AU2000265052A1 - Somatostatin analogs for the treatment of cancer - Google Patents

Somatostatin analogs for the treatment of cancer

Info

Publication number
AU2000265052A1
AU2000265052A1 AU2000265052A AU6505200A AU2000265052A1 AU 2000265052 A1 AU2000265052 A1 AU 2000265052A1 AU 2000265052 A AU2000265052 A AU 2000265052A AU 6505200 A AU6505200 A AU 6505200A AU 2000265052 A1 AU2000265052 A1 AU 2000265052A1
Authority
AU
Australia
Prior art keywords
cancer
treatment
peptides
somatostatin
agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2000265052A
Inventor
Manu Jaggi
Archna Mathur
Rama Mukherjee
Sudhanand Prasad
Anu T. Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dabur Research Foundation
Original Assignee
Dabur Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dabur Research Foundation filed Critical Dabur Research Foundation
Publication of AU2000265052A1 publication Critical patent/AU2000265052A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention encompasses novel peptides that are agonists to somatostatin and the use of the agonists for treatment of cancer. The invention particularly relates to the design and synthesis of novel analogs of somatostatin incorporating alpha , alpha -dialkylated amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
AU2000265052A 2000-07-31 2000-07-31 Somatostatin analogs for the treatment of cancer Abandoned AU2000265052A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/020872 WO2002010215A1 (en) 2000-07-31 2000-07-31 Somatostatin analogs for the treatment of cancer

Publications (1)

Publication Number Publication Date
AU2000265052A1 true AU2000265052A1 (en) 2002-02-13

Family

ID=21741640

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2000265052A Abandoned AU2000265052A1 (en) 2000-07-31 2000-07-31 Somatostatin analogs for the treatment of cancer

Country Status (6)

Country Link
EP (1) EP1198478B1 (en)
AT (1) ATE291587T1 (en)
AU (1) AU2000265052A1 (en)
CA (1) CA2385910A1 (en)
DE (1) DE60018937T2 (en)
WO (1) WO2002010215A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057214A1 (en) 2001-12-28 2003-07-17 Somatocor Pharmaceuticals, Inc. Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands
EP2161037A3 (en) 2003-04-22 2010-05-26 Ipsen Pharma Camptothecin-Somatostatin conjugates
CN103501823B (en) 2011-02-17 2018-05-04 杜兰教育基金委员会 Multi-component combination and their purposes
JP2016503402A (en) 2012-11-01 2016-02-04 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエＩｐｓｅｎ Ｐｈａｒｍａ Ｓ．Ａ．Ｓ． Somatostatin analogs and dimers thereof
TWI523863B (en) 2012-11-01 2016-03-01 艾普森藥品公司 Somatostatin-dopamine chimeric analogs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH679045A5 (en) * 1987-06-29 1991-12-13 Sandoz Ag

Also Published As

Publication number Publication date
CA2385910A1 (en) 2002-02-07
DE60018937D1 (en) 2005-04-28
DE60018937T2 (en) 2006-03-30
ATE291587T1 (en) 2005-04-15
EP1198478B1 (en) 2005-03-23
WO2002010215A1 (en) 2002-02-07
EP1198478A1 (en) 2002-04-24

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