NO177009C - Analogifremgangsmåte ved fremstilling av insulinanaloger - Google Patents

Analogifremgangsmåte ved fremstilling av insulinanaloger

Info

Publication number
NO177009C
NO177009C NO863474A NO863474A NO177009C NO 177009 C NO177009 C NO 177009C NO 863474 A NO863474 A NO 863474A NO 863474 A NO863474 A NO 863474A NO 177009 C NO177009 C NO 177009C
Authority
NO
Norway
Prior art keywords
preparation
analogous procedure
insulin analogues
analogues
insulin
Prior art date
Application number
NO863474A
Other languages
English (en)
Norwegian (no)
Other versions
NO863474L (no
NO863474D0 (no
NO177009B (no
Inventor
Jens Joergen Veilgaard Brange
Kjeld Norris
Mogens Trier Hansen
Original Assignee
Novo Nordisk As
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK395685A external-priority patent/DK395685D0/da
Priority claimed from DK467785A external-priority patent/DK467785D0/da
Application filed by Novo Nordisk As, Novo Industri As filed Critical Novo Nordisk As
Publication of NO863474D0 publication Critical patent/NO863474D0/no
Publication of NO863474L publication Critical patent/NO863474L/no
Publication of NO177009B publication Critical patent/NO177009B/no
Publication of NO177009C publication Critical patent/NO177009C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
NO863474A 1985-08-30 1986-08-29 Analogifremgangsmåte ved fremstilling av insulinanaloger NO177009C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK395685A DK395685D0 (da) 1985-08-30 1985-08-30 Peptider
DK467785A DK467785D0 (da) 1985-10-14 1985-10-14 Peptider

Publications (4)

Publication Number Publication Date
NO863474D0 NO863474D0 (no) 1986-08-29
NO863474L NO863474L (no) 1987-03-02
NO177009B NO177009B (no) 1995-03-27
NO177009C true NO177009C (no) 1995-07-05

Family

ID=26067291

Family Applications (2)

Application Number Title Priority Date Filing Date
NO863474A NO177009C (no) 1985-08-30 1986-08-29 Analogifremgangsmåte ved fremstilling av insulinanaloger
NO2000005C NO2000005I1 (no) 1985-08-30 2000-07-21 Insulin aspart

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2000005C NO2000005I1 (no) 1985-08-30 2000-07-21 Insulin aspart

Country Status (25)

Country Link
US (1) US5618913A (ja)
EP (1) EP0214826B1 (ja)
JP (1) JP2662390B2 (ja)
KR (1) KR940000756B1 (ja)
CN (1) CN1029977C (ja)
AR (1) AR241801A1 (ja)
AT (1) ATE113061T1 (ja)
AU (1) AU593274B2 (ja)
CA (1) CA1306212C (ja)
CS (1) CS275613B6 (ja)
DD (1) DD268976A5 (ja)
DE (2) DE10075008I2 (ja)
ES (1) ES2001624A6 (ja)
FI (1) FI102182B (ja)
GR (1) GR862233B (ja)
HU (1) HU206518B (ja)
IE (1) IE66138B1 (ja)
IL (1) IL79887A (ja)
LU (1) LU90484I2 (ja)
NL (1) NL990042I2 (ja)
NO (2) NO177009C (ja)
NZ (1) NZ217406A (ja)
PH (1) PH25772A (ja)
PT (1) PT83278B (ja)
YU (2) YU46023B (ja)

Families Citing this family (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
IE62879B1 (en) * 1987-02-25 1995-03-08 Novo Nordisk As Novel insulin derivatives
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
US4992417A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogues
CA1340772C (en) 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
AU616205B2 (en) * 1988-07-20 1991-10-24 Novo Nordisk A/S Human insulin analogs and preparations containing them
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
KR910700262A (ko) * 1988-12-23 1991-03-14 안네 제케르 사람 인슐린 유사체
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
AU631868B2 (en) * 1989-04-20 1992-12-10 Mount Sinai School Of Medicine Of The City University Of New York, The Hepatospecific insulin analogues
US5208217A (en) * 1989-04-20 1993-05-04 Mount Sinai School Of Medicine Of The City University Of New York Hepatospecific insulin analogues
DK155690D0 (da) * 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
DK158390D0 (da) * 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
DK10191D0 (da) * 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
DK33591D0 (ja) * 1991-02-27 1991-02-27 Novo Nordisk As
IL102240A0 (en) * 1991-06-21 1993-01-14 Lilly Co Eli Insulin analogs
PL310007A1 (en) * 1992-12-18 1995-11-13 Lilly Co Eli Insulin analogues
ES2130428T3 (es) * 1993-06-21 1999-07-01 Novo Nordisk As Cristales de insulina asp-b28.
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
US5504188A (en) * 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
WO1996010417A1 (en) * 1994-10-04 1996-04-11 Novo Nordisk A/S PREPARATIONS CONTAINING AspB28 HUMAN INSULIN AND NICOTINAMIDE
US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
US5646242A (en) 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
US5700904A (en) * 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder
ATE208208T1 (de) * 1996-06-20 2001-11-15 Novo Nordisk As Halogenid-enthaltende insulinzubereitungen
ZA984697B (en) 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
DE19726167B4 (de) * 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
EP1039920A4 (en) 1997-10-24 2003-05-28 Lilly Co Eli INSULIN ANALOGS ACYLATED BY FATTY ACID
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
WO1999042482A1 (en) * 1998-02-23 1999-08-26 Neurocrine Biosciences, Inc. Methods for treatment of diabetes using peptide analogues of insulin
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
AUPP609198A0 (en) * 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
PT1141014E (pt) 1999-01-06 2005-04-29 Genentech Inc Variante mutante do factor de crescimento semelhante a insulina (igf-i)
JP2002535967A (ja) 1999-01-06 2002-10-29 ジェネンテック・インコーポレーテッド インシュリン様成長因子(igf)i変異体
US6746853B1 (en) * 1999-05-19 2004-06-08 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
CN1125081C (zh) * 1999-09-08 2003-10-22 中国科学院上海生物化学研究所 重组天然和新型人胰岛素及其制备方法
US7022674B2 (en) * 1999-12-16 2006-04-04 Eli Lilly And Company Polypeptide compositions with improved stability
WO2001072323A2 (en) 2000-03-24 2001-10-04 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
EP1292324A2 (en) * 2000-05-05 2003-03-19 Novo Nordisk A/S Critical illness neuropathy
EP1282437B1 (en) 2000-05-16 2008-03-19 Genentech, Inc. Treatment of cartilage disorders
AR025646A1 (es) * 2000-09-13 2002-12-04 Beta Lab Sa Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
JP4563675B2 (ja) 2001-10-12 2010-10-13 ハイ・ポイント・ファーマスーティカルズ、エルエルシー 置換ピペリジン類、およびヒスタミンh3受容体関連疾患の治療のためのその使用
CN100424179C (zh) 2001-11-19 2008-10-08 诺沃挪第克公司 制备胰岛素化合物的方法
GB0206792D0 (en) 2002-03-22 2002-05-01 Leuven K U Res & Dev Normoglycemia
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
US7193035B2 (en) 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
US7871607B2 (en) * 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
EP1615698B1 (en) 2003-04-11 2010-09-29 High Point Pharmaceuticals, LLC New amide derivatives and pharmaceutical use thereof
JP4781264B2 (ja) 2003-06-27 2011-09-28 ノボ・ノルデイスク・エー/エス 医療用液体組成物の高水分遮断容器
WO2005005477A2 (en) * 2003-07-11 2005-01-20 Novo Nordisk A/S Stabilised insulin compositions
US20060183667A1 (en) * 2003-07-11 2006-08-17 Novo Nordisk A/S Stabilised insulin compositions
ES2328579T3 (es) * 2003-07-25 2009-11-16 Conjuchem Biotechnologies Inc. Derivados de insulina de larga duracion y procedimientos asociados.
PT2107069E (pt) 2003-08-05 2013-04-23 Novo Nordisk As Novos derivados de insulina
BRPI0413276B8 (pt) 2003-08-05 2021-05-25 Novo Nordisk As derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
US20060287221A1 (en) 2003-11-13 2006-12-21 Novo Nordisk A/S Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia
WO2005046716A1 (en) * 2003-11-13 2005-05-26 Novo Nordisk A/S Soluble pharmaceutical compositions for parenteral administration comprising a glp-1 peptide and a insulin peptide of short time action for treatment of diabetes and bulimia
CN104826116A (zh) 2003-11-20 2015-08-12 诺沃挪第克公司 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂
ES2369895T3 (es) 2003-12-03 2011-12-07 Novo Nordisk A/S Insulina monocatenaria.
ATE483580T1 (de) 2003-12-22 2010-10-15 Novo Nordisk As Durchsichtiger, flexibler, undurchlässiger kunststoffbehälter zur lagerung von pharmazeutischen flüssigkeiten
ES2397241T3 (es) 2004-01-21 2013-03-05 Novo Nordisk Health Care Ag Conjugación de péptidos mediante transglutaminasa
CA2580313C (en) 2004-07-19 2016-03-15 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
CN102140875B (zh) 2004-11-04 2014-11-26 亨特道格拉斯有限公司 用于建筑开口的单轨道层叠板体遮蔽件
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
US20080171695A1 (en) 2005-02-02 2008-07-17 Novo Nordisk A/S Insulin Derivatives
WO2006082204A1 (en) 2005-02-02 2006-08-10 Novo Nordisk A/S Insulin derivatives
AU2006264966B2 (en) 2005-07-04 2013-02-21 High Point Pharmaceuticals, Llc Histamine H3 receptor antagonists
ES2426345T3 (es) 2005-07-20 2013-10-22 Eli Lilly And Company Compuesto unidos en posición 1-amino
CN102660614A (zh) 2005-08-16 2012-09-12 诺沃-诺迪斯克有限公司 制备成熟胰岛素多肽的方法
PL1926749T3 (pl) 2005-09-14 2011-12-30 Sanofi Aventis Deutschland Cięcie prekursorów insuliny przez wariant trypsyny
PL1951658T3 (pl) 2005-11-17 2013-02-28 Lilly Co Eli Antagoniści receptora glukagonu, preparatyka i zastosowania terapeutyczne
EP2505593A1 (en) 2005-12-28 2012-10-03 Novo Nordisk A/S Compositions comprising an acylated insulin and zinc and method of making the said compositions
WO2007081824A2 (en) * 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
JP2009527526A (ja) * 2006-02-21 2009-07-30 ノボ・ノルデイスク・エー/エス 単鎖インスリンのアナログとその製薬的製剤
ATE482977T1 (de) 2006-02-27 2010-10-15 Novo Nordisk As Insulinderivate
EP1996224B1 (en) 2006-03-15 2012-11-07 Novo Nordisk A/S Mixtures of amylin and insulin
KR101280333B1 (ko) 2006-03-28 2013-07-02 하이 포인트 파마슈티칼스, 엘엘씨 히스타민 h3 수용체 활성을 갖는 벤조티아졸
WO2007127704A1 (en) 2006-04-24 2007-11-08 Eli Lilly And Company Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
KR101441444B1 (ko) 2006-05-09 2014-09-18 노보 노르디스크 에이/에스 인슐린 유도체
US8796205B2 (en) 2006-05-09 2014-08-05 Novo Nordisk A/S Insulin derivative
CA2659570C (en) 2006-05-29 2015-10-06 High Point Pharmaceuticals, Llc 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
CA2652989A1 (en) * 2006-06-08 2007-12-13 Diabecore Medical Inc. Derivatized insulin oligomers
DE102006031955A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
ES2542146T3 (es) 2006-07-31 2015-07-31 Novo Nordisk A/S Insulinas extendidas PEGiladas.
KR101699370B1 (ko) 2006-09-22 2017-02-14 노보 노르디스크 에이/에스 프로테아제 내성 인슐린 유사체
WO2008043033A2 (en) 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
WO2008049711A1 (en) * 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
US20120214963A1 (en) * 2011-02-23 2012-08-23 Elona Biotechnologies Aspart proinsulin compositions and methods of producing aspart insulin analogs therefrom
US10100098B2 (en) 2006-12-13 2018-10-16 Stelis Biopharma Private Limited Insulin production methods and proinsulin constructs
CN101674812B (zh) 2007-04-30 2013-12-11 诺沃-诺迪斯克有限公司 干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物
WO2008139496A1 (en) * 2007-05-16 2008-11-20 Bigtec Private Limited Recombinant human insulin and a method thereof
WO2008145730A1 (en) 2007-06-01 2008-12-04 Novo Nordisk A/S Stable non-aqueous pharmaceutical compositions
EP2514406A1 (en) 2007-06-01 2012-10-24 Novo Nordisk A/S Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier
WO2008152106A1 (en) 2007-06-13 2008-12-18 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
WO2009021955A1 (en) 2007-08-13 2009-02-19 Novo Nordisk A/S Rapid acting insulin analogues
EP2178911A2 (en) * 2007-08-13 2010-04-28 Novo Nordisk A/S Rapid acting insulin analogues
EP2178912B1 (en) 2007-08-15 2015-07-08 Novo Nordisk A/S Insulin analogues with an acyl and aklylene glycol moiety
ES2526924T3 (es) 2007-08-15 2015-01-16 Novo Nordisk A/S Insulinas con una fracción acilo que comprende unidades repetitivas de aminoácidos que contienen alquilenglicol
NZ584825A (en) 2007-11-20 2013-03-28 Ambrx Inc Modified insulin polypeptides and their uses
DK2229407T3 (en) 2008-01-09 2017-02-27 Sanofi Aventis Deutschland NEW INSULIN DERIVATIVES WITH EXTREMELY DELAYED TIME / EFFECTS PROFILE
WO2009115469A1 (en) 2008-03-18 2009-09-24 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
ES2563553T3 (es) 2008-04-01 2016-03-15 Novo Nordisk A/S Conjugados de insulina-albúmina
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
US20110195896A1 (en) * 2008-04-22 2011-08-11 Case Western Reserve University Isoform-specific insulin analogues
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
KR20120129875A (ko) * 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
JP5903269B2 (ja) 2008-08-07 2016-04-13 バイオコン リミテッド インスリン化合物の調製方法
DE102008051834A1 (de) 2008-10-17 2010-04-22 Sanofi-Aventis Deutschland Gmbh Kombination von einem Insulin und einem GLP-1-Agonisten
WO2010043566A2 (de) 2008-10-17 2010-04-22 Sanofi-Aventis Deutschland Gmbh Kombination von einem insulin und einem glp-1-agonisten
DE102008053048A1 (de) 2008-10-24 2010-04-29 Sanofi-Aventis Deutschland Gmbh Kombination von einem Insulin und einem GLP-1-Agonisten
DE102009038210A1 (de) 2009-08-20 2011-03-03 Sanofi-Aventis Deutschland Gmbh Kombination von einem Insulin und einem GLP-1-Agonisten
ES2607003T3 (es) 2008-10-30 2017-03-28 Novo Nordisk A/S Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria
AU2009316802B2 (en) 2008-11-21 2015-02-26 Vtv Therapeutics Llc Adamantyl benzamide compounds
FR2943538B1 (fr) 2009-03-27 2011-05-20 Adocia Formulation a action rapide d'insuline recombinante humaine
US9018190B2 (en) 2009-03-27 2015-04-28 Adocia Functionalized oligosaccharides
EP2451471A1 (de) 2009-07-06 2012-05-16 Sanofi-Aventis Deutschland GmbH Langsamwirkende insulinzubereitungen
HUE030499T2 (hu) 2009-07-06 2017-05-29 Sanofi Aventis Deutschland Metionint tartalmazó vizes készítmények
TW201105346A (en) 2009-07-06 2011-02-16 Sanofi Aventis Deutschland Heat-stable and vibration-stable insulin preparations
RU2556340C2 (ru) 2009-07-31 2015-07-10 Санофи-Авентис Дойчланд Гмбх Композиция инсулина длительного действия
PE20120918A1 (es) 2009-07-31 2012-08-14 Sanofi Aventis Deutschland Profarmacos que comprenden un conjugado de insulina-conector
US8399407B2 (en) * 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
ES2855146T3 (es) 2009-11-13 2021-09-23 Sanofi Aventis Deutschland Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
US9707176B2 (en) 2009-11-13 2017-07-18 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist and methionine
US8637096B2 (en) 2009-12-04 2014-01-28 Curtis C. Stojan Compositions and method for enhancing insulin activity
NZ600477A (en) 2009-12-11 2014-07-25 Univ Case Western Reserve Insulin analogues with chlorinated amino acids
EP2359843A1 (en) 2010-01-21 2011-08-24 Sanofi Pharmaceutical composition for treating a metabolic syndrome
TW201141513A (en) 2010-04-14 2011-12-01 Sanofi Aventis Insulin-siRNA conjugates
WO2011141407A1 (en) 2010-05-10 2011-11-17 Novo Nordisk A/S Process for the preparation of insulin-zinc complexes
EP2582719B1 (en) 2010-06-16 2016-08-10 Indiana University Research and Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
CA2802510A1 (en) 2010-06-23 2011-12-29 Novo Nordisk A/S Insulin derivatives containing additional disulfide bonds
MX346786B (es) 2010-08-17 2017-03-31 Ambrx Inc Polipeptidos de relaxina modificados y sus usos.
PT2611458T (pt) 2010-08-30 2016-12-16 Sanofi Aventis Deutschland Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2
EP2438930A1 (en) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrugs comprising an exendin linker conjugate
RU2013123515A (ru) 2010-10-27 2014-12-10 Ново Нордиск А/С Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
PL2632478T3 (pl) 2010-10-27 2020-03-31 Novo Nordisk A/S Leczenie cukrzycy z zastosowaniem zastrzyków insuliny podawanych w różnych odstępach czasu
US20130331320A1 (en) 2010-12-14 2013-12-12 Novo Nordisk A/S Fast-acting insulin in combination with long-acting insulin
AU2012213432B2 (en) * 2011-02-01 2016-10-13 Novo Nordisk A/S Purification of insulin
EP2670368A4 (en) 2011-02-03 2015-04-15 Pharmedica Ltd NEW ORAL DISSOLUTION FILMS FOR INSULIN DELIVERY FOR THE TREATMENT OF DIABETES
WO2012115638A1 (en) 2011-02-23 2012-08-30 Elona Biotechnologies Glargine proinsulin compositions and methods of producing glargine insulin analogs therefrom
WO2012115637A1 (en) * 2011-02-23 2012-08-30 Elona Biotechnologies Aspart proinsulin compositions and methods of producing aspart insulin analogs
WO2012123519A2 (en) 2011-03-15 2012-09-20 Novo Nordisk A/S Human insulin analogues and derivatives comprising cysteine substitutions
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
US20130011378A1 (en) 2011-06-17 2013-01-10 Tzung-Horng Yang Stable formulations of a hyaluronan-degrading enzyme
EP2548570A1 (en) 2011-07-19 2013-01-23 Sanofi Pharmaceutical composition for treating a metabolic syndrome
PT2750699E (pt) 2011-08-29 2015-11-03 Sanofi Aventis Deutschland Acelerómetro pendular
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
US20130231281A1 (en) 2011-11-02 2013-09-05 Adocia Rapid acting insulin formulation comprising an oligosaccharide
US9458219B2 (en) * 2011-12-15 2016-10-04 Shanghai Hengrui Pharmaceutical Co., Ltd. Human insulin analogue and acylated derivative thereof
CN104114183A (zh) 2011-12-20 2014-10-22 印第安纳大学研究及科技有限公司 用于治疗糖尿病的基于ctp的胰岛素类似物
WO2013153000A2 (en) 2012-04-11 2013-10-17 Novo Nordisk A/S Insulin formulations
JP6262206B2 (ja) 2012-05-01 2018-01-17 ノヴォ ノルディスク アー/エス 医薬組成物
US20130315891A1 (en) 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
CA2880085C (en) 2012-06-04 2021-09-07 Diamedica Inc. Human tissue kallikrein 1 glycosylation isoforms
AU2013323669B2 (en) 2012-09-26 2018-03-01 Indiana University Research And Technology Corporation Insulin analog dimers
US9700599B2 (en) 2012-11-13 2017-07-11 Adocia Rapid-acting insulin formulation comprising a substituted anionic compound
CA2890048C (en) 2012-12-03 2022-05-03 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
WO2014093696A2 (en) 2012-12-12 2014-06-19 Massachusetts Institute Of Technology Insulin derivatives for diabetes treatment
CN104994864B (zh) 2012-12-19 2018-05-29 沃克哈特有限公司 包含人胰岛素或其类似物或衍生物的稳定水性组合物
JP2016505601A (ja) 2012-12-26 2016-02-25 ウォックハート リミテッド 医薬組成物
TWI780236B (zh) 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
RU2678134C2 (ru) 2013-03-14 2019-01-23 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Конъюгаты инсулин-инкретин
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
JP2016531847A (ja) 2013-09-30 2016-10-13 ウォックハート リミテッド 医薬組成物
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
CN112957455A (zh) 2014-01-09 2021-06-15 赛诺菲 胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂
WO2015104311A1 (en) 2014-01-09 2015-07-16 Sanofi Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives
SG11201604706TA (en) 2014-01-09 2016-07-28 Sanofi Sa Stabilized pharmaceutical formulations of insulin aspart
FR3020947B1 (fr) 2014-05-14 2018-08-31 Adocia Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations
US9795678B2 (en) 2014-05-14 2017-10-24 Adocia Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound
US9656017B2 (en) 2014-06-20 2017-05-23 Howard E. Greene Infusion delivery devices and methods
WO2016001862A1 (en) 2014-07-04 2016-01-07 Wockhardt Limited Extended release formulations of insulins
US10232020B2 (en) 2014-09-24 2019-03-19 Indiana University Research And Technology Corporation Incretin-insulin conjugates
BR112017004544A2 (pt) 2014-10-06 2018-01-23 Univ Case Western Reserve insulina de cadeia simples, composição farmacêutica e método para tratar diabetes mellitus
ES2946247T3 (es) 2014-11-21 2023-07-14 Merck Sharp & Dohme Llc Agonistas parciales del receptor de insulina
CN107206058A (zh) 2014-12-12 2017-09-26 赛诺菲-安万特德国有限公司 甘精胰岛素/利西拉来固定比率配制剂
TW201630622A (zh) 2014-12-16 2016-09-01 美國禮來大藥廠 速效胰島素組合物
CN105884879A (zh) * 2015-01-26 2016-08-24 漳州博欣生物技术有限公司 一种胰岛素类似物的化学合成方法
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患之治療
JP2018531900A (ja) 2015-08-25 2018-11-01 ノヴォ ノルディスク アー/エス 新規インスリン誘導体及びその医学的使用
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
FR3043557B1 (fr) 2015-11-16 2019-05-31 Adocia Composition a action rapide d'insuline comprenant un citrate substitue
EP3442997A2 (en) 2016-04-15 2019-02-20 Indiana University Research & Technology Corporation Fgf21 c-terminal peptide optimization
GB201607918D0 (en) 2016-05-06 2016-06-22 Arecor Ltd Novel formulations
EP3922260A3 (en) 2016-05-24 2022-06-15 Merck Sharp & Dohme Corp. Insulin receptor partial agonists and glp-1 analogues
EP3463413A4 (en) 2016-05-25 2020-03-04 Merck Sharp & Dohme Corp. PARTIAL INSULIN RECEPTOR AGONISTS
EP3495384A4 (en) 2016-08-02 2020-02-26 Jiangsu Hengrui Medicine Co., Ltd. ACYLATED DERIVATIVE OF HUMAN INSULIN OR ANALOGUE OF IT
CN109803639B (zh) 2016-09-29 2024-01-02 艾瑞克有限公司 新制剂
HUE055231T2 (hu) 2016-12-16 2021-11-29 Novo Nordisk As Inzulint tartalmazó gyógyászati készítmények
EP3592377A4 (en) 2017-03-09 2021-02-17 Diamedica Inc. DOSAGE FORMS OF TISSUE KALLIKREIN 1
GB201707188D0 (en) 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
GB201707187D0 (en) 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
GB201707189D0 (en) 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
PE20200017A1 (es) 2017-06-01 2020-01-06 Lilly Co Eli Composiciones de insulina de rapida accion
EP3668892A1 (en) 2017-08-17 2020-06-24 Novo Nordisk A/S Novel acylated insulin analogues and uses thereof
CA3094304A1 (en) 2018-04-04 2019-10-10 Arecor Limited Medical infusion pump system for the delivery of an insulin compound
EP3773473A1 (en) 2018-04-04 2021-02-17 Arecor Limited Medical infusion pump system for the delivery of an insulin compound
CA3094237A1 (en) 2018-04-04 2019-10-10 Arecor Limited Medical infusion pump system for the delivery of an insulin compound
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
WO2020051812A1 (zh) * 2018-09-12 2020-03-19 美药星(南京)制药有限公司 一种新型门冬胰岛素原的结构和制备门冬胰岛素的方法
KR20200082618A (ko) 2018-12-31 2020-07-08 주식회사 폴루스 인슐린 과발현용 램프 태그 및 이를 이용한 인슐린의 제조방법
CN114787184A (zh) * 2019-12-11 2022-07-22 诺和诺德股份有限公司 新型胰岛素类似物及其用途
MX2022008130A (es) 2019-12-30 2022-10-03 Gan & Lee Pharmaceuticals Co Ltd Derivado de insulina.
CA3166496A1 (en) 2019-12-30 2021-07-08 Gan & Lee Pharmaceuticals Co., Ltd. Long-acting glp-1 compound
GB202004814D0 (en) 2020-04-01 2020-05-13 Arecor Ltd Novel formulations
WO2023225534A1 (en) 2022-05-18 2023-11-23 Protomer Technologies Inc. Aromatic boron-containing compounds and related insulin analogs

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2252157C3 (de) * 1972-10-25 1976-03-18 Hoechst Ag Zwischenprodukte zur herstellung von insulin, insulin-analogen und -derivaten und verfahren zur herstellung von insulin, insulin analogen und derivaten
US4652525A (en) * 1978-04-19 1987-03-24 The Regents Of The University Of California Recombinant bacterial plasmids containing the coding sequences of insulin genes
US4565785A (en) * 1978-06-08 1986-01-21 The President And Fellows Of Harvard College Recombinant DNA molecule
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
IE50892B1 (en) * 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
US4340674A (en) * 1980-05-05 1982-07-20 The Upjohn Company Cointegrate plasmids and their construction from plasmids of Escherichia and Streptomyces
US4351901A (en) * 1980-03-24 1982-09-28 Cetus Corporation Method for single nucleotide alteration
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
ZA824218B (en) * 1981-06-29 1983-04-27 Cetus Corp Plasmid for producing human insulin
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
US5559094A (en) * 1994-08-02 1996-09-24 Eli Lilly And Company AspB1 insulin analogs

Also Published As

Publication number Publication date
HUT42526A (en) 1987-07-28
FI863512A0 (fi) 1986-08-29
DE3650101T2 (de) 1995-02-23
FI102182B1 (fi) 1998-10-30
HU206518B (en) 1992-11-30
IE862317L (en) 1987-02-28
IE66138B1 (en) 1995-12-13
NL990042I1 (nl) 2000-02-01
ATE113061T1 (de) 1994-11-15
AU593274B2 (en) 1990-02-08
JPS6253999A (ja) 1987-03-09
DE10075008I2 (de) 2004-10-21
NO863474L (no) 1987-03-02
NL990042I2 (nl) 2000-03-01
CN86106574A (zh) 1988-08-03
YU4188A (en) 1990-06-30
AR241801A1 (es) 1992-12-30
CS8606310A2 (en) 1990-09-12
YU46857B (sh) 1994-06-24
KR870002165A (ko) 1987-03-30
NZ217406A (en) 1989-05-29
KR940000756B1 (ko) 1994-01-29
CS275613B6 (en) 1992-03-18
PT83278B (pt) 1989-03-30
DE3650101D1 (de) 1994-11-24
GR862233B (en) 1986-12-31
EP0214826A3 (en) 1987-06-03
FI863512A (fi) 1987-03-01
AU6206686A (en) 1987-03-05
EP0214826A2 (en) 1987-03-18
ES2001624A6 (es) 1988-06-01
PT83278A (en) 1986-09-01
NO863474D0 (no) 1986-08-29
IL79887A (en) 1991-11-21
IL79887A0 (en) 1986-11-30
PH25772A (en) 1991-10-18
LU90484I2 (fr) 2000-02-21
CN1029977C (zh) 1995-10-11
CA1306212C (en) 1992-08-11
JP2662390B2 (ja) 1997-10-08
DD268976A5 (de) 1989-06-14
US5618913A (en) 1997-04-08
EP0214826B1 (en) 1994-10-19
DE10075008I1 (de) 2000-05-18
YU148486A (en) 1991-04-30
FI102182B (fi) 1998-10-30
NO2000005I1 (no) 2000-07-21
NO177009B (no) 1995-03-27
YU46023B (sh) 1992-12-21

Similar Documents

Publication Publication Date Title
NO177009C (no) Analogifremgangsmåte ved fremstilling av insulinanaloger
NO171453C (no) Fremgangsmaate for fremstilling av krystallinsk paroxetin-hydroklorid-hemihydrat
NO170540C (no) En analogifremgangsmaate for fremstilling av 1-hydroksy-2-pyridoner
NO863574L (no) Fremgangsmaate ved fremstilling av tetrafluorbenzosyre.
NO862587D0 (no) Fremgangsmaate for fremstilling av en injiserbar opploesning inneholdende et antitumorantracyklin-glykosid.
NO864782D0 (no) Fremgangsmaate ved fremstilling av kinolon-derivater.
NO861474L (no) Fremgangsmaate ved fremstilling av fenetanolaminderivater.
NO864515L (no) Fremgangsmaate for fremstilling av heterocyliske oxazoloner
NO851330L (no) Fremgangsmaate ved fremstilling av pyrrolidonderivater
NO860794L (no) Fremgangsmaate ved fremstilling av klordioksyd.
IT1200400B (it) Procedimento per la preparazione di 2-alchil ciclopent-2-enoni
NO851758L (no) Fremgangsmaate ved fremstilling av isokinolinderivater
NO862233D0 (no) Fremgangsmaate ved fremstilling av imidazoquinazolinderivater.
IT8519652A0 (it) Procedimento per la preparazionedi alfa-omega-aloperfluorocarburi
NO851638L (no) Fremgangsmaate ved fremstilling av iminothiazolidin-derivater
NO864525D0 (no) Fremgangsmaate ved fremstilling av aryleddiksyrederivater.
NO861239L (no) Fremgangsmaate ved fremstilling av klordioksyd.
NO864386L (no) Fremgangsmaate ved fremstilling av uretaner.
NO863297D0 (no) Fremgangsmaate ved fremstilling av karbamidsyre-estere.
IT1191806B (it) Procedimento per la preparazione di 2-bromo-alfa-ergocriptina
IT1190358B (it) Procedimento per la preparazione di l-carnitina
NO863769D0 (no) Fremgangsmaate for fremstilling av 4-hydroksy-2-oksopyrrolin-1-yl-acetamid.
NO863388D0 (no) Fremgangsmaate ved fremstilling av cyclohexanalkansyrer.
NO864087L (no) Fremgangsmaate for fremstilling av aroylthiazoloner.
RO91930A2 (ro) Procedeu pentru prepararea butirolactonei

Legal Events

Date Code Title Description
MK1K Patent expired
MK1K Patent expired