NO341412B1 - Diketo-piperazin- og –piperidinderivater, farmasøytiske blandinger omfattende slike, slike blandinger omfattende ytterligere anti-HIV midler og slike blandinger for behandling av sykdom - Google Patents

Info

Publication number

NO341412B1

NO341412B1 NO20084257A NO20084257A NO341412B1 NO 341412 B1 NO341412 B1 NO 341412B1 NO 20084257 A NO20084257 A NO 20084257A NO 20084257 A NO20084257 A NO 20084257A NO 341412 B1 NO341412 B1 NO 341412B1

Authority

NO

Norway

Prior art keywords

group

heteroaryl

alkyl

phenyl

aryl

Prior art date

2006-04-25

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• 239000000203 mixture Substances 0.000 title claims description 258
• 238000011282 treatment Methods 0.000 title claims description 24
• 239000008194 pharmaceutical composition Substances 0.000 title description 9
• 201000010099 disease Diseases 0.000 title description 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 4
• 239000002259 anti human immunodeficiency virus agent Substances 0.000 title description 3
• 229940124411 anti-hiv antiviral agent Drugs 0.000 title description 3
• 150000003053 piperidines Chemical class 0.000 title description 3
• BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims description 224
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 119
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• 125000001072 heteroaryl group Chemical group 0.000 claims description 75
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• 125000000217 alkyl group Chemical group 0.000 claims description 60
• 125000003118 aryl group Chemical group 0.000 claims description 56
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 41
• RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 39
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• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 33
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• 239000001257 hydrogen Substances 0.000 claims description 32
• 239000003112 inhibitor Substances 0.000 claims description 32
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• 125000000168 pyrrolyl group Chemical group 0.000 claims description 3
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• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 2
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 2
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 2
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• OHPPTYAIBXOCNX-UHFFFAOYSA-N tert-butyl 4-[1-[2-(dimethylamino)ethyl]-3-phenylpyrazol-4-yl]piperazine-1-carboxylate Chemical compound C=1C=CC=CC=1C1=NN(CCN(C)C)C=C1N1CCN(C(=O)OC(C)(C)C)CC1 OHPPTYAIBXOCNX-UHFFFAOYSA-N 0.000 description 1
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• SEDZOYHHAIAQIW-UHFFFAOYSA-N trimethylsilyl azide Chemical compound C[Si](C)(C)N=[N+]=[N-] SEDZOYHHAIAQIW-UHFFFAOYSA-N 0.000 description 1
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