NO319434B1 - Farmasoytisk oral doseform av ranolazin-preparater med depotvirkning og en komprimert tablett. - Google Patents
Farmasoytisk oral doseform av ranolazin-preparater med depotvirkning og en komprimert tablett. Download PDFInfo
- Publication number
- NO319434B1 NO319434B1 NO20011191A NO20011191A NO319434B1 NO 319434 B1 NO319434 B1 NO 319434B1 NO 20011191 A NO20011191 A NO 20011191A NO 20011191 A NO20011191 A NO 20011191A NO 319434 B1 NO319434 B1 NO 319434B1
- Authority
- NO
- Norway
- Prior art keywords
- ranolazine
- dosage form
- pharmaceutical dosage
- form according
- phthalate
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9980498P | 1998-09-10 | 1998-09-10 | |
| US09/321,522 US6303607B1 (en) | 1998-09-10 | 1999-05-27 | Method for administering a sustained release ranolanolazine formulation |
| PCT/US1999/020967 WO2000013686A2 (fr) | 1998-09-10 | 1999-09-09 | Formulations de ranolazine a liberation lente |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20011191D0 NO20011191D0 (no) | 2001-03-08 |
| NO20011191L NO20011191L (no) | 2001-04-30 |
| NO319434B1 true NO319434B1 (no) | 2005-08-15 |
Family
ID=26796494
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20011191A NO319434B1 (no) | 1998-09-10 | 2001-03-08 | Farmasoytisk oral doseform av ranolazin-preparater med depotvirkning og en komprimert tablett. |
| NO20011192A NO320986B1 (no) | 1998-09-10 | 2001-03-08 | Anvendelse av ranolazin og minst ett pH-avhengig bindemiddel for fremstilling av ranolazinpreparater med depotvirkning |
| NO20054324A NO20054324L (no) | 1998-09-10 | 2005-09-20 | Anvendelse av ranolazin og minst ett pH-avhengig bindemiddel for fremstilling av ranolazinpreparater med depotvirkning |
| NO2009005C NO2009005I1 (no) | 1998-09-10 | 2009-03-05 | Ranolazin samt salter og solvater derav |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20011192A NO320986B1 (no) | 1998-09-10 | 2001-03-08 | Anvendelse av ranolazin og minst ett pH-avhengig bindemiddel for fremstilling av ranolazinpreparater med depotvirkning |
| NO20054324A NO20054324L (no) | 1998-09-10 | 2005-09-20 | Anvendelse av ranolazin og minst ett pH-avhengig bindemiddel for fremstilling av ranolazinpreparater med depotvirkning |
| NO2009005C NO2009005I1 (no) | 1998-09-10 | 2009-03-05 | Ranolazin samt salter og solvater derav |
Country Status (33)
| Country | Link |
|---|---|
| US (14) | US6303607B1 (fr) |
| EP (3) | EP1527779A1 (fr) |
| JP (2) | JP3745621B2 (fr) |
| KR (1) | KR100475759B1 (fr) |
| CN (2) | CN1193757C (fr) |
| AR (3) | AR022085A1 (fr) |
| AT (2) | ATE285774T1 (fr) |
| AU (4) | AU744071B2 (fr) |
| BR (2) | BR9913626A (fr) |
| CA (2) | CA2343376C (fr) |
| CY (1) | CY2008020I2 (fr) |
| CZ (2) | CZ301341B6 (fr) |
| DE (3) | DE69922964T2 (fr) |
| DK (2) | DK1096937T3 (fr) |
| ES (2) | ES2234302T3 (fr) |
| FR (1) | FR09C0001I2 (fr) |
| GE (1) | GEP20053420B (fr) |
| HK (2) | HK1040060A1 (fr) |
| HU (2) | HUP0104088A3 (fr) |
| IL (6) | IL141893A0 (fr) |
| LU (1) | LU91504I2 (fr) |
| MX (2) | MXPA01002599A (fr) |
| NL (1) | NL300371I2 (fr) |
| NO (4) | NO319434B1 (fr) |
| NZ (2) | NZ510386A (fr) |
| PL (3) | PL196263B1 (fr) |
| PT (2) | PT1109558E (fr) |
| RU (2) | RU2214233C2 (fr) |
| SI (2) | SI1096937T1 (fr) |
| TR (2) | TR200101261T2 (fr) |
| TW (1) | TWI241911B (fr) |
| UA (2) | UA75027C2 (fr) |
| WO (2) | WO2000013686A2 (fr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303607B1 (en) * | 1998-09-10 | 2001-10-16 | Cv Therapeutics, Inc. | Method for administering a sustained release ranolanolazine formulation |
| US6479496B1 (en) * | 1998-09-10 | 2002-11-12 | Cv Therapeutics, Inc. | Methods for treating angina with ranolazine |
| EP2033633A3 (fr) | 2000-02-18 | 2009-07-08 | Cv Therapeutics, Inc. | Inhibiteurs d'oxydation d'acide gras partiel dans le traitement d'une insuffisance cardiaque congestive |
| AU2001277938A1 (en) * | 2000-07-21 | 2002-02-05 | Cv Therapeutics, Inc. | Method for treating angina |
| WO2002032427A1 (fr) * | 2000-10-20 | 2002-04-25 | Galephar M/F | Formulation stable administrable par voie orale contenant un derive de benzimidazole |
| FR2830447B1 (fr) * | 2001-10-09 | 2004-04-16 | Flamel Tech Sa | Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques |
| US8101209B2 (en) * | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| US20030220344A1 (en) * | 2002-04-04 | 2003-11-27 | Luiz Belardinelli | Method of treating arrhythmias |
| US20080109040A1 (en) * | 2002-04-04 | 2008-05-08 | Luiz Belardinelli | Method of treating arrhythmias |
| IL164221A0 (en) * | 2002-04-09 | 2005-12-18 | Flamel Tech Sa | Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillim |
| CA2480826C (fr) | 2002-04-09 | 2012-02-07 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
| CA2486712C (fr) * | 2002-05-21 | 2012-01-03 | Cv Therapeutics, Inc. | Methode permettant de traiter le diabete |
| US8822473B2 (en) * | 2002-05-21 | 2014-09-02 | Gilead Sciences, Inc. | Method of treating diabetes |
| TWI350762B (en) | 2004-02-12 | 2011-10-21 | Euro Celtique Sa | Particulates |
| GB0403098D0 (en) | 2004-02-12 | 2004-03-17 | Euro Celtique Sa | Extrusion |
| AU2006203890A1 (en) * | 2005-01-06 | 2006-07-13 | Gilead Sciences, Inc. | Sustained release pharmaceutical formulations comprising ranolazine |
| FR2886150B1 (fr) * | 2005-05-24 | 2007-08-24 | Flamel Technologies Sa | Forme pharmaceutique orale a base d'au moins un principe actif dont la solubilite varie en fonction des conditions de ph gastrique |
| WO2007016350A2 (fr) * | 2005-07-28 | 2007-02-08 | Supernus Pharmaceuticals, Inc. | Preparation en comprimes a liberation modifiee presentant des proprietes mecaniques ameliorees |
| WO2007108362A1 (fr) * | 2006-03-17 | 2007-09-27 | Konica Minolta Holdings, Inc. | Dispositif électroluminescent organique, dispositif d'éclairage et d'affichage |
| FI20060501L (fi) * | 2006-05-22 | 2007-11-23 | Biohit Oyj | Koostumus ja menetelmä asetaldehydin sitomiseksi vatsassa |
| JP2010518170A (ja) * | 2007-02-13 | 2010-05-27 | ギリアード・パロ・アルト・インコーポレイテッド | 冠微小血管疾患の処置のためのラノラジンの使用 |
| US20090312340A1 (en) * | 2007-02-13 | 2009-12-17 | Whedy Wang | Use of ranolazine for the treatment of cardiovascular diseases |
| EP2136780A1 (fr) * | 2007-02-13 | 2009-12-30 | CV Therapeutics Inc. | Utilisation de la ranolazine pour le traitement de maladies cardiovasculaires |
| US20080193530A1 (en) * | 2007-02-13 | 2008-08-14 | Brent Blackburn | Use of ranolazine for the treatment of non-coronary microvascular diseases |
| US20090111826A1 (en) * | 2007-02-13 | 2009-04-30 | Louis Lange | Use of ranolazine for the treatment of cardiovascular diseases |
| US7943620B2 (en) * | 2007-03-07 | 2011-05-17 | Concert Pharmaceuticals, Inc. | Anti-anginal compounds |
| WO2008116083A1 (fr) * | 2007-03-22 | 2008-09-25 | Cv Therapeutics, Inc. | Utilisation de ranolazine contre un taux élevé de peptide natriurétique de type b |
| KR20100033490A (ko) * | 2007-05-31 | 2010-03-30 | 질레드 팔로 알토 인코포레이티드 | 상승된 뇌-형 나트륨이뇨 펩티드에 대한 라놀라진 |
| CN101066253B (zh) * | 2007-06-07 | 2011-01-05 | 北京本草天源药物研究院 | 一种雷诺嗪缓释片 |
| EP2155697B1 (fr) * | 2007-06-13 | 2012-11-28 | Auspex Pharmaceuticals, Inc. | Pipérazines substituées |
| US20090012103A1 (en) * | 2007-07-05 | 2009-01-08 | Matthew Abelman | Substituted heterocyclic compounds |
| US20090076018A1 (en) * | 2007-09-15 | 2009-03-19 | Protia, Llc | Deuterium-enriched ranolazine |
| WO2009100380A1 (fr) * | 2008-02-06 | 2009-08-13 | Cv Therapeutics, Inc. | Utilisation de ranolazine pour traiter la douleur |
| US20100292217A1 (en) * | 2009-05-14 | 2010-11-18 | Gilead Palo Alto, Inc. | Ranolazine for the treatment of cns disorders |
| EP2515880B1 (fr) | 2009-05-28 | 2019-11-27 | Lupin Limited | Nouvelles compositions pharmaceutiques de ranolazine |
| US20120177729A1 (en) * | 2009-09-25 | 2012-07-12 | Lupin Limited | Sustained release composition of ranolazine |
| TWI508726B (zh) | 2009-12-21 | 2015-11-21 | Gilead Sciences Inc | 治療心房纖維性顫動之方法 |
| TW201215392A (en) | 2010-06-16 | 2012-04-16 | Gilead Sciences Inc | Use of ranolazine for treating pulmonary hypertension |
| EP2524688B1 (fr) | 2011-05-11 | 2013-05-01 | ratiopharm GmbH | Composition de libération modifiée comportant de la ranolazine |
| NO3175985T3 (fr) | 2011-07-01 | 2018-04-28 | ||
| US20140221286A1 (en) | 2011-09-21 | 2014-08-07 | Gilead Sciences, Inc. | Sodium channel blockers reduce glucagon secretion |
| WO2014176557A2 (fr) * | 2013-04-26 | 2014-10-30 | Chanrx Corporation | Méthodes d'étalonnage de l'administration de vanoxérine pour mettre fin à des épisodes aigus d'arythmie cardiaque, restaurer un rythme sinusal normal, prévenir la récidive d'arythmies cardiaques et maintenir un rythme sinusal normal chez un mammifère |
| CN104758265B (zh) * | 2014-01-07 | 2019-05-17 | 四川海思科制药有限公司 | 一种雷诺嗪缓释片药物组合物及其制备方法 |
| AR101476A1 (es) | 2014-08-07 | 2016-12-21 | Acerta Pharma Bv | Métodos para tratar cánceres, enfermedades inmunes y autoinmunes, y enfermedades inflamatorias en base a la tasa de ocupación de la tirosin quinasa de bruton (btk) y a la tasa de resíntesis de la tirosin quinasa de bruton (btk) |
| TW201717919A (zh) | 2015-07-02 | 2017-06-01 | 國際藥品股份公司 | 雷諾多重壓縮錠劑 |
| WO2018001582A1 (fr) | 2016-06-30 | 2018-01-04 | Interquim, S.A. | Comprimés multiples à base de ranolazine |
| AR110252A1 (es) | 2016-11-30 | 2019-03-13 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como inhibidores de la quinasa cam |
| US10898444B2 (en) | 2017-06-01 | 2021-01-26 | Sun Pharmaceutical Industries Limited | Extended release multiparticulates of ranolazine |
| CN112438955A (zh) * | 2019-08-30 | 2021-03-05 | 深圳翰宇药业股份有限公司 | 一种雷诺嗪缓释组合物及其制备方法 |
| JP2023507626A (ja) | 2019-12-16 | 2023-02-24 | テナックス・セラピューティクス，インコーポレイテッド | 駆出率が保たれた心不全を伴う肺高血圧症（ＰＨ－ＨＦ－ｐＥＦ）を治療するためのレボシメンダン |
| CN110898024A (zh) * | 2019-12-17 | 2020-03-24 | 卓和药业集团有限公司 | 一种治疗心绞痛的药物组合物及制备方法 |
| GR1010345B (el) * | 2021-12-16 | 2022-11-28 | Φαρματεν Α.Β.Ε.Ε., | Δισκια παρατεταμενης αποδεσμευσης που περιλαμβανουν ρανολαζινη και μεθοδος παραγωγης αυτων |
| GR1010510B (el) * | 2022-06-07 | 2023-07-20 | Ελπεν Α.Ε. Φαρμακευτικη Βιομηχανια, | Στερεες φαρμακοτεχνικες μορφες παρατεταμενης αποδεσμευσης ρανολαζινης |
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| IL81419A0 (en) * | 1986-01-30 | 1987-08-31 | Syntex Inc | Long acting sustained release pharmaceutical compositions containing dihydropyridines and their preparation |
| DE69033967T2 (de) * | 1989-06-23 | 2002-12-19 | Syntex (U.S.A.) Llc, Palo Alto | Ranolazin und verwandte Piperazine zur Behandlung von Schockzuständen |
| US5527545A (en) | 1989-09-18 | 1996-06-18 | Recordati S.A. Chemical And Pharmaceutical Company | Liquid-suspension controlled-release pharmaceutical composition |
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| JPH08259446A (ja) * | 1995-01-24 | 1996-10-08 | Mitsui Toatsu Chem Inc | 持効性医薬製剤 |
| JPH08310946A (ja) * | 1995-05-19 | 1996-11-26 | Yuutoku Yakuhin Kogyo Kk | 経皮吸収製剤 |
| JPH09188617A (ja) * | 1996-01-08 | 1997-07-22 | Pola Chem Ind Inc | 徐放性医薬組成物 |
| US6479496B1 (en) * | 1998-09-10 | 2002-11-12 | Cv Therapeutics, Inc. | Methods for treating angina with ranolazine |
| US6303607B1 (en) * | 1998-09-10 | 2001-10-16 | Cv Therapeutics, Inc. | Method for administering a sustained release ranolanolazine formulation |
-
1999
- 1999-05-27 US US09/321,522 patent/US6303607B1/en not_active Expired - Lifetime
- 1999-09-09 EP EP04030151A patent/EP1527779A1/fr not_active Withdrawn
- 1999-09-09 BR BR9913626-0A patent/BR9913626A/pt not_active Application Discontinuation
- 1999-09-09 ES ES99948196T patent/ES2234302T3/es not_active Expired - Lifetime
- 1999-09-09 DE DE69922964T patent/DE69922964T2/de not_active Expired - Lifetime
- 1999-09-09 AT AT99948196T patent/ATE285774T1/de active
- 1999-09-09 RU RU2001109431/14A patent/RU2214233C2/ru active Protection Beyond IP Right Term
- 1999-09-09 PL PL348249A patent/PL196263B1/pl unknown
- 1999-09-09 EP EP99968627A patent/EP1109558B1/fr not_active Expired - Lifetime
- 1999-09-09 CA CA002343376A patent/CA2343376C/fr not_active Expired - Lifetime
- 1999-09-09 GE GE4322A patent/GEP20053420B/en unknown
- 1999-09-09 UA UA2001031622A patent/UA75027C2/uk unknown
- 1999-09-09 ES ES99968627T patent/ES2177346T3/es not_active Expired - Lifetime
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- 1999-09-09 CZ CZ20010879A patent/CZ301375B6/cs not_active IP Right Cessation
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2000
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2001
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2002
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2003
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2004
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2005
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- 2005-09-07 US US11/221,450 patent/US20060147521A1/en not_active Abandoned
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- 2005-10-11 JP JP2005296674A patent/JP2006096757A/ja active Pending
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2006
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2007
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2008
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