DK0904783T3 - Benzoe(b)thiophen derivater til sænkning af blodpladetælling - Google Patents

Benzoe(b)thiophen derivater til sænkning af blodpladetælling

Info

Publication number
DK0904783T3
DK0904783T3 DK98306570T DK98306570T DK0904783T3 DK 0904783 T3 DK0904783 T3 DK 0904783T3 DK 98306570 T DK98306570 T DK 98306570T DK 98306570 T DK98306570 T DK 98306570T DK 0904783 T3 DK0904783 T3 DK 0904783T3
Authority
DK
Denmark
Prior art keywords
platelet count
benzoe
thiophene derivatives
lowering platelet
lowering
Prior art date
Application number
DK98306570T
Other languages
English (en)
Inventor
Mark Chandrakant Lakshmanan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0904783T3 publication Critical patent/DK0904783T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
DK98306570T 1997-08-21 1998-08-18 Benzoe(b)thiophen derivater til sænkning af blodpladetælling DK0904783T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5620397P 1997-08-21 1997-08-21

Publications (1)

Publication Number Publication Date
DK0904783T3 true DK0904783T3 (da) 2002-09-02

Family

ID=22002873

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98306570T DK0904783T3 (da) 1997-08-21 1998-08-18 Benzoe(b)thiophen derivater til sænkning af blodpladetælling

Country Status (22)

Country Link
US (1) US6103740A (da)
EP (1) EP0904783B1 (da)
JP (1) JP2001515015A (da)
KR (1) KR20010023075A (da)
CN (1) CN1275886A (da)
AT (1) ATE220905T1 (da)
AU (1) AU741882B2 (da)
BR (1) BR9811962A (da)
CA (1) CA2301806A1 (da)
DE (1) DE69806705T2 (da)
DK (1) DK0904783T3 (da)
EA (1) EA001582B1 (da)
ES (1) ES2181132T3 (da)
HR (1) HRP20000094A2 (da)
HU (1) HUP0002715A3 (da)
IL (1) IL134551A0 (da)
NO (1) NO20000750L (da)
NZ (1) NZ502842A (da)
PL (1) PL338700A1 (da)
PT (1) PT904783E (da)
TR (1) TR200000453T2 (da)
WO (1) WO1999008525A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624800D0 (en) * 1996-11-29 1997-01-15 Lilly Co Eli Methods of preventing breast cancer
US6353003B1 (en) 1998-06-17 2002-03-05 Eli Lilly And Company Method for reducing levels of homocysteine and C-reactive protein
AU3885901A (en) * 1999-09-21 2001-04-24 Emory University Methods and compositions for treating platelet-related disorders
US8021854B2 (en) * 2007-10-05 2011-09-20 Attila Mady Method of treating vascular disease
US20090092693A1 (en) * 2007-10-05 2009-04-09 Mady Attila Platelet manipulation to prevent and treat endovascular disease and its sequelae, to prevent and treat arrhythmias and to prevent malignancy

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4447620A (en) * 1982-06-08 1984-05-08 The Upjohn Company Imidazolyl-substituted benzothiophenes
US5075321A (en) * 1987-03-24 1991-12-24 University Of Pennsylvania Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes
US4847276A (en) * 1988-09-06 1989-07-11 Merrell Dow Pharmaceuticals Inc. Treatment of thromobocytosis with 5-(4-chlorophenyl)-2,4-diemthyl-3H-1,2,4-triazole-3-thione
JPH0517357A (ja) * 1991-07-05 1993-01-26 Nissan Chem Ind Ltd 血小板減少療法剤
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US5424334A (en) * 1991-12-19 1995-06-13 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US5445941A (en) * 1993-06-21 1995-08-29 Eli Lilly And Company Method for screening anti-osteoporosis agents
US5391557A (en) * 1993-10-15 1995-02-21 Eli Lilly And Company Methods for the treatment of peri-menopausal syndrome
US5476862A (en) * 1993-12-21 1995-12-19 Eli Lilly And Company Methods of increasing thrombomodulin expression
US5441965A (en) * 1993-12-21 1995-08-15 Eli Lilly And Company Methods of inhibiting thrombin
US6025373A (en) * 1997-04-22 2000-02-15 Eli Lilly And Company Methods for reducing fibrinogen

Also Published As

Publication number Publication date
WO1999008525A1 (en) 1999-02-25
DE69806705T2 (de) 2003-03-20
NZ502842A (en) 2001-11-30
PL338700A1 (en) 2000-11-20
NO20000750D0 (no) 2000-02-15
EA001582B1 (ru) 2001-06-25
KR20010023075A (ko) 2001-03-26
HUP0002715A3 (en) 2002-12-28
DE69806705D1 (de) 2002-08-29
EP0904783B1 (en) 2002-07-24
IL134551A0 (en) 2001-04-30
CN1275886A (zh) 2000-12-06
ES2181132T3 (es) 2003-02-16
NO20000750L (no) 2000-04-13
ATE220905T1 (de) 2002-08-15
AU741882B2 (en) 2001-12-13
US6103740A (en) 2000-08-15
HRP20000094A2 (en) 2000-08-31
AU8830698A (en) 1999-03-08
BR9811962A (pt) 2000-08-15
CA2301806A1 (en) 1999-02-25
EP0904783A1 (en) 1999-03-31
EA200000243A1 (ru) 2000-10-30
TR200000453T2 (tr) 2000-08-21
JP2001515015A (ja) 2001-09-18
HUP0002715A2 (hu) 2001-06-28
PT904783E (pt) 2002-10-31

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