MX9203163A - Esteres morfolinoetilicos de acido micofenolico y composiciones. - Google Patents

Esteres morfolinoetilicos de acido micofenolico y composiciones.

Info

Publication number
MX9203163A
MX9203163A MX9203163A MX9203163A MX9203163A MX 9203163 A MX9203163 A MX 9203163A MX 9203163 A MX9203163 A MX 9203163A MX 9203163 A MX9203163 A MX 9203163A MX 9203163 A MX9203163 A MX 9203163A
Authority
MX
Mexico
Prior art keywords
agents
compositions
mycophenolic acid
morpholinoethyl esters
morpholinoethyl
Prior art date
Application number
MX9203163A
Other languages
English (en)
Inventor
Peter H Nelson
Chee-Liang Leo Gu
Anthony C Allison
Elsie M Eugui
William A Lee
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9203163(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of MX9203163A publication Critical patent/MX9203163A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
MX9203163A 1987-01-30 1992-06-23 Esteres morfolinoetilicos de acido micofenolico y composiciones. MX9203163A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions

Publications (1)

Publication Number Publication Date
MX9203163A true MX9203163A (es) 1992-07-31

Family

ID=21733252

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9203163A MX9203163A (es) 1987-01-30 1992-06-23 Esteres morfolinoetilicos de acido micofenolico y composiciones.

Country Status (26)

Country Link
US (7) US4753935A (es)
EP (1) EP0281713B1 (es)
JP (1) JPS63188672A (es)
KR (1) KR940003758B1 (es)
AT (1) ATE68180T1 (es)
AU (1) AU599728B2 (es)
CA (1) CA1333285C (es)
DE (2) DE19675020I2 (es)
DK (1) DK166675B1 (es)
ES (1) ES2038190T3 (es)
FI (1) FI85141C (es)
GE (1) GEP20094816B (es)
GR (1) GR3002866T3 (es)
HK (1) HK125893A (es)
HU (2) HU201927B (es)
IE (1) IE60750B1 (es)
IL (1) IL84833A (es)
LU (1) LU88795I2 (es)
LV (1) LV5748B4 (es)
MX (1) MX9203163A (es)
NL (1) NL960019I2 (es)
NO (2) NO171680C (es)
NZ (1) NZ222922A (es)
PH (1) PH23819A (es)
PT (1) PT86343B (es)
ZA (1) ZA879414B (es)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
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US5177072A (en) * 1987-01-30 1993-01-05 Syntex (U.S.A.) Inc. Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives
WO1990009788A1 (en) * 1989-02-23 1990-09-07 The University Of North Carolina At Chapel Hill Etoposide analogues
US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
CN1129908A (zh) * 1993-06-25 1996-08-28 美因坎普营销私人有限公司 治疗剂
DK0724581T3 (da) * 1993-09-15 1999-08-02 Syntex Inc Krystallinsk vandfri mycophenolatmofetil og intravenøs formulering deraf
JP3844491B2 (ja) * 1993-10-01 2006-11-15 シンテックス（ユー・エス・エイ）インコーポレイテッド ミコフェノール酸モフェチル高用量経口用懸濁剤
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US6225073B1 (en) * 1994-07-07 2001-05-01 Dade Behring Marburg Gmbh Immunoassay for mycophenolic acid
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US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
AU1707700A (en) * 1998-10-29 2000-05-22 Bristol-Myers Squibb Company Novel inhibitors of impdh enzyme
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
IN188985B (es) 1998-12-09 2002-11-30 Biocon Ltd
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
AU5553801A (en) * 2000-04-24 2001-11-07 Bristol Myers Squibb Co Heterocycles that are inhibitors of impdh enzyme
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
GB0124953D0 (en) * 2001-10-17 2001-12-05 Novartis Ag Organic Compounds
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
AU2003261354A1 (en) * 2002-08-02 2004-02-23 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
WO2004089946A1 (en) * 2003-04-07 2004-10-21 Biocon Limited Microwave synthesis of mycophenolate
US20070082947A1 (en) * 2003-05-14 2007-04-12 D Orazio Daniel Use of phthalide derivatives for the treatment and prevention of diabetes mellitus
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
ES2308226T3 (es) * 2003-09-11 2008-12-01 Sandoz Ag Proceso para la produccion de micofenolato mofetil.
JP2007505854A (ja) * 2003-09-23 2007-03-15 ディーエスエム アイピー アセッツ ビー．ブイ． 糖尿病の治療および予防用組成物
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WO2005105769A2 (en) * 2004-04-27 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg - Mycophenolate mofetil impurity
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
CA2573781A1 (en) * 2004-07-20 2006-02-02 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Processes for preparation of crystalline mycophenolate sodium
AU2005274681A1 (en) * 2004-08-16 2006-02-23 Verva Pharmaceuticals Pty Ltd Metabolism-modulating agents and uses therefor
EP1844041A4 (en) * 2005-01-20 2009-08-05 Apotex Fermentation Inc IMPROVED PROCESS FOR THE PREPARATION OF MYCOPHENOLATE MOFETIL
WO2006086498A2 (en) * 2005-02-08 2006-08-17 Aspreva Pharmaceuticals Sa Treatment of vascular, autoimmune and inflammatory diseases using low dosages of impdh inhibitors
WO2006086500A2 (en) * 2005-02-08 2006-08-17 Aspreva Pharmaceuticals Sa Compositions and methods for treating vascular, autoimmune and inflammatory diseases
US20080280977A1 (en) * 2005-04-26 2008-11-13 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
WO2007093346A1 (en) * 2006-02-13 2007-08-23 Novartis Ag High dosage of mycophenolic acid (mpa)
WO2008003637A2 (en) * 2006-07-05 2008-01-10 Dsm Ip Assets B.V. Isolation and use of amine salts of mycophenolic acid
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US20080188653A1 (en) 2007-02-04 2008-08-07 Formosa Laboratories, Inc. Process for Preparation of Mycophenolate Mofetil
CN100484930C (zh) * 2007-03-16 2009-05-06 重庆大新药业股份有限公司 一种吗替麦考酚酯的制备方法
US8273739B2 (en) * 2007-06-27 2012-09-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Method for the purification of mycophenolate mofetil
WO2009010503A1 (en) * 2007-07-18 2009-01-22 Dsm Ip Assets B.V. Mycophenolic acid recycling in a method for the preparation of mycophenolate mofetil
US20090076000A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched mycophenolate mofetil
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
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KR100975520B1 (ko) * 2008-02-01 2010-08-12 종근당바이오 주식회사 마이코페놀레이트 모페틸의 개선된 제조방법
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US20100010082A1 (en) * 2008-07-09 2010-01-14 Aspreva International Ltd. Formulations for treating eye disorders
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FI124873B (fi) 2009-10-06 2015-02-27 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
FI20096026L (fi) 2009-10-06 2011-04-07 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
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GB201100786D0 (en) 2011-01-18 2011-03-02 Ems Sa Pharmaceutical compositions of immunosuppressants
CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
WO2013041205A1 (de) 2011-09-19 2013-03-28 Pyxirion Pharma Gmbh Neue therapeutische konzepte zur behandlung von gefässerkrankungen
RS57497B1 (sr) 2013-03-14 2018-10-31 Alkermes Pharma Ireland Ltd Prolekovi fumarata i njihova upotreba u lečenju raznih bolesti
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
WO2015013422A1 (en) * 2013-07-23 2015-01-29 University Of Tennessee Research Foundation Immunosuppressive compounds and therapeutics
KR101856889B1 (ko) * 2014-01-10 2018-05-10 후지필름 가부시키가이샤 5-하이드록시-1h-이미다졸-4-카복사마이드의 유효 투여량 또는 감수성의 예측 방법 및 예측 장치, 잔토신 1인산의 양의 측정 방법 그리고 골수 이형성 증후군의 처치제 및 처치 방법
EP3110793B1 (en) 2014-02-24 2019-08-21 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
WO2017210262A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
US11918684B2 (en) 2017-03-13 2024-03-05 Liqmeds Worldwide Limited Pharmaceutical composition of oral suspension of immunosuppressive agents
US10835489B2 (en) * 2018-03-09 2020-11-17 University Of Saskatchewan Modified release formulations of mycophenolate mofetil
CN110526885A (zh) * 2019-08-20 2019-12-03 上海英诺富成生物科技有限公司 麦考酚酸的前体药物及其制备方法
CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
CN117177749A (zh) 2021-03-03 2023-12-05 萨那生物科技公司 与心肌细胞疗法一起使用的免疫抑制疗法以及相关的方法和组合物

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US3777020A (en) * 1972-08-14 1973-12-04 Lilly Co Eli Psoriasis treatment with mycophenolic acid
US3868454A (en) * 1972-08-14 1975-02-25 Lilly Co Eli Psoriasis treatment with mycophenolic acid derivatives
US3880995A (en) * 1973-05-14 1975-04-29 Lilly Co Eli Treatment of arthritis with mycophenolic acid and derivatives
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Also Published As

Publication number Publication date
KR940003758B1 (ko) 1994-04-30
LV5748A4 (lv) 1996-10-20
US4868153A (en) 1989-09-19
IE873397L (en) 1988-07-30
US4753935A (en) 1988-06-28
NO1997007I1 (no) 1997-07-01
ATE68180T1 (de) 1991-10-15
NO875240D0 (no) 1987-12-15
US4808592A (en) 1989-02-28
NZ222922A (en) 1990-09-26
ES2038190T3 (es) 1993-07-16
FI85141B (fi) 1991-11-29
IL84833A0 (en) 1988-06-30
PT86343B (pt) 1991-02-08
US4948793A (en) 1990-08-14
IL84833A (en) 1992-03-29
DE19675020I2 (de) 2002-11-07
FI875502A (fi) 1988-07-31
KR880009016A (ko) 1988-09-13
JPS63188672A (ja) 1988-08-04
HK125893A (en) 1993-11-19
NL960019I1 (nl) 1996-10-01
CA1333285C (en) 1994-11-29
LV5748B4 (lv) 1997-02-20
FI85141C (fi) 1992-03-10
FI875502A0 (fi) 1987-12-15
US4992467A (en) 1991-02-12
EP0281713A1 (en) 1988-09-14
GEP20094816B (en) 2009-11-10
EP0281713B1 (en) 1991-10-09
NO171680C (no) 1993-04-21
PH23819A (en) 1989-11-23
PT86343A (en) 1988-01-01
DK166675B1 (da) 1993-06-28
JPH0571591B2 (es) 1993-10-07
HU201927B (en) 1991-01-28
NO171680B (no) 1993-01-11
NL960019I2 (nl) 1997-06-02
HUT47567A (en) 1989-03-28
AU8254087A (en) 1988-08-04
US4786637A (en) 1988-11-22
AU599728B2 (en) 1990-07-26
DE3773660D1 (de) 1991-11-14
NO875240L (no) 1988-08-01
IE60750B1 (en) 1994-08-10
DK658787A (da) 1988-07-31
GR3002866T3 (en) 1993-01-25
HU210350A9 (en) 1995-03-28
ZA879414B (en) 1989-08-30
LU88795I2 (fr) 1996-11-05
US4952579A (en) 1990-08-28
DK658787D0 (da) 1987-12-15

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