NO324049B1 - Benzimidazol-derivater, anvendelse av disse for fremstilling av terapeutisk middel for behandling av sykdommer samt farmasoytiske preparater omfattende slike - Google Patents
Benzimidazol-derivater, anvendelse av disse for fremstilling av terapeutisk middel for behandling av sykdommer samt farmasoytiske preparater omfattende slike Download PDFInfo
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- NO324049B1 NO324049B1 NO20023415A NO20023415A NO324049B1 NO 324049 B1 NO324049 B1 NO 324049B1 NO 20023415 A NO20023415 A NO 20023415A NO 20023415 A NO20023415 A NO 20023415A NO 324049 B1 NO324049 B1 NO 324049B1
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- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 229940124597 therapeutic agent Drugs 0.000 title claims description 6
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title abstract description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 7
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- HUPQYPMULVBQDL-UHFFFAOYSA-N pentanoic acid Chemical compound CCCCC(O)=O.CCCCC(O)=O HUPQYPMULVBQDL-UHFFFAOYSA-N 0.000 description 1
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- JCBJVAJGLKENNC-UHFFFAOYSA-M potassium ethyl xanthate Chemical compound [K+].CCOC([S-])=S JCBJVAJGLKENNC-UHFFFAOYSA-M 0.000 description 1
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- PTLIIZJLRPOFJR-UHFFFAOYSA-N tert-butyl hydrogen sulfite Chemical compound CC(C)(C)OS(O)=O PTLIIZJLRPOFJR-UHFFFAOYSA-N 0.000 description 1
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- LZGVDNRJCGPNDS-UHFFFAOYSA-N trinitromethane Chemical compound [O-][N+](=O)C([N+]([O-])=O)[N+]([O-])=O LZGVDNRJCGPNDS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000007533 | 2000-01-17 | ||
| JP2000392303 | 2000-12-25 | ||
| PCT/JP2001/000271 WO2001053291A1 (fr) | 2000-01-17 | 2001-01-17 | Derives benzimidazoles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20023415D0 NO20023415D0 (no) | 2002-07-16 |
| NO20023415L NO20023415L (no) | 2002-07-16 |
| NO324049B1 true NO324049B1 (no) | 2007-08-06 |
Family
ID=26583615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20023415A NO324049B1 (no) | 2000-01-17 | 2002-07-16 | Benzimidazol-derivater, anvendelse av disse for fremstilling av terapeutisk middel for behandling av sykdommer samt farmasoytiske preparater omfattende slike |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1249450B1 (ko) |
| JP (1) | JP4059671B2 (ko) |
| KR (2) | KR100763779B1 (ko) |
| CN (2) | CN1198819C (ko) |
| AT (1) | ATE375156T1 (ko) |
| AU (2) | AU777813B2 (ko) |
| CA (1) | CA2396908A1 (ko) |
| CZ (1) | CZ301504B6 (ko) |
| DE (1) | DE60130865T2 (ko) |
| DK (1) | DK1249450T3 (ko) |
| ES (1) | ES2295128T3 (ko) |
| HK (1) | HK1050009A1 (ko) |
| IL (1) | IL150565A0 (ko) |
| NO (1) | NO324049B1 (ko) |
| NZ (1) | NZ520028A (ko) |
| PT (1) | PT1249450E (ko) |
| RU (1) | RU2263674C2 (ko) |
| SI (1) | SI1249450T1 (ko) |
| WO (1) | WO2001053291A1 (ko) |
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| AU2002233698B2 (en) * | 2001-02-22 | 2007-11-08 | Teijin Limited | Benzo(b)thiophene derivative and process for producing the same |
| EP1298130B1 (en) | 2001-05-07 | 2008-08-13 | Teijin Pharma Limited | 3-hydroxymethylbenzo b thiophene derivatives and process for their preparation |
| KR100902799B1 (ko) * | 2001-08-24 | 2009-06-12 | 데이진 가부시키가이샤 | 키마제 저해제 및 ａｃｅ 저해제를 유효성분으로 함유하는약제 |
| CL2004001034A1 (es) * | 2003-05-14 | 2005-03-28 | Teijin Pharma Ltd | Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r |
| WO2005018672A1 (ja) * | 2003-08-22 | 2005-03-03 | Teijin Pharma Limited | キマーゼ阻害剤を有効成分として含有する薬剤 |
| JPWO2006052026A1 (ja) * | 2004-11-12 | 2008-05-29 | 帝人ファーマ株式会社 | ベンズイミダゾール誘導体の酸性塩及びその結晶 |
| WO2007021033A1 (ja) | 2005-08-18 | 2007-02-22 | Teijin Pharma Limited | 複数の薬物保持部位がある錠剤 |
| EP3205337A1 (en) | 2005-08-18 | 2017-08-16 | Teijin Pharma Limited | Formulation having accurate dose-dividing function |
| WO2007049812A1 (ja) | 2005-10-27 | 2007-05-03 | Teijin Pharma Limited | ３－ヒドロキシメチルベンゾ［ｂ］チオフェン誘導体およびその製造方法 |
| JP2007145827A (ja) | 2005-10-27 | 2007-06-14 | Teijin Pharma Ltd | ベンゾ［ｂ］チオフェン誘導体およびその製造方法 |
| PE20070698A1 (es) | 2005-11-14 | 2007-08-17 | Teijin Pharma Ltd | Comprimido de disgregacion rapida intraoral que contiene hidrocloruro de ambroxol |
| UA95788C2 (en) * | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
| WO2008147697A1 (en) * | 2007-05-22 | 2008-12-04 | Boehringer Ingelheim International Gmbh | Benzimidazolone chymase inhibitors |
| TWI443090B (zh) | 2007-05-25 | 2014-07-01 | Abbvie Deutschland | 作為代謝性麩胺酸受體２（ｍｇｌｕ２ 受體）之正向調節劑之雜環化合物 |
| WO2008153129A1 (ja) * | 2007-06-14 | 2008-12-18 | Teijin Pharma Limited | 尿酸値低下剤 |
| WO2009133964A1 (ja) * | 2008-04-28 | 2009-11-05 | 国立大学法人九州大学 | 酸化ストレス抑制剤 |
| WO2010030500A1 (en) * | 2008-09-09 | 2010-03-18 | Boehringer Ingelheim International Gmbh | Aza-benzimidazolone chymase inhibitors |
| MX2011003239A (es) | 2008-09-26 | 2011-04-28 | Merck Sharp & Dohme | Nuevos derivados de bencimidazol ciclicos utiles como agentes anti-diabeticos. |
| EP2348857B1 (en) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| MX2011004505A (es) | 2008-10-29 | 2011-05-31 | Merck Sharp & Dohme | Derivados novedosos de bencimidazol ciclico, utiles como agentes antidiabeticos. |
| CA2741672A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| WO2011062550A1 (en) * | 2009-11-18 | 2011-05-26 | Astrazeneca Ab | Benzoimidazole compounds and uses thereof |
| US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| MX348131B (es) | 2011-02-25 | 2017-05-26 | Merck Sharp & Dohme | Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos. |
| AU2013255470B2 (en) * | 2012-05-04 | 2015-09-17 | Novartis Ag | Complement pathway modulators and uses thereof |
| US20140045746A1 (en) | 2012-08-02 | 2014-02-13 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| EP2906040B1 (en) | 2012-08-22 | 2021-02-17 | Merck Sharp & Dohme Corp. | Novel benzimidazole tetrahydropyran derivatives |
| ES2755087T3 (es) | 2012-08-22 | 2020-04-21 | Merck Sharp & Dohme | Derivados de benzimidazol hexahidrofuro[3,2-b]furano útiles como activadores de proteína cinasa activada por AMP |
| US9540364B2 (en) | 2012-08-22 | 2017-01-10 | Merck Sharp & Dohme Corp. | Benzimidazole tetrahydrofuran derivatives |
| US9290517B2 (en) | 2012-08-22 | 2016-03-22 | Merck Sharp & Dohme Corp. | Azabenzimidazole hexahydrofuro[3,2-b]furan derivatives |
| WO2014031465A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel azabenzimidazole tetrahydropyran derivatives |
| US9868733B2 (en) | 2012-08-22 | 2018-01-16 | Merck Sharp & Dohme Corp. | Azabenzimidazole tetrahydrofuran derivatives |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| US10519115B2 (en) | 2013-11-15 | 2019-12-31 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2015089809A1 (en) | 2013-12-19 | 2015-06-25 | Merck Sharp & Dohme Corp. | Antidiabetic substituted heteroaryl compounds |
| CN111004125B (zh) * | 2019-12-24 | 2022-11-22 | 东华理工大学 | 一种缩醛或缩酮化合物的制备方法 |
| CN116903541B (zh) * | 2023-08-14 | 2023-12-08 | 中国环境科学研究院 | 用于酚类污染物检测的酰基咪唑类化合物、制备方法及应用 |
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| FR2430950A1 (fr) * | 1978-07-10 | 1980-02-08 | Delalande Sa | Nouveaux derives heterocycliques de la benzimidazole, leur procede de preparation et leur application en therapeutique |
| DE2928055A1 (de) * | 1978-07-12 | 1980-01-31 | Eastman Kodak Co | Verfahren zur verbesserung der widerstandsfaehigkeit von polyesterformkoerpern gegenueber einem abbau durch u.v.- licht |
| JPS62212386A (ja) * | 1986-03-14 | 1987-09-18 | Suntory Ltd | ２−ピリジルメチルベンズイミダゾ−ル誘導体 |
| JPH01265089A (ja) * | 1988-04-15 | 1989-10-23 | Zeria Pharmaceut Co Ltd | 新規１−（イミダゾール−４−イル）メチルベンズイミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤 |
| GB9225141D0 (en) * | 1992-12-01 | 1993-01-20 | Smithkline Beecham Corp | Chemical compounds |
| US5527597A (en) * | 1995-03-01 | 1996-06-18 | Southern Mills, Inc. | Stretchable flame resistant fabric |
| WO1999026932A1 (en) * | 1997-11-26 | 1999-06-03 | Axys Pharmaceuticals, Inc. | By amidino group substituted heterocyclic derivatives and their use as anticoagulants |
| TR200100047T2 (tr) * | 1998-07-15 | 2001-10-22 | Teijin Limited | Tiyobenzimidazol türevleri |
| CA2376785A1 (en) * | 1999-06-28 | 2001-01-04 | Janssen Pharmaceutica N.V. | Benzimidazoles and imidazopyridines as respiratory syncytial virus replication inhibitors |
| CZ2001153A3 (cs) * | 1999-07-14 | 2001-06-13 | Teijin Ltd | Thiobenzimidazolové deriváty |
-
2001
- 2001-01-17 CZ CZ20022442A patent/CZ301504B6/cs not_active IP Right Cessation
- 2001-01-17 AT AT01901397T patent/ATE375156T1/de not_active IP Right Cessation
- 2001-01-17 CN CNB018066623A patent/CN1198819C/zh not_active Expired - Fee Related
- 2001-01-17 IL IL15056501A patent/IL150565A0/xx not_active IP Right Cessation
- 2001-01-17 AU AU27049/01A patent/AU777813B2/en not_active Ceased
- 2001-01-17 KR KR1020027009200A patent/KR100763779B1/ko not_active IP Right Cessation
- 2001-01-17 KR KR1020077010650A patent/KR20070057276A/ko active IP Right Grant
- 2001-01-17 CN CNB2005100526041A patent/CN100415723C/zh not_active Expired - Fee Related
- 2001-01-17 RU RU2002122105/04A patent/RU2263674C2/ru not_active IP Right Cessation
- 2001-01-17 JP JP2001553765A patent/JP4059671B2/ja not_active Expired - Fee Related
- 2001-01-17 CA CA002396908A patent/CA2396908A1/en not_active Abandoned
- 2001-01-17 PT PT01901397T patent/PT1249450E/pt unknown
- 2001-01-17 DK DK01901397T patent/DK1249450T3/da active
- 2001-01-17 SI SI200130792T patent/SI1249450T1/sl unknown
- 2001-01-17 EP EP01901397A patent/EP1249450B1/en not_active Expired - Lifetime
- 2001-01-17 ES ES01901397T patent/ES2295128T3/es not_active Expired - Lifetime
- 2001-01-17 DE DE60130865T patent/DE60130865T2/de not_active Expired - Lifetime
- 2001-01-17 WO PCT/JP2001/000271 patent/WO2001053291A1/ja active IP Right Grant
- 2001-01-17 NZ NZ520028A patent/NZ520028A/en unknown
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2002
- 2002-07-16 NO NO20023415A patent/NO324049B1/no not_active IP Right Cessation
-
2003
- 2003-03-31 HK HK03102300A patent/HK1050009A1/xx not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2001053291A1 (fr) | 2001-07-26 |
| CA2396908A1 (en) | 2001-07-26 |
| NO20023415D0 (no) | 2002-07-16 |
| IL150565A0 (en) | 2003-02-12 |
| SI1249450T1 (sl) | 2008-04-30 |
| DE60130865D1 (de) | 2007-11-22 |
| KR100763779B1 (ko) | 2007-10-05 |
| CN1680339A (zh) | 2005-10-12 |
| DK1249450T3 (da) | 2008-02-11 |
| CN100415723C (zh) | 2008-09-03 |
| AU2005200172A1 (en) | 2005-02-10 |
| AU2005200172B2 (en) | 2007-08-23 |
| RU2002122105A (ru) | 2004-01-10 |
| JP4059671B2 (ja) | 2008-03-12 |
| EP1249450B1 (en) | 2007-10-10 |
| NO20023415L (no) | 2002-07-16 |
| ES2295128T3 (es) | 2008-04-16 |
| ATE375156T1 (de) | 2007-10-15 |
| EP1249450A4 (en) | 2003-04-09 |
| KR20020065929A (ko) | 2002-08-14 |
| AU777813B2 (en) | 2004-11-04 |
| CZ301504B6 (cs) | 2010-03-24 |
| CN1418211A (zh) | 2003-05-14 |
| KR20070057276A (ko) | 2007-06-04 |
| EP1249450A1 (en) | 2002-10-16 |
| HK1050009A1 (en) | 2003-06-06 |
| PT1249450E (pt) | 2008-01-02 |
| DE60130865T2 (de) | 2008-07-17 |
| NZ520028A (en) | 2004-07-30 |
| AU2704901A (en) | 2001-07-31 |
| CN1198819C (zh) | 2005-04-27 |
| RU2263674C2 (ru) | 2005-11-10 |
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