物质的检测方法

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