DK728588A - Gaercelle omfattende en dna-konstruktion, der tilvejebringer ekspression og secernering af et ikke-gaerprotein, samt dobbeltstrenget dna-molekyle - Google Patents
Gaercelle omfattende en dna-konstruktion, der tilvejebringer ekspression og secernering af et ikke-gaerprotein, samt dobbeltstrenget dna-molekyleInfo
- Publication number
- DK728588A DK728588A DK728588A DK728588A DK728588A DK 728588 A DK728588 A DK 728588A DK 728588 A DK728588 A DK 728588A DK 728588 A DK728588 A DK 728588A DK 728588 A DK728588 A DK 728588A
- Authority
- DK
- Denmark
- Prior art keywords
- yeast
- protein
- encodes
- precursor polypeptide
- precursor
- Prior art date
Links
- 108020004414 DNA Proteins 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000053602 DNA Human genes 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 238000010276 construction Methods 0.000 title 1
- 239000002243 precursor Substances 0.000 abstract 8
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108010058643 Fungal Proteins Proteins 0.000 abstract 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 238000003776 cleavage reaction Methods 0.000 abstract 3
- 230000013595 glycosylation Effects 0.000 abstract 3
- 238000006206 glycosylation reaction Methods 0.000 abstract 3
- 230000007017 scission Effects 0.000 abstract 3
- 108091026890 Coding region Proteins 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 101150045458 KEX2 gene Proteins 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 102000005593 Endopeptidases Human genes 0.000 abstract 1
- 108010059378 Endopeptidases Proteins 0.000 abstract 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
- 108010076181 Proinsulin Proteins 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 241000235070 Saccharomyces Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000005026 transcription initiation Effects 0.000 abstract 1
- 230000005030 transcription termination Effects 0.000 abstract 1
- 210000005253 yeast cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK200500130A DK176075B1 (da) | 1987-12-30 | 2005-01-27 | Gærcelle opfattende en DNA-konstruktion, der tilvejbringer ekspression og secernering af et ikke-gærprotein, samt dobbeltstrenget DNA-molekyle |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13968287A | 1987-12-30 | 1987-12-30 | |
| US13968287 | 1987-12-30 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK728588D0 DK728588D0 (da) | 1988-12-29 |
| DK728588A true DK728588A (da) | 1989-07-01 |
| DK175910B1 DK175910B1 (da) | 2005-06-13 |
Family
ID=22487825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198807285A DK175910B1 (da) | 1987-12-30 | 1988-12-29 | Gærcelle omfattende en DNA-konstruktion, der tilvejebringer ekspression og secernering af et ikke-gærprotein, samt dobbeltstrenget DNA-molekyle |
| DK200500130A DK176075B1 (da) | 1987-12-30 | 2005-01-27 | Gærcelle opfattende en DNA-konstruktion, der tilvejbringer ekspression og secernering af et ikke-gærprotein, samt dobbeltstrenget DNA-molekyle |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK200500130A DK176075B1 (da) | 1987-12-30 | 2005-01-27 | Gærcelle opfattende en DNA-konstruktion, der tilvejbringer ekspression og secernering af et ikke-gærprotein, samt dobbeltstrenget DNA-molekyle |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5602034A (da) |
| EP (1) | EP0324274B1 (da) |
| JP (1) | JP2793215B2 (da) |
| AT (1) | ATE97441T1 (da) |
| AU (1) | AU616228B2 (da) |
| CA (1) | CA1340772C (da) |
| DE (1) | DE3885728T2 (da) |
| DK (2) | DK175910B1 (da) |
| ES (1) | ES2059547T3 (da) |
| FI (1) | FI100995B (da) |
| HK (1) | HK139994A (da) |
| IE (1) | IE62087B1 (da) |
| IL (1) | IL88802A0 (da) |
| NO (1) | NO178829C (da) |
| PT (1) | PT89367B (da) |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5170964A (ja) * | 1974-12-16 | 1976-06-19 | Hohnen Oil | Haisuinoshoriho |
| ATE95236T1 (de) | 1983-04-25 | 1993-10-15 | Chiron Corp | Hybrid-dns-synthesis von reifen insulinaehnlichen wachstumsfaktoren. |
| US5010182A (en) * | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
| JPH06500470A (ja) * | 1990-09-04 | 1994-01-20 | メルク エンド カンパニー インコーポレーテッド | メチロトローフ酵母細胞におけるインスリン様成長因子の産生 |
| US5612198A (en) * | 1990-09-04 | 1997-03-18 | The Salk Institute | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
| ATE177472T1 (de) * | 1990-09-14 | 1999-03-15 | Chiron Corp | Expression von makrophagen-induzierbaren proteinen (mips) in hefezellen |
| DK0574402T3 (da) | 1990-11-26 | 1998-05-18 | Chiron Corp | Ekspression af PACE i værtsceller og fremgangsmåder til anvendelse deraf |
| DK300090D0 (da) * | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
| ES2177528T3 (es) * | 1991-04-01 | 2002-12-16 | Merck & Co Inc | Genes que influyen en la actividad proteolitica de pichia y usoso de los mismos. |
| US6348327B1 (en) | 1991-12-06 | 2002-02-19 | Genentech, Inc. | Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells |
| PT682710E (pt) * | 1993-02-10 | 2004-03-31 | Unilever Nv | Processo de isolamento utilizando proteinas imobilizadas com capacidades de ligacao especificas |
| US5538863A (en) * | 1993-07-01 | 1996-07-23 | Immunex Corporation | Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide |
| US6451562B1 (en) | 1993-12-22 | 2002-09-17 | Human Genome Sciences, Inc. | Polypeptides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) polynucleotides |
| US6495129B1 (en) | 1994-03-08 | 2002-12-17 | Human Genome Sciences, Inc. | Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3) |
| US5629167A (en) | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| US5639642A (en) * | 1994-06-16 | 1997-06-17 | Novo Nordisk A/S | Synthetic leader peptide sequences |
| ZA954983B (en) * | 1994-06-17 | 1996-02-14 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| HRP940432B1 (en) * | 1994-08-05 | 2003-10-31 | Pliva Pharm & Chem Works | Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin |
| WO1996007744A1 (en) * | 1994-09-08 | 1996-03-14 | Chiron Corporation | A method of improved production of insulin-like growth factor |
| GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
| ZA9610456B (en) * | 1995-12-20 | 1997-06-20 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| CA2266543C (en) * | 1996-09-24 | 2003-12-09 | Cadus Pharmaceutical Corporation | Methods and compositions for identifying receptor effectors |
| WO1998013473A1 (en) | 1996-09-25 | 1998-04-02 | Vanderbilt University | Genetically engineered yeast with modified signal peptidase complex |
| JP4341859B2 (ja) | 1996-12-13 | 2009-10-14 | ノバルティス バクシンズ アンド ダイアグノスティックス， インコーポレーテッド | 酵母での異種タンパク質の発現の方法 |
| KR100381494B1 (ko) * | 1997-06-30 | 2003-07-22 | 바이오 테크놀로지 제네랄 코오포레이션 | 인간인슐린의제조방법 |
| US6068993A (en) * | 1997-07-02 | 2000-05-30 | Biobras Sa | Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin |
| US6410264B1 (en) | 1997-08-05 | 2002-06-25 | Chiron Corporation | Pichia pastoris gene sequences and methods for their use |
| BR9813930A (pt) | 1997-11-06 | 2006-12-19 | Chiron Spa | antìgeno neisserial |
| WO1999036544A2 (en) | 1998-01-14 | 1999-07-22 | Chiron S.P.A. | Neisseria meningitidis antigens |
| EP1049790A1 (en) | 1998-01-23 | 2000-11-08 | Novo Nordisk A/S | Process for making desired polypeptides in yeast |
| GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| JP5102414B2 (ja) | 1998-05-01 | 2012-12-19 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 髄膜炎菌抗原および組成物 |
| WO2001031019A2 (en) | 1999-10-29 | 2001-05-03 | Chiron Spa | Neisserial antigenic peptides |
| WO2000005389A2 (en) * | 1998-07-20 | 2000-02-03 | Unilever N.V. | Production of proteins |
| PT1105485E (pt) | 1998-08-21 | 2006-11-30 | Immunex Corp | Dna e polipeptídeos de il-1 epsilon humana |
| CN100392082C (zh) | 1999-04-30 | 2008-06-04 | 启龙股份公司 | 保守的奈瑟球菌抗原 |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| CN1416352B (zh) | 2000-01-17 | 2011-05-25 | 启龙股份公司 | 含有脑膜炎奈瑟球菌b血清群外膜蛋白质的外膜囊(omv)疫苗 |
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| US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
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| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
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| WO1990001063A1 (en) * | 1988-07-23 | 1990-02-08 | Delta Biotechnology Limited | New secretory leader sequences |
-
1988
- 1988-12-22 CA CA000586916A patent/CA1340772C/en not_active Expired - Fee Related
- 1988-12-23 DE DE88312306T patent/DE3885728T2/de not_active Expired - Lifetime
- 1988-12-23 ES ES88312306T patent/ES2059547T3/es not_active Expired - Lifetime
- 1988-12-23 AT AT88312306T patent/ATE97441T1/de not_active IP Right Cessation
- 1988-12-23 EP EP88312306A patent/EP0324274B1/en not_active Expired - Lifetime
- 1988-12-26 IL IL88802A patent/IL88802A0/xx unknown
- 1988-12-28 FI FI886008A patent/FI100995B/fi not_active IP Right Cessation
- 1988-12-28 NO NO885786A patent/NO178829C/no unknown
- 1988-12-29 DK DK198807285A patent/DK175910B1/da not_active IP Right Cessation
- 1988-12-30 JP JP63335685A patent/JP2793215B2/ja not_active Expired - Lifetime
- 1988-12-30 IE IE389688A patent/IE62087B1/en not_active IP Right Cessation
- 1988-12-30 AU AU27650/88A patent/AU616228B2/en not_active Expired
- 1988-12-30 PT PT89367A patent/PT89367B/pt not_active IP Right Cessation
-
1994
- 1994-09-27 US US08/313,540 patent/US5602034A/en not_active Ceased
- 1994-12-08 HK HK139994A patent/HK139994A/xx not_active IP Right Cessation
-
1998
- 1998-08-27 US US09/140,858 patent/USRE37343E1/en not_active Expired - Lifetime
-
2005
- 2005-01-27 DK DK200500130A patent/DK176075B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI886008A (fi) | 1989-07-01 |
| AU2765088A (en) | 1989-07-06 |
| CA1340772C (en) | 1999-09-28 |
| USRE37343E1 (en) | 2001-08-28 |
| IE883896L (en) | 1989-06-30 |
| ES2059547T3 (es) | 1994-11-16 |
| EP0324274A1 (en) | 1989-07-19 |
| EP0324274B1 (en) | 1993-11-18 |
| DK176075B1 (da) | 2006-04-10 |
| DE3885728T2 (de) | 1994-03-10 |
| PT89367A (pt) | 1989-12-29 |
| PT89367B (pt) | 1993-09-30 |
| IL88802A0 (en) | 1989-07-31 |
| NO178829C (no) | 1996-06-12 |
| JPH022339A (ja) | 1990-01-08 |
| AU616228B2 (en) | 1991-10-24 |
| FI100995B (fi) | 1998-03-31 |
| DK200500130A (da) | 2005-01-27 |
| DE3885728D1 (de) | 1993-12-23 |
| ATE97441T1 (de) | 1993-12-15 |
| NO885786L (no) | 1989-07-03 |
| NO178829B (no) | 1996-03-04 |
| IE62087B1 (en) | 1994-12-14 |
| DK175910B1 (da) | 2005-06-13 |
| DK728588D0 (da) | 1988-12-29 |
| HK139994A (en) | 1994-12-16 |
| US5602034A (en) | 1997-02-11 |
| NO885786D0 (no) | 1988-12-28 |
| JP2793215B2 (ja) | 1998-09-03 |
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