NO313195B1 - Nye benzimidazolderivater med antihistaminaktivitet og farmasöytisk preparat inneholdende disse - Google Patents

Nye benzimidazolderivater med antihistaminaktivitet og farmasöytisk preparat inneholdende disse Download PDF

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Publication number
NO313195B1
NO313195B1 NO19972525A NO972525A NO313195B1 NO 313195 B1 NO313195 B1 NO 313195B1 NO 19972525 A NO19972525 A NO 19972525A NO 972525 A NO972525 A NO 972525A NO 313195 B1 NO313195 B1 NO 313195B1
Authority
NO
Norway
Prior art keywords
ethyl
antihistamine
benzimidazole derivatives
activity
new
Prior art date
Application number
NO19972525A
Other languages
English (en)
Norwegian (no)
Other versions
NO972525L (no
NO972525D0 (no
Inventor
Aurelio Orjales
Victor Rubio
Maravillas Bordell
Original Assignee
Espanola Prod Quimicos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Espanola Prod Quimicos filed Critical Espanola Prod Quimicos
Publication of NO972525D0 publication Critical patent/NO972525D0/no
Publication of NO972525L publication Critical patent/NO972525L/no
Publication of NO313195B1 publication Critical patent/NO313195B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO19972525A 1996-06-04 1997-06-03 Nye benzimidazolderivater med antihistaminaktivitet og farmasöytisk preparat inneholdende disse NO313195B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (3)

Publication Number Publication Date
NO972525D0 NO972525D0 (no) 1997-06-03
NO972525L NO972525L (no) 1997-12-05
NO313195B1 true NO313195B1 (no) 2002-08-26

Family

ID=8295035

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19972525A NO313195B1 (no) 1996-06-04 1997-06-03 Nye benzimidazolderivater med antihistaminaktivitet og farmasöytisk preparat inneholdende disse
NO2011008C NO2011008I2 (no) 1996-06-04 2011-05-24 Bilastine eller et addisjonssalt derav

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2011008C NO2011008I2 (no) 1996-06-04 2011-05-24 Bilastine eller et addisjonssalt derav

Country Status (27)

Country Link
US (1) US5877187A (Direct)
EP (1) EP0818454B1 (Direct)
JP (1) JP4218991B2 (Direct)
CN (1) CN1105716C (Direct)
AR (1) AR008386A1 (Direct)
AT (1) ATE264317T1 (Direct)
AU (1) AU725700B2 (Direct)
BR (1) BR9703276A (Direct)
CA (1) CA2206754C (Direct)
CZ (1) CZ289278B6 (Direct)
DE (2) DE122011000006I1 (Direct)
DK (1) DK0818454T3 (Direct)
ES (1) ES2124167B1 (Direct)
FR (1) FR11C0023I2 (Direct)
HR (1) HRP970307B1 (Direct)
HU (1) HU227598B1 (Direct)
IN (1) IN186319B (Direct)
LU (1) LU91798I2 (Direct)
MX (1) MXPA97004127A (Direct)
NO (2) NO313195B1 (Direct)
PL (1) PL188908B1 (Direct)
PT (1) PT818454E (Direct)
RU (1) RU2182150C2 (Direct)
SI (1) SI0818454T1 (Direct)
TR (1) TR199700464A2 (Direct)
TW (1) TW438794B (Direct)
ZA (1) ZA974893B (Direct)

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KR20010053282A (ko) 1998-07-01 2001-06-25 다케다 야쿠힌 고교 가부시키가이샤 레티노이드-관련 수용체 기능 조절제
DK1133477T3 (da) 1998-11-27 2004-06-21 Abbott Gmbh & Co Kg Substituerede benzimidazoler og deres anvendelse som parpinhibitorer
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
US7612095B2 (en) * 2002-04-19 2009-11-03 Faes Farma, S.A. Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazole-2-yl]-1-piperidinyl]ethyl]-αα-dimethyl-benzeneacetic acid
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
RU2333208C2 (ru) * 2002-06-13 2008-09-10 Вертекс Фармасьютикалз Инкорпорейтед Производные 2-уреидо-6-гетероарил-3н-бензимидазол-6-карбоновой кислоты и родственные соединения в качестве ингибиторов гиразы и/или топоизомеразы iv для лечения бактериальных инфекций
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
US8367704B2 (en) 2008-02-12 2013-02-05 Yuhan Corporation Process for preparation of 2-methyl-2′ phenylpropionic acid derivatives and novel intermediate compounds
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
EP2969019A1 (en) * 2013-03-15 2016-01-20 Hercules Incorporated Composition and method of producing personal care compositions with improved deposition properties
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
EP3327012B1 (en) * 2015-07-24 2021-03-17 Urquima, S.A. Crystalline forms of bilastine and preparation methods thereof
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (en) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
EP3453384B1 (en) 2017-09-07 2020-05-27 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine
ES2858573T3 (es) 2017-10-16 2021-09-30 Faes Farma Sa Composiciones acuosas que comprenden bilastina y mometasona
PL3641735T3 (pl) 2017-12-18 2021-09-06 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Kompozycja farmaceutyczna tabletki zawierająca bilastynę w postaci 3 i rozpuszczalny w wodzie wypełniacz
ES2835287T3 (es) 2017-12-18 2021-06-22 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica de comprimido que comprende la forma polimórfica 3 de bilastina y aluminometasilicato de magnesio
MA51612B1 (fr) 2018-01-18 2021-06-30 Faes Farma Sa Compositions ophtalmiques comprenant de la bilastine, une bêta-cyclodextrine et au moins un agent gélifiant
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
US20230414597A1 (en) 2020-11-18 2023-12-28 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
CA3200779A1 (en) 2020-12-23 2022-06-30 Strusi ORAZIO LUCA A non-micronized bilastine composition
WO2023156559A1 (en) 2022-02-17 2023-08-24 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins

Family Cites Families (5)

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GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
US5294631A (en) * 1990-04-13 1994-03-15 Smithkline Beecham Corporation Substituted benzimidazoles useful as angiotension II receptor antagonists
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
DE9320925U1 (de) * 1992-08-03 1995-08-31 Georgetown University, Washington, D.C. Terfenadin-Metabolite und deren optisch reine Isomere für die Behandlung von allergischen Störungen
JP3712208B2 (ja) * 1993-06-25 2005-11-02 メレルファーマスーティカルズ インコーポレイテッド 抗ヒスタミン性の４−ジフェニルメチル／ジフェニルメトキシピペリジン誘導体類を製造する新規な中間体

Also Published As

Publication number Publication date
PL320358A1 (en) 1997-12-08
NO972525L (no) 1997-12-05
TR199700464A3 (tr) 1997-12-21
TR199700464A2 (xx) 1997-12-21
NO972525D0 (no) 1997-06-03
FR11C0023I1 (Direct) 2011-08-19
ZA974893B (en) 1997-12-30
ATE264317T1 (de) 2004-04-15
JPH1059961A (ja) 1998-03-03
AU2467297A (en) 1997-12-11
HU9700997D0 (en) 1997-07-28
HU227598B1 (en) 2011-09-28
NO2011008I2 (no) 2012-05-14
DE122011000006I1 (de) 2011-06-16
CZ289278B6 (cs) 2001-12-12
AR008386A1 (es) 2000-01-19
IN186319B (Direct) 2001-08-04
LU91798I2 (fr) 2011-05-23
CN1176964A (zh) 1998-03-25
AU725700B2 (en) 2000-10-19
BR9703276A (pt) 2004-08-17
ES2124167B1 (es) 1999-09-16
CN1105716C (zh) 2003-04-16
EP0818454A1 (en) 1998-01-14
US5877187A (en) 1999-03-02
JP4218991B2 (ja) 2009-02-04
CA2206754A1 (en) 1997-12-04
FR11C0023I2 (fr) 2012-03-16
DK0818454T3 (da) 2004-07-12
HRP970307B1 (en) 2002-02-28
TW438794B (en) 2001-06-07
HRP970307A2 (en) 1998-04-30
SI0818454T1 (en) 2004-08-31
CZ172397A3 (en) 1997-12-17
CA2206754C (en) 2007-01-23
DE69728608T2 (de) 2005-04-21
PL188908B1 (pl) 2005-05-31
DE69728608D1 (de) 2004-05-19
RU2182150C2 (ru) 2002-05-10
NO2011008I1 (no) 2011-06-06
HUP9700997A1 (hu) 1999-09-28
EP0818454B1 (en) 2004-04-14
MXPA97004127A (es) 2005-07-25
ES2124167A1 (es) 1999-01-16
PT818454E (pt) 2004-08-31

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