CN100402516C - 一种霉酚酸莫啡酯的制备方法 - Google Patents
一种霉酚酸莫啡酯的制备方法 Download PDFInfo
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- CN100402516C CN100402516C CNB2005101004890A CN200510100489A CN100402516C CN 100402516 C CN100402516 C CN 100402516C CN B2005101004890 A CNB2005101004890 A CN B2005101004890A CN 200510100489 A CN200510100489 A CN 200510100489A CN 100402516 C CN100402516 C CN 100402516C
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- preparation
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- mycophenolate mofetil
- acetate
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CNB2005101004890A CN100402516C (zh) | 2005-10-18 | 2005-10-18 | 一种霉酚酸莫啡酯的制备方法 |
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CNB2005101004890A CN100402516C (zh) | 2005-10-18 | 2005-10-18 | 一种霉酚酸莫啡酯的制备方法 |
Publications (2)
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CN1772745A CN1772745A (zh) | 2006-05-17 |
CN100402516C true CN100402516C (zh) | 2008-07-16 |
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CNB2005101004890A Active CN100402516C (zh) | 2005-10-18 | 2005-10-18 | 一种霉酚酸莫啡酯的制备方法 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1974564B (zh) * | 2006-12-15 | 2010-05-12 | 丽珠集团新北江制药股份有限公司 | 一种霉酚酸莫啡酯的制备方法 |
CN100484930C (zh) * | 2007-03-16 | 2009-05-06 | 重庆大新药业股份有限公司 | 一种吗替麦考酚酯的制备方法 |
WO2009003878A1 (en) * | 2007-06-29 | 2009-01-08 | Dsm Ip Assets B.V. | Method for the preparation of mycophenolate mofetil |
CN102924413B (zh) * | 2012-10-23 | 2014-12-31 | 福建科瑞药业有限公司 | 一种霉酚酸莫啡酯纯化脱色方法 |
CN106866595B (zh) * | 2017-03-04 | 2019-03-08 | 丽珠集团新北江制药股份有限公司 | 一种吗替麦考酚酯制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0281713B1 (en) * | 1987-01-30 | 1991-10-09 | Syntex (U.S.A.) Inc. | Morpholinoethylester of mycophenolic acid and derivatives thereof, their preparation and use in pharmaceutical compositions |
US5247083A (en) * | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
CN1143366A (zh) * | 1994-02-18 | 1997-02-19 | 辛泰克斯(美国)公司 | 4-霉酚酸-氨基衍生物 |
WO2000034503A2 (en) * | 1998-12-09 | 2000-06-15 | Biocon India Limited | Methods of producing esters of mycophenolate |
CN1520411A (zh) * | 2001-06-08 | 2004-08-11 | ����˹��ҩ�﹫˾ | 霉酚酸莫啡酯的制备方法 |
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2005
- 2005-10-18 CN CNB2005101004890A patent/CN100402516C/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0281713B1 (en) * | 1987-01-30 | 1991-10-09 | Syntex (U.S.A.) Inc. | Morpholinoethylester of mycophenolic acid and derivatives thereof, their preparation and use in pharmaceutical compositions |
US5247083A (en) * | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
CN1143366A (zh) * | 1994-02-18 | 1997-02-19 | 辛泰克斯(美国)公司 | 4-霉酚酸-氨基衍生物 |
WO2000034503A2 (en) * | 1998-12-09 | 2000-06-15 | Biocon India Limited | Methods of producing esters of mycophenolate |
CN1520411A (zh) * | 2001-06-08 | 2004-08-11 | ����˹��ҩ�﹫˾ | 霉酚酸莫啡酯的制备方法 |
Non-Patent Citations (2)
Title |
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. R.B.Wanger and H.D.Zook.Synthetic Organic Chemistry. 1952 |
. R.B.Wanger and H.D.Zook.Synthetic Organic Chemistry. 1952 * |
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Publication number | Publication date |
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CN1772745A (zh) | 2006-05-17 |
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Assignee: HEC Pharmaceutical Company Assignor: Dongyangguang Pharmaceutical Co., Ltd., Guangdong Contract record no.: 2011440000028 Denomination of invention: Prepn process of Mycophenolate mofetil Granted publication date: 20080716 License type: Common License Open date: 20060517 Record date: 20110120 |
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