DE69129770T2 - Biologisch abbaubare hochmolekulare Polymere, ihre Herstellung und ihre Verwendung - Google Patents

Biologisch abbaubare hochmolekulare Polymere, ihre Herstellung und ihre Verwendung

Info

Publication number
DE69129770T2
DE69129770T2 DE69129770T DE69129770T DE69129770T2 DE 69129770 T2 DE69129770 T2 DE 69129770T2 DE 69129770 T DE69129770 T DE 69129770T DE 69129770 T DE69129770 T DE 69129770T DE 69129770 T2 DE69129770 T2 DE 69129770T2
Authority
DE
Germany
Prior art keywords
molecular weight
production
high molecular
weight polymers
biodegradable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69129770T
Other languages
English (en)
Other versions
DE69129770D1 (de
Inventor
Minoru Yamada
Toshiro Heya
Yasuaki Ogawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE69129770D1 publication Critical patent/DE69129770D1/de
Application granted granted Critical
Publication of DE69129770T2 publication Critical patent/DE69129770T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/90—Purification; Drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69129770T 1990-04-13 1991-04-10 Biologisch abbaubare hochmolekulare Polymere, ihre Herstellung und ihre Verwendung Expired - Lifetime DE69129770T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9851090 1990-04-13

Publications (2)

Publication Number Publication Date
DE69129770D1 DE69129770D1 (de) 1998-08-20
DE69129770T2 true DE69129770T2 (de) 1998-11-19

Family

ID=14221647

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69129770T Expired - Lifetime DE69129770T2 (de) 1990-04-13 1991-04-10 Biologisch abbaubare hochmolekulare Polymere, ihre Herstellung und ihre Verwendung

Country Status (6)

Country Link
US (1) US5585460A (de)
EP (1) EP0452111B1 (de)
AT (1) ATE168391T1 (de)
CA (1) CA2040141C (de)
DE (1) DE69129770T2 (de)
HU (1) HUT59943A (de)

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MY108621A (en) * 1990-08-01 1996-10-31 Novartis Ag Polylactide preparation and purification
NZ276088A (en) 1993-11-19 1999-07-29 Janssen Pharmaceutica Nv [(1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-6,7,8,9-tetrahydro-4h- pyrido[1,2-a]-pyrimidin-4-one derivatives (ie risperidone)
US5942597A (en) * 1995-08-21 1999-08-24 The Procter & Gamble Company Solvent extraction of polyhydroxyalkanoates from biomass
TW448055B (en) * 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
US5821299A (en) * 1996-02-16 1998-10-13 The Proctor & Gamble Company Solvent extraction of polyhydroxy-alkanoates from biomass facilitated by the use of marginal nonsolvent
US5980948A (en) * 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
AU6971598A (en) * 1997-04-15 1998-11-11 Monsanto Company Methods of pha extraction and recovery using non-halogenated solvents
EP0973930B1 (de) * 1997-04-15 2007-06-13 Metabolix, Inc. Hochtemperatur-pha extraktion mit schlecht-lösenden lösungsmittel für pha
US5989463A (en) * 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
EP2196484B1 (de) 1997-12-22 2012-08-22 Metabolix, Inc. Polyhydroxyalkanoatzusammensetzungen mit kontrollierten Abbaugeschwindigkeiten
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
EP2305324B1 (de) 1999-03-25 2014-09-17 Metabolix, Inc. Medizinische Geräte und Anwendungen aus Polyhydroxyalkanoat-Polymeren
EP1310517B2 (de) * 2000-08-07 2010-11-17 Wako Pure Chemical Industries, Ltd. Milchsäurepolymer und verfahren zu dessen herstellung
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
TW200526267A (en) * 2001-06-29 2005-08-16 Takeda Chemical Industries Ltd Controlled release composition and method of producing the same
TWI225416B (en) † 2001-06-29 2004-12-21 Takeda Chemical Industries Ltd Sustained-release composition and process for producing the same
WO2003055470A1 (fr) * 2001-12-26 2003-07-10 Takeda Chemical Industries, Ltd. Nouvelle microsphere et son procede de production
EP1509182A4 (de) 2002-05-31 2009-12-30 Titan Pharmaceuticals Inc Implantierbare polymere vorrichtung zur verzögerten freisetzung von buprenorphin
KR100709015B1 (ko) * 2002-11-13 2007-04-18 (주)아모레퍼시픽 지속적 약물방출이 가능한 고분자 미립구 및 그 제조방법
CN1777426A (zh) 2003-03-31 2006-05-24 泰坦医药品公司 用于持续释放多巴胺受体激动剂的可植入聚合物装置
ES2527857T3 (es) 2003-05-08 2015-01-30 Tepha, Inc. Tejidos y fibras médicas de polihidroxialcanoato
TW200529890A (en) * 2004-02-10 2005-09-16 Takeda Pharmaceutical Sustained-release preparations
TW200613012A (en) * 2004-07-02 2006-05-01 Takeda Pharmaceuticals Co Sustained-release composition, process for producing the same and use of the same
WO2006015276A2 (en) 2004-08-03 2006-02-09 Tepha, Inc. Non-curling polyhydroxyalkanoate sutures
US7342048B2 (en) * 2005-04-28 2008-03-11 Nipro Corporation Bioabsorbable pharmaceutical formulation
WO2007084460A2 (en) 2006-01-18 2007-07-26 Qps, Llc Pharmaceutical compositions with enhanced stability
US20070179276A1 (en) * 2006-01-31 2007-08-02 Purac Biochem Bv Method for the purification of resorbable polymers from residual monomers
US8076448B2 (en) 2006-10-11 2011-12-13 Tolmar Therapeutics, Inc. Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US8414424B2 (en) * 2006-12-12 2013-04-09 Acushnet Company Anti-counterfeiting system using compound additives
WO2008075762A1 (en) * 2006-12-18 2008-06-26 Takeda Pharmaceutical Company Limited Sustained-release composition and method for producing the same
HUE025842T2 (en) 2007-02-15 2016-04-28 Tolmar Therapeutics Inc Poly (lactide / glycolide) with reduced fracture properties and methods for producing polymers
DE102007020951A1 (de) * 2007-05-04 2008-11-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren und Vorrichtung zur Reinigung eines resorbierbaren Polyesters
CA2742361C (en) * 2008-11-07 2013-07-30 Samyang Corporation Highly purified polylactic acid or a derivative thereof, a salt of the same, and purification method thereof
EP2411440B1 (de) * 2009-03-23 2018-01-17 Micell Technologies, Inc. Verbesserte biologisch abbaubare polymere
US8293444B2 (en) 2009-06-24 2012-10-23 Xerox Corporation Purified polyester resins for toner performance improvement
JP5959728B2 (ja) 2013-04-11 2016-08-02 三井化学株式会社 乳酸―グリコール酸共重合体の製造法またはその塩の製造法
US10500303B2 (en) 2014-08-15 2019-12-10 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US20160106804A1 (en) 2014-10-15 2016-04-21 Yuhua Li Pharmaceutical composition with improved stability
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
CA2969429C (en) 2014-12-11 2020-10-27 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
CN112940234B (zh) * 2021-01-28 2022-05-03 广东粤港澳大湾区黄埔材料研究院 一种高纯度聚乙丙交酯的制备方法

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US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
EP0190833B1 (de) * 1985-02-07 1991-03-27 Takeda Chemical Industries, Ltd. Verfahren zur Herstellung von Mikrokapseln
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
DE3708916A1 (de) * 1987-03-19 1988-09-29 Boehringer Ingelheim Kg Verfahren zur reinigung resorbierbarer polyester
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
US5182258A (en) * 1989-03-20 1993-01-26 Orbon Corporation Systemic delivery of polypeptides through the eye

Also Published As

Publication number Publication date
CA2040141C (en) 2002-05-14
US5585460A (en) 1996-12-17
CA2040141A1 (en) 1991-10-14
ATE168391T1 (de) 1998-08-15
EP0452111A2 (de) 1991-10-16
EP0452111B1 (de) 1998-07-15
HUT59943A (en) 1992-07-28
DE69129770D1 (de) 1998-08-20
HU911222D0 (en) 1991-10-28
EP0452111A3 (en) 1992-08-05

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP