ES8200678A1 - Un procedimiento para la produccion de 10-(4-piperidinil)-10, 11-dihidro-dibenzo b,f 1,4 oxarepinas; tiazepinas y diaze-pinas. - Google Patents

Un procedimiento para la produccion de 10-(4-piperidinil)-10, 11-dihidro-dibenzo b,f 1,4 oxarepinas; tiazepinas y diaze-pinas.

Info

Publication number
ES8200678A1
ES8200678A1 ES495516A ES495516A ES8200678A1 ES 8200678 A1 ES8200678 A1 ES 8200678A1 ES 495516 A ES495516 A ES 495516A ES 495516 A ES495516 A ES 495516A ES 8200678 A1 ES8200678 A1 ES 8200678A1
Authority
ES
Spain
Prior art keywords
production
pharmaceutical compositions
compositions containing
dibenzazepine derivatives
sleep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495516A
Other languages
English (en)
Other versions
ES495516A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES495516A0 publication Critical patent/ES495516A0/es
Publication of ES8200678A1 publication Critical patent/ES8200678A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 10-(4-PIPERIDINIL)-10,11-DIHIDRO-DIBENZO (B,F) (1,4) OXACEPINAS; -TIAZEPINAS Y DIAZEPINAS DE FORMULA (I), EN LA QUE R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADIALES Y Z ES -O-, -S- O -NR-, SIENDO R UNO DE VARIOS TIPOS DE RADIALES. CONSISTE EN LA REDUCCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1, R2, R3 Y Z TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), POR CUALQUIER METODO CONVENCIONAL, CON UN AGENTE REDUCTOR ADECUADO, EN UN DISOLVENTE INERTE A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y LA DE REFLUJO DE LA DISOLUCION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS ACTIVIDADES NEUROLEPTICA, ANTIDEPRESIVA E INDUCTORA DEL SUEÑO.
ES495516A 1979-10-01 1980-09-30 Un procedimiento para la produccion de 10-(4-piperidinil)-10, 11-dihidro-dibenzo b,f 1,4 oxarepinas; tiazepinas y diaze-pinas. Expired ES8200678A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH883679 1979-10-01
CH1132279 1979-12-20
CH26880 1980-01-14

Publications (2)

Publication Number Publication Date
ES495516A0 ES495516A0 (es) 1981-11-16
ES8200678A1 true ES8200678A1 (es) 1981-11-16

Family

ID=27171952

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495516A Expired ES8200678A1 (es) 1979-10-01 1980-09-30 Un procedimiento para la produccion de 10-(4-piperidinil)-10, 11-dihidro-dibenzo b,f 1,4 oxarepinas; tiazepinas y diaze-pinas.

Country Status (12)

Country Link
US (1) US4360525A (es)
EP (1) EP0026469B1 (es)
CA (1) CA1173829A (es)
DE (1) DE3069716D1 (es)
DK (1) DK414180A (es)
ES (1) ES8200678A1 (es)
FI (1) FI803030A (es)
IE (1) IE50249B1 (es)
IL (1) IL61161A (es)
NZ (1) NZ195079A (es)
PH (1) PH16253A (es)
PT (1) PT71850B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH646696A5 (de) 1980-11-28 1984-12-14 Sandoz Ag Dibenzazepine, ihre herstellung und verwendung.
EP0343307A1 (en) * 1988-05-26 1989-11-29 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. 4-Piperidinealkanamine derivatives
US5312819A (en) * 1990-08-20 1994-05-17 Sandoz Ltd. Pharmaceutical compositions comprising clozapine and a radical scavenger
US5461047A (en) * 1993-06-16 1995-10-24 G. D. Searle & Co. 2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
US5354747A (en) * 1993-06-16 1994-10-11 G. D. Searle & Co. 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
US5420270A (en) * 1993-10-07 1995-05-30 G. D. Searle & Co. Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5488046A (en) * 1993-11-03 1996-01-30 G. D. Searle & Co. Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
EP0878475A3 (en) * 1997-05-15 1998-11-25 Meiji Seika Kaisha, Ltd. 5-(4-Piperidinyl)dibenzothiazepine derivatives and 5-(4-piperidinyl)dibenzoxazepine derivatives, and antiarrhythmic agents
AU2003290735A1 (en) * 2002-12-06 2004-06-30 Eli Lilly And Company Inhibitors of monoamine uptake

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL256049A (es) * 1959-09-22
IN108354B (es) * 1966-12-08 1975-08-16 Ciba Geigy
CA918659A (en) * 1969-07-31 1973-01-09 Yoshitomi Pharmaceutical Industries 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines
US3676432A (en) * 1970-08-31 1972-07-11 Robins Co Inc A H 11,12-DIHYDRODIBENZ{8 b,f{9 AZOCIN-6(5H)-ONES
US3660406A (en) * 1970-10-26 1972-05-02 American Cyanamid Co 2-chloro-7-hydroxy-11-(1-piperazinyl)dibenz(b f)(1 4)oxazepines

Also Published As

Publication number Publication date
IE802033L (en) 1981-04-01
EP0026469A1 (en) 1981-04-08
DE3069716D1 (en) 1985-01-10
ES495516A0 (es) 1981-11-16
PT71850A (en) 1980-10-01
US4360525A (en) 1982-11-23
IL61161A (en) 1984-03-30
DK414180A (da) 1981-04-02
FI803030A (fi) 1981-04-02
EP0026469B1 (en) 1984-11-28
PH16253A (en) 1983-08-16
NZ195079A (en) 1984-07-06
PT71850B (en) 1981-10-22
IE50249B1 (en) 1986-03-05
IL61161A0 (en) 1980-11-30
CA1173829A (en) 1984-09-04

Similar Documents

Publication Publication Date Title
HUT37418A (en) Process for producing new 2,2'-imino-bis/ethanol/ derivatives and pharmaceutical compositions sontaining them as active agents
EP0500143A3 (en) Pharmaceutical composition comprising an aminoglycoside phosphate
MY101791A (en) New benzimidazole derivatives
EP0279149A3 (en) Benzimidazole derivatives, process for their production and a pharmaceutical composition containing the same
IL94433A0 (en) Aminophenol derivatives,their preparation and pharmaceutical compositions containing them
ES8200678A1 (es) Un procedimiento para la produccion de 10-(4-piperidinil)-10, 11-dihidro-dibenzo b,f 1,4 oxarepinas; tiazepinas y diaze-pinas.
ES8605532A1 (es) Un procedimiento para preparar derivados de aminoglicosido
ES483661A1 (es) Procedimiento para la obtencion de derivados de 1,4-dihidro-piridina sila-sustituidos
ES478048A1 (es) Procedimiento para la obtencion de difenil-imidazolil-meta- nos sustituidos.
ES8502440A1 (es) Procedimiento para preparar acepinoindoles.
SE8405588D0 (sv) New compounds
SE8302979D0 (sv) Piperazine derivatives, their production and pharmaceutical compositions containing them
ES8106304A1 (es) Un procedimiento para la preparacion de fenil-quinolicidinas
HUT63151A (en) Process for producing new benzimidazole-2-sulfonamide and imidazopyuridine-2-sylfonamide derivatives, as well as pharmaceutical compositions comprising same as active ingredient
HUT47124A (en) Process for producing pharmaceutical compositions comprising organic platinum complex as active ingredient and the active ingredients
ZA845931B (en) 1-(4'-alkylsulphonylphenyl)-2-amino-1,3-propanediol n-substituted derivatives
SE8306225D0 (sv) 2-piperazinyl-quinazoline derivatives, their production and pharmaceutical compositions containing them
ES8203334A1 (es) Procedimiento para la obtencion de dehidropeptidos
AU581856B2 (en) 1-(4'-alkylthiophenyl)-2-amino-1, 3-propanediol N-substituted derivatives
ES8504166A1 (es) Un metodo de preparar derivados de 6,11-dihidrodibenz(b,e) oxepina.
MY100083A (en) Diazepinoindoles, their production and pharmaceutical compositions containing them.
ES8401483A1 (es) Procedimiento para preparar nuevas furobenzazepinas.
JO1531B1 (en) New near-compounds