NO318798B1 - Isotiazolderivater nyttige som anti-cancer midler, anvendelse og fremgangsmate for fremstilling derav, samt farmasoytisk sammensetning - Google Patents

Info

Publication number

NO318798B1

NO318798B1 NO20006071A NO20006071A NO318798B1 NO 318798 B1 NO318798 B1 NO 318798B1 NO 20006071 A NO20006071 A NO 20006071A NO 20006071 A NO20006071 A NO 20006071A NO 318798 B1 NO318798 B1 NO 318798B1

Authority

NO

Norway

Prior art keywords

carboxylic acid

isothiazole

acid amide

ureido

methylbenzyloxy

Prior art date

1998-06-04

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• 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 15
• 238000002360 preparation method Methods 0.000 title claims description 19
• 239000002246 antineoplastic agent Substances 0.000 title claims description 5
• 238000000034 method Methods 0.000 title abstract description 87
• 150000003854 isothiazoles Chemical class 0.000 title description 4
• 150000001875 compounds Chemical class 0.000 claims abstract description 230
• 150000003839 salts Chemical class 0.000 claims abstract description 32
• 241000124008 Mammalia Species 0.000 claims abstract description 11
• 230000003463 hyperproliferative effect Effects 0.000 claims abstract description 11
• 229940002612 prodrug Drugs 0.000 claims abstract description 11
• 239000000651 prodrug Substances 0.000 claims abstract description 11
• 239000012453 solvate Substances 0.000 claims abstract description 6
• -1 dimethyl-amino, hydroxy, pyrrolidinyl Chemical group 0.000 claims description 122
• BEPMYBTTZSNHPS-UHFFFAOYSA-N 1,2-thiazole-4-carboxamide Chemical compound NC(=O)C=1C=NSC=1 BEPMYBTTZSNHPS-UHFFFAOYSA-N 0.000 claims description 33
• 206010028980 Neoplasm Diseases 0.000 claims description 25
• 210000004027 cell Anatomy 0.000 claims description 21
• 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims description 20
• 238000011282 treatment Methods 0.000 claims description 20
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
• 208000035475 disorder Diseases 0.000 claims description 15
• 201000011510 cancer Diseases 0.000 claims description 14
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
• 210000002307 prostate Anatomy 0.000 claims description 10
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
• 125000000217 alkyl group Chemical group 0.000 claims description 8
• 210000000481 breast Anatomy 0.000 claims description 8
• 210000004072 lung Anatomy 0.000 claims description 8
• 229910052717 sulfur Inorganic materials 0.000 claims description 8
• 239000003112 inhibitor Substances 0.000 claims description 7
• HXHAJRMTJXHJJZ-UHFFFAOYSA-N 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide Chemical compound S1N=C(OCC=2C(=CC(Br)=CC=2F)F)C(C(=O)N)=C1NC(=O)NCCCCN1CCCC1 HXHAJRMTJXHJJZ-UHFFFAOYSA-N 0.000 claims description 6
• 208000024770 Thyroid neoplasm Diseases 0.000 claims description 6
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• DYTGJDKRYVLILD-UHFFFAOYSA-N 3-[(2,6-difluoro-4-methylphenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide Chemical compound FC1=CC(C)=CC(F)=C1COC1=NSC(NC(=O)NCCCCN2CCCC2)=C1C(N)=O DYTGJDKRYVLILD-UHFFFAOYSA-N 0.000 claims description 5
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 5
• 125000005843 halogen group Chemical group 0.000 claims description 5
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
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• 238000004519 manufacturing process Methods 0.000 claims description 5
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• ZBGPVZIUOBZFOK-UHFFFAOYSA-N (2,6-difluoro-4-methylphenyl)methanol Chemical compound CC1=CC(F)=C(CO)C(F)=C1 ZBGPVZIUOBZFOK-UHFFFAOYSA-N 0.000 claims description 4
• 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 4
• AMLIAESKGXHWSE-UHFFFAOYSA-N 3-[(2-fluoro-4-methylphenyl)methoxy]-5-[5-(propan-2-ylamino)pentylcarbamoylamino]-1,2-thiazole-4-carboxamide Chemical compound NC(=O)C1=C(NC(=O)NCCCCCNC(C)C)SN=C1OCC1=CC=C(C)C=C1F AMLIAESKGXHWSE-UHFFFAOYSA-N 0.000 claims description 4
• NYYQETQHPXRWLV-UHFFFAOYSA-N 3-[(4-chloro-2,6-difluorophenyl)methoxy]-5-[2-(1-methylpyrrolidin-2-yl)ethylcarbamoylamino]-1,2-thiazole-4-carboxamide Chemical compound CN1CCCC1CCNC(=O)NC1=C(C(N)=O)C(OCC=2C(=CC(Cl)=CC=2F)F)=NS1 NYYQETQHPXRWLV-UHFFFAOYSA-N 0.000 claims description 4
• AHTAYKWZFAVPQM-UHFFFAOYSA-N 5-(3-pyrrolidin-1-ylpropylcarbamoylamino)-3-[(2,3,6-trifluoro-4-methylphenyl)methoxy]-1,2-thiazole-4-carboxamide Chemical compound FC1=C(F)C(C)=CC(F)=C1COC1=NSC(NC(=O)NCCCN2CCCC2)=C1C(N)=O AHTAYKWZFAVPQM-UHFFFAOYSA-N 0.000 claims description 4
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• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
• 229940088598 enzyme Drugs 0.000 claims description 4
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• 239000003102 growth factor Substances 0.000 claims description 4
• 125000000623 heterocyclic group Chemical group 0.000 claims description 4
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
• 210000004185 liver Anatomy 0.000 claims description 4
• 229910052757 nitrogen Inorganic materials 0.000 claims description 4
• 229910052760 oxygen Inorganic materials 0.000 claims description 4
• 125000001424 substituent group Chemical group 0.000 claims description 4
• DMPWHQMAGPTBSL-UHFFFAOYSA-N (2,3,6-trifluoro-4-methylphenyl)methanol Chemical compound CC1=CC(F)=C(CO)C(F)=C1F DMPWHQMAGPTBSL-UHFFFAOYSA-N 0.000 claims description 3
• KLHRZAAZABAKME-UHFFFAOYSA-N (3-chloro-2,6-difluorophenyl)methanol Chemical compound OCC1=C(F)C=CC(Cl)=C1F KLHRZAAZABAKME-UHFFFAOYSA-N 0.000 claims description 3
• CJGOKVYRNUALRJ-UHFFFAOYSA-N (4-bromo-2,3,6-trifluorophenyl)methanol Chemical compound OCC1=C(F)C=C(Br)C(F)=C1F CJGOKVYRNUALRJ-UHFFFAOYSA-N 0.000 claims description 3
• HFCXEWPMPAOGBM-UHFFFAOYSA-N 3-[(2-fluoro-4-methylphenyl)methoxy]-5-[3-(4-methylpiperazin-1-yl)propylcarbamoylamino]-1,2-thiazole-4-carboxamide Chemical compound C1CN(C)CCN1CCCNC(=O)NC1=C(C(N)=O)C(OCC=2C(=CC(C)=CC=2)F)=NS1 HFCXEWPMPAOGBM-UHFFFAOYSA-N 0.000 claims description 3
• KBASJCBTQBVBOG-UHFFFAOYSA-N 3-[(4-chloro-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide Chemical compound S1N=C(OCC=2C(=CC(Cl)=CC=2F)F)C(C(=O)N)=C1NC(=O)NCCCCN1CCCC1 KBASJCBTQBVBOG-UHFFFAOYSA-N 0.000 claims description 3
• KTXCVYMMHAFUTM-UHFFFAOYSA-N 5-(dimethylcarbamoylamino)-3-propylsulfanyl-1,2-thiazole-4-carboxamide Chemical compound CCCSC1=NSC(NC(=O)N(C)C)=C1C(N)=O KTXCVYMMHAFUTM-UHFFFAOYSA-N 0.000 claims description 3
• MUMZOQWBQONBKS-UHFFFAOYSA-N 5-(methylcarbamoylamino)-3-propylsulfanyl-1,2-thiazole-4-carboxamide Chemical compound CCCSC1=NSC(NC(=O)NC)=C1C(N)=O MUMZOQWBQONBKS-UHFFFAOYSA-N 0.000 claims description 3
• YUSUZAPDAOMLRF-UHFFFAOYSA-N 5-[4-[bis(2-hydroxyethyl)amino]butylcarbamoylamino]-3-[(2,6-difluoro-4-methylphenyl)methoxy]-1,2-thiazole-4-carboxamide Chemical compound FC1=CC(C)=CC(F)=C1COC1=NSC(NC(=O)NCCCCN(CCO)CCO)=C1C(N)=O YUSUZAPDAOMLRF-UHFFFAOYSA-N 0.000 claims description 3
• 229940123587 Cell cycle inhibitor Drugs 0.000 claims description 3
• 239000002168 alkylating agent Substances 0.000 claims description 3
• 229940100198 alkylating agent Drugs 0.000 claims description 3
• 230000002280 anti-androgenic effect Effects 0.000 claims description 3
• 230000003388 anti-hormonal effect Effects 0.000 claims description 3
• 239000000051 antiandrogen Substances 0.000 claims description 3
• 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 claims description 3
• 239000003795 chemical substances by application Substances 0.000 claims description 3
• 239000003937 drug carrier Substances 0.000 claims description 3
• 229910052736 halogen Inorganic materials 0.000 claims description 3
• 150000002367 halogens Chemical class 0.000 claims description 3
• 206010020718 hyperplasia Diseases 0.000 claims description 3
• 210000001672 ovary Anatomy 0.000 claims description 3
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 3
• ZHKDUZIFNFQCPE-UHFFFAOYSA-N (4-chloro-2,3,6-trifluorophenyl)methanol Chemical compound OCC1=C(F)C=C(Cl)C(F)=C1F ZHKDUZIFNFQCPE-UHFFFAOYSA-N 0.000 claims description 2
• GRIBVKFHFTZOCK-UHFFFAOYSA-N 3-[(2,5-difluoro-4-methylphenyl)methoxy]-5-[4-(3-hydroxypyrrolidin-1-yl)butylcarbamoylamino]-1,2-thiazole-4-carboxamide Chemical compound C1=C(F)C(C)=CC(F)=C1COC1=NSC(NC(=O)NCCCCN2CC(O)CC2)=C1C(N)=O GRIBVKFHFTZOCK-UHFFFAOYSA-N 0.000 claims description 2
• HCYLBNPHRUPOIC-UHFFFAOYSA-N 3-[(4-bromo-2,3,6-trifluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide Chemical compound S1N=C(OCC=2C(=C(F)C(Br)=CC=2F)F)C(C(=O)N)=C1NC(=O)NCCCCN1CCCC1 HCYLBNPHRUPOIC-UHFFFAOYSA-N 0.000 claims description 2
• NKGBEPBSPHYERX-UHFFFAOYSA-N 3-[(4-chloro-2,3,6-trifluorophenyl)methoxy]-5-[(3-hydroxy-5-pyrrolidin-1-ylpentyl)carbamoylamino]-1,2-thiazole-4-carboxamide Chemical compound S1N=C(OCC=2C(=C(F)C(Cl)=CC=2F)F)C(C(=O)N)=C1NC(=O)NCCC(O)CCN1CCCC1 NKGBEPBSPHYERX-UHFFFAOYSA-N 0.000 claims description 2
• AVBLJLMYGYPZBD-UHFFFAOYSA-N 3-[(4-chloro-2,6-difluorophenyl)methoxy]-5-(4-imidazol-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide Chemical compound S1N=C(OCC=2C(=CC(Cl)=CC=2F)F)C(C(=O)N)=C1NC(=O)NCCCCN1C=CN=C1 AVBLJLMYGYPZBD-UHFFFAOYSA-N 0.000 claims description 2
• FCFPJFILHKCMHU-UHFFFAOYSA-N 3-[(4-chloro-2,6-difluorophenyl)methoxy]-5-[4-[ethyl(2-hydroxyethyl)amino]butylcarbamoylamino]-1,2-thiazole-4-carboxamide Chemical compound NC(=O)C1=C(NC(=O)NCCCCN(CCO)CC)SN=C1OCC1=C(F)C=C(Cl)C=C1F FCFPJFILHKCMHU-UHFFFAOYSA-N 0.000 claims description 2
• FLIJOUHDTCIKLC-UHFFFAOYSA-N 3-ethoxy-5-(methylcarbamoylamino)-1,2-thiazole-4-carboxamide Chemical compound CCOC1=NSC(NC(=O)NC)=C1C(N)=O FLIJOUHDTCIKLC-UHFFFAOYSA-N 0.000 claims description 2
• 229940113081 5 Hydroxytryptamine 3 receptor antagonist Drugs 0.000 claims description 2
• VGFOJFVFHLTSSU-UHFFFAOYSA-N 5-(dimethylcarbamoylamino)-3-ethylsulfanyl-1,2-thiazole-4-carboxamide Chemical compound CCSC1=NSC(NC(=O)N(C)C)=C1C(N)=O VGFOJFVFHLTSSU-UHFFFAOYSA-N 0.000 claims description 2
• WJMRRSQFRXEXHM-UHFFFAOYSA-N 5-(methylcarbamoylamino)-3-methylsulfanyl-1,2-thiazole-4-carboxamide Chemical compound CNC(=O)NC=1SN=C(SC)C=1C(N)=O WJMRRSQFRXEXHM-UHFFFAOYSA-N 0.000 claims description 2
• BWBOZLVPMOSDEO-UHFFFAOYSA-N 5-(methylcarbamoylamino)-3-propan-2-ylsulfanyl-1,2-thiazole-4-carboxamide Chemical compound CNC(=O)NC=1SN=C(SC(C)C)C=1C(N)=O BWBOZLVPMOSDEO-UHFFFAOYSA-N 0.000 claims description 2
• RVEJKOFDHFCLKB-UHFFFAOYSA-N 5-[[3-aminopropyl(methyl)carbamoyl]amino]-3-[(2,3,6-trifluoro-4-methylphenyl)methoxy]-1,2-thiazole-4-carboxamide Chemical compound NC(=O)C1=C(NC(=O)N(CCCN)C)SN=C1OCC1=C(F)C=C(C)C(F)=C1F RVEJKOFDHFCLKB-UHFFFAOYSA-N 0.000 claims description 2
• 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims description 2
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• 125000002636 imidazolinyl group Chemical group 0.000 claims description 2
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• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 2
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• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
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• OXBJJTHWZCVWHV-UHFFFAOYSA-N 5-(methylcarbamoylamino)-3-propoxy-1,2-thiazole-4-carboxamide Chemical compound CCCOC1=NSC(NC(=O)NC)=C1C(N)=O OXBJJTHWZCVWHV-UHFFFAOYSA-N 0.000 claims 1
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