ES8401483A1 - Procedimiento para preparar nuevas furobenzazepinas. - Google Patents

Procedimiento para preparar nuevas furobenzazepinas.

Info

Publication number
ES8401483A1
ES8401483A1 ES82516489A ES516489A ES8401483A1 ES 8401483 A1 ES8401483 A1 ES 8401483A1 ES 82516489 A ES82516489 A ES 82516489A ES 516489 A ES516489 A ES 516489A ES 8401483 A1 ES8401483 A1 ES 8401483A1
Authority
ES
Spain
Prior art keywords
furobenzazepines
production
pharmaceutical compositions
compositions containing
sleep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES82516489A
Other languages
English (en)
Other versions
ES516489A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH662881A external-priority patent/CH646974A5/de
Priority claimed from CH207782A external-priority patent/CH650509A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8401483A1 publication Critical patent/ES8401483A1/es
Publication of ES516489A0 publication Critical patent/ES516489A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 4-PIPERAZINIL-10H-FURO 3,2-C 1BENZAZEPINAS DE FORMULA (I), EN LA QUE R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES; Y R3Y R4 SON HIDROGENO O ALQUILO INFERIOR C1-4.CONSISTE EN LA REACCION DE UN DERIVADO DE 10H-FURO 3,2-C 1BENZAZEPINA QUE TIENE UN GRUPO SALIENTE O UN GRUPO CARBONILO EN POSICION 4, DE FORMULA (I), CON UN COMPUESTO DE FORMULA (III), EN LAS QUE X, Y Y Z PUEDEN SER VARIOS TIPOS DE RADICALES, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO INERTE,A UNA TEMPERATURA ENTRE 50JC Y 170JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD NEUROLEPTICA.
ES82516489A 1981-10-16 1982-10-14 Procedimiento para preparar nuevas furobenzazepinas. Granted ES516489A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH662881A CH646974A5 (en) 1981-10-16 1981-10-16 Furobenzazepines, their preparation and use
CH207782A CH650509A5 (en) 1982-04-05 1982-04-05 Furobenzazepines, their preparation and use

Publications (2)

Publication Number Publication Date
ES8401483A1 true ES8401483A1 (es) 1983-12-16
ES516489A0 ES516489A0 (es) 1983-12-16

Family

ID=25689444

Family Applications (1)

Application Number Title Priority Date Filing Date
ES82516489A Granted ES516489A0 (es) 1981-10-16 1982-10-14 Procedimiento para preparar nuevas furobenzazepinas.

Country Status (16)

Country Link
AU (1) AU8936982A (es)
BE (1) BE894623A (es)
CA (1) CA1193596A (es)
DE (1) DE3236937A1 (es)
DK (1) DK457082A (es)
ES (1) ES516489A0 (es)
FI (1) FI823437L (es)
FR (1) FR2514767A1 (es)
GB (1) GB2107711B (es)
HU (1) HU189184B (es)
IT (1) IT1189389B (es)
NL (1) NL8203954A (es)
NZ (1) NZ202170A (es)
PH (1) PH20263A (es)
PT (1) PT75677A (es)
SE (1) SE8205849L (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0001401A1 (en) * 1977-09-29 1979-04-18 Sandoz Ag Thienobenzazepine derivatives, processes for their production and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
HU189184B (en) 1986-06-30
FI823437L (fi) 1983-04-17
IT8249285A0 (it) 1982-10-15
DK457082A (da) 1983-04-17
GB2107711B (en) 1985-04-17
PT75677A (en) 1982-11-01
NZ202170A (en) 1985-11-08
SE8205849L (sv) 1983-04-17
FR2514767B1 (es) 1984-01-27
CA1193596A (en) 1985-09-17
SE8205849D0 (sv) 1982-10-14
IT1189389B (it) 1988-02-04
GB2107711A (en) 1983-05-05
PH20263A (en) 1986-11-14
FI823437A0 (fi) 1982-10-08
BE894623A (fr) 1983-04-07
FR2514767A1 (fr) 1983-04-22
ES516489A0 (es) 1983-12-16
AU8936982A (en) 1983-04-21
DE3236937A1 (de) 1983-05-05
NL8203954A (nl) 1983-05-16

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