NO316377B1 - Kinolin- og kinoksalinforbindelser som inhiberer blodplateavledet vekstfaktor og/eller P56<O>lck</O>-tyrosinkinase, farmas degree ytisk blandinginneholdende detsamme samt anvendelse derav - Google Patents
Kinolin- og kinoksalinforbindelser som inhiberer blodplateavledet vekstfaktor og/eller P56<O>lck</O>-tyrosinkinase, farmas degree ytisk blandinginneholdende detsamme samt anvendelse derav Download PDFInfo
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- NO316377B1 NO316377B1 NO19995817A NO995817A NO316377B1 NO 316377 B1 NO316377 B1 NO 316377B1 NO 19995817 A NO19995817 A NO 19995817A NO 995817 A NO995817 A NO 995817A NO 316377 B1 NO316377 B1 NO 316377B1
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- Norway
- Prior art keywords
- ylamino
- cyclohexanol
- dimethoxyquinoxalin
- compound according
- trans
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/54—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
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- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
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- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
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- Neurology (AREA)
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- Hematology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US86445597A | 1997-05-28 | 1997-05-28 | |
US97261497A | 1997-11-18 | 1997-11-18 | |
PCT/US1998/011000 WO1998054157A1 (en) | 1997-05-28 | 1998-05-28 | QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR p561ck TYROSINE KINASES |
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NO995817D0 NO995817D0 (no) | 1999-11-26 |
NO995817L NO995817L (no) | 1999-11-26 |
NO316377B1 true NO316377B1 (no) | 2004-01-19 |
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NO19995819A NO323721B1 (no) | 1997-05-28 | 1999-11-26 | Kinolin- og kinoksalinforbindelser som inhiberer blodplateavledet vekstfaktor og/eller P56lck-tyrosinkinase og farmasoytisk formulering inneholdende det samme, samt anvendelse derav |
NO19995817A NO316377B1 (no) | 1997-05-28 | 1999-11-26 | Kinolin- og kinoksalinforbindelser som inhiberer blodplateavledet vekstfaktor og/eller P56<O>lck</O>-tyrosinkinase, farmas degree ytisk blandinginneholdende detsamme samt anvendelse derav |
NO19995818A NO323720B1 (no) | 1997-05-28 | 1999-11-26 | Kinolin- og kinoksalinforbindelser som inhiberer blodplateavledet vekstfaktor og/eller P561ck-tyrosinkinase |
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NO19995819A NO323721B1 (no) | 1997-05-28 | 1999-11-26 | Kinolin- og kinoksalinforbindelser som inhiberer blodplateavledet vekstfaktor og/eller P56lck-tyrosinkinase og farmasoytisk formulering inneholdende det samme, samt anvendelse derav |
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NO19995818A NO323720B1 (no) | 1997-05-28 | 1999-11-26 | Kinolin- og kinoksalinforbindelser som inhiberer blodplateavledet vekstfaktor og/eller P561ck-tyrosinkinase |
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NO306992B1 (no) * | 1993-01-28 | 2000-01-24 | Takeda Chemical Industries Ltd | Quinolinderivater, farmasoeytiske preparater inneholdende forbindelsene og anvendelsen av forbindelsene |
DE4426373A1 (de) * | 1994-07-26 | 1996-02-01 | Bayer Ag | 3-Substituierte Chinolin-5-carbonsäurederivate und Verfahren zu ihrer Herstellung |
CA2260999C (en) | 1996-07-19 | 2006-07-11 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds, their production and use in tyrosine kinase inhibition |
AU5574798A (en) * | 1997-01-21 | 1998-08-07 | Nissan Chemical Industries Ltd. | Industrial antimicrobial/mildew-proofing agents, algicides and antifouling agents containing n-quinoxalylanilines |
KR100425638B1 (ko) * | 1997-05-28 | 2004-04-03 | 아벤티스 파마슈티칼스 인크. | 혈소판-유도된 성장 인자 및/또는 P56lck 티로신키나제를 억제하는 퀴놀린 및 퀴녹살린 화합물 |
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1998
- 1998-05-28 KR KR10-1999-7010972A patent/KR100425638B1/ko not_active IP Right Cessation
- 1998-05-28 EP EP98925041A patent/EP1001945B1/en not_active Expired - Lifetime
- 1998-05-28 BR BR9809501-3A patent/BR9809501A/pt not_active Application Discontinuation
- 1998-05-28 KR KR10-1999-7011036A patent/KR100440756B1/ko not_active IP Right Cessation
- 1998-05-28 BR BR9809515-3A patent/BR9809515A/pt not_active Application Discontinuation
- 1998-05-28 EP EP98925022A patent/EP0991628B1/en not_active Expired - Lifetime
- 1998-05-28 CA CA002291750A patent/CA2291750A1/en not_active Abandoned
- 1998-05-28 UA UA99127137A patent/UA57790C2/uk unknown
- 1998-05-28 AP APAP/P/1999/001711A patent/AP1362A/en active
- 1998-05-28 CA CA002291774A patent/CA2291774A1/en not_active Abandoned
- 1998-05-28 EA EA199901086A patent/EA002600B1/ru not_active IP Right Cessation
- 1998-05-28 AU AU77079/98A patent/AU751188C/en not_active Ceased
- 1998-05-28 AP APAP/P/1999/001710A patent/AP1554A/en active
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- 1998-05-28 JP JP50096499A patent/JP2002513417A/ja not_active Ceased
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- 1998-05-28 AP APAP/P/1999/001709A patent/AP1444A/en active
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- 1998-05-28 WO PCT/US1998/011036 patent/WO1998054158A1/en active IP Right Grant
- 1998-05-28 CN CNB98806538XA patent/CN1140516C/zh not_active Expired - Fee Related
- 1998-05-28 SK SK1579-99A patent/SK157999A3/sk unknown
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- 1998-05-28 CZ CZ0418099A patent/CZ296845B6/cs not_active IP Right Cessation
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- 1998-05-28 HU HU0002084A patent/HUP0002084A3/hu unknown
- 1998-05-28 AU AU77062/98A patent/AU747026B2/en not_active Ceased
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- 1998-05-28 JP JP50098799A patent/JP2002500676A/ja not_active Ceased
- 1998-05-28 ES ES98925022T patent/ES2235331T3/es not_active Expired - Lifetime
- 1998-05-28 WO PCT/US1998/010999 patent/WO1998054156A1/en active IP Right Grant
- 1998-05-28 PL PL98337087A patent/PL195552B1/pl not_active IP Right Cessation
- 1998-05-28 PL PL337086A patent/PL194980B1/pl unknown
- 1998-05-28 CN CN98806454A patent/CN1280572A/zh active Pending
- 1998-05-28 AT AT98925022T patent/ATE286886T1/de not_active IP Right Cessation
- 1998-05-28 SK SK1581-99A patent/SK158199A3/sk unknown
- 1998-05-28 SK SK1580-99A patent/SK158099A3/sk unknown
- 1998-05-28 SK SK114-2005A patent/SK286084B6/sk not_active IP Right Cessation
- 1998-05-28 DE DE69842077T patent/DE69842077D1/de not_active Expired - Lifetime
- 1998-05-28 SI SI9830741T patent/SI0991628T1/ unknown
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- 1998-05-28 DE DE69842151T patent/DE69842151D1/de not_active Expired - Lifetime
- 1998-05-28 JP JP50096599A patent/JP2002500675A/ja not_active Ceased
- 1998-05-28 IL IL13300798A patent/IL133007A/xx not_active IP Right Cessation
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- 1998-05-28 WO PCT/US1998/011000 patent/WO1998054157A1/en active IP Right Grant
- 1998-05-28 DK DK98925022T patent/DK0991628T3/da active
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- 1998-05-28 CN CN98806430A patent/CN1261353A/zh active Pending
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1999
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- 1999-11-26 NO NO19995819A patent/NO323721B1/no unknown
- 1999-11-26 NO NO19995817A patent/NO316377B1/no unknown
- 1999-11-26 NO NO19995818A patent/NO323720B1/no unknown
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- 1999-12-14 BG BG104006A patent/BG64445B1/bg unknown
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2000
- 2000-11-23 HK HK00107502A patent/HK1028042A1/xx not_active IP Right Cessation
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