ES2181132T3 - Derivados de benzo(b)tiofeno para disminuir el contenido de plaquetas. - Google Patents
Derivados de benzo(b)tiofeno para disminuir el contenido de plaquetas.Info
- Publication number
- ES2181132T3 ES2181132T3 ES98306570T ES98306570T ES2181132T3 ES 2181132 T3 ES2181132 T3 ES 2181132T3 ES 98306570 T ES98306570 T ES 98306570T ES 98306570 T ES98306570 T ES 98306570T ES 2181132 T3 ES2181132 T3 ES 2181132T3
- Authority
- ES
- Spain
- Prior art keywords
- plates
- thiophen
- benzo
- derivatives
- decrease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000004802 benzothiophens Chemical class 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 2
- 239000002131 composite material Substances 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE PRESENTA UNA PREPARACION DE UNA FORMULACION FARMACEUTICA PARA HACER DESCENDER CON SEGURIDAD EL NUMERO DE PLAQUETAS EN UN HUMANO QUE UTILIZA UN COMPUESTO DE LA FORMULA (I) EN LA R SUP,1 Y R 3 SON, INDEPENDIENTEMENTE, -H, -CH 3 , -CO (ALQUIL C 1-C 6 ), O -COAR, EN DONDE AR ES FENILO OPCIONALMENTE SUSTITUIDO; R 3 SE SELECCIONA ENTRE EL GRUPO QUE CONSTA DE PIRROLIDINA, PIPERIDINA, Y HEXAMETILENEIMINO; TAMBIEN SE PRESENTAN LAS SALES O SOLVATOS FARMACOLOGICAMENTE ACEPTABLES DEL COMPUESTO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5620397P | 1997-08-21 | 1997-08-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2181132T3 true ES2181132T3 (es) | 2003-02-16 |
Family
ID=22002873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98306570T Expired - Lifetime ES2181132T3 (es) | 1997-08-21 | 1998-08-18 | Derivados de benzo(b)tiofeno para disminuir el contenido de plaquetas. |
Country Status (22)
Country | Link |
---|---|
US (1) | US6103740A (es) |
EP (1) | EP0904783B1 (es) |
JP (1) | JP2001515015A (es) |
KR (1) | KR20010023075A (es) |
CN (1) | CN1275886A (es) |
AT (1) | ATE220905T1 (es) |
AU (1) | AU741882B2 (es) |
BR (1) | BR9811962A (es) |
CA (1) | CA2301806A1 (es) |
DE (1) | DE69806705T2 (es) |
DK (1) | DK0904783T3 (es) |
EA (1) | EA001582B1 (es) |
ES (1) | ES2181132T3 (es) |
HR (1) | HRP20000094A2 (es) |
HU (1) | HUP0002715A3 (es) |
IL (1) | IL134551A0 (es) |
NO (1) | NO20000750L (es) |
NZ (1) | NZ502842A (es) |
PL (1) | PL338700A1 (es) |
PT (1) | PT904783E (es) |
TR (1) | TR200000453T2 (es) |
WO (1) | WO1999008525A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9624800D0 (en) * | 1996-11-29 | 1997-01-15 | Lilly Co Eli | Methods of preventing breast cancer |
US6353003B1 (en) | 1998-06-17 | 2002-03-05 | Eli Lilly And Company | Method for reducing levels of homocysteine and C-reactive protein |
WO2001021259A2 (en) * | 1999-09-21 | 2001-03-29 | Emory University | Use and compositions for treating platelet-related disorders using anagrelide |
US8021854B2 (en) * | 2007-10-05 | 2011-09-20 | Attila Mady | Method of treating vascular disease |
US20090092693A1 (en) * | 2007-10-05 | 2009-04-09 | Mady Attila | Platelet manipulation to prevent and treat endovascular disease and its sequelae, to prevent and treat arrhythmias and to prevent malignancy |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
US4447620A (en) * | 1982-06-08 | 1984-05-08 | The Upjohn Company | Imidazolyl-substituted benzothiophenes |
US5075321A (en) * | 1987-03-24 | 1991-12-24 | University Of Pennsylvania | Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes |
US4847276A (en) * | 1988-09-06 | 1989-07-11 | Merrell Dow Pharmaceuticals Inc. | Treatment of thromobocytosis with 5-(4-chlorophenyl)-2,4-diemthyl-3H-1,2,4-triazole-3-thione |
JPH0517357A (ja) * | 1991-07-05 | 1993-01-26 | Nissan Chem Ind Ltd | 血小板減少療法剤 |
JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
US5445941A (en) * | 1993-06-21 | 1995-08-29 | Eli Lilly And Company | Method for screening anti-osteoporosis agents |
US5391557A (en) * | 1993-10-15 | 1995-02-21 | Eli Lilly And Company | Methods for the treatment of peri-menopausal syndrome |
US5441965A (en) * | 1993-12-21 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting thrombin |
US5476862A (en) * | 1993-12-21 | 1995-12-19 | Eli Lilly And Company | Methods of increasing thrombomodulin expression |
US6025373A (en) * | 1997-04-22 | 2000-02-15 | Eli Lilly And Company | Methods for reducing fibrinogen |
-
1998
- 1998-08-04 US US09/129,324 patent/US6103740A/en not_active Expired - Fee Related
- 1998-08-17 CN CN98810105A patent/CN1275886A/zh active Pending
- 1998-08-17 AU AU88306/98A patent/AU741882B2/en not_active Ceased
- 1998-08-17 NZ NZ502842A patent/NZ502842A/en unknown
- 1998-08-17 KR KR1020007001694A patent/KR20010023075A/ko not_active Application Discontinuation
- 1998-08-17 IL IL13455198A patent/IL134551A0/xx unknown
- 1998-08-17 HU HU0002715A patent/HUP0002715A3/hu unknown
- 1998-08-17 JP JP2000509285A patent/JP2001515015A/ja not_active Withdrawn
- 1998-08-17 WO PCT/US1998/017018 patent/WO1999008525A1/en not_active Application Discontinuation
- 1998-08-17 CA CA002301806A patent/CA2301806A1/en not_active Abandoned
- 1998-08-17 EA EA200000243A patent/EA001582B1/ru not_active IP Right Cessation
- 1998-08-17 BR BR9811962-1A patent/BR9811962A/pt not_active IP Right Cessation
- 1998-08-17 TR TR2000/00453T patent/TR200000453T2/xx unknown
- 1998-08-17 PL PL98338700A patent/PL338700A1/xx unknown
- 1998-08-18 AT AT98306570T patent/ATE220905T1/de not_active IP Right Cessation
- 1998-08-18 DE DE69806705T patent/DE69806705T2/de not_active Expired - Fee Related
- 1998-08-18 DK DK98306570T patent/DK0904783T3/da active
- 1998-08-18 EP EP98306570A patent/EP0904783B1/en not_active Expired - Lifetime
- 1998-08-18 ES ES98306570T patent/ES2181132T3/es not_active Expired - Lifetime
- 1998-08-18 PT PT98306570T patent/PT904783E/pt unknown
-
2000
- 2000-02-15 NO NO20000750A patent/NO20000750L/no unknown
- 2000-02-21 HR HR20000094A patent/HRP20000094A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US6103740A (en) | 2000-08-15 |
DE69806705D1 (de) | 2002-08-29 |
JP2001515015A (ja) | 2001-09-18 |
HUP0002715A2 (hu) | 2001-06-28 |
CN1275886A (zh) | 2000-12-06 |
DK0904783T3 (da) | 2002-09-02 |
PT904783E (pt) | 2002-10-31 |
WO1999008525A1 (en) | 1999-02-25 |
EP0904783B1 (en) | 2002-07-24 |
IL134551A0 (en) | 2001-04-30 |
PL338700A1 (en) | 2000-11-20 |
HUP0002715A3 (en) | 2002-12-28 |
BR9811962A (pt) | 2000-08-15 |
HRP20000094A2 (en) | 2000-08-31 |
EA001582B1 (ru) | 2001-06-25 |
CA2301806A1 (en) | 1999-02-25 |
NO20000750L (no) | 2000-04-13 |
NO20000750D0 (no) | 2000-02-15 |
EP0904783A1 (en) | 1999-03-31 |
DE69806705T2 (de) | 2003-03-20 |
TR200000453T2 (tr) | 2000-08-21 |
ATE220905T1 (de) | 2002-08-15 |
AU8830698A (en) | 1999-03-08 |
AU741882B2 (en) | 2001-12-13 |
EA200000243A1 (ru) | 2000-10-30 |
KR20010023075A (ko) | 2001-03-26 |
NZ502842A (en) | 2001-11-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR001332A1 (es) | Nuevos compuestos antagonistas de la taquicinina, proceso para obtenerlos y composiciones farmaceuticas que los contienen. | |
ATE325093T1 (de) | ß2-OXO-1-PYRROLIDINDERIVATE UND IHRE PHARMAZEUTISCHE VERWENDUNGß | |
EE200300033A (et) | Tsüklopentanoindoolid, nende kasutamine ravimi valmistamiseks ning neid sisaldav farmatseutiline kompositsioon | |
SE8804629D0 (sv) | New therapeutically active compounds | |
SE9504661D0 (sv) | New compounds | |
AR020001A1 (es) | COMPUESTOS ACTIVADORES DE hPPARGAMMA Y hPPARALFA, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN, METODO PARA EL TRATAMIENTO Y/O PREVENCION DE UNAENFERMEDAD MEDIADA POR LOS MISMOS, Y SU USO PARA LA ELABORACION DE UN MEDICAMENTO | |
AR008878A1 (es) | Antagonistas del receptor de vitronectina, un metodo para su preparacion, una composicion farmaceutica que los contiene y el uso de las mismas para la preparacion de un medicamento. | |
CA2207835A1 (fr) | Nouveaux derives du 3-(piperid-4-yl) 1,2-benzisoxazole et du 3-(piperazin-4-yl) 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent | |
CO5271700A1 (es) | Composicion farmaceutica que comprende acido 3-[2,4-dimetil-5-(2-oxo-1,2-dihidro-indol-3-ilidenmetil)-1h-pirrol-3-il]-propionico, uno o mas compuestos polihidrocarbilo y un vehiculo farmaceuticamente aceptable | |
UY26372A1 (es) | "imidazo-3-il-aminas bicíclicas procedimiento para su preparación y medicamentos que las contienen " | |
ES2160648T3 (es) | Derivados de piridina. | |
LV10954A (lv) | Benzimidazola atvasinajumi to iegusanas panemiens un tos saturosa farmaceitiska kompozicija | |
DE69713300D1 (de) | Benzopyran derivate mit leukotrien-antagonistischer wirkung | |
ES2181132T3 (es) | Derivados de benzo(b)tiofeno para disminuir el contenido de plaquetas. | |
FR2680172B1 (fr) | Nouvelles piperazinylalcoyl-3 dihydro-2,3 4h-benzoxazine-1,3 ones-4 substituees, leur preparation et leur application en therapeutique. | |
ES2066390T3 (es) | Nuevos derivados del espiro-(4.5)-decano, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
TR200200473T2 (tr) | Rar selektif retinoid agonistleri. | |
AR006281A1 (es) | Utilizacion de (+)-alfa-(2,3-dimetoxifenil)-1-[2-(4-fluorofenil)etil]-4- piperidinometanol o sus sales de adicion de acidos farmaceuticamenteaceptables en el tratamineto de trastornos depresivos y trastornos bipolares | |
EE04058B1 (et) | Benso[c]kinolisiini derivaadid, nende valmistamine ja kasutamine 5a-reduktaasi inhibiitoritena | |
SE9504662D0 (sv) | New compounds | |
FI922428A (fi) | Nya 2-amino-5-cyan-1,4-dihydropyridiner, foerfarande foer deras framstaellning och deras anvaendning i laekemedel | |
DE69813263D1 (de) | Hydrazono-benzazulen-derivate, pharmazeutische zusammensetzungen und zwischenprodukte | |
ES8200678A1 (es) | Un procedimiento para la produccion de 10-(4-piperidinil)-10, 11-dihidro-dibenzo b,f 1,4 oxarepinas; tiazepinas y diaze-pinas. | |
UY27001A1 (es) | Derivados de la indolilpiperidina como agentes antihistamínicos y antialérgicos | |
AR023452A1 (es) | Utilizacion del osanetant para preparacion de medicamentos utiles en el tratamiento de los trastornos del humor |