ES2038190T3 - Ester morfolinoetilico de acido micofenolico y derivados del mismo, su preparacion y uso en composiciones farmaceuticas. - Google Patents

Ester morfolinoetilico de acido micofenolico y derivados del mismo, su preparacion y uso en composiciones farmaceuticas.

Info

Publication number
ES2038190T3
ES2038190T3 ES198787311021T ES87311021T ES2038190T3 ES 2038190 T3 ES2038190 T3 ES 2038190T3 ES 198787311021 T ES198787311021 T ES 198787311021T ES 87311021 T ES87311021 T ES 87311021T ES 2038190 T3 ES2038190 T3 ES 2038190T3
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
derivatives
preparation
mycophenolic acid
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787311021T
Other languages
English (en)
Inventor
Peter H. Nelson
Anthony C. Allison
William A. Lee
Chee-Liang Leo Gu
Elsie M. Eugui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2038190(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of ES2038190T3 publication Critical patent/ES2038190T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)

Abstract

LOS COMPUESTOS FARMACEUTICOS DE FORMULA A, EN LA QUE Z ES HIDROGENO O -C(O)R, SIENDO R ALQUILO DE CADENA CORTA O ARILO, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, SON UTILES COMO AGENTES INMUNOSUPRESORES, ANTIINFLAMATORIOS, ANTITUMORALES, ANTIVIRICOS Y ANTI-PSORIASIS.
ES198787311021T 1987-01-30 1987-12-15 Ester morfolinoetilico de acido micofenolico y derivados del mismo, su preparacion y uso en composiciones farmaceuticas. Expired - Lifetime ES2038190T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ES2038190T3 true ES2038190T3 (es) 1993-07-16

Family

ID=21733252

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787311021T Expired - Lifetime ES2038190T3 (es) 1987-01-30 1987-12-15 Ester morfolinoetilico de acido micofenolico y derivados del mismo, su preparacion y uso en composiciones farmaceuticas.

Country Status (26)

Country Link
US (7) US4753935A (es)
EP (1) EP0281713B1 (es)
JP (1) JPS63188672A (es)
KR (1) KR940003758B1 (es)
AT (1) ATE68180T1 (es)
AU (1) AU599728B2 (es)
CA (1) CA1333285C (es)
DE (2) DE19675020I2 (es)
DK (1) DK166675B1 (es)
ES (1) ES2038190T3 (es)
FI (1) FI85141C (es)
GE (1) GEP20094816B (es)
GR (1) GR3002866T3 (es)
HK (1) HK125893A (es)
HU (2) HU201927B (es)
IE (1) IE60750B1 (es)
IL (1) IL84833A (es)
LU (1) LU88795I2 (es)
LV (1) LV5748B4 (es)
MX (1) MX9203163A (es)
NL (1) NL960019I2 (es)
NO (2) NO171680C (es)
NZ (1) NZ222922A (es)
PH (1) PH23819A (es)
PT (1) PT86343B (es)
ZA (1) ZA879414B (es)

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* Cited by examiner, † Cited by third party
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WO1990009788A1 (en) * 1989-02-23 1990-09-07 The University Of North Carolina At Chapel Hill Etoposide analogues
US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
DE69421280T2 (de) * 1993-06-25 2000-07-13 Main Camp Marketing Pty Ltd Therapeutisches agens
ATE173475T1 (de) * 1993-09-15 1998-12-15 Syntex Inc Kristallines, wasserfreies mofetilmycophenolat und zubereitungen zu deren intravenösen anwendung
CN1089583C (zh) * 1993-10-01 2002-08-28 辛泰克斯（美国）公司 霉酚酸2－(4－吗啉代)乙酯高剂量口服悬浮剂
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
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US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US6225073B1 (en) 1994-07-07 2001-05-01 Dade Behring Marburg Gmbh Immunoassay for mycophenolic acid
ID18663A (id) 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
CA2348267A1 (en) * 1998-10-29 2000-05-11 Henry H. Gu Novel inhibitors of impdh enzyme
AU764479B2 (en) 1998-10-29 2003-08-21 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of IMPDH enzyme
IN188985B (es) 1998-12-09 2002-11-30 Biocon Ltd
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
EP1276739A2 (en) * 2000-04-24 2003-01-22 Bristol-Myers Squibb Company Heterocycles that are inhibitors of impdh enzyme
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
GB0124953D0 (en) * 2001-10-17 2001-12-05 Novartis Ag Organic Compounds
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
WO2004012746A2 (en) * 2002-08-02 2004-02-12 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
AU2003231924A1 (en) * 2003-04-07 2004-11-01 Biocon Limited Microwave synthesis of mycophenolate
ES2327639T3 (es) * 2003-05-14 2009-11-02 Dsm Ip Assets B.V. Uso de derivados de ftalida para el tratamiento y prevecion de diabetes mellitus.
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
EP1667987B1 (en) * 2003-09-11 2008-07-23 Sandoz AG Process for the production of mycophenolate mofetil
WO2005027661A1 (en) * 2003-09-23 2005-03-31 Dsm Ip Assets B.V. Compositions for the treatment and prevention of diabetes mellitus
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CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US7439373B2 (en) * 2004-07-20 2008-10-21 TEVA Gyógyszergyár Zártkörúen Múködö Részvénytársaság Crystalline mycophenolate sodium
JP2008517584A (ja) * 2004-08-16 2008-05-29 アディポジェン ファーマシューティカルズ ピーティーワイ リミテッド 代謝調節薬剤およびそのための使用
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CA2940845C (en) 2014-02-24 2019-09-24 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
WO2017210262A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
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CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
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Also Published As

Publication number Publication date
MX9203163A (es) 1992-07-31
HU201927B (en) 1991-01-28
DK658787D0 (da) 1987-12-15
GR3002866T3 (en) 1993-01-25
LV5748B4 (lv) 1997-02-20
AU8254087A (en) 1988-08-04
US4786637A (en) 1988-11-22
ATE68180T1 (de) 1991-10-15
CA1333285C (en) 1994-11-29
HU210350A9 (en) 1995-03-28
PH23819A (en) 1989-11-23
NO1997007I1 (no) 1997-07-01
NO875240L (no) 1988-08-01
DE3773660D1 (de) 1991-11-14
GEP20094816B (en) 2009-11-10
PT86343B (pt) 1991-02-08
JPH0571591B2 (es) 1993-10-07
FI875502A0 (fi) 1987-12-15
AU599728B2 (en) 1990-07-26
DK166675B1 (da) 1993-06-28
ZA879414B (en) 1989-08-30
IL84833A (en) 1992-03-29
US4952579A (en) 1990-08-28
KR880009016A (ko) 1988-09-13
NZ222922A (en) 1990-09-26
IE60750B1 (en) 1994-08-10
EP0281713B1 (en) 1991-10-09
LU88795I2 (fr) 1996-11-05
HUT47567A (en) 1989-03-28
FI85141B (fi) 1991-11-29
DE19675020I2 (de) 2002-11-07
JPS63188672A (ja) 1988-08-04
US4753935A (en) 1988-06-28
NO171680B (no) 1993-01-11
IE873397L (en) 1988-07-30
US4992467A (en) 1991-02-12
EP0281713A1 (en) 1988-09-14
FI875502A (fi) 1988-07-31
DK658787A (da) 1988-07-31
NL960019I2 (nl) 1997-06-02
US4868153A (en) 1989-09-19
NO875240D0 (no) 1987-12-15
LV5748A4 (lv) 1996-10-20
HK125893A (en) 1993-11-19
FI85141C (fi) 1992-03-10
US4948793A (en) 1990-08-14
IL84833A0 (en) 1988-06-30
KR940003758B1 (ko) 1994-04-30
NO171680C (no) 1993-04-21
US4808592A (en) 1989-02-28
NL960019I1 (nl) 1996-10-01
PT86343A (en) 1988-01-01

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