NO178829C - Dobbelt-trådet DNA-molekyl som medförer forbedret ekspresjon - Google Patents
Dobbelt-trådet DNA-molekyl som medförer forbedret ekspresjonInfo
- Publication number
- NO178829C NO178829C NO885786A NO885786A NO178829C NO 178829 C NO178829 C NO 178829C NO 885786 A NO885786 A NO 885786A NO 885786 A NO885786 A NO 885786A NO 178829 C NO178829 C NO 178829C
- Authority
- NO
- Norway
- Prior art keywords
- yeast
- encodes
- precursor polypeptide
- precursor
- protein
- Prior art date
Links
- 108020004414 DNA Proteins 0.000 title abstract 4
- 102000053602 DNA Human genes 0.000 title abstract 2
- 239000002243 precursor Substances 0.000 abstract 8
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108010058643 Fungal Proteins Proteins 0.000 abstract 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 238000003776 cleavage reaction Methods 0.000 abstract 3
- 230000013595 glycosylation Effects 0.000 abstract 3
- 238000006206 glycosylation reaction Methods 0.000 abstract 3
- 230000007017 scission Effects 0.000 abstract 3
- 108091026890 Coding region Proteins 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 101150045458 KEX2 gene Proteins 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 102000005593 Endopeptidases Human genes 0.000 abstract 1
- 108010059378 Endopeptidases Proteins 0.000 abstract 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
- 108010076181 Proinsulin Proteins 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 241000235070 Saccharomyces Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000005026 transcription initiation Effects 0.000 abstract 1
- 230000005030 transcription termination Effects 0.000 abstract 1
- 210000005253 yeast cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13968287A | 1987-12-30 | 1987-12-30 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO885786D0 NO885786D0 (no) | 1988-12-28 |
| NO885786L NO885786L (no) | 1989-07-03 |
| NO178829B NO178829B (no) | 1996-03-04 |
| NO178829C true NO178829C (no) | 1996-06-12 |
Family
ID=22487825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO885786A NO178829C (no) | 1987-12-30 | 1988-12-28 | Dobbelt-trådet DNA-molekyl som medförer forbedret ekspresjon |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5602034A (de) |
| EP (1) | EP0324274B1 (de) |
| JP (1) | JP2793215B2 (de) |
| AT (1) | ATE97441T1 (de) |
| AU (1) | AU616228B2 (de) |
| CA (1) | CA1340772C (de) |
| DE (1) | DE3885728T2 (de) |
| DK (2) | DK175910B1 (de) |
| ES (1) | ES2059547T3 (de) |
| FI (1) | FI100995B (de) |
| HK (1) | HK139994A (de) |
| IE (1) | IE62087B1 (de) |
| IL (1) | IL88802A0 (de) |
| NO (1) | NO178829C (de) |
| PT (1) | PT89367B (de) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5170964A (ja) * | 1974-12-16 | 1976-06-19 | Hohnen Oil | Haisuinoshoriho |
| EP0561137B1 (de) | 1983-04-25 | 2002-07-03 | Chiron Corporation | Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren |
| US5010182A (en) * | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
| WO1992004363A1 (en) * | 1990-09-04 | 1992-03-19 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
| US5612198A (en) * | 1990-09-04 | 1997-03-18 | The Salk Institute | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
| CA2091266A1 (en) * | 1990-09-14 | 1992-03-15 | Patricia Tekamp-Olson | Expression of macrophage inducible proteins (mips) in yeast cells |
| IE914102A1 (en) | 1990-11-26 | 1992-06-03 | Genetics Inst | Expression of pace in host cells and methods of use thereof |
| DK300090D0 (da) * | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
| WO1992017595A1 (en) * | 1991-04-01 | 1992-10-15 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Genes which influence pichia proteolytic activity, and uses therefor |
| US6348327B1 (en) | 1991-12-06 | 2002-02-19 | Genentech, Inc. | Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells |
| DK0682710T3 (da) * | 1993-02-10 | 2004-03-01 | Unilever Nv | Isolationsmetode, ved hvilken der anvendes immobiliserede proteiner med specifikke kapaciteter |
| US5538863A (en) * | 1993-07-01 | 1996-07-23 | Immunex Corporation | Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide |
| US6451562B1 (en) | 1993-12-22 | 2002-09-17 | Human Genome Sciences, Inc. | Polypeptides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) polynucleotides |
| US6495129B1 (en) | 1994-03-08 | 2002-12-17 | Human Genome Sciences, Inc. | Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3) |
| US5629167A (en) | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| US5639642A (en) * | 1994-06-16 | 1997-06-17 | Novo Nordisk A/S | Synthetic leader peptide sequences |
| RU2167939C2 (ru) * | 1994-06-16 | 2001-05-27 | Ново Нордиск А/С | Способ продуцирования полипептида в дрожжах |
| ZA954983B (en) * | 1994-06-17 | 1996-02-14 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| HRP940432B1 (en) * | 1994-08-05 | 2003-10-31 | Pliva Pharm & Chem Works | Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin |
| EP0779927A1 (de) * | 1994-09-08 | 1997-06-25 | Chiron Corporation | Methode zur gesteigerten herstellung von insulin-ähnlichem wachstumsfaktor |
| GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
| ZA9610456B (en) * | 1995-12-20 | 1997-06-20 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| JP2001501097A (ja) * | 1996-09-24 | 2001-01-30 | ケイダス ファーマスーティカル コーポレイション | レセプターエフェクターを同定する方法及び組成物 |
| US6197545B1 (en) | 1996-09-25 | 2001-03-06 | Vanderbilt University | Genetically engineered yeast with modified signal peptidase complex |
| EP0948538B1 (de) | 1996-12-13 | 2008-06-11 | Novartis Vaccines and Diagnostics, Inc. | Analyse und separation von pdgf-proteinen |
| KR100381494B1 (ko) * | 1997-06-30 | 2003-07-22 | 바이오 테크놀로지 제네랄 코오포레이션 | 인간인슐린의제조방법 |
| US6068993A (en) * | 1997-07-02 | 2000-05-30 | Biobras Sa | Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin |
| JP2001512684A (ja) | 1997-08-05 | 2001-08-28 | カイロン コーポレイション | 新規のｐｉｃｈｉａｐａｓｔｏｒｉｓ遺伝子配列およびそれらの使用方法 |
| CA2308606A1 (en) | 1997-11-06 | 1999-05-20 | Chiron S.P.A. | Neisserial antigens |
| ATE446368T1 (de) | 1998-01-14 | 2009-11-15 | Novartis Vaccines & Diagnostic | Antigene aus neisseria meningitidis |
| WO1999037793A1 (en) * | 1998-01-23 | 1999-07-29 | Novo Nordisk A/S | Process for making desired polypeptides in yeast |
| GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| EP2261345A3 (de) | 1998-05-01 | 2012-01-11 | Novartis Vaccines and Diagnostics, Inc. | Antigene und Zusammensetzungen gegen Neisseria meningitidis |
| AU5504999A (en) * | 1998-07-20 | 2000-02-14 | Frenken, Leon Gerardus Joseph | Production of proteins |
| CA2340790C (en) | 1998-08-21 | 2012-07-10 | Immunex Corporation | Human il-1 epsilon dna and polypeptides |
| RU2245366C2 (ru) | 1999-04-30 | 2005-01-27 | Чирон С.Р.Л. | Антиген neisseria, кодирующая его нуклеиновая кислота, их использование |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| PT2275552E (pt) | 1999-10-29 | 2015-12-07 | Glaxosmithkline Biolog Sa | Péptidos antigénicos de neisseria |
| ES2588917T3 (es) | 2000-01-17 | 2016-11-07 | Glaxosmithkline Biologicals Sa | Vacuna de VME suplementada contra meningococo |
| JP2003528149A (ja) | 2000-03-24 | 2003-09-24 | ジェネンテック・インコーポレーテッド | 軟骨性疾患の治療のためのインスリンの使用 |
| US6605450B1 (en) | 2000-05-25 | 2003-08-12 | Chiron Corporation | Iron regulation of the PpSEC10 transcriptional regulatory region of Pichia pastoris and methods of use |
| WO2002012509A1 (en) * | 2000-07-26 | 2002-02-14 | Korea Research Institute Of Bioscience And Biotechnology | Novel cell wall anchor proteins derived from yeast, genes thereof and cell surface expression systems using the same |
| MXPA03003690A (es) | 2000-10-27 | 2004-05-05 | Chiron Spa | Acidos nucleicos y proteinas de los grupos a y b de estreptococos. |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| EP1405912B8 (de) * | 2001-07-06 | 2012-10-24 | The Chemo-Sero-Therapeutic Research Institute | Genetisch modifiziertes ecarin und verfahren zu dessen herstellung |
| ES2312649T3 (es) | 2001-12-12 | 2009-03-01 | Novartis Vaccines And Diagnostics S.R.L. | Inmunizacion frente a chlamydia trachomatis. |
| WO2003100020A2 (en) * | 2002-05-24 | 2003-12-04 | Restoragen, Inc. | Methods and constructs for high yield expression of clostripain |
| AU2003243316A1 (en) * | 2002-05-24 | 2003-12-12 | Nps Allelix Corp. | Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides |
| DE60335497D1 (de) | 2002-09-13 | 2011-02-03 | Cornell Res Foundation Inc | Ergillus-phytasen |
| WO2004046177A2 (en) | 2002-11-15 | 2004-06-03 | Chiron Srl | Unexpected surface proteins in neisseria meningitidis |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| AU2004261941B2 (en) | 2003-07-25 | 2008-04-10 | Amgen Inc. | Antagonists and agonists of LDCAM and methods of use |
| ME01366B (me) * | 2003-11-21 | 2013-12-20 | Nps Allelix Corp | POSTUPAK ZA PROIZVODNJU PEPTIDA 2 NALIK NA GLUKAGON l NJIHOVIH ANALOGA |
| MXPA06006392A (es) | 2003-12-05 | 2007-03-15 | Childrens Hosp Medical Center | Composiciones de oligosacaridos y uso de estas en el tratamiento de infecciones. |
| NZ548256A (en) | 2004-02-02 | 2010-02-26 | Ambrx Inc | Modified human four helical bundle polypeptides and their uses |
| WO2006069220A2 (en) * | 2004-12-22 | 2006-06-29 | Ambrx, Inc. | Modified human growth hormone |
| US7632924B2 (en) | 2004-06-18 | 2009-12-15 | Ambrx, Inc. | Antigen-binding polypeptides and their uses |
| MX2007000728A (es) * | 2004-07-21 | 2007-03-15 | Ambrx Inc | Polipeptidos biosinteticos que utilizan amino acidos no naturalmente codificados. |
| AU2005319518B2 (en) * | 2004-12-22 | 2010-09-09 | Ambrx, Inc. | Compositions of aminoacyl-tRNA synthetase and uses thereof |
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| CA2927595C (en) | 2004-12-22 | 2023-01-31 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
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| US7825231B2 (en) | 2005-06-01 | 2010-11-02 | Darren P. Wolfe | Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy |
| US20100135959A1 (en) * | 2005-06-03 | 2010-06-03 | Ambrx, Inc. | Human Interferon Molecules and Their Uses |
| EP1937824B1 (de) | 2005-08-18 | 2013-03-13 | Ambrx, Inc. | trna-zusammensetzungen und deren verwendungen |
| CA2625540C (en) * | 2005-11-08 | 2017-03-21 | Ambrx, Inc. | Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides |
| WO2007059312A2 (en) | 2005-11-16 | 2007-05-24 | Ambrx, Inc. | Methods and compositions comprising non-natural amino acids |
| US20080317670A1 (en) * | 2005-12-14 | 2008-12-25 | Ambrx, Inc. | Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides |
| WO2008020335A2 (en) | 2006-06-09 | 2008-02-21 | Novartis Ag | Immunogenic compositions for streptococcus agalactiae |
| PT2064333E (pt) * | 2006-09-08 | 2014-06-09 | Ambrx Inc | Supressor híbrido arnt para células de vertebrados |
| EP2061878B1 (de) * | 2006-09-08 | 2014-01-08 | Ambrx, Inc. | Hybridunterdrücker-trna für wirbeltierzellen |
| CN106008699A (zh) * | 2006-09-08 | 2016-10-12 | Ambrx公司 | 经修饰的人类血浆多肽或Fc骨架和其用途 |
| JPWO2008032659A1 (ja) * | 2006-09-14 | 2010-01-21 | 独立行政法人産業技術総合研究所 | 効率向上型分泌シグナルペプチド及びそれらを利用したタンパク質生産方法 |
| HRP20120522T1 (hr) | 2007-03-30 | 2012-08-31 | Ambrx | Modificirani fgf-21 polipeptidi i njihova uporaba |
| CN103965347B (zh) | 2007-05-02 | 2017-07-18 | Ambrx公司 | 经修饰干扰素β多肽和其用途 |
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| IL63270A0 (en) | 1980-08-05 | 1981-10-30 | Univ Leland Stanford Junior | Eukaryotic autonomously replicating segment |
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| US4546082A (en) * | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
| DE3382547D1 (de) | 1983-01-12 | 1992-05-27 | Chiron Corp | Sekretorische expression in eukaryoten. |
| CA1341302C (en) | 1983-02-22 | 2001-10-09 | Rae Lyn Burke | Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein |
| US4546083A (en) | 1983-04-22 | 1985-10-08 | Stolle Research & Development Corporation | Method and device for cell culture growth |
| WO1984004330A1 (en) * | 1983-04-22 | 1984-11-08 | Amgen | Secretion of exogenous polypeptides from yeast |
| NZ207926A (en) * | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
| EP0561137B1 (de) * | 1983-04-25 | 2002-07-03 | Chiron Corporation | Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren |
| US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| DE3587759T2 (de) | 1984-05-11 | 1994-07-07 | Chiron Corp., Emeryville, Calif. | Erhöhte Hefetranskription unter Verwendung einer Hybridkonstruktion der Promotorregion. |
| JPS6156078A (ja) * | 1984-07-27 | 1986-03-20 | Suntory Ltd | 酵母を宿主とする分泌発現ベクタ− |
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| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| US5010182A (en) | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
| HU213571B (en) * | 1988-07-23 | 1997-08-28 | Delta Biotechnology Ltd | Process for producing peptides and dna sequences |
-
1988
- 1988-12-22 CA CA000586916A patent/CA1340772C/en not_active Expired - Fee Related
- 1988-12-23 EP EP88312306A patent/EP0324274B1/de not_active Expired - Lifetime
- 1988-12-23 AT AT88312306T patent/ATE97441T1/de not_active IP Right Cessation
- 1988-12-23 DE DE88312306T patent/DE3885728T2/de not_active Expired - Lifetime
- 1988-12-23 ES ES88312306T patent/ES2059547T3/es not_active Expired - Lifetime
- 1988-12-26 IL IL88802A patent/IL88802A0/xx unknown
- 1988-12-28 NO NO885786A patent/NO178829C/no unknown
- 1988-12-28 FI FI886008A patent/FI100995B/fi not_active IP Right Cessation
- 1988-12-29 DK DK198807285A patent/DK175910B1/da not_active IP Right Cessation
- 1988-12-30 IE IE389688A patent/IE62087B1/en not_active IP Right Cessation
- 1988-12-30 PT PT89367A patent/PT89367B/pt not_active IP Right Cessation
- 1988-12-30 JP JP63335685A patent/JP2793215B2/ja not_active Expired - Lifetime
- 1988-12-30 AU AU27650/88A patent/AU616228B2/en not_active Expired
-
1994
- 1994-09-27 US US08/313,540 patent/US5602034A/en not_active Ceased
- 1994-12-08 HK HK139994A patent/HK139994A/en not_active IP Right Cessation
-
1998
- 1998-08-27 US US09/140,858 patent/USRE37343E1/en not_active Expired - Lifetime
-
2005
- 2005-01-27 DK DK200500130A patent/DK176075B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3885728T2 (de) | 1994-03-10 |
| ES2059547T3 (es) | 1994-11-16 |
| AU616228B2 (en) | 1991-10-24 |
| PT89367A (pt) | 1989-12-29 |
| NO885786D0 (no) | 1988-12-28 |
| DK176075B1 (da) | 2006-04-10 |
| NO178829B (no) | 1996-03-04 |
| ATE97441T1 (de) | 1993-12-15 |
| EP0324274B1 (de) | 1993-11-18 |
| DK175910B1 (da) | 2005-06-13 |
| USRE37343E1 (en) | 2001-08-28 |
| AU2765088A (en) | 1989-07-06 |
| FI886008L (fi) | 1989-07-01 |
| DK728588A (da) | 1989-07-01 |
| EP0324274A1 (de) | 1989-07-19 |
| JPH022339A (ja) | 1990-01-08 |
| HK139994A (en) | 1994-12-16 |
| PT89367B (pt) | 1993-09-30 |
| NO885786L (no) | 1989-07-03 |
| IE62087B1 (en) | 1994-12-14 |
| FI100995B (fi) | 1998-03-31 |
| US5602034A (en) | 1997-02-11 |
| DK728588D0 (da) | 1988-12-29 |
| DK200500130A (da) | 2005-01-27 |
| IE883896L (en) | 1989-06-30 |
| DE3885728D1 (de) | 1993-12-23 |
| IL88802A0 (en) | 1989-07-31 |
| JP2793215B2 (ja) | 1998-09-03 |
| CA1340772C (en) | 1999-09-28 |
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