NO333531B1 - Vedvarende frigivelsessammensetning, farmasoytikum, fremgangsmate for fremstilling derav samt anvendelse - Google Patents
Vedvarende frigivelsessammensetning, farmasoytikum, fremgangsmate for fremstilling derav samt anvendelse Download PDFInfo
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- NO333531B1 NO333531B1 NO20035737A NO20035737A NO333531B1 NO 333531 B1 NO333531 B1 NO 333531B1 NO 20035737 A NO20035737 A NO 20035737A NO 20035737 A NO20035737 A NO 20035737A NO 333531 B1 NO333531 B1 NO 333531B1
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- Prior art keywords
- molecular weight
- lactic acid
- salt
- polymer
- sustained release
- Prior art date
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- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P15/18—Feminine contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| JP2001199462 | 2001-06-29 | ||
| JP2001340980 | 2001-11-06 | ||
| PCT/JP2002/006526 WO2003002091A2 (en) | 2001-06-29 | 2002-06-28 | Sustained-release composition comprising lactic acid-glycolic acid copolymer and process for producing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20035737D0 NO20035737D0 (no) | 2003-12-19 |
| NO20035737L NO20035737L (no) | 2004-02-20 |
| NO333531B1 true NO333531B1 (no) | 2013-07-01 |
Family
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| NO20035737A NO333531B1 (no) | 2001-06-29 | 2003-12-19 | Vedvarende frigivelsessammensetning, farmasoytikum, fremgangsmate for fremstilling derav samt anvendelse |
Country Status (32)
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| EP (2) | EP1399133B2 (sk) |
| JP (3) | JP5491318B2 (sk) |
| KR (3) | KR20090096755A (sk) |
| CN (1) | CN1535141B (sk) |
| AR (1) | AR034640A1 (sk) |
| AT (1) | ATE429903T1 (sk) |
| AU (1) | AU2002311630B2 (sk) |
| BR (1) | BR0210572A (sk) |
| CA (1) | CA2451718C (sk) |
| CO (1) | CO5540368A2 (sk) |
| CY (1) | CY1109272T1 (sk) |
| CZ (1) | CZ306388B6 (sk) |
| DE (1) | DE60232147D1 (sk) |
| DK (1) | DK1399133T4 (sk) |
| ES (1) | ES2324156T5 (sk) |
| HK (1) | HK1061802A1 (sk) |
| HU (1) | HU230152B1 (sk) |
| IL (1) | IL159060A0 (sk) |
| MX (1) | MXPA03011440A (sk) |
| MY (1) | MY139606A (sk) |
| NO (1) | NO333531B1 (sk) |
| NZ (1) | NZ529968A (sk) |
| PE (1) | PE20030069A1 (sk) |
| PL (1) | PL212531B1 (sk) |
| PT (1) | PT1399133E (sk) |
| RU (2) | RU2297240C2 (sk) |
| SI (1) | SI1399133T2 (sk) |
| SK (1) | SK287568B6 (sk) |
| TW (1) | TWI225416B (sk) |
| WO (1) | WO2003002091A2 (sk) |
| ZA (1) | ZA200309153B (sk) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101139112B1 (ko) * | 2002-06-25 | 2012-04-30 | 다케다 야쿠힌 고교 가부시키가이샤 | 서방성 조성물의 제조 방법 |
| ATE369388T1 (de) * | 2002-09-24 | 2007-08-15 | Asahi Kasei Chemicals Corp | Glycolsaüre copolymer und verfahren zu dessen herstellung |
| TW200529890A (en) | 2004-02-10 | 2005-09-16 | Takeda Pharmaceutical | Sustained-release preparations |
| TW200613012A (en) * | 2004-07-02 | 2006-05-01 | Takeda Pharmaceuticals Co | Sustained-release composition, process for producing the same and use of the same |
| DE602006000381T2 (de) * | 2005-04-28 | 2008-12-18 | Nipro Corp., Osaka | Bioabsorbierbare pharmazeutische Zusammensetzung enthaltend einen PLGA-Copolymer |
| US20070196416A1 (en) | 2006-01-18 | 2007-08-23 | Quest Pharmaceutical Services | Pharmaceutical compositions with enhanced stability |
| ES2791698T3 (es) | 2006-12-18 | 2020-11-05 | Takeda Pharmaceuticals Co | Composición de liberación sostenida y método para producir la misma |
| PL3660073T3 (pl) | 2007-02-15 | 2023-12-27 | Tolmar International Limited | Poli(laktyd-ko-glikolid) o niskim nagłym uwalnianiu |
| KR101008462B1 (ko) * | 2007-07-26 | 2011-01-14 | 조남열 | 치어류 이동용 어도 장치 |
| KR100969641B1 (ko) * | 2007-11-12 | 2010-07-14 | 민선영 | 저수지의 제방용 어도 |
| KR100969642B1 (ko) * | 2007-11-15 | 2010-07-12 | 민선영 | 하천의 보용 어도 |
| TWI477266B (zh) * | 2009-11-05 | 2015-03-21 | Taiwan Biotech Co Ltd | 連續製備微粒的方法、裝置及其收集單元 |
| US8641900B2 (en) | 2009-11-05 | 2014-02-04 | Taiwan Biotech Co., Ltd | Method and device for continuously preparing microspheres, and collection unit thereof |
| WO2012140487A1 (en) * | 2011-04-11 | 2012-10-18 | Cellcura Asa | Protein-free culture media products for manufacturing viral-based vaccines |
| JP6246712B2 (ja) | 2012-07-12 | 2017-12-13 | 武田薬品工業株式会社 | マイクロカプセル粉末の製造方法 |
| RU2572992C2 (ru) * | 2012-08-28 | 2016-01-20 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Курская государственная сельскохозяйственная академия имени И.И. Иванова" | Способ получения микрокапсул водорастворимых препаратов пестицидов |
| WO2014168134A1 (ja) | 2013-04-11 | 2014-10-16 | 三井化学株式会社 | 乳酸―グリコール酸共重合体の製造法またはその塩の製造法 |
| RU2537248C1 (ru) * | 2013-05-24 | 2014-12-27 | Екатерина Евгеньевна Быковская | Способ получения микрокапсул гетероциклических соединений триазинового ряда |
| RU2537173C1 (ru) * | 2013-05-24 | 2014-12-27 | Александр Александрович Кролевец | Способ получения микрокапсул гетероциклических соединений триазинового ряда |
| WO2015088990A1 (en) | 2013-12-09 | 2015-06-18 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
| CN106456704A (zh) | 2014-04-16 | 2017-02-22 | Veyx-药物有限公司 | 兽药组合物和其应用 |
| TW201618783A (zh) | 2014-08-07 | 2016-06-01 | 艾森塔製藥公司 | 以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法 |
| CN104224731A (zh) * | 2014-09-11 | 2014-12-24 | 北京天晟泰丰医药科技有限公司 | 一种不含致敏性辅料的九肽微球的制备方法 |
| JP5938762B1 (ja) | 2015-09-01 | 2016-06-22 | 日揮株式会社 | マイクロカプセル製剤及びその製造方法 |
| CN110856690B (zh) * | 2018-08-22 | 2024-07-02 | 深圳善康医药科技股份有限公司 | 一种植入剂包膜及干燥装置 |
| WO2021234731A1 (en) * | 2020-05-18 | 2021-11-25 | Dr Reddy's Institute Of Life Sciences | Sustained release compositions |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| JPH0678425B2 (ja) | 1984-07-06 | 1994-10-05 | 和光純薬工業株式会社 | 重合体の新規製造法 |
| CA1256638A (en) * | 1984-07-06 | 1989-06-27 | Motoaki Tanaka | Polymer and its production |
| EP0190833B1 (en) | 1985-02-07 | 1991-03-27 | Takeda Chemical Industries, Ltd. | Method for producing microcapsule |
| JPH0720859B2 (ja) | 1985-02-07 | 1995-03-08 | 武田薬品工業株式会社 | マイクロカプセルの製造法 |
| JP2551756B2 (ja) | 1985-05-07 | 1996-11-06 | 武田薬品工業株式会社 | ポリオキシカルボン酸エステルおよびその製造法 |
| US5110904A (en) | 1989-08-07 | 1992-05-05 | Abbott Laboratories | Lhrh analogs |
| CA1339679C (en) | 1988-02-10 | 1998-02-17 | Tap Pharmaceuticals Inc. | Reduced size lhrh analogs |
| JP3200706B2 (ja) | 1990-04-13 | 2001-08-20 | 武田薬品工業株式会社 | 生体内分解型高分子重合物 |
| DE69129770T2 (de) * | 1990-04-13 | 1998-11-19 | Takeda Chemical Industries Ltd | Biologisch abbaubare hochmolekulare Polymere, ihre Herstellung und ihre Verwendung |
| CA2079509C (en) * | 1991-10-01 | 2002-05-14 | Shigeyuki Takada | Prolonged release microparticle preparation and production of the same |
| JP3277342B2 (ja) * | 1992-09-02 | 2002-04-22 | 武田薬品工業株式会社 | 徐放性マイクロカプセルの製造法 |
| TW333456B (en) | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
| NZ260909A (en) * | 1993-07-05 | 1995-04-27 | Takeda Chemical Industries Ltd | Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution |
| JP3761594B2 (ja) * | 1993-07-05 | 2006-03-29 | 武田薬品工業株式会社 | 徐放性製剤の製造法 |
| JPH08259460A (ja) | 1995-01-23 | 1996-10-08 | Takeda Chem Ind Ltd | 徐放性製剤の製造法 |
| CA2192782C (en) * | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| JPH11269094A (ja) | 1998-01-16 | 1999-10-05 | Takeda Chem Ind Ltd | 徐放性組成物、その製造法および用途 |
| PL341733A1 (en) * | 1998-01-16 | 2001-05-07 | Takeda Chemical Industries Ltd | Prolonged release composition, method of obtaining same and application thereof |
| CA2355186C (en) * | 1998-12-15 | 2008-03-18 | Takeda Chemical Industries, Ltd. | Process for producing polymer |
| JP3716146B2 (ja) * | 1998-12-15 | 2005-11-16 | 武田薬品工業株式会社 | ポリマーの製造方法 |
| JP2002114667A (ja) | 2000-10-11 | 2002-04-16 | Ltt Institute Co Ltd | 徐放性製剤用組成物、その製造法および徐放性マイクロカプセル製剤 |
| AR034641A1 (es) * | 2001-06-29 | 2004-03-03 | Takeda Pharmaceutical | Composicion de liberacion controlada y metodo para producirla |
| KR101139112B1 (ko) * | 2002-06-25 | 2012-04-30 | 다케다 야쿠힌 고교 가부시키가이샤 | 서방성 조성물의 제조 방법 |
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- 2002-06-26 AR ARP020102405A patent/AR034640A1/es not_active Application Discontinuation
- 2002-06-27 MY MYPI20022432A patent/MY139606A/en unknown
- 2002-06-27 PE PE2002000577A patent/PE20030069A1/es not_active Application Discontinuation
- 2002-06-28 AT AT02738837T patent/ATE429903T1/de active
- 2002-06-28 HU HU0400382A patent/HU230152B1/hu unknown
- 2002-06-28 NZ NZ529968A patent/NZ529968A/en not_active IP Right Cessation
- 2002-06-28 EP EP02738837A patent/EP1399133B2/en not_active Expired - Lifetime
- 2002-06-28 IL IL15906002A patent/IL159060A0/xx active IP Right Grant
- 2002-06-28 KR KR1020097017748A patent/KR20090096755A/ko not_active Application Discontinuation
- 2002-06-28 RU RU2004102503/15A patent/RU2297240C2/ru active
- 2002-06-28 ES ES02738837T patent/ES2324156T5/es not_active Expired - Lifetime
- 2002-06-28 KR KR1020097017747A patent/KR100988178B1/ko active IP Right Grant
- 2002-06-28 US US10/479,516 patent/US20040241229A1/en not_active Abandoned
- 2002-06-28 PL PL367491A patent/PL212531B1/pl not_active IP Right Cessation
- 2002-06-28 WO PCT/JP2002/006526 patent/WO2003002091A2/en active Application Filing
- 2002-06-28 MX MXPA03011440A patent/MXPA03011440A/es active IP Right Grant
- 2002-06-28 CN CN028130413A patent/CN1535141B/zh not_active Expired - Lifetime
- 2002-06-28 KR KR10-2003-7017111A patent/KR20040018401A/ko active Search and Examination
- 2002-06-28 SK SK1561-2003A patent/SK287568B6/sk unknown
- 2002-06-28 CA CA2451718A patent/CA2451718C/en not_active Expired - Fee Related
- 2002-06-28 DE DE60232147T patent/DE60232147D1/de not_active Expired - Lifetime
- 2002-06-28 SI SI200230837T patent/SI1399133T2/sl unknown
- 2002-06-28 EP EP09155256A patent/EP2108363A1/en not_active Withdrawn
- 2002-06-28 DK DK02738837.0T patent/DK1399133T4/da active
- 2002-06-28 BR BR0210572-1A patent/BR0210572A/pt not_active Application Discontinuation
- 2002-06-28 PT PT02738837T patent/PT1399133E/pt unknown
- 2002-06-28 AU AU2002311630A patent/AU2002311630B2/en not_active Expired
- 2002-06-28 CZ CZ2003-3492A patent/CZ306388B6/cs not_active IP Right Cessation
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- 2003-12-19 NO NO20035737A patent/NO333531B1/no not_active IP Right Cessation
- 2003-12-22 CO CO03111730A patent/CO5540368A2/es not_active Application Discontinuation
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2004
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- 2006-12-05 RU RU2006143104/15A patent/RU2434644C2/ru active
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