DE60130865D1 - Benzimidazol-derivate als menschliche chymase - inhibitoren - Google Patents
Benzimidazol-derivate als menschliche chymase - inhibitorenInfo
- Publication number
- DE60130865D1 DE60130865D1 DE60130865T DE60130865T DE60130865D1 DE 60130865 D1 DE60130865 D1 DE 60130865D1 DE 60130865 T DE60130865 T DE 60130865T DE 60130865 T DE60130865 T DE 60130865T DE 60130865 D1 DE60130865 D1 DE 60130865D1
- Authority
- DE
- Germany
- Prior art keywords
- halo
- optionally substituted
- oxo
- trihalomethyl
- alk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000007533 | 2000-01-17 | ||
JP2000007533 | 2000-01-17 | ||
JP2000392303 | 2000-12-25 | ||
JP2000392303 | 2000-12-25 | ||
PCT/JP2001/000271 WO2001053291A1 (fr) | 2000-01-17 | 2001-01-17 | Derives benzimidazoles |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60130865D1 true DE60130865D1 (de) | 2007-11-22 |
DE60130865T2 DE60130865T2 (de) | 2008-07-17 |
Family
ID=26583615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60130865T Expired - Lifetime DE60130865T2 (de) | 2000-01-17 | 2001-01-17 | Benzimidazol-derivate als menschliche chymase - inhibitoren |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1249450B1 (de) |
JP (1) | JP4059671B2 (de) |
KR (2) | KR20070057276A (de) |
CN (2) | CN100415723C (de) |
AT (1) | ATE375156T1 (de) |
AU (2) | AU777813B2 (de) |
CA (1) | CA2396908A1 (de) |
CZ (1) | CZ301504B6 (de) |
DE (1) | DE60130865T2 (de) |
DK (1) | DK1249450T3 (de) |
ES (1) | ES2295128T3 (de) |
HK (1) | HK1050009A1 (de) |
IL (1) | IL150565A0 (de) |
NO (1) | NO324049B1 (de) |
NZ (1) | NZ520028A (de) |
PT (1) | PT1249450E (de) |
RU (1) | RU2263674C2 (de) |
SI (1) | SI1249450T1 (de) |
WO (1) | WO2001053291A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1362854B1 (de) * | 2001-02-22 | 2007-10-31 | Teijin Pharma Limited | Benzo[b[thiophenderivate und Verfahren zu deren Herstellung |
US6774245B2 (en) * | 2001-05-07 | 2004-08-10 | Teijin Limited | 3-Hydroxymethylbenzo[b]thiophene derivatives and process for their preparation |
NZ528291A (en) * | 2001-08-24 | 2007-03-30 | Teijin Ltd | Drugs containing chymase inhibitor and ace inhibitor as the active ingredients |
CL2004001034A1 (es) * | 2003-05-14 | 2005-03-28 | Teijin Pharma Ltd | Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r |
AU2004266536A1 (en) * | 2003-08-22 | 2005-03-03 | Teijin Pharma Limited | Drug containing chymase inhibitor as the active ingredient |
WO2006052026A1 (ja) * | 2004-11-12 | 2006-05-18 | Teijin Pharma Limited | ベンズイミダゾール誘導体の酸性塩及びその結晶 |
EP1915988A4 (de) | 2005-08-18 | 2012-07-25 | Teijin Pharma Ltd | Tablette mit mehreren arzneihaltigen segmenten |
CN101291656B (zh) | 2005-08-18 | 2012-11-07 | 帝人制药株式会社 | 具有准确的用量分割功能的制剂 |
EP1947097A1 (de) | 2005-10-27 | 2008-07-23 | Teijin Pharma Limited | Benzo[b]thiophenderivat und verfahren zu dessen herstellung |
BRPI0617924A2 (pt) | 2005-10-27 | 2016-08-23 | Teijin Pharma Ltd | processo de produção, e, composto |
PE20070698A1 (es) | 2005-11-14 | 2007-08-17 | Teijin Pharma Ltd | Comprimido de disgregacion rapida intraoral que contiene hidrocloruro de ambroxol |
UA95788C2 (en) * | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
WO2008147697A1 (en) * | 2007-05-22 | 2008-12-04 | Boehringer Ingelheim International Gmbh | Benzimidazolone chymase inhibitors |
EP2167464B1 (de) | 2007-05-25 | 2014-12-03 | AbbVie Deutschland GmbH & Co KG | Heterocyclische verbindungen als positive modulatoren des metabotropen glutamatrezeptors 2 (mglu2-rezeptor) |
WO2008153129A1 (ja) * | 2007-06-14 | 2008-12-18 | Teijin Pharma Limited | 尿酸値低下剤 |
WO2009133964A1 (ja) * | 2008-04-28 | 2009-11-05 | 国立大学法人九州大学 | 酸化ストレス抑制剤 |
CA2736522C (en) * | 2008-09-09 | 2016-09-13 | Boehringer Ingelheim International Gmbh | Aza-benzimidazolone chymase inhibitors |
CA2737694C (en) | 2008-09-26 | 2013-07-02 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
CN102264228A (zh) | 2008-10-22 | 2011-11-30 | 默沙东公司 | 用于抗糖尿病药的新的环状苯并咪唑衍生物 |
WO2010051176A1 (en) | 2008-10-29 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
CA2777746C (en) * | 2009-11-18 | 2019-05-14 | Astrazeneca Ab | Benzoimidazole compounds and uses thereof |
WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
CA2826649C (en) | 2011-02-25 | 2016-07-26 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
PT2855456T (pt) * | 2012-05-04 | 2017-07-10 | Novartis Ag | Moduladores da via do complemento e usos dos mesmos |
US20140045746A1 (en) | 2012-08-02 | 2014-02-13 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
US9527839B2 (en) | 2012-08-22 | 2016-12-27 | Merck Sharp & Dohme Corp. | Benzimidazole tetrahydropyran derivatives |
EP2887807B1 (de) | 2012-08-22 | 2019-09-18 | Merck Sharp & Dohme Corp. | Benzimidazol-hexahydrofuro[3,2-b]furanderivate als amp-aktivierte proteinkinase-aktivatoren |
WO2014031441A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole tetrahydrofuran derivatives |
US9868733B2 (en) | 2012-08-22 | 2018-01-16 | Merck Sharp & Dohme Corp. | Azabenzimidazole tetrahydrofuran derivatives |
US9382243B2 (en) | 2012-08-22 | 2016-07-05 | Merck Sharp & Dohme Corp. | Azabenzimidazole tetrahydropyran derivatives |
WO2014031515A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel azabenzimidazole hexahydrofuro[3,2-b]furan derivatives |
US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
ES2747973T3 (es) | 2013-11-15 | 2020-03-12 | Merck Sharp & Dohme | Compuestos tricíclicos antidiabéticos |
WO2015089809A1 (en) | 2013-12-19 | 2015-06-25 | Merck Sharp & Dohme Corp. | Antidiabetic substituted heteroaryl compounds |
CN111004125B (zh) * | 2019-12-24 | 2022-11-22 | 东华理工大学 | 一种缩醛或缩酮化合物的制备方法 |
CN116903541B (zh) * | 2023-08-14 | 2023-12-08 | 中国环境科学研究院 | 用于酚类污染物检测的酰基咪唑类化合物、制备方法及应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2430950A1 (fr) * | 1978-07-10 | 1980-02-08 | Delalande Sa | Nouveaux derives heterocycliques de la benzimidazole, leur procede de preparation et leur application en therapeutique |
DE2928055A1 (de) * | 1978-07-12 | 1980-01-31 | Eastman Kodak Co | Verfahren zur verbesserung der widerstandsfaehigkeit von polyesterformkoerpern gegenueber einem abbau durch u.v.- licht |
JPS62212386A (ja) * | 1986-03-14 | 1987-09-18 | Suntory Ltd | 2−ピリジルメチルベンズイミダゾ−ル誘導体 |
JPH01265089A (ja) * | 1988-04-15 | 1989-10-23 | Zeria Pharmaceut Co Ltd | 新規1−(イミダゾール−4−イル)メチルベンズイミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤 |
GB9225141D0 (en) * | 1992-12-01 | 1993-01-20 | Smithkline Beecham Corp | Chemical compounds |
US5527597A (en) * | 1995-03-01 | 1996-06-18 | Southern Mills, Inc. | Stretchable flame resistant fabric |
WO1999026932A1 (en) * | 1997-11-26 | 1999-06-03 | Axys Pharmaceuticals, Inc. | By amidino group substituted heterocyclic derivatives and their use as anticoagulants |
JP3923255B2 (ja) * | 1998-07-15 | 2007-05-30 | 帝人株式会社 | チオベンズイミダゾール誘導体 |
BR0011997A (pt) * | 1999-06-28 | 2002-03-05 | Janssen Pharmaceutica Nv | Inibidores da replicação do vìrus sincicial respiratório |
CZ2001153A3 (cs) * | 1999-07-14 | 2001-06-13 | Teijin Ltd | Thiobenzimidazolové deriváty |
-
2001
- 2001-01-17 DE DE60130865T patent/DE60130865T2/de not_active Expired - Lifetime
- 2001-01-17 NZ NZ520028A patent/NZ520028A/en unknown
- 2001-01-17 KR KR1020077010650A patent/KR20070057276A/ko active IP Right Grant
- 2001-01-17 CN CNB2005100526041A patent/CN100415723C/zh not_active Expired - Fee Related
- 2001-01-17 CA CA002396908A patent/CA2396908A1/en not_active Abandoned
- 2001-01-17 AT AT01901397T patent/ATE375156T1/de not_active IP Right Cessation
- 2001-01-17 AU AU27049/01A patent/AU777813B2/en not_active Ceased
- 2001-01-17 EP EP01901397A patent/EP1249450B1/de not_active Expired - Lifetime
- 2001-01-17 JP JP2001553765A patent/JP4059671B2/ja not_active Expired - Fee Related
- 2001-01-17 ES ES01901397T patent/ES2295128T3/es not_active Expired - Lifetime
- 2001-01-17 WO PCT/JP2001/000271 patent/WO2001053291A1/ja active IP Right Grant
- 2001-01-17 SI SI200130792T patent/SI1249450T1/sl unknown
- 2001-01-17 DK DK01901397T patent/DK1249450T3/da active
- 2001-01-17 CN CNB018066623A patent/CN1198819C/zh not_active Expired - Fee Related
- 2001-01-17 IL IL15056501A patent/IL150565A0/xx not_active IP Right Cessation
- 2001-01-17 KR KR1020027009200A patent/KR100763779B1/ko not_active IP Right Cessation
- 2001-01-17 CZ CZ20022442A patent/CZ301504B6/cs not_active IP Right Cessation
- 2001-01-17 PT PT01901397T patent/PT1249450E/pt unknown
- 2001-01-17 RU RU2002122105/04A patent/RU2263674C2/ru not_active IP Right Cessation
-
2002
- 2002-07-16 NO NO20023415A patent/NO324049B1/no not_active IP Right Cessation
-
2003
- 2003-03-31 HK HK03102300A patent/HK1050009A1/xx not_active IP Right Cessation
-
2005
- 2005-01-14 AU AU2005200172A patent/AU2005200172B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP1249450A4 (de) | 2003-04-09 |
NO324049B1 (no) | 2007-08-06 |
EP1249450A1 (de) | 2002-10-16 |
CA2396908A1 (en) | 2001-07-26 |
ES2295128T3 (es) | 2008-04-16 |
NO20023415D0 (no) | 2002-07-16 |
EP1249450B1 (de) | 2007-10-10 |
JP4059671B2 (ja) | 2008-03-12 |
CZ301504B6 (cs) | 2010-03-24 |
ATE375156T1 (de) | 2007-10-15 |
WO2001053291A1 (fr) | 2001-07-26 |
KR20020065929A (ko) | 2002-08-14 |
RU2263674C2 (ru) | 2005-11-10 |
AU2005200172A1 (en) | 2005-02-10 |
AU2005200172B2 (en) | 2007-08-23 |
AU777813B2 (en) | 2004-11-04 |
AU2704901A (en) | 2001-07-31 |
KR20070057276A (ko) | 2007-06-04 |
IL150565A0 (en) | 2003-02-12 |
CN1198819C (zh) | 2005-04-27 |
CN1418211A (zh) | 2003-05-14 |
SI1249450T1 (sl) | 2008-04-30 |
KR100763779B1 (ko) | 2007-10-05 |
NO20023415L (no) | 2002-07-16 |
DE60130865T2 (de) | 2008-07-17 |
HK1050009A1 (en) | 2003-06-06 |
PT1249450E (pt) | 2008-01-02 |
CN100415723C (zh) | 2008-09-03 |
CN1680339A (zh) | 2005-10-12 |
RU2002122105A (ru) | 2004-01-10 |
DK1249450T3 (da) | 2008-02-11 |
NZ520028A (en) | 2004-07-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60130865D1 (de) | Benzimidazol-derivate als menschliche chymase - inhibitoren | |
NO20062004L (no) | Forlenget frigjoring farmasoytiske blandinger omfattene aplindor og derivater derav | |
DE502004005959D1 (de) | Pyrimidin-2-on-verbindungen und ihre verwendung als dopamin-d3-rezeptorliganden | |
ATE540938T1 (de) | Neue benzoxazinonderivate als langwirksame betamimetika zur behandlung von atemwegserkrankungen | |
ZA200203315B (en) | Stable salts of novel derivatives of 3,3-diphenylpropylamines. | |
ECSP055644A (es) | Derivados de la quinolil-propil-piperidina y su utilización | |
DE60233736D1 (de) | Chinolinderivat und chinazolinderivat, die die selbstphosphorylierung des hepatocytus-proliferator-rezeptors hemmen, und diese enthaltende medizinische zusammensetzung | |
RU2003136097A (ru) | Производные фенилпиридинкарбонилпиперазина | |
DE69132713D1 (de) | Benzylidenthiazolidinderivate, ihre Herstellung und ihre Anwendung als Lipidperoxid-Inhibitoren | |
MXPA05010760A (es) | Derivados de acido 2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)alquil fosfonico y su uso como antagonistas de receptor de n-metil-d-aspartato (nmda). | |
ATE502936T1 (de) | 2, 6-di-(hetero-)aryl-4-amido-pyrimidine als adenosin-rezeptor-antagonisten | |
ATE510830T1 (de) | Chromen-4-on-derivate als selbstbräunungssubstanz | |
CY1110465T1 (el) | Υποκατεστημενα παραγωγα ιμιδαζολινης | |
ES2172436A1 (es) | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. | |
KR950032194A (ko) | 신규푸린유도체 및 그 약학적으로 허용되는 염 | |
DE69414396D1 (de) | Acylphenylglycin-derivat und dieses als aktivbestandteil enthaltendes vorbeugungs -und heilmittel gegen durch erhöhte collagenaseaktivität verursachte krankheiten | |
BR0108251A (pt) | Derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável, composição farmacêutica, agente contendo um derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável, e, uso de um derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável | |
JPH083044A (ja) | 骨粗鬆症の予防または治療剤 | |
HUP0002715A2 (hu) | Benzotiofénszármazékok alkalmazása trombocitaszám csökkentésére szolgáló gyógyszerkészítmények előállítására | |
AR035219A1 (es) | Compuesto de 1, 2, 3, 4, 4a, 5, 6, 7, 8, 8 a-decahidroisoquinolina, su uso para preparar una composicion farmaceutica, dicha composicion farmaceutica y procedimiento para preparar dicho compuesto | |
ATE229520T1 (de) | Benzothiophenderivate als antithrombotische mitteln und zwischenprodukte | |
HUP0204131A2 (hu) | Szacharinszármazékok, mint orálisan aktív elasztáz inhibitorok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
DE60333095D1 (de) | Imidazolverbindungen und ihre verwendung als alpha-2 adrenorezeptorliganden |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |