MXPA04003625A - Sintesis de analogos de ciclosporina. - Google Patents

Sintesis de analogos de ciclosporina.

Info

Publication number
MXPA04003625A
MXPA04003625A MXPA04003625A MXPA04003625A MXPA04003625A MX PA04003625 A MXPA04003625 A MX PA04003625A MX PA04003625 A MXPA04003625 A MX PA04003625A MX PA04003625 A MXPA04003625 A MX PA04003625A MX PA04003625 A MXPA04003625 A MX PA04003625A
Authority
MX
Mexico
Prior art keywords
isomers
isatx247
cyclosporine
derivatives
mixtures
Prior art date
Application number
MXPA04003625A
Other languages
English (en)
Inventor
Adam Jean-Michel
Original Assignee
Sotechnika Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sotechnika Inc filed Critical Sotechnika Inc
Publication of MXPA04003625A publication Critical patent/MXPA04003625A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/08—Antiallergic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins

Abstract

El invento esta dirigido hacia mezclas isomeras de analogos de ciclosporina que son estructuralmente similares a la ciclosporina A. Las mezclas poseen eficacia afianzada y reducida toxicidad con respecto a los isomeros individuales y por sobre ciclosporinas que ocurren naturalmente y derivados de ciclosporina actualmente conocidos. Las presentaciones del presente invento estan dirigidas hacia cis y trans-isoeros de analogos de ciclosporina A que se ha denominado ISAtx247 exhiben una combinacion de mayor potencia y menor toxicidad con respecto a ciclosporinas que ocurren naturalmente y que se conocen actualmente. Los isomeros ISAtx247 y derivados alcalinados, arilados y deuterados se sintetizan mediante vias esteren-selectivas en las que las condiciones particulares de una reaccion determinan el grado de estereoselectividad. Las vias estereo-selectivas podran utilizar una reaccion Wittigm o un reactivo organo-metalico que comprende elementos inorganicos tales como boro, silicon, titanio, y litio. La tasa de isomeros en una mezcal pondra variar de entre alrededor de 10 a 90 por ciento segun peso del isomero (E) hasta alrededor de 90 a 10 por ciento segun peso del isomero (Z), de acuerdo al peso total de la mezcla.
MXPA04003625A 2001-10-19 2002-10-17 Sintesis de analogos de ciclosporina. MXPA04003625A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34620101P 2001-10-19 2001-10-19
US37059602P 2002-04-05 2002-04-05
PCT/CA2002/001559 WO2003033526A2 (en) 2001-10-19 2002-10-17 Synthesis of cyclosporin analogs

Publications (1)

Publication Number Publication Date
MXPA04003625A true MXPA04003625A (es) 2004-12-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04003625A MXPA04003625A (es) 2001-10-19 2002-10-17 Sintesis de analogos de ciclosporina.

Country Status (28)

Country Link
US (13) US7141648B2 (es)
EP (2) EP1436321B9 (es)
JP (3) JP4261355B2 (es)
KR (2) KR101006206B1 (es)
CN (1) CN100334106C (es)
AT (2) ATE425178T1 (es)
AU (2) AU2002331509B2 (es)
BR (1) BRPI0213658A8 (es)
CA (1) CA2461740C (es)
CO (1) CO5580836A2 (es)
CY (1) CY1105111T1 (es)
DE (2) DE60213115T2 (es)
DK (2) DK1714977T3 (es)
ES (2) ES2326040T3 (es)
HK (1) HK1062568A1 (es)
HR (2) HRP20040355B1 (es)
IL (3) IL160763A0 (es)
MA (1) MA27293A1 (es)
MX (1) MXPA04003625A (es)
NO (1) NO332459B1 (es)
NZ (1) NZ531944A (es)
PL (2) PL210841B1 (es)
PT (2) PT1436321E (es)
RU (1) RU2321593C9 (es)
SI (1) SI1436321T1 (es)
TN (1) TNSN04068A1 (es)
WO (1) WO2003033526A2 (es)
ZA (1) ZA200402269B (es)

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