NO315118B1 - 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazinderivater samt farmasöytiske sammensetninger inneholdende slike - Google Patents

1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazinderivater samt farmasöytiske sammensetninger inneholdende slike Download PDF

Info

Publication number
NO315118B1
NO315118B1 NO20000394A NO20000394A NO315118B1 NO 315118 B1 NO315118 B1 NO 315118B1 NO 20000394 A NO20000394 A NO 20000394A NO 20000394 A NO20000394 A NO 20000394A NO 315118 B1 NO315118 B1 NO 315118B1
Authority
NO
Norway
Prior art keywords
group
alkyl
phenyl
pyrido
compound according
Prior art date
Application number
NO20000394A
Other languages
English (en)
Norwegian (no)
Other versions
NO20000394D0 (no
NO20000394L (no
Inventor
Ferrer Jordi Gracia
Maria Isabel Crespo Crespo
Noverola Armando Vega
Garcia Andres Fernandez
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of NO20000394D0 publication Critical patent/NO20000394D0/no
Publication of NO20000394L publication Critical patent/NO20000394L/no
Publication of NO315118B1 publication Critical patent/NO315118B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20000394A 1997-07-29 2000-01-26 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazinderivater samt farmasöytiske sammensetninger inneholdende slike NO315118B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009701670A ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.
PCT/EP1998/004340 WO1999006404A1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them

Publications (3)

Publication Number Publication Date
NO20000394D0 NO20000394D0 (no) 2000-01-26
NO20000394L NO20000394L (no) 2000-03-27
NO315118B1 true NO315118B1 (no) 2003-07-14

Family

ID=8300216

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20000394A NO315118B1 (no) 1997-07-29 2000-01-26 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazinderivater samt farmasöytiske sammensetninger inneholdende slike

Country Status (36)

Country Link
US (2) US6407108B1 (sl)
EP (1) EP1001955B1 (sl)
JP (1) JP4320118B2 (sl)
KR (1) KR20010022353A (sl)
CN (1) CN1135231C (sl)
AR (1) AR015927A1 (sl)
AT (1) ATE207069T1 (sl)
AU (1) AU737709B2 (sl)
BG (1) BG64448B1 (sl)
BR (1) BR9810829B1 (sl)
CA (1) CA2298935A1 (sl)
CO (1) CO4970780A1 (sl)
CZ (1) CZ290208B6 (sl)
DE (1) DE69802100T2 (sl)
DK (1) DK1001955T3 (sl)
EE (1) EE04313B1 (sl)
EG (1) EG24041A (sl)
ES (2) ES2137113B1 (sl)
HK (1) HK1024914A1 (sl)
HU (1) HUP0004708A3 (sl)
ID (1) ID24506A (sl)
IL (1) IL134081A (sl)
MY (1) MY118796A (sl)
NO (1) NO315118B1 (sl)
NZ (1) NZ502356A (sl)
PE (1) PE111099A1 (sl)
PL (1) PL191031B1 (sl)
PT (1) PT1001955E (sl)
RU (1) RU2202552C2 (sl)
SI (1) SI1001955T1 (sl)
SK (1) SK284046B6 (sl)
TR (1) TR200000243T2 (sl)
TW (1) TW542837B (sl)
UA (1) UA60339C2 (sl)
WO (1) WO1999006404A1 (sl)
ZA (1) ZA986248B (sl)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2792938B1 (fr) 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
PT1212089E (pt) 1999-08-21 2006-08-31 Altana Pharma Ag Combinacao sinergica de roflumilast e salmeterol
WO2002080974A1 (fr) * 2001-04-04 2002-10-17 Sankyo Company, Limited Utilisation medicale d'inhibiteur de production de cytokine
HU229442B1 (hu) * 2001-09-19 2013-12-30 Takeda Gmbh Nem-szteroid gyulladásgátlók és PDE4 inhibitorok kombinációi és alkalmazásuk
FR2832711B1 (fr) * 2001-11-26 2004-01-30 Warner Lambert Co Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
CN100572381C (zh) * 2002-11-06 2009-12-23 Aska制药株式会社 吡唑并二氮杂萘衍生物
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
RU2246496C1 (ru) * 2003-09-12 2005-02-20 Тец Виктор Вениаминович Вещество с противовирусной и антибактериальной активностью на основе производных 2,8-дитиоксо-1h-пирано[2,3-d, 6,5-d`] дипиримидина и их 10-аза-аналогов
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
CA2610888C (en) * 2005-06-10 2011-02-08 Merck & Co., Inc. Inhibitors of akt activity
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CA2622605A1 (en) 2005-09-15 2007-03-22 Aska Pharmaceutical Co., Ltd. Heterocycle compound, and production process and application thereof
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
CA2660836A1 (en) 2006-08-07 2008-02-21 Incyte Corporation Triazolotriazines as kinase inhibitors
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス,インコーポレイティド 4−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EA026126B1 (ru) 2006-11-22 2017-03-31 Инсайт Холдингс Корпорейшн Имидазотриазины и имидазопиримидины в качестве ингибиторов киназы
WO2009089027A1 (en) * 2008-01-09 2009-07-16 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Service, National Institutes Of Health Phosphodiesterase inhibitors
WO2009143211A2 (en) 2008-05-21 2009-11-26 Incyte Corporation Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
SG182297A1 (en) 2009-12-31 2012-08-30 Ct Nac Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
BR112012019302B1 (pt) 2010-02-03 2022-06-21 Incyte Holdings Corporation Imidazo[1,2-b] [1,2,4]triazinas como inibidores de c-met, composição que as compreende e métodos in vitro de inibir a atividade de c-met cinase, de inibir a via de sinalização da hgf/c-met cinase em uma célula e de inibir a atividade proliferativa de uma célula
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013005041A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
WO2013004984A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3122670A1 (de) 1981-06-06 1982-12-23 Dr. Karl Thomae Gmbh, 7950 Biberach "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
PH21834A (en) * 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
JP3120857B2 (ja) * 1990-02-19 2000-12-25 中外製薬株式会社 新規な縮合複素環化合物とこれを用いた抗喘息剤
DK0612321T3 (da) * 1991-10-09 1999-12-13 Syntex Inc Pyridopyridazinon- og pyridazinthionforbindelser med PDE IV inhiberende aktivitet
GB9514465D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds

Also Published As

Publication number Publication date
KR20010022353A (ko) 2001-03-15
BR9810829A (pt) 2000-07-25
US6407108B1 (en) 2002-06-18
DK1001955T3 (da) 2001-11-19
EE04313B1 (et) 2004-06-15
PE111099A1 (es) 1999-11-18
JP4320118B2 (ja) 2009-08-26
AU8861298A (en) 1999-02-22
BR9810829B1 (pt) 2009-08-11
EP1001955B1 (en) 2001-10-17
WO1999006404A1 (en) 1999-02-11
ZA986248B (en) 1999-02-05
CZ2000333A3 (cs) 2000-05-17
US20020183326A1 (en) 2002-12-05
SK862000A3 (en) 2000-07-11
IL134081A0 (en) 2001-04-30
DE69802100D1 (de) 2001-11-22
BG104112A (en) 2001-01-31
CZ290208B6 (cs) 2002-06-12
IL134081A (en) 2004-02-08
DE69802100T2 (de) 2002-03-14
EP1001955A1 (en) 2000-05-24
NZ502356A (en) 2001-03-30
ID24506A (id) 2000-07-20
BG64448B1 (en) 2005-02-28
CN1266434A (zh) 2000-09-13
NO20000394D0 (no) 2000-01-26
EE200000052A (et) 2000-10-16
AR015927A1 (es) 2001-05-30
NO20000394L (no) 2000-03-27
HK1024914A1 (en) 2000-10-27
ES2137113B1 (es) 2000-09-16
HUP0004708A3 (en) 2002-11-28
PL338214A1 (en) 2000-10-09
PT1001955E (pt) 2002-02-28
CA2298935A1 (en) 1999-02-11
SI1001955T1 (sl) 2002-02-28
UA60339C2 (uk) 2003-10-15
CN1135231C (zh) 2004-01-21
CO4970780A1 (es) 2000-11-07
PL191031B1 (pl) 2006-03-31
TR200000243T2 (tr) 2000-07-21
RU2202552C2 (ru) 2003-04-20
ATE207069T1 (de) 2001-11-15
ES2162466T3 (es) 2001-12-16
HUP0004708A2 (hu) 2001-07-30
AU737709B2 (en) 2001-08-30
TW542837B (en) 2003-07-21
JP2001512121A (ja) 2001-08-21
SK284046B6 (sk) 2004-08-03
MY118796A (en) 2005-01-31
ES2137113A1 (es) 1999-12-01
EG24041A (en) 2008-04-03

Similar Documents

Publication Publication Date Title
NO315118B1 (no) 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazinderivater samt farmasöytiske sammensetninger inneholdende slike
CA2557541C (en) Pyrimidine derivatives
TW378210B (en) Tetracyclic derivatives; process of preparation and use
TW406082B (en) Pyridazino quinoline compounds
CA3123897C (en) Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CZ224195A3 (en) The use of pyrrolopyridine derivatives for preparing pharmaceutical preparations
MX2008001020A (es) Un monohidrato de pirrolo[1-2-b]pirazol piridin quinolin substituido como inhibidor de factor de crecimiento de transformacion-beta (tgf-beta).
JP2008523070A (ja) バニロイド受容体サブタイプ1(vr1)に対する拮抗薬およびこの使用
AU4564500A (en) 4,5,6,7-tetrahydroindazole derivatives as antitumor agents
JPH03215489A (ja) Paf拮抗作用を有する新規ヘトラゼピン、その製造方法及び該ヘトラゼピンを含有する医薬組成物
CN106456653A (zh) 高胰岛素血症相关病症的治疗
JPH0412269B2 (sl)
CA2990004A1 (en) Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
MX2007006172A (es) Nuevos derivados de piridotienopirimidina.
IL126206A (en) History 2 - (3H) - Oxazolone and their use as COX-2 enzyme inhibitors, processes for their preparation and pharmaceutical preparations containing them
WO1995007893A1 (en) Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands
CZ265498A3 (cs) Triazolové deriváty, způsob jejich výroby a farmaceutický prostředek s jejich obsahem
NO136251B (sl)
TW201120048A (en) Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands
JP2009502832A (ja) 新規ピリド[3’,2’:4,5]フロ[3,2−d]ピリミジン誘導体
CN116283993B (zh) 一种嘧啶类化合物及其制备方法和应用
MXPA00000910A (en) 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
BRPI0903803B1 (pt) Composto, processo de preparação, composição farmacêutica e uso dos compostos
TWI325322B (en) Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one; and 7-pyrimidiny-2,3-dihydroimidazo[1,2-a] pyrimidin-5(1h)one derivatives
EP4021910A1 (en) New therapeutic agents for the treatment of haematological pathologies

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees