LV5748B4 - Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums - Google Patents

Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums

Info

Publication number
LV5748B4
LV5748B4 LV960221A LV960221A LV5748B4 LV 5748 B4 LV5748 B4 LV 5748B4 LV 960221 A LV960221 A LV 960221A LV 960221 A LV960221 A LV 960221A LV 5748 B4 LV5748 B4 LV 5748B4
Authority
LV
Latvia
Prior art keywords
agents
acquisition
morpholinoethyl ester
mycophenolate
mycophenolate morpholinoethyl
Prior art date
Application number
LV960221A
Other languages
English (en)
Other versions
LV5748A4 (lv
Inventor
Peter H Nelson
Anthony C Allison
William A Lee
Chee-Liang Leo Gu
Elsie M Eugui
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV5748(B4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of LV5748A4 publication Critical patent/LV5748A4/lv
Publication of LV5748B4 publication Critical patent/LV5748B4/lv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
LV960221A 1987-01-30 1996-07-05 Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums LV5748B4 (lv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
EP87311021A EP0281713B1 (en) 1987-01-30 1987-12-15 Morpholinoethylester of mycophenolic acid and derivatives thereof, their preparation and use in pharmaceutical compositions

Publications (2)

Publication Number Publication Date
LV5748A4 LV5748A4 (lv) 1996-10-20
LV5748B4 true LV5748B4 (lv) 1997-02-20

Family

ID=21733252

Family Applications (1)

Application Number Title Priority Date Filing Date
LV960221A LV5748B4 (lv) 1987-01-30 1996-07-05 Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums

Country Status (26)

Country Link
US (7) US4753935A (lv)
EP (1) EP0281713B1 (lv)
JP (1) JPS63188672A (lv)
KR (1) KR940003758B1 (lv)
AT (1) ATE68180T1 (lv)
AU (1) AU599728B2 (lv)
CA (1) CA1333285C (lv)
DE (2) DE19675020I2 (lv)
DK (1) DK166675B1 (lv)
ES (1) ES2038190T3 (lv)
FI (1) FI85141C (lv)
GE (1) GEP20094816B (lv)
GR (1) GR3002866T3 (lv)
HK (1) HK125893A (lv)
HU (2) HU201927B (lv)
IE (1) IE60750B1 (lv)
IL (1) IL84833A (lv)
LU (1) LU88795I2 (lv)
LV (1) LV5748B4 (lv)
MX (1) MX9203163A (lv)
NL (1) NL960019I2 (lv)
NO (2) NO171680C (lv)
NZ (1) NZ222922A (lv)
PH (1) PH23819A (lv)
PT (1) PT86343B (lv)
ZA (1) ZA879414B (lv)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
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US5177072A (en) * 1987-01-30 1993-01-05 Syntex (U.S.A.) Inc. Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives
WO1990009788A1 (en) * 1989-02-23 1990-09-07 The University Of North Carolina At Chapel Hill Etoposide analogues
US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
CN1129908A (zh) * 1993-06-25 1996-08-28 美因坎普营销私人有限公司 治疗剂
BR9407469A (pt) 1993-09-15 1996-11-12 Syntex Inc Micofenolato mofetil anidro cristalino e formulação intravenosa do mesmo
PT721335E (pt) * 1993-10-01 2005-11-30 Roche Palo Alto Llc Suspensoes orais em altas doses de micofenolato de mofetil
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
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ID18663A (id) * 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
WO2000026197A1 (en) * 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Novel inhibitors of impdh enzyme
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
JP2002528499A (ja) 1998-10-29 2002-09-03 ブリストル−マイヤーズ スクイブ カンパニー Ｉｍｐｄｈ酵素のインヒビターであるアミノ核誘導化合物
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
IN188985B (lv) 1998-12-09 2002-11-30 Biocon Ltd
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
CA2407370A1 (en) * 2000-04-24 2001-11-01 Bristol-Myers Squibb Company Heterocycles that are inhibitors of impdh enzyme
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
GB0124953D0 (en) * 2001-10-17 2001-12-05 Novartis Ag Organic Compounds
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
AU2003231924A1 (en) * 2003-04-07 2004-11-01 Biocon Limited Microwave synthesis of mycophenolate
CN100562314C (zh) * 2003-05-14 2009-11-25 帝斯曼知识产权资产管理有限公司 苯并呋喃酮衍生物用于治疗和预防糖尿病的用途
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
US20070032483A1 (en) * 2003-09-11 2007-02-08 Julia Greil Process for the production of mycophenolate mofetil
KR20060121887A (ko) * 2003-09-23 2006-11-29 디에스엠 아이피 어셋츠 비.브이. 진성 당뇨병의 치료 및 예방용 조성물
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CA2555454C (en) * 2004-04-27 2009-12-15 Sandor Molnar Mycophenolate mofetil impurity
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DE602005020014D1 (de) * 2004-07-20 2010-04-29 Teva Gyogyszergyar Zartkoeruen Kristallines mycophenolat-natrium
EP1786415A4 (en) * 2004-08-16 2010-01-20 Verva Pharmaceuticals Pty METABOLISM MODULATION AGENTS AND USES THEREOF
US20080300404A1 (en) * 2005-01-20 2008-12-04 Apotex Fermentation Inc. Process for the Preparation of Mycophenolate Mofetil
WO2006086498A2 (en) * 2005-02-08 2006-08-17 Aspreva Pharmaceuticals Sa Treatment of vascular, autoimmune and inflammatory diseases using low dosages of impdh inhibitors
WO2006086500A2 (en) * 2005-02-08 2006-08-17 Aspreva Pharmaceuticals Sa Compositions and methods for treating vascular, autoimmune and inflammatory diseases
US20080280977A1 (en) * 2005-04-26 2008-11-13 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
KR20080094788A (ko) * 2006-02-13 2008-10-24 노파르티스 아게 고복용량의 미코페놀산(엠피에이)
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WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
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CN100484930C (zh) * 2007-03-16 2009-05-06 重庆大新药业股份有限公司 一种吗替麦考酚酯的制备方法
WO2009000834A1 (en) * 2007-06-27 2008-12-31 Dsm Ip Assets B.V. Method for the purification of mycophenolate mofetil
WO2009010503A1 (en) * 2007-07-18 2009-01-22 Dsm Ip Assets B.V. Mycophenolic acid recycling in a method for the preparation of mycophenolate mofetil
US20090076000A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched mycophenolate mofetil
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WO2009084008A1 (en) * 2007-12-28 2009-07-09 Cadila Healthcare Limited Process for preparing mycophenolate mofetil
KR100975520B1 (ko) * 2008-02-01 2010-08-12 종근당바이오 주식회사 마이코페놀레이트 모페틸의 개선된 제조방법
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FI20096026L (fi) 2009-10-06 2011-04-07 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
FI124873B (fi) 2009-10-06 2015-02-27 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
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CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
WO2013041205A1 (de) 2011-09-19 2013-03-28 Pyxirion Pharma Gmbh Neue therapeutische konzepte zur behandlung von gefässerkrankungen
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
SG11201507371RA (en) 2013-03-14 2015-10-29 Alkermes Pharma Ireland Ltd Prodrugs of fumarates and their use in treating various deseases
WO2015013422A1 (en) * 2013-07-23 2015-01-29 University Of Tennessee Research Foundation Immunosuppressive compounds and therapeutics
JP6294357B2 (ja) * 2014-01-10 2018-03-14 富士フイルム株式会社 ５−ヒドロキシ−１ｈ−イミダゾール−４−カルボキサミドの有効投与量または感受性の予測方法および予測装置、キサントシン一リン酸の量の測定方法ならびに骨髄異形成症候群の処置剤および処置方法
JP6337135B2 (ja) 2014-02-24 2018-06-06 アルカーメス ファーマ アイルランド リミテッド フマル酸エステルのスルホンアミドプロドラッグ及びスルフィンアミドプロドラッグ並びに種々の疾患の治療におけるその使用
CA3026241A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
WO2018167628A1 (en) 2017-03-13 2018-09-20 Ftf Pharma Private Limited Pharmaceutical composition of oral suspension of immunosuppressive agents
US10835489B2 (en) * 2018-03-09 2020-11-17 University Of Saskatchewan Modified release formulations of mycophenolate mofetil
CN110526885A (zh) * 2019-08-20 2019-12-03 上海英诺富成生物科技有限公司 麦考酚酸的前体药物及其制备方法
CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
CN117177749A (zh) 2021-03-03 2023-12-05 萨那生物科技公司 与心肌细胞疗法一起使用的免疫抑制疗法以及相关的方法和组合物

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Also Published As

Publication number Publication date
US4808592A (en) 1989-02-28
ZA879414B (en) 1989-08-30
AU8254087A (en) 1988-08-04
NL960019I2 (nl) 1997-06-02
PH23819A (en) 1989-11-23
LU88795I2 (fr) 1996-11-05
HU201927B (en) 1991-01-28
NO875240L (no) 1988-08-01
ATE68180T1 (de) 1991-10-15
HU210350A9 (en) 1995-03-28
LV5748A4 (lv) 1996-10-20
KR940003758B1 (ko) 1994-04-30
PT86343B (pt) 1991-02-08
GEP20094816B (en) 2009-11-10
IE873397L (en) 1988-07-30
FI875502A0 (fi) 1987-12-15
ES2038190T3 (es) 1993-07-16
FI85141C (fi) 1992-03-10
IE60750B1 (en) 1994-08-10
DK166675B1 (da) 1993-06-28
CA1333285C (en) 1994-11-29
NO875240D0 (no) 1987-12-15
NO171680C (no) 1993-04-21
FI85141B (fi) 1991-11-29
IL84833A (en) 1992-03-29
KR880009016A (ko) 1988-09-13
DE19675020I2 (de) 2002-11-07
HUT47567A (en) 1989-03-28
FI875502A (fi) 1988-07-31
DK658787A (da) 1988-07-31
NO1997007I1 (no) 1997-07-01
NO171680B (no) 1993-01-11
NL960019I1 (nl) 1996-10-01
DK658787D0 (da) 1987-12-15
US4786637A (en) 1988-11-22
AU599728B2 (en) 1990-07-26
EP0281713A1 (en) 1988-09-14
JPS63188672A (ja) 1988-08-04
US4992467A (en) 1991-02-12
NZ222922A (en) 1990-09-26
DE3773660D1 (de) 1991-11-14
IL84833A0 (en) 1988-06-30
EP0281713B1 (en) 1991-10-09
US4753935A (en) 1988-06-28
JPH0571591B2 (lv) 1993-10-07
GR3002866T3 (en) 1993-01-25
MX9203163A (es) 1992-07-31
PT86343A (en) 1988-01-01
US4868153A (en) 1989-09-19
US4948793A (en) 1990-08-14
US4952579A (en) 1990-08-28
HK125893A (en) 1993-11-19

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