ES2177528T3 - Genes que influyen en la actividad proteolitica de pichia y usoso de los mismos. - Google Patents
Genes que influyen en la actividad proteolitica de pichia y usoso de los mismos.Info
- Publication number
- ES2177528T3 ES2177528T3 ES92910129T ES92910129T ES2177528T3 ES 2177528 T3 ES2177528 T3 ES 2177528T3 ES 92910129 T ES92910129 T ES 92910129T ES 92910129 T ES92910129 T ES 92910129T ES 2177528 T3 ES2177528 T3 ES 2177528T3
- Authority
- ES
- Spain
- Prior art keywords
- genes
- pichia
- themselves
- influence
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000235648 Pichia Species 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 230000002797 proteolythic effect Effects 0.000 title abstract 3
- 238000012512 characterization method Methods 0.000 abstract 2
- 238000002955 isolation Methods 0.000 abstract 2
- 241000894007 species Species 0.000 abstract 2
- 230000002950 deficient Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/938—Pichia
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
SE DESCRIBEN EL AISLAMIENTO Y LA CARACTERIZACION DE GENES IMPLICADOS EN EL PROCESAMIENTO PROTEOLITICO EN ESPECIES DEL GENES PICHIA. LA DISPONIBILIDAD DE TALES GENES HA FACULTADO LA GENERACION DE RAZAS DE PICHIA QUE SON DEFICIENTES EN LA ACTIVIDAD PROTEOLITICA Y UTILES COMO HUESPEDES PARA LA EXPRESION DE PRODUCTOS RECOMBINANTES PROTEOLITICAMENTE SENSIBLES. TAMBIEN SE DESCRIBEN EL AISLAMIENTO Y LA CARACTERIZACION DE GENES ADICIONALES PROCEDENTES DE ESPECIES DEL GENE PICHIA, ASI COMO USOS PARA ESTO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67891691A | 1991-04-01 | 1991-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2177528T3 true ES2177528T3 (es) | 2002-12-16 |
Family
ID=24724845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92910129T Expired - Lifetime ES2177528T3 (es) | 1991-04-01 | 1992-03-31 | Genes que influyen en la actividad proteolitica de pichia y usoso de los mismos. |
Country Status (9)
Country | Link |
---|---|
US (5) | US5324660A (es) |
EP (1) | EP0578746B1 (es) |
JP (2) | JPH06506117A (es) |
AT (1) | ATE220105T1 (es) |
AU (1) | AU661844B2 (es) |
CA (1) | CA2105064A1 (es) |
DE (1) | DE69232666T2 (es) |
ES (1) | ES2177528T3 (es) |
WO (1) | WO1992017595A1 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5612198A (en) * | 1990-09-04 | 1997-03-18 | The Salk Institute | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
WO1992017595A1 (en) * | 1991-04-01 | 1992-10-15 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Genes which influence pichia proteolytic activity, and uses therefor |
FR2692907B1 (fr) * | 1992-06-25 | 1995-06-30 | Rhone Poulenc Rorer Sa | Levures kluyveromyces modifiees, preparation et utilisation. |
US5674728A (en) * | 1993-11-03 | 1997-10-07 | Novartis Corporation | Aspergillus niger vacuolar aspartyl protease |
AU2733895A (en) * | 1994-06-17 | 1996-01-15 | Novo Nordisk A/S | A fungus wherein the area gene has been modified and an area gene from aspergillus oryzae |
US5594119A (en) * | 1994-09-20 | 1997-01-14 | Novo Nordisk A/S | Gene encoding carboxypeptidase of aspergillus niger |
US5861280A (en) * | 1995-03-20 | 1999-01-19 | Novo Nordisk A/S | Host cell expressing reduced levels of a metalloprotease and methods using the host cell in protein production |
US6107057A (en) * | 1995-09-25 | 2000-08-22 | Chiron Corporation | Pichia secretory leader for protein expression |
US6153424A (en) * | 1995-11-09 | 2000-11-28 | Zymogenetics, Inc. | Protease-deficient strains of Pichia methanolica |
CN1160465C (zh) * | 1995-12-15 | 2004-08-04 | 诺沃奇梅兹有限公司 | 其中areA、pepC和/或pepE基因已被灭活的真菌 |
CN1120235C (zh) | 1996-03-27 | 2003-09-03 | 诺沃奇梅兹有限公司 | 碱性蛋白酶缺陷型丝状真菌 |
US6110703A (en) * | 1996-07-05 | 2000-08-29 | Novo Nordisk A/S | Method for the production of polypeptides |
JP4091119B2 (ja) * | 1996-09-19 | 2008-05-28 | ノボザイムス アクティーゼルスカブ | 新規な宿主細胞およびタンパク質生産方法 |
JP2001512684A (ja) | 1997-08-05 | 2001-08-28 | カイロン コーポレイション | 新規のpichiapastoris遺伝子配列およびそれらの使用方法 |
US6183953B1 (en) | 1997-09-15 | 2001-02-06 | Zymogenetics, Inc. | Chromosomal mutagenesis in Pichia methanolica |
JP2001516577A (ja) * | 1997-09-15 | 2001-10-02 | ザイモジェネティクス,インコーポレイティド | ピキア・メタノリカにおける染色体の突然変異誘発 |
AU9231898A (en) * | 1997-09-15 | 1999-04-05 | Zymogenetics Inc. | Protease-deficient strains of (pichia methanolica) |
US6605450B1 (en) | 2000-05-25 | 2003-08-12 | Chiron Corporation | Iron regulation of the PpSEC10 transcriptional regulatory region of Pichia pastoris and methods of use |
US20060034830A1 (en) * | 2000-06-28 | 2006-02-16 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GalGlcNAcMan5GLcNAc2 glycoform |
US20060257399A1 (en) * | 2000-06-28 | 2006-11-16 | Glycofi, Inc. | Immunoglobulins comprising predominantly a Man5GIcNAc2 glycoform |
US20060034828A1 (en) * | 2000-06-28 | 2006-02-16 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GlcNAcMAN5GLCNAC2 glycoform |
US20060029604A1 (en) * | 2000-06-28 | 2006-02-09 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform |
JP4211603B2 (ja) | 2001-05-29 | 2009-01-21 | 旭硝子株式会社 | シゾサッカロマイセス・ポンベ(Schizosaccharomycespombe)宿主の構築方法および異種タンパク質の製造方法 |
US20060034829A1 (en) * | 2001-12-27 | 2006-02-16 | Gerngross Tillman U | Immunoglobulins comprising predominantly a MAN3GLCNAC2 glycoform |
US20060024292A1 (en) * | 2001-12-27 | 2006-02-02 | Gerngross Tillman U | Immunoglobulins comprising predominantly a Gal2GlcNAc2Man3GlcNAc2 glycoform |
WO2003091431A1 (fr) * | 2002-04-26 | 2003-11-06 | Kirin Beer Kabushiki Kaisha | Methylotrophe produisant une chaine de sucre de type mammifere |
US7514253B2 (en) * | 2003-05-16 | 2009-04-07 | Glycofi, Inc. | URA5 gene and methods for stable genetic integration in yeast |
US8268582B2 (en) | 2003-10-22 | 2012-09-18 | Keck Graduate Institute | Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy |
EP1766002B1 (en) | 2004-06-21 | 2015-11-18 | Novozymes A/S | Stably maintained multiple copies of at least two orf in the same orientation |
CA2531616A1 (en) * | 2004-12-28 | 2006-06-28 | Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd.) | High strength thin steel sheet having high hydrogen embrittlement resisting property and high workability |
AU2005336263A1 (en) * | 2005-09-09 | 2007-03-15 | Glycofi, Inc. | Immunoglobulin comprising predominantly a man7GlcNAc2, Man8GlcNAc2 glycoform |
ES2539378T3 (es) * | 2009-02-26 | 2015-06-30 | Glaxosmithkline Llc | Células huésped y procedimientos de uso |
EP2494050A4 (en) * | 2009-10-30 | 2013-10-30 | Merck Sharp & Dohme | FACTOR FOR STIMULATING GRANULOCYTES AND MONOCYTES PRODUCED IN GLYCOMODIFIED PICHIA PASTORIS |
WO2011073883A1 (en) | 2009-12-14 | 2011-06-23 | Centre Hospitalier Universitaire Vaudois (Chuv) | Pichia pastoris deficient in endogenous secreted protease |
CA2811789A1 (en) | 2010-10-06 | 2012-04-12 | Bp Corporation North America Inc. | Variant cbh i polypeptides with reduced product inhibition |
EP3752617A1 (en) | 2018-02-12 | 2020-12-23 | Lonza Ltd. | Host cell for producing a protein of interest |
EP3884037A1 (en) * | 2018-11-19 | 2021-09-29 | Basf Se | A recombinant yeast cell |
KR102699074B1 (ko) | 2019-01-11 | 2024-08-26 | 론자 리미티드 | 재조합 숙주 세포에서 탄소 공급원 조절된 단백질 생산 |
WO2020201369A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Mut- methylotrophic yeast |
WO2020200414A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Protein production in mut-methylotrophic yeast |
WO2020200415A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Mut- methylotrophic yeast |
WO2021198431A1 (en) | 2020-04-01 | 2021-10-07 | Lonza Ltd | Helper factors for expressing proteins in yeast |
WO2022069613A1 (en) | 2020-09-30 | 2022-04-07 | Lonza Ltd | Host cells overexpressing translational factors |
WO2024133538A1 (en) | 2022-12-20 | 2024-06-27 | Lonza Ltd | Host cells with pat1 knockout for increased specific protein productivity |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4546082A (en) * | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
SE8300693L (sv) * | 1983-02-09 | 1984-08-10 | Sven Lofdahl | Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta |
ATE95236T1 (de) * | 1983-04-25 | 1993-10-15 | Chiron Corp | Hybrid-dns-synthesis von reifen insulinaehnlichen wachstumsfaktoren. |
IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
GB8327880D0 (en) * | 1983-10-18 | 1983-11-16 | Ajinomoto Kk | Saccharomyces cerevisiae |
US4839295A (en) * | 1984-06-08 | 1989-06-13 | Pierce Chemical Company | Measurement of protein using bicinchoninic acid |
EP0173378B1 (en) * | 1984-07-27 | 1991-06-12 | Unilever N.V. | Process for preparing a polypeptide by culturing a transformed microorganism, a transformed microorganism suitable therefor and dna sequences suitable for preparing such microorganism |
US4879231A (en) * | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
US4837148A (en) * | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
US4855231A (en) * | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
US4885242A (en) * | 1984-10-30 | 1989-12-05 | Phillips Petroleum Company | Genes from pichia histidine pathway and uses thereof |
GB8521496D0 (en) * | 1985-08-29 | 1985-10-02 | Ciba Geigy Ag | Repressible yeast promoters |
US4882279A (en) * | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
US4895800A (en) * | 1985-11-26 | 1990-01-23 | Phillips Petroleum Company | Yeast production of hepatitis B surface antigen |
US4812405A (en) * | 1986-02-18 | 1989-03-14 | Phillips Petroleum Company | Double auxotrophic mutants of Pichia pastoris and methods for preparation |
GB2188933A (en) * | 1986-04-10 | 1987-10-14 | Bayer Ag | Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby |
US5002876A (en) * | 1986-09-22 | 1991-03-26 | Phillips Petroleum Company | Yeast production of human tumor necrosis factor |
US4929555A (en) * | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
EP0343231A4 (en) * | 1987-11-02 | 1990-09-05 | The Salk Institute Biotechnology Industrial Associates, Inc. | Production of animal lysozyme c via secretion from pichia pastoris and composition therefor |
CA1340772C (en) * | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
EP0327797B1 (de) * | 1988-01-05 | 2003-09-03 | Roche Diagnostics GmbH | Verfahren zur Herstellung von Proteinen oder proteinhaltigen Genprodukten |
EP0336056B1 (en) * | 1988-01-27 | 1995-04-05 | M & D RESEARCH CO., LTD. | Protease |
AU614121B2 (en) * | 1988-05-04 | 1991-08-22 | Novartis Ag | Improvements in the production of polypeptides |
WO1990000191A1 (en) * | 1988-07-01 | 1990-01-11 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Production of rabies glycoprotein g and composition therefor |
GB8819826D0 (en) * | 1988-08-20 | 1988-09-21 | Kabivitrum Ab | Glycosylated igf-1 |
IL91512A0 (en) * | 1988-09-09 | 1990-04-29 | Salk Inst Biotech Ind | Production of interluekin-2 poly-peptides in pichia pastoris yeast cells |
JPH04501662A (ja) * | 1988-09-26 | 1992-03-26 | ザ・サルク・インスティチュート・バイオテクノロジー/インダストリアル・アソシエイツ・インコーポレーテッド | 混合給送組換え酵母発酵 |
US5204252A (en) * | 1989-02-08 | 1993-04-20 | Henkel Research Corporation | Candida tropicalis transformation system |
DD297841A5 (de) * | 1989-02-13 | 1992-01-23 | The Salk Institute Biotechnology/Industrial Associates,Us | Herstellung von superoxiddismutase in pichia pastoris hefezellen |
FR2645175B1 (fr) * | 1989-03-31 | 1994-02-18 | Transgene Sa | Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche |
US5122465A (en) * | 1989-06-12 | 1992-06-16 | Phillips Petroleum Company | Strains of pichia pastoris created by interlocus recombination |
US5231010A (en) * | 1989-09-13 | 1993-07-27 | Bayer Aktiengesellschaft | Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof |
WO1991005057A1 (en) * | 1989-09-28 | 1991-04-18 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Cd4 production in pichia pastoris |
US5258302A (en) * | 1990-07-03 | 1993-11-02 | The Salk Institute Biotechnology/Industrial Associates, Inc. | DNA for expression of aprotinin in methylotrophic yeast cells |
CA2090969C (en) * | 1990-09-04 | 2001-08-21 | Russell Arthur Brierley | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
JPH06503718A (ja) * | 1990-09-05 | 1994-04-28 | メルク エンド カンパニー インコーポレーテッド | メチロトローフ酵母細胞におけるヒトリゾチムの産生とその効率的な分泌 |
JPH07108232B2 (ja) * | 1990-10-09 | 1995-11-22 | エム・ディ・リサーチ株式会社 | ペプチド又は蛋白質の製造方法 |
US5231178A (en) * | 1991-01-16 | 1993-07-27 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Method for the purification of intact, correctly-folded insulin-like growth factor-1 |
WO1992013951A1 (en) * | 1991-02-04 | 1992-08-20 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Production of human serum albumin in methylotrophic yeast cells |
WO1992017595A1 (en) * | 1991-04-01 | 1992-10-15 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Genes which influence pichia proteolytic activity, and uses therefor |
US5213010A (en) * | 1991-05-07 | 1993-05-25 | Toshiba Kikai Kabushiki Kaisha | Driver power transmitting apparatus of twin shaft extruders |
AU3061092A (en) * | 1991-10-31 | 1993-06-07 | Salk Institute Biotechnology/Industrial Associates, Inc., The | Recombinant amyloid precursor protein inhibitor domain and treatment of various disease states |
-
1992
- 1992-03-31 WO PCT/US1992/002521 patent/WO1992017595A1/en active IP Right Grant
- 1992-03-31 AT AT92910129T patent/ATE220105T1/de not_active IP Right Cessation
- 1992-03-31 DE DE69232666T patent/DE69232666T2/de not_active Expired - Fee Related
- 1992-03-31 AU AU17505/92A patent/AU661844B2/en not_active Expired
- 1992-03-31 ES ES92910129T patent/ES2177528T3/es not_active Expired - Lifetime
- 1992-03-31 EP EP92910129A patent/EP0578746B1/en not_active Expired - Lifetime
- 1992-03-31 CA CA002105064A patent/CA2105064A1/en not_active Abandoned
- 1992-03-31 JP JP4509369A patent/JPH06506117A/ja not_active Withdrawn
-
1993
- 1993-07-06 US US08/088,633 patent/US5324660A/en not_active Expired - Lifetime
-
1994
- 1994-05-16 US US08/245,756 patent/US5541112A/en not_active Expired - Fee Related
-
1995
- 1995-05-16 US US08/441,750 patent/US5691166A/en not_active Expired - Lifetime
- 1995-05-16 US US08/441,751 patent/US5831053A/en not_active Expired - Lifetime
-
1997
- 1997-01-22 US US08/787,806 patent/US6051419A/en not_active Expired - Fee Related
-
2002
- 2002-10-01 JP JP2002288639A patent/JP2003159090A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US5691166A (en) | 1997-11-25 |
AU661844B2 (en) | 1995-08-10 |
JPH06506117A (ja) | 1994-07-14 |
US5324660A (en) | 1994-06-28 |
US6051419A (en) | 2000-04-18 |
US5541112A (en) | 1996-07-30 |
JP2003159090A (ja) | 2003-06-03 |
EP0578746B1 (en) | 2002-07-03 |
CA2105064A1 (en) | 1992-10-02 |
WO1992017595A1 (en) | 1992-10-15 |
US5831053A (en) | 1998-11-03 |
EP0578746A1 (en) | 1994-01-19 |
AU1750592A (en) | 1992-11-02 |
DE69232666T2 (de) | 2003-03-20 |
DE69232666D1 (de) | 2002-08-08 |
ATE220105T1 (de) | 2002-07-15 |
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