LV5748B4 - Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums - Google Patents

Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums

Info

Publication number
LV5748B4
LV5748B4 LV960221A LV960221A LV5748B4 LV 5748 B4 LV5748 B4 LV 5748B4 LV 960221 A LV960221 A LV 960221A LV 960221 A LV960221 A LV 960221A LV 5748 B4 LV5748 B4 LV 5748B4
Authority
LV
Latvia
Prior art keywords
agents
acquisition
morpholinoethyl ester
mycophenolate
mycophenolate morpholinoethyl
Prior art date
Application number
LV960221A
Other languages
English (en)
Other versions
LV5748A4 (lv
Inventor
Peter H Nelson
Anthony C Allison
William A Lee
Chee-Liang Leo Gu
Elsie M Eugui
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV5748(B4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of LV5748A4 publication Critical patent/LV5748A4/lv
Publication of LV5748B4 publication Critical patent/LV5748B4/lv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LV960221A 1987-01-30 1996-07-05 Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums LV5748B4 (lv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
EP87311021A EP0281713B1 (en) 1987-01-30 1987-12-15 Morpholinoethylester of mycophenolic acid and derivatives thereof, their preparation and use in pharmaceutical compositions

Publications (2)

Publication Number Publication Date
LV5748A4 LV5748A4 (lv) 1996-10-20
LV5748B4 true LV5748B4 (lv) 1997-02-20

Family

ID=21733252

Family Applications (1)

Application Number Title Priority Date Filing Date
LV960221A LV5748B4 (lv) 1987-01-30 1996-07-05 Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums

Country Status (26)

Country Link
US (7) US4753935A (lv)
EP (1) EP0281713B1 (lv)
JP (1) JPS63188672A (lv)
KR (1) KR940003758B1 (lv)
AT (1) ATE68180T1 (lv)
AU (1) AU599728B2 (lv)
CA (1) CA1333285C (lv)
DE (2) DE19675020I2 (lv)
DK (1) DK166675B1 (lv)
ES (1) ES2038190T3 (lv)
FI (1) FI85141C (lv)
GE (1) GEP20094816B (lv)
GR (1) GR3002866T3 (lv)
HK (1) HK125893A (lv)
HU (2) HU201927B (lv)
IE (1) IE60750B1 (lv)
IL (1) IL84833A (lv)
LU (1) LU88795I2 (lv)
LV (1) LV5748B4 (lv)
MX (1) MX9203163A (lv)
NL (1) NL960019I2 (lv)
NO (2) NO171680C (lv)
NZ (1) NZ222922A (lv)
PH (1) PH23819A (lv)
PT (1) PT86343B (lv)
ZA (1) ZA879414B (lv)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177072A (en) * 1987-01-30 1993-01-05 Syntex (U.S.A.) Inc. Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives
WO1990009788A1 (en) * 1989-02-23 1990-09-07 The University Of North Carolina At Chapel Hill Etoposide analogues
US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
ES2140541T3 (es) * 1993-06-25 2000-03-01 Main Camp Marketing Pty Ltd Agente terapeutico.
KR100349772B1 (ko) * 1993-09-15 2002-12-28 신텍스(미국) 인크. 결정성무수물미코페놀레이트모페틸및그의정맥제형
RU2150942C1 (ru) * 1993-10-01 2000-06-20 Синтекс (Ю.ЭС.ЭЙ.) Инк. Оральные суспензии, содержащие высокие дозы мофетила микофенолята
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US6225073B1 (en) * 1994-07-07 2001-05-01 Dade Behring Marburg Gmbh Immunoassay for mycophenolic acid
ID18663A (id) 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
AU1707700A (en) 1998-10-29 2000-05-22 Bristol-Myers Squibb Company Novel inhibitors of impdh enzyme
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
WO2000025780A1 (en) 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
IN188985B (lv) 1998-12-09 2002-11-30 Biocon Ltd
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
CA2407370A1 (en) * 2000-04-24 2001-11-01 Bristol-Myers Squibb Company Heterocycles that are inhibitors of impdh enzyme
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
GB0124953D0 (en) * 2001-10-17 2001-12-05 Novartis Ag Organic Compounds
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
AU2003231924A1 (en) * 2003-04-07 2004-11-01 Biocon Limited Microwave synthesis of mycophenolate
DE602004022035D1 (de) * 2003-05-14 2009-08-27 Dsm Ip Assets Bv Verwendung von pthalide derivativen zur behandlung
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
CA2537958C (en) * 2003-09-11 2013-06-11 Sandoz Ag Process for the production of mycophenolate mofetil
WO2005027661A1 (en) * 2003-09-23 2005-03-31 Dsm Ip Assets B.V. Compositions for the treatment and prevention of diabetes mellitus
WO2005033089A1 (en) * 2003-10-07 2005-04-14 Biocon Limited Salt of 6-(1, 3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid with n, n-dimethyl-imidodicarbonimidic diamide
EP1740564A2 (en) * 2004-04-26 2007-01-10 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Process for preparation of mycophenolic acid and ester derivatives thereof
WO2005105769A2 (en) * 2004-04-27 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg - Mycophenolate mofetil impurity
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2006012385A2 (en) * 2004-07-20 2006-02-02 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Crystalline mycophenolate sodium
US7915255B2 (en) * 2004-08-16 2011-03-29 Verva Pharmaceuticals Pty Ltd Metabolism-modulating agents and uses therefor
WO2006076802A1 (en) * 2005-01-20 2006-07-27 Apotex Fermentation Inc. An improved process for the preparation of mycophenolate mofetil
WO2006086498A2 (en) * 2005-02-08 2006-08-17 Aspreva Pharmaceuticals Sa Treatment of vascular, autoimmune and inflammatory diseases using low dosages of impdh inhibitors
WO2006086500A2 (en) * 2005-02-08 2006-08-17 Aspreva Pharmaceuticals Sa Compositions and methods for treating vascular, autoimmune and inflammatory diseases
US20080281111A1 (en) * 2005-04-26 2008-11-13 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
JP2009526771A (ja) * 2006-02-13 2009-07-23 ノバルティス アクチエンゲゼルシャフト 高投与量のミコフェノール酸（ｍｐａ）
WO2008003637A2 (en) * 2006-07-05 2008-01-10 Dsm Ip Assets B.V. Isolation and use of amine salts of mycophenolic acid
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
US20080188653A1 (en) * 2007-02-04 2008-08-07 Formosa Laboratories, Inc. Process for Preparation of Mycophenolate Mofetil
CN100484930C (zh) * 2007-03-16 2009-05-06 重庆大新药业股份有限公司 一种吗替麦考酚酯的制备方法
US8273739B2 (en) * 2007-06-27 2012-09-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Method for the purification of mycophenolate mofetil
WO2009010503A1 (en) * 2007-07-18 2009-01-22 Dsm Ip Assets B.V. Mycophenolic acid recycling in a method for the preparation of mycophenolate mofetil
US20090076000A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched mycophenolate mofetil
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
WO2009084008A1 (en) * 2007-12-28 2009-07-09 Cadila Healthcare Limited Process for preparing mycophenolate mofetil
KR100975520B1 (ko) * 2008-02-01 2010-08-12 종근당바이오 주식회사 마이코페놀레이트 모페틸의 개선된 제조방법
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
JP2011527339A (ja) * 2008-07-09 2011-10-27 アスプレバ インターナショナル リミテッド 眼障害を処置するためのミコフェノール酸ナトリウムのｐＨ特異的な溶液
CL2009002207A1 (es) 2008-12-23 2011-02-18 Gilead Pharmasset Llc Compuestos derivados de 3-hidroxi-5-(9h-purin-9-il)tetrahidrofuran-2-il, inhibidor de la replicacion de arn viral dependiente de arn; composicion farmaceutica; uso para el tratamiento de hepatitis c.
SG172363A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Synthesis of purine nucleosides
WO2010075517A2 (en) * 2008-12-23 2010-07-01 Pharmasset, Inc. Nucleoside analogs
FI124873B (fi) 2009-10-06 2015-02-27 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
FI20096026L (fi) 2009-10-06 2011-04-07 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
AP3515A (en) 2010-03-31 2016-01-11 Gilead Pharmasset Llc Nucleoside phosphoramidates
GB201100786D0 (en) 2011-01-18 2011-03-02 Ems Sa Pharmaceutical compositions of immunosuppressants
CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
WO2013041205A1 (de) 2011-09-19 2013-03-28 Pyxirion Pharma Gmbh Neue therapeutische konzepte zur behandlung von gefässerkrankungen
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
SG11201507371RA (en) 2013-03-14 2015-10-29 Alkermes Pharma Ireland Ltd Prodrugs of fumarates and their use in treating various deseases
WO2015013422A1 (en) * 2013-07-23 2015-01-29 University Of Tennessee Research Foundation Immunosuppressive compounds and therapeutics
KR101856889B1 (ko) * 2014-01-10 2018-05-10 후지필름 가부시키가이샤 5-하이드록시-1h-이미다졸-4-카복사마이드의 유효 투여량 또는 감수성의 예측 방법 및 예측 장치, 잔토신 1인산의 양의 측정 방법 그리고 골수 이형성 증후군의 처치제 및 처치 방법
CA2940845C (en) 2014-02-24 2019-09-24 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
CA3026241A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
WO2018167628A1 (en) 2017-03-13 2018-09-20 Ftf Pharma Private Limited Pharmaceutical composition of oral suspension of immunosuppressive agents
US10835489B2 (en) * 2018-03-09 2020-11-17 University Of Saskatchewan Modified release formulations of mycophenolate mofetil
WO2020039263A2 (en) 2018-08-18 2020-02-27 Ftf Pharma Private Limited Pharmaceutical suspension for oral dosage
CN110526885A (zh) * 2019-08-20 2019-12-03 上海英诺富成生物科技有限公司 麦考酚酸的前体药物及其制备方法
CN113549040B (zh) * 2020-04-23 2024-08-06 鲁南制药集团股份有限公司 一种吗替麦考酚酯杂质d的制备方法
CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
WO2022187379A1 (en) 2021-03-03 2022-09-09 Sana Biotechnology, Inc. Immunosuppressive therapies for use with cardiomyocyte cell therapies, and associated methods and compositions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1157100A (en) * 1966-09-27 1969-07-02 Ici Ltd Pharmaceutical Compositions
GB1173942A (en) * 1967-06-06 1969-12-10 Bellon Labor Sa Roger New 2,3-Dihydro-1,4-Benzoxazines
GB1261060A (en) * 1969-09-09 1972-01-19 Ici Ltd Phthalen-1-one derivatives
JPS5542995B2 (lv) * 1972-02-24 1980-11-04
US3825571A (en) * 1971-07-31 1974-07-23 Chugai Pharmaceutical Co Ltd Mycophenolic acid derivatives
JPS563353B2 (lv) * 1972-03-02 1981-01-24
JPS5529994B2 (lv) * 1972-03-02 1980-08-07
US3777020A (en) * 1972-08-14 1973-12-04 Lilly Co Eli Psoriasis treatment with mycophenolic acid
US3868454A (en) * 1972-08-14 1975-02-25 Lilly Co Eli Psoriasis treatment with mycophenolic acid derivatives
US3880995A (en) * 1973-05-14 1975-04-29 Lilly Co Eli Treatment of arthritis with mycophenolic acid and derivatives
US3903071A (en) * 1973-05-22 1975-09-02 Lilly Co Eli Mycophenolic acid derivatives
US3905894A (en) * 1973-10-02 1975-09-16 Murskauskone Oy Apparatus for wet fine screening
JPS5724380A (en) * 1980-07-22 1982-02-08 Chugai Pharmaceut Co Ltd Preparation of mycophenolic acid derivative
JPS57183777A (en) * 1981-05-01 1982-11-12 Ajinomoto Co Inc Preparation of mycophenolic acid derivative
JPS57183776A (en) * 1981-05-01 1982-11-12 Ajinomoto Co Inc Preparation of mycophenolic acid derivative
IT1150194B (it) * 1982-02-23 1986-12-10 Chiesi Farma Spa Formulazioni farmaceutiche ad attivita'antiinfiammatoria, analgesica,antipiretica e gastroprotettiva

Also Published As

Publication number Publication date
IL84833A (en) 1992-03-29
DE3773660D1 (de) 1991-11-14
PH23819A (en) 1989-11-23
AU599728B2 (en) 1990-07-26
JPS63188672A (ja) 1988-08-04
GEP20094816B (en) 2009-11-10
ES2038190T3 (es) 1993-07-16
US4948793A (en) 1990-08-14
IE873397L (en) 1988-07-30
FI875502A (fi) 1988-07-31
ZA879414B (en) 1989-08-30
GR3002866T3 (en) 1993-01-25
IE60750B1 (en) 1994-08-10
US4952579A (en) 1990-08-28
IL84833A0 (en) 1988-06-30
US4808592A (en) 1989-02-28
KR880009016A (ko) 1988-09-13
NO875240D0 (no) 1987-12-15
AU8254087A (en) 1988-08-04
NL960019I2 (nl) 1997-06-02
FI85141C (fi) 1992-03-10
DK658787D0 (da) 1987-12-15
EP0281713B1 (en) 1991-10-09
HUT47567A (en) 1989-03-28
US4992467A (en) 1991-02-12
DK166675B1 (da) 1993-06-28
DK658787A (da) 1988-07-31
US4786637A (en) 1988-11-22
NO171680B (no) 1993-01-11
HU201927B (en) 1991-01-28
MX9203163A (es) 1992-07-31
ATE68180T1 (de) 1991-10-15
LV5748A4 (lv) 1996-10-20
LU88795I2 (fr) 1996-11-05
HU210350A9 (en) 1995-03-28
NL960019I1 (nl) 1996-10-01
NZ222922A (en) 1990-09-26
PT86343A (en) 1988-01-01
KR940003758B1 (ko) 1994-04-30
JPH0571591B2 (lv) 1993-10-07
PT86343B (pt) 1991-02-08
EP0281713A1 (en) 1988-09-14
NO875240L (no) 1988-08-01
US4868153A (en) 1989-09-19
DE19675020I2 (de) 2002-11-07
FI85141B (fi) 1991-11-29
FI875502A0 (fi) 1987-12-15
NO1997007I1 (no) 1997-07-01
NO171680C (no) 1993-04-21
US4753935A (en) 1988-06-28
HK125893A (en) 1993-11-19
CA1333285C (en) 1994-11-29

Similar Documents

Publication Publication Date Title
LV5748A4 (lv) Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums
NO173867C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzamider
GR3020848T3 (en) 1,8-Naphthyridin-2-one derivatives
FI900461A0 (fi) Imidazopyridaziner, deras framstaellning och anvaendning.
FI881816A (fi) Nya bicykliska foereningar, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska blandningar.
ATE96446T1 (de) Estramustin-ester.
ES2055235T3 (es) Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation.
DK451389A (da) 2-substituerede 4,5-diaryl-thioimidazoler samt farmaceutisk praeparat indeholdende saadanne forbindelser
SE8204791D0 (sv) Process for preparing alkoxy-vincaminic acid esters and alkoxy-apovincaminic acid esters