NO178829C - Dobbelt-trådet DNA-molekyl som medförer forbedret ekspresjon - Google Patents
Dobbelt-trådet DNA-molekyl som medförer forbedret ekspresjonInfo
- Publication number
- NO178829C NO178829C NO885786A NO885786A NO178829C NO 178829 C NO178829 C NO 178829C NO 885786 A NO885786 A NO 885786A NO 885786 A NO885786 A NO 885786A NO 178829 C NO178829 C NO 178829C
- Authority
- NO
- Norway
- Prior art keywords
- yeast
- encodes
- precursor polypeptide
- precursor
- protein
- Prior art date
Links
- 108020004414 DNA Proteins 0.000 title abstract 4
- 102000053602 DNA Human genes 0.000 title abstract 2
- 239000002243 precursor Substances 0.000 abstract 8
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108010058643 Fungal Proteins Proteins 0.000 abstract 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 238000003776 cleavage reaction Methods 0.000 abstract 3
- 230000013595 glycosylation Effects 0.000 abstract 3
- 238000006206 glycosylation reaction Methods 0.000 abstract 3
- 230000007017 scission Effects 0.000 abstract 3
- 108091026890 Coding region Proteins 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 101150045458 KEX2 gene Proteins 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 102000005593 Endopeptidases Human genes 0.000 abstract 1
- 108010059378 Endopeptidases Proteins 0.000 abstract 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
- 108010076181 Proinsulin Proteins 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 241000235070 Saccharomyces Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000005026 transcription initiation Effects 0.000 abstract 1
- 230000005030 transcription termination Effects 0.000 abstract 1
- 210000005253 yeast cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13968287A | 1987-12-30 | 1987-12-30 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO885786D0 NO885786D0 (no) | 1988-12-28 |
| NO885786L NO885786L (no) | 1989-07-03 |
| NO178829B NO178829B (no) | 1996-03-04 |
| NO178829C true NO178829C (no) | 1996-06-12 |
Family
ID=22487825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO885786A NO178829C (no) | 1987-12-30 | 1988-12-28 | Dobbelt-trådet DNA-molekyl som medförer forbedret ekspresjon |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5602034A (da) |
| EP (1) | EP0324274B1 (da) |
| JP (1) | JP2793215B2 (da) |
| AT (1) | ATE97441T1 (da) |
| AU (1) | AU616228B2 (da) |
| CA (1) | CA1340772C (da) |
| DE (1) | DE3885728T2 (da) |
| DK (2) | DK175910B1 (da) |
| ES (1) | ES2059547T3 (da) |
| FI (1) | FI100995B (da) |
| HK (1) | HK139994A (da) |
| IE (1) | IE62087B1 (da) |
| IL (1) | IL88802A0 (da) |
| NO (1) | NO178829C (da) |
| PT (1) | PT89367B (da) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5170964A (ja) * | 1974-12-16 | 1976-06-19 | Hohnen Oil | Haisuinoshoriho |
| DE3486216T2 (de) | 1983-04-25 | 1994-02-17 | Chiron Corp | Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren. |
| US5010182A (en) * | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
| US5612198A (en) * | 1990-09-04 | 1997-03-18 | The Salk Institute | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
| CA2090969C (en) * | 1990-09-04 | 2001-08-21 | Russell Arthur Brierley | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
| WO1992005198A1 (en) * | 1990-09-14 | 1992-04-02 | Chiron Corporation | EXPRESSION OF MACROPHAGE INDUCIBLE PROTEINS (MIPs) IN YEAST CELLS |
| EP0785273A1 (en) | 1990-11-26 | 1997-07-23 | Genetics Institute, Inc. | Paired basic amino acid converting enzyme and DNA sequence encoding it |
| DK300090D0 (da) * | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
| EP0578746B1 (en) * | 1991-04-01 | 2002-07-03 | Merck & Co., Inc. | GENES WHICH INFLUENCE $i(PICHIA) PROTEOLYTIC ACTIVITY, AND USES THEREFOR |
| US6348327B1 (en) | 1991-12-06 | 2002-02-19 | Genentech, Inc. | Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells |
| WO1994018330A1 (en) * | 1993-02-10 | 1994-08-18 | Unilever N.V. | Immobilized proteins with specific binding capacities and their use in processes and products |
| US5538863A (en) * | 1993-07-01 | 1996-07-23 | Immunex Corporation | Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide |
| US6623942B2 (en) | 1994-03-08 | 2003-09-23 | Human Genome Sciences, Inc. | Macrophage inflammatory protein-4 (MIP-4) polynucleotides |
| US6495129B1 (en) | 1994-03-08 | 2002-12-17 | Human Genome Sciences, Inc. | Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3) |
| US5629167A (en) | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| US5639642A (en) * | 1994-06-16 | 1997-06-17 | Novo Nordisk A/S | Synthetic leader peptide sequences |
| RU2167939C2 (ru) * | 1994-06-16 | 2001-05-27 | Ново Нордиск А/С | Способ продуцирования полипептида в дрожжах |
| ZA954983B (en) * | 1994-06-17 | 1996-02-14 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| HRP940432B1 (en) * | 1994-08-05 | 2003-10-31 | Pliva Pharm & Chem Works | Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin |
| WO1996007744A1 (en) * | 1994-09-08 | 1996-03-14 | Chiron Corporation | A method of improved production of insulin-like growth factor |
| GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
| ZA9610456B (en) * | 1995-12-20 | 1997-06-20 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| JP2001501097A (ja) * | 1996-09-24 | 2001-01-30 | ケイダス ファーマスーティカル コーポレイション | レセプターエフェクターを同定する方法及び組成物 |
| US6197545B1 (en) | 1996-09-25 | 2001-03-06 | Vanderbilt University | Genetically engineered yeast with modified signal peptidase complex |
| WO1998025963A1 (en) | 1996-12-13 | 1998-06-18 | Chiron Corporation | Analysis and separation of platelet-derived growth factor proteins |
| KR100381494B1 (ko) * | 1997-06-30 | 2003-07-22 | 바이오 테크놀로지 제네랄 코오포레이션 | 인간인슐린의제조방법 |
| US6068993A (en) * | 1997-07-02 | 2000-05-30 | Biobras Sa | Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin |
| EP1003889A1 (en) | 1997-08-05 | 2000-05-31 | Chiron Corporation | NOVEL $i(PICHIA PASTORIS) GENE SEQUENCES AND METHODS FOR THEIR USE |
| EP1029052B1 (en) | 1997-11-06 | 2010-08-04 | Novartis Vaccines and Diagnostics S.r.l. | Neisserial antigens |
| AU1979599A (en) | 1998-01-14 | 1999-08-02 | Chiron S.P.A. | (neisseria meningitidis) antigens |
| JP2003525570A (ja) * | 1998-01-23 | 2003-09-02 | ノボ ノルディスク アクティーゼルスカブ | 酵母において所望のポリペプチドを産生する方法 |
| GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| CN100379757C (zh) | 1998-05-01 | 2008-04-09 | 希龙公司 | 脑膜炎奈瑟球菌抗原和组合物 |
| AU5504999A (en) * | 1998-07-20 | 2000-02-14 | Frenken, Leon Gerardus Joseph | Production of proteins |
| PT1105485E (pt) | 1998-08-21 | 2006-11-30 | Immunex Corp | Dna e polipeptídeos de il-1 epsilon humana |
| ES2522667T3 (es) | 1999-04-30 | 2014-11-17 | Novartis Vaccines And Diagnostics S.R.L. | Antígenos Neisseriales conservados |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| PT2275551E (pt) | 1999-10-29 | 2015-06-29 | Novartis Vaccines & Diagnostic | Péptidos antigénicos de neisseria |
| CA2871789C (en) | 2000-01-17 | 2017-04-04 | Novartis Vaccines And Diagnostics S.R.L. | Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins |
| JP2003528149A (ja) | 2000-03-24 | 2003-09-24 | ジェネンテック・インコーポレーテッド | 軟骨性疾患の治療のためのインスリンの使用 |
| AU2002210126A1 (en) | 2000-05-25 | 2001-12-03 | Chiron Corporation | Iron regulation of the ppsec10 transcriptional regulatory region of pichia pastoris and methods of use |
| CN100365125C (zh) * | 2000-07-26 | 2008-01-30 | 韩国生命工学研究院 | 来源于酵母的新型细胞壁锚定蛋白及其基因和使用其的细胞表面表达系统 |
| US7939087B2 (en) | 2000-10-27 | 2011-05-10 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acids and proteins from Streptococcus groups A & B |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| US20050164365A1 (en) * | 2001-07-06 | 2005-07-28 | Juridical Foundation The Chemosero-Therapeutic Research Institute | Genetically modified ecarin and process for producing the same |
| DE60228758D1 (de) | 2001-12-12 | 2008-10-16 | Novartis Vaccines & Diagnostic | Immunisierung gegen chlamydia tracheomatis |
| DE60330564D1 (de) * | 2002-05-24 | 2010-01-28 | Restoragen Inc | Verfahren und konstrukte zur expression von clostripain mit hoher ausbeute |
| EP1572720A4 (en) * | 2002-05-24 | 2008-12-24 | Nps Allelix Corp | PROCESS FOR THE ENZYMATIC PRODUCTION OF GLP-2 (1-34) AND GLP-2 (1-33) PEPTIDES |
| EP1604008B1 (en) | 2002-09-13 | 2010-12-22 | Cornell Research Foundation, Inc. | Using mutations to improve aspergillus phytases |
| DK2279746T3 (da) | 2002-11-15 | 2013-11-25 | Novartis Vaccines & Diagnostic | Overfladeproteiner i neisseria meningitidis |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| EP1648935A2 (en) | 2003-07-25 | 2006-04-26 | Amgen Inc. | Antagonists and agonists of ldcam and methods of use |
| SI1704234T1 (sl) * | 2003-11-21 | 2012-08-31 | Nps Pharma Inc | Proizvodnja glukagonu podobnih peptidov 2 in analogov |
| EP2497478A3 (en) | 2003-12-05 | 2012-11-07 | Children's Hospital Medical Center | Oligosaccaride compositions and use thereof in the treatment of infection |
| US8778880B2 (en) * | 2004-02-02 | 2014-07-15 | Ambrx, Inc. | Human growth hormone modified at position 35 |
| KR101699142B1 (ko) * | 2004-06-18 | 2017-01-23 | 암브룩스, 인코포레이티드 | 신규 항원-결합 폴리펩티드 및 이의 용도 |
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| EP2284191A3 (en) | 2004-12-22 | 2011-07-20 | Ambrx, Inc. | Process for the preparation of hGH |
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| US8080391B2 (en) | 2004-12-22 | 2011-12-20 | Ambrx, Inc. | Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer |
| US7825231B2 (en) * | 2005-06-01 | 2010-11-02 | Darren P. Wolfe | Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy |
| CA2609205A1 (en) * | 2005-06-03 | 2006-12-14 | Ambrx, Inc. | Improved human interferon molecules and their uses |
| WO2007021297A1 (en) | 2005-08-18 | 2007-02-22 | Ambrx, Inc. | COMPOSITIONS OF tRNA AND USES THEREOF |
| HRP20110404T1 (hr) * | 2005-11-08 | 2011-08-31 | Ambrx | Ubrzivači za modifikaciju ne-prirodnih aminokiselina i polipeptida ne-prirodnih aminokiselina |
| US20090018029A1 (en) | 2005-11-16 | 2009-01-15 | Ambrx, Inc. | Methods and Compositions Comprising Non-Natural Amino Acids |
| ES2529065T3 (es) * | 2005-12-14 | 2015-02-16 | Ambrx, Inc. | Composiciones que contienen, procedimientos que implican y usos de aminoácidos no naturales y polipéptidos |
| DK2054431T3 (da) | 2006-06-09 | 2012-01-02 | Novartis Ag | Konformere af bakterielle adhæsiner |
| DK2064333T3 (da) * | 2006-09-08 | 2014-05-05 | Ambrx Inc | Suppressor-trna-transkription i hvirveldyrceller |
| DK2615108T3 (da) | 2006-09-08 | 2017-01-30 | Ambrx Inc | Modificeret humant plasmapolypeptid eller fc scaffolds og deres anvendelser |
| PT2061878E (pt) * | 2006-09-08 | 2014-04-22 | Ambrx Inc | Supressor híbrido arnt para células de vertebrados |
| WO2008032659A1 (fr) * | 2006-09-14 | 2008-03-20 | National Institute Of Advanced Industrial Science And Technology | Peptide signal de sécrétion doté d'une efficacité améliorée, et procédé de production de protéine au moyen dudit peptide |
| PL2068909T3 (pl) | 2007-03-30 | 2012-09-28 | Ambrx Inc | Modyfikowane polipeptydy fgf-21 i ich zastosowanie |
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| IL63270A0 (en) | 1980-08-05 | 1981-10-30 | Univ Leland Stanford Junior | Eukaryotic autonomously replicating segment |
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| US4546083A (en) | 1983-04-22 | 1985-10-08 | Stolle Research & Development Corporation | Method and device for cell culture growth |
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| NZ207926A (en) * | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
| DE3486216T2 (de) * | 1983-04-25 | 1994-02-17 | Chiron Corp | Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren. |
| US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| DE3587759T2 (de) | 1984-05-11 | 1994-07-07 | Chiron Corp., Emeryville, Calif. | Erhöhte Hefetranskription unter Verwendung einer Hybridkonstruktion der Promotorregion. |
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| EP0192738A4 (en) * | 1984-08-29 | 1987-06-25 | Chiron Corp | EXPRESSION OF HUMAN CONJUNCTIVE TISSUE ACTIVATOR AND RELATED PEPTIDES. |
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| AU5912586A (en) | 1985-06-20 | 1986-12-24 | Salk Institute Biotechnology/Industrial Associates, Inc., The | Alpha-factor leader peptide-facilitated secretion from transformed s cerevisiae |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| US5010182A (en) | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
| KR100195632B1 (ko) * | 1988-07-23 | 1999-06-15 | 스티븐 조지 가랜드 | 펩티드 및 dna 배열 |
-
1988
- 1988-12-22 CA CA000586916A patent/CA1340772C/en not_active Expired - Fee Related
- 1988-12-23 AT AT88312306T patent/ATE97441T1/de not_active IP Right Cessation
- 1988-12-23 ES ES88312306T patent/ES2059547T3/es not_active Expired - Lifetime
- 1988-12-23 DE DE88312306T patent/DE3885728T2/de not_active Expired - Lifetime
- 1988-12-23 EP EP88312306A patent/EP0324274B1/en not_active Expired - Lifetime
- 1988-12-26 IL IL88802A patent/IL88802A0/xx unknown
- 1988-12-28 NO NO885786A patent/NO178829C/no unknown
- 1988-12-28 FI FI886008A patent/FI100995B/fi not_active IP Right Cessation
- 1988-12-29 DK DK198807285A patent/DK175910B1/da not_active IP Right Cessation
- 1988-12-30 PT PT89367A patent/PT89367B/pt not_active IP Right Cessation
- 1988-12-30 AU AU27650/88A patent/AU616228B2/en not_active Expired
- 1988-12-30 IE IE389688A patent/IE62087B1/en not_active IP Right Cessation
- 1988-12-30 JP JP63335685A patent/JP2793215B2/ja not_active Expired - Lifetime
-
1994
- 1994-09-27 US US08/313,540 patent/US5602034A/en not_active Ceased
- 1994-12-08 HK HK139994A patent/HK139994A/en not_active IP Right Cessation
-
1998
- 1998-08-27 US US09/140,858 patent/USRE37343E1/en not_active Expired - Lifetime
-
2005
- 2005-01-27 DK DK200500130A patent/DK176075B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2059547T3 (es) | 1994-11-16 |
| US5602034A (en) | 1997-02-11 |
| DK175910B1 (da) | 2005-06-13 |
| FI886008L (fi) | 1989-07-01 |
| IE883896L (en) | 1989-06-30 |
| DK728588A (da) | 1989-07-01 |
| AU616228B2 (en) | 1991-10-24 |
| FI100995B (fi) | 1998-03-31 |
| IE62087B1 (en) | 1994-12-14 |
| DK200500130A (da) | 2005-01-27 |
| CA1340772C (en) | 1999-09-28 |
| AU2765088A (en) | 1989-07-06 |
| DE3885728T2 (de) | 1994-03-10 |
| HK139994A (en) | 1994-12-16 |
| DE3885728D1 (de) | 1993-12-23 |
| USRE37343E1 (en) | 2001-08-28 |
| NO885786D0 (no) | 1988-12-28 |
| JPH022339A (ja) | 1990-01-08 |
| IL88802A0 (en) | 1989-07-31 |
| JP2793215B2 (ja) | 1998-09-03 |
| NO178829B (no) | 1996-03-04 |
| ATE97441T1 (de) | 1993-12-15 |
| PT89367A (pt) | 1989-12-29 |
| EP0324274A1 (en) | 1989-07-19 |
| PT89367B (pt) | 1993-09-30 |
| DK176075B1 (da) | 2006-04-10 |
| EP0324274B1 (en) | 1993-11-18 |
| NO885786L (no) | 1989-07-03 |
| DK728588D0 (da) | 1988-12-29 |
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