DE69806705D1 - Benzo(b)thiophene Derivaten zur Verringerung der Blutplätchenzahl - Google Patents

Benzo(b)thiophene Derivaten zur Verringerung der Blutplätchenzahl

Info

Publication number
DE69806705D1
DE69806705D1 DE69806705T DE69806705T DE69806705D1 DE 69806705 D1 DE69806705 D1 DE 69806705D1 DE 69806705 T DE69806705 T DE 69806705T DE 69806705 T DE69806705 T DE 69806705T DE 69806705 D1 DE69806705 D1 DE 69806705D1
Authority
DE
Germany
Prior art keywords
benzo
platelet counts
thiophene derivatives
reduce platelet
coar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69806705T
Other languages
English (en)
Other versions
DE69806705T2 (de
Inventor
Mark Chandrakant Lakshmanan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69806705D1 publication Critical patent/DE69806705D1/de
Application granted granted Critical
Publication of DE69806705T2 publication Critical patent/DE69806705T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
DE69806705T 1997-08-21 1998-08-18 Benzo(b)thiophene Derivaten zur Verringerung der Blutplätchenzahl Expired - Fee Related DE69806705T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5620397P 1997-08-21 1997-08-21

Publications (2)

Publication Number Publication Date
DE69806705D1 true DE69806705D1 (de) 2002-08-29
DE69806705T2 DE69806705T2 (de) 2003-03-20

Family

ID=22002873

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69806705T Expired - Fee Related DE69806705T2 (de) 1997-08-21 1998-08-18 Benzo(b)thiophene Derivaten zur Verringerung der Blutplätchenzahl

Country Status (22)

Country Link
US (1) US6103740A (de)
EP (1) EP0904783B1 (de)
JP (1) JP2001515015A (de)
KR (1) KR20010023075A (de)
CN (1) CN1275886A (de)
AT (1) ATE220905T1 (de)
AU (1) AU741882B2 (de)
BR (1) BR9811962A (de)
CA (1) CA2301806A1 (de)
DE (1) DE69806705T2 (de)
DK (1) DK0904783T3 (de)
EA (1) EA001582B1 (de)
ES (1) ES2181132T3 (de)
HR (1) HRP20000094A2 (de)
HU (1) HUP0002715A3 (de)
IL (1) IL134551A0 (de)
NO (1) NO20000750L (de)
NZ (1) NZ502842A (de)
PL (1) PL338700A1 (de)
PT (1) PT904783E (de)
TR (1) TR200000453T2 (de)
WO (1) WO1999008525A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624800D0 (en) * 1996-11-29 1997-01-15 Lilly Co Eli Methods of preventing breast cancer
US6353003B1 (en) 1998-06-17 2002-03-05 Eli Lilly And Company Method for reducing levels of homocysteine and C-reactive protein
WO2001021259A2 (en) * 1999-09-21 2001-03-29 Emory University Use and compositions for treating platelet-related disorders using anagrelide
US8021854B2 (en) * 2007-10-05 2011-09-20 Attila Mady Method of treating vascular disease
US20090092693A1 (en) * 2007-10-05 2009-04-09 Mady Attila Platelet manipulation to prevent and treat endovascular disease and its sequelae, to prevent and treat arrhythmias and to prevent malignancy

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4447620A (en) * 1982-06-08 1984-05-08 The Upjohn Company Imidazolyl-substituted benzothiophenes
US5075321A (en) * 1987-03-24 1991-12-24 University Of Pennsylvania Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes
US4847276A (en) * 1988-09-06 1989-07-11 Merrell Dow Pharmaceuticals Inc. Treatment of thromobocytosis with 5-(4-chlorophenyl)-2,4-diemthyl-3H-1,2,4-triazole-3-thione
JPH0517357A (ja) * 1991-07-05 1993-01-26 Nissan Chem Ind Ltd 血小板減少療法剤
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US5424334A (en) * 1991-12-19 1995-06-13 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US5445941A (en) * 1993-06-21 1995-08-29 Eli Lilly And Company Method for screening anti-osteoporosis agents
US5391557A (en) * 1993-10-15 1995-02-21 Eli Lilly And Company Methods for the treatment of peri-menopausal syndrome
US5441965A (en) * 1993-12-21 1995-08-15 Eli Lilly And Company Methods of inhibiting thrombin
US5476862A (en) * 1993-12-21 1995-12-19 Eli Lilly And Company Methods of increasing thrombomodulin expression
US6025373A (en) * 1997-04-22 2000-02-15 Eli Lilly And Company Methods for reducing fibrinogen

Also Published As

Publication number Publication date
US6103740A (en) 2000-08-15
JP2001515015A (ja) 2001-09-18
HUP0002715A2 (hu) 2001-06-28
CN1275886A (zh) 2000-12-06
DK0904783T3 (da) 2002-09-02
PT904783E (pt) 2002-10-31
WO1999008525A1 (en) 1999-02-25
EP0904783B1 (de) 2002-07-24
IL134551A0 (en) 2001-04-30
PL338700A1 (en) 2000-11-20
HUP0002715A3 (en) 2002-12-28
BR9811962A (pt) 2000-08-15
HRP20000094A2 (en) 2000-08-31
EA001582B1 (ru) 2001-06-25
CA2301806A1 (en) 1999-02-25
NO20000750L (no) 2000-04-13
ES2181132T3 (es) 2003-02-16
NO20000750D0 (no) 2000-02-15
EP0904783A1 (de) 1999-03-31
DE69806705T2 (de) 2003-03-20
TR200000453T2 (tr) 2000-08-21
ATE220905T1 (de) 2002-08-15
AU8830698A (en) 1999-03-08
AU741882B2 (en) 2001-12-13
EA200000243A1 (ru) 2000-10-30
KR20010023075A (ko) 2001-03-26
NZ502842A (en) 2001-11-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee