HUP0002715A2 - Benzotiofénszármazékok alkalmazása trombocitaszám csökkentésére szolgáló gyógyszerkészítmények előállítására - Google Patents
Benzotiofénszármazékok alkalmazása trombocitaszám csökkentésére szolgáló gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP0002715A2 HUP0002715A2 HU0002715A HUP0002715A HUP0002715A2 HU P0002715 A2 HUP0002715 A2 HU P0002715A2 HU 0002715 A HU0002715 A HU 0002715A HU P0002715 A HUP0002715 A HU P0002715A HU P0002715 A2 HUP0002715 A2 HU P0002715A2
- Authority
- HU
- Hungary
- Prior art keywords
- production
- benzotiophen
- derivatives
- group
- pharmaceutical compositions
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
- -1 hexamethyleneimino group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Abstract
A találmány tárgya (I) általános képletű vegyület, ahol a képletben R1és R3 jelentése egymástól függetlenül hidrogénatom, metilcsoport, -CO-(1-6 szénatomos)alkilcsoport vagy -COAr-csoport, amelyen belül Arjelentése kívánt esetben helyettesített fenilcsoport, és R2 jelentésepirrolidin-, piperidin- vagy hexametilénimino-csoport, vagy ezenvegyületek gyógyászatilag elfogadható sói vagy szolvátjai alkalmazásatrombocitaszám csökkentésére alkalmas gyógyszerkészítményekelőállítására. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5620397P | 1997-08-21 | 1997-08-21 | |
PCT/US1998/017018 WO1999008525A1 (en) | 1997-08-21 | 1998-08-17 | Methods for lowering platelet counts |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0002715A2 true HUP0002715A2 (hu) | 2001-06-28 |
HUP0002715A3 HUP0002715A3 (en) | 2002-12-28 |
Family
ID=22002873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0002715A HUP0002715A3 (en) | 1997-08-21 | 1998-08-17 | Use of benzotiophen derivatives for production of pharmaceutical compositions for lowering platelet counts |
Country Status (22)
Country | Link |
---|---|
US (1) | US6103740A (hu) |
EP (1) | EP0904783B1 (hu) |
JP (1) | JP2001515015A (hu) |
KR (1) | KR20010023075A (hu) |
CN (1) | CN1275886A (hu) |
AT (1) | ATE220905T1 (hu) |
AU (1) | AU741882B2 (hu) |
BR (1) | BR9811962A (hu) |
CA (1) | CA2301806A1 (hu) |
DE (1) | DE69806705T2 (hu) |
DK (1) | DK0904783T3 (hu) |
EA (1) | EA001582B1 (hu) |
ES (1) | ES2181132T3 (hu) |
HR (1) | HRP20000094A2 (hu) |
HU (1) | HUP0002715A3 (hu) |
IL (1) | IL134551A0 (hu) |
NO (1) | NO20000750L (hu) |
NZ (1) | NZ502842A (hu) |
PL (1) | PL338700A1 (hu) |
PT (1) | PT904783E (hu) |
TR (1) | TR200000453T2 (hu) |
WO (1) | WO1999008525A1 (hu) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9624800D0 (en) * | 1996-11-29 | 1997-01-15 | Lilly Co Eli | Methods of preventing breast cancer |
US6353003B1 (en) | 1998-06-17 | 2002-03-05 | Eli Lilly And Company | Method for reducing levels of homocysteine and C-reactive protein |
AU3885901A (en) * | 1999-09-21 | 2001-04-24 | Emory University | Methods and compositions for treating platelet-related disorders |
US8021854B2 (en) * | 2007-10-05 | 2011-09-20 | Attila Mady | Method of treating vascular disease |
US20090092693A1 (en) * | 2007-10-05 | 2009-04-09 | Mady Attila | Platelet manipulation to prevent and treat endovascular disease and its sequelae, to prevent and treat arrhythmias and to prevent malignancy |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
US4447620A (en) * | 1982-06-08 | 1984-05-08 | The Upjohn Company | Imidazolyl-substituted benzothiophenes |
US5075321A (en) * | 1987-03-24 | 1991-12-24 | University Of Pennsylvania | Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes |
US4847276A (en) * | 1988-09-06 | 1989-07-11 | Merrell Dow Pharmaceuticals Inc. | Treatment of thromobocytosis with 5-(4-chlorophenyl)-2,4-diemthyl-3H-1,2,4-triazole-3-thione |
JPH0517357A (ja) * | 1991-07-05 | 1993-01-26 | Nissan Chem Ind Ltd | 血小板減少療法剤 |
JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
US5445941A (en) * | 1993-06-21 | 1995-08-29 | Eli Lilly And Company | Method for screening anti-osteoporosis agents |
US5391557A (en) * | 1993-10-15 | 1995-02-21 | Eli Lilly And Company | Methods for the treatment of peri-menopausal syndrome |
US5476862A (en) * | 1993-12-21 | 1995-12-19 | Eli Lilly And Company | Methods of increasing thrombomodulin expression |
US5441965A (en) * | 1993-12-21 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting thrombin |
US6025373A (en) * | 1997-04-22 | 2000-02-15 | Eli Lilly And Company | Methods for reducing fibrinogen |
-
1998
- 1998-08-04 US US09/129,324 patent/US6103740A/en not_active Expired - Fee Related
- 1998-08-17 EA EA200000243A patent/EA001582B1/ru not_active IP Right Cessation
- 1998-08-17 PL PL98338700A patent/PL338700A1/xx unknown
- 1998-08-17 CN CN98810105A patent/CN1275886A/zh active Pending
- 1998-08-17 HU HU0002715A patent/HUP0002715A3/hu unknown
- 1998-08-17 BR BR9811962-1A patent/BR9811962A/pt not_active IP Right Cessation
- 1998-08-17 TR TR2000/00453T patent/TR200000453T2/xx unknown
- 1998-08-17 JP JP2000509285A patent/JP2001515015A/ja not_active Withdrawn
- 1998-08-17 IL IL13455198A patent/IL134551A0/xx unknown
- 1998-08-17 AU AU88306/98A patent/AU741882B2/en not_active Ceased
- 1998-08-17 WO PCT/US1998/017018 patent/WO1999008525A1/en not_active Application Discontinuation
- 1998-08-17 KR KR1020007001694A patent/KR20010023075A/ko not_active Application Discontinuation
- 1998-08-17 NZ NZ502842A patent/NZ502842A/en unknown
- 1998-08-17 CA CA002301806A patent/CA2301806A1/en not_active Abandoned
- 1998-08-18 EP EP98306570A patent/EP0904783B1/en not_active Expired - Lifetime
- 1998-08-18 DK DK98306570T patent/DK0904783T3/da active
- 1998-08-18 DE DE69806705T patent/DE69806705T2/de not_active Expired - Fee Related
- 1998-08-18 ES ES98306570T patent/ES2181132T3/es not_active Expired - Lifetime
- 1998-08-18 PT PT98306570T patent/PT904783E/pt unknown
- 1998-08-18 AT AT98306570T patent/ATE220905T1/de not_active IP Right Cessation
-
2000
- 2000-02-15 NO NO20000750A patent/NO20000750L/no unknown
- 2000-02-21 HR HR20000094A patent/HRP20000094A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999008525A1 (en) | 1999-02-25 |
DK0904783T3 (da) | 2002-09-02 |
DE69806705T2 (de) | 2003-03-20 |
NZ502842A (en) | 2001-11-30 |
PL338700A1 (en) | 2000-11-20 |
NO20000750D0 (no) | 2000-02-15 |
EA001582B1 (ru) | 2001-06-25 |
KR20010023075A (ko) | 2001-03-26 |
HUP0002715A3 (en) | 2002-12-28 |
DE69806705D1 (de) | 2002-08-29 |
EP0904783B1 (en) | 2002-07-24 |
IL134551A0 (en) | 2001-04-30 |
CN1275886A (zh) | 2000-12-06 |
ES2181132T3 (es) | 2003-02-16 |
NO20000750L (no) | 2000-04-13 |
ATE220905T1 (de) | 2002-08-15 |
AU741882B2 (en) | 2001-12-13 |
US6103740A (en) | 2000-08-15 |
HRP20000094A2 (en) | 2000-08-31 |
AU8830698A (en) | 1999-03-08 |
BR9811962A (pt) | 2000-08-15 |
CA2301806A1 (en) | 1999-02-25 |
EP0904783A1 (en) | 1999-03-31 |
EA200000243A1 (ru) | 2000-10-30 |
TR200000453T2 (tr) | 2000-08-21 |
JP2001515015A (ja) | 2001-09-18 |
PT904783E (pt) | 2002-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0400636A2 (hu) | Azetidinszármazékokat tartalmazó gyógyszerkészítmények, új azetidinszármazékok és előállításuk | |
KR20050085991A (en) | Compounds exhibiting thrombopoietin receptor agonism | |
HUP0204246A2 (hu) | Új tiazolo[4,5-d]pirimidin-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
DE60208568D1 (de) | Prostaglandinanaloga als ep4-rezeptoragonisten | |
WO2001009103A3 (en) | Imidazole antiproliferative agents | |
HUP0204245A2 (hu) | Új N-aza-biciklo-amid-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
DK0928788T3 (da) | Imidazolidin-4-on-derivater, der er nyttige som anticancer-midler | |
CY1109915T1 (el) | Φαρμακευτικες συνθεσεις οιστρογονων μεσων | |
HUP0203528A2 (hu) | CCR5 antagonistákként alkalmazható piperidinszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
NO944911L (no) | Ikke-peptid-takykininreseptorantagonister | |
NO20015172L (no) | 1-metyl-erytromycin-derivater | |
HUP0204283A2 (hu) | (Kinolil-propil)-piperidin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
HUP0401235A2 (hu) | 5-HT6 receptor affinitással rendelkező arilszulfonil-származékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
AP9801321A0 (en) | 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-h-indole derivatives. | |
AU2003269923A8 (en) | 2- (phenoxymethyl)- and 2- (phenylthiomethyl)-morpholine derivatives for use as selective norepinephrine reuptake inhibitors | |
HK1052697A1 (en) | Novel benzothiadiazine derivatives, preparation method and pharmaceutical compositions containing same. | |
HUP0302961A2 (hu) | (Aminoalkoxibenzoil) benzofuránok vagy benzotiofének, eljárás ilyen vegyületek előállítására és ilyen vegyületeket tartalmazó készítmények | |
AU2001269540A1 (en) | Serotonin reuptake inhibitors | |
NO961797L (no) | Anvendelse av benzopyranderivater for fremstilling av farmasöytiske sammensetninger beregnet for behandling av patologier forbundet med den Na+-uavhengige C1-HCO3-utbytter | |
HUP0002715A2 (hu) | Benzotiofénszármazékok alkalmazása trombocitaszám csökkentésére szolgáló gyógyszerkészítmények előállítására | |
HUP0002929A2 (hu) | Tachikinin receptor antagonista hatású 2-acilamino-propán-aminok és az ezeket tartalmazó gyógyszerkészítmények | |
NO20022123L (no) | Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII | |
HUP0303457A2 (hu) | Antimikrobiális hatású 2-piridonok, ezeket tartalmazó készítmények és alkalmazásuk | |
NZ543068A (en) | Substituted 4-(alkyl-amide)-piperidine derivatives, processes for their preparation, and pharmaceutical compositions containing them | |
NO944577L (no) | Hemming av effekten av amyloidogene proteiner |