YU2397A - 2-phenyl-3-aroylbenzothiophenes using for medicaments obtaining - Google Patents

2-phenyl-3-aroylbenzothiophenes using for medicaments obtaining

Info

Publication number
YU2397A
YU2397A YU2397A YU2397A YU2397A YU 2397 A YU2397 A YU 2397A YU 2397 A YU2397 A YU 2397A YU 2397 A YU2397 A YU 2397A YU 2397 A YU2397 A YU 2397A
Authority
YU
Yugoslavia
Prior art keywords
phenyl
aroylbenzothiophenes
medicaments
obtaining
hexamethyleneimino
Prior art date
Application number
YU2397A
Other languages
Serbo-Croatian (sh)
Serbian (sr)
Inventor
Maria Luisa Brandi
Francesco Tonelli
Original Assignee
Eli Lilly Company
Lilly Corporate Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603150.5A external-priority patent/GB9603150D0/en
Application filed by Eli Lilly Company, Lilly Corporate Center filed Critical Eli Lilly Company
Publication of YU2397A publication Critical patent/YU2397A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Opisana je upotreba jedinjenja formule I u kojoj su R1 i R3 nezavisno vodonik, -CH3, -C(=O)-(C1-C6 alkil), ili -C(O=)- Ar, gde je Ar opciono supstituisan fenil; R2 je izabran od grupe koja sadrži pirolidin, heksametilenimino i piperidino; ili farmaceutski prihvatljive soli i njihove rastvore; za dobijanje medikamenta upotrebljivog za inhibiciju kancera debelog creva.Described is the use of a compound of formula I wherein R 1 and R 3 are independently hydrogen, -CH 3, -C (= O) - (C 1 -C 6 alkyl), or -C (O =) - Ar, wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneimino and piperidino; or pharmaceutically acceptable salts and solutions thereof; to obtain a medicament useful for the inhibition of colon cancer.

YU2397A 1996-01-29 1997-01-24 2-phenyl-3-aroylbenzothiophenes using for medicaments obtaining YU2397A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1077296P 1996-01-29 1996-01-29
GBGB9603150.5A GB9603150D0 (en) 1996-02-15 1996-02-15 Methods of inhibiting colon tumors

Publications (1)

Publication Number Publication Date
YU2397A true YU2397A (en) 1999-11-22

Family

ID=26308709

Family Applications (1)

Application Number Title Priority Date Filing Date
YU2397A YU2397A (en) 1996-01-29 1997-01-24 2-phenyl-3-aroylbenzothiophenes using for medicaments obtaining

Country Status (19)

Country Link
EP (1) EP0921799A4 (en)
JP (1) JP2000503994A (en)
KR (1) KR19990082054A (en)
CN (1) CN1209745A (en)
AR (1) AR010978A1 (en)
AU (1) AU707892B2 (en)
BR (1) BR9700778A (en)
CO (1) CO4761062A1 (en)
CZ (1) CZ235498A3 (en)
EA (1) EA001104B1 (en)
ID (1) ID15917A (en)
IL (1) IL125521A (en)
MX (1) MX9806036A (en)
NO (1) NO983451D0 (en)
NZ (1) NZ331105A (en)
PL (1) PL328147A1 (en)
TW (1) TW446560B (en)
WO (1) WO1997026877A1 (en)
YU (1) YU2397A (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
KR950010891A (en) * 1993-10-15 1995-05-15 피터 지. 스트링거 How to treat resistant tumors
US5574047A (en) * 1993-12-21 1996-11-12 Eli Lilly And Company Methods of inhibiting imperfect tissue repair

Also Published As

Publication number Publication date
EA199800677A1 (en) 1999-02-25
NO983451L (en) 1998-07-27
EA001104B1 (en) 2000-10-30
KR19990082054A (en) 1999-11-15
AU707892B2 (en) 1999-07-22
ID15917A (en) 1997-08-21
CO4761062A1 (en) 1999-04-27
MX9806036A (en) 1998-11-29
IL125521A0 (en) 1999-03-12
CN1209745A (en) 1999-03-03
PL328147A1 (en) 1999-01-18
EP0921799A4 (en) 2002-03-13
IL125521A (en) 2001-11-25
JP2000503994A (en) 2000-04-04
EP0921799A1 (en) 1999-06-16
AR010978A1 (en) 2000-08-02
CZ235498A3 (en) 1999-02-17
BR9700778A (en) 1998-10-06
AU2123997A (en) 1997-08-20
NO983451D0 (en) 1998-07-27
NZ331105A (en) 2000-06-23
TW446560B (en) 2001-07-21
WO1997026877A1 (en) 1997-07-31

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