IL84833A - Morpholinoethylester of mycophenolic acid and derivatives thereof,their preparation and pharmaceutical compositions containing them - Google Patents

Morpholinoethylester of mycophenolic acid and derivatives thereof,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL84833A
IL84833A IL84833A IL8483387A IL84833A IL 84833 A IL84833 A IL 84833A IL 84833 A IL84833 A IL 84833A IL 8483387 A IL8483387 A IL 8483387A IL 84833 A IL84833 A IL 84833A
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
morpholinoethylester
derivatives
preparation
compositions containing
Prior art date
Application number
IL84833A
Other languages
English (en)
Other versions
IL84833A0 (en
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL84833(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of IL84833A0 publication Critical patent/IL84833A0/xx
Publication of IL84833A publication Critical patent/IL84833A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL84833A 1987-01-30 1987-12-15 Morpholinoethylester of mycophenolic acid and derivatives thereof,their preparation and pharmaceutical compositions containing them IL84833A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions

Publications (2)

Publication Number Publication Date
IL84833A0 IL84833A0 (en) 1988-06-30
IL84833A true IL84833A (en) 1992-03-29

Family

ID=21733252

Family Applications (1)

Application Number Title Priority Date Filing Date
IL84833A IL84833A (en) 1987-01-30 1987-12-15 Morpholinoethylester of mycophenolic acid and derivatives thereof,their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (7) US4753935A (es)
EP (1) EP0281713B1 (es)
JP (1) JPS63188672A (es)
KR (1) KR940003758B1 (es)
AT (1) ATE68180T1 (es)
AU (1) AU599728B2 (es)
CA (1) CA1333285C (es)
DE (2) DE3773660D1 (es)
DK (1) DK166675B1 (es)
ES (1) ES2038190T3 (es)
FI (1) FI85141C (es)
GE (1) GEP20094816B (es)
GR (1) GR3002866T3 (es)
HK (1) HK125893A (es)
HU (2) HU201927B (es)
IE (1) IE60750B1 (es)
IL (1) IL84833A (es)
LU (1) LU88795I2 (es)
LV (1) LV5748B4 (es)
MX (1) MX9203163A (es)
NL (1) NL960019I2 (es)
NO (2) NO171680C (es)
NZ (1) NZ222922A (es)
PH (1) PH23819A (es)
PT (1) PT86343B (es)
ZA (1) ZA879414B (es)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177072A (en) * 1987-01-30 1993-01-05 Syntex (U.S.A.) Inc. Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives
AU632796B2 (en) * 1989-02-23 1993-01-14 University Of North Carolina At Chapel Hill, The Etoposide analogues
US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
NZ267567A (en) * 1993-06-25 1997-10-24 Main Camp Marketing Pty Ltd Su Treatment of inflammatory conditions using various indole, benzoquinone and benzofuran derivatives; method of plant material extraction; celery seed extract
CN1060770C (zh) * 1993-09-15 2001-01-17 辛泰克斯（美国）公司 无水结晶霉酚酸2－(4－吗啉代)乙酯(mycophenolate mofetil)及其静脉用制剂
PL177323B1 (pl) * 1993-10-01 1999-10-29 Syntex Inc Kompozycja farmaceutyczna zawierająca mykofenolan mofetylu lub kwas mykofenolowy i sposób wytwarzania kompozycji farmaceutycznej zawierającej mykofenolan mofetylu lub kwas mykofenolowy
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
US6225073B1 (en) * 1994-07-07 2001-05-01 Dade Behring Marburg Gmbh Immunoassay for mycophenolic acid
ID18663A (id) 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
WO2000025780A1 (en) 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
WO2000026197A1 (en) * 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Novel inhibitors of impdh enzyme
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
IN188985B (es) 1998-12-09 2002-11-30 Biocon Ltd
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
EP1276739A2 (en) * 2000-04-24 2003-01-22 Bristol-Myers Squibb Company Heterocycles that are inhibitors of impdh enzyme
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
GB0124953D0 (en) * 2001-10-17 2001-12-05 Novartis Ag Organic Compounds
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
AU2003231924A1 (en) * 2003-04-07 2004-11-01 Biocon Limited Microwave synthesis of mycophenolate
CN100562314C (zh) * 2003-05-14 2009-11-25 帝斯曼知识产权资产管理有限公司 苯并呋喃酮衍生物用于治疗和预防糖尿病的用途
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
EP1667987B1 (en) * 2003-09-11 2008-07-23 Sandoz AG Process for the production of mycophenolate mofetil
EP1662906A1 (en) * 2003-09-23 2006-06-07 DSM IP Assets B.V. Compositions for the treatment and prevention of diabetes mellitus
WO2005033089A1 (en) * 2003-10-07 2005-04-14 Biocon Limited Salt of 6-(1, 3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid with n, n-dimethyl-imidodicarbonimidic diamide
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US7358247B2 (en) * 2004-04-27 2008-04-15 TEVA Gyógyszergyár Zártköruen Muködö Részvénytársaság Mycophenolate mofetil impurity
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JP2008506783A (ja) * 2004-07-20 2008-03-06 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ ミコフェノール酸ナトリウムの結晶形の調製方法
CA2577169A1 (en) * 2004-08-16 2006-02-23 The University Of Queensland Metabolism-modulating agents and uses therefor
US20080300404A1 (en) * 2005-01-20 2008-12-04 Apotex Fermentation Inc. Process for the Preparation of Mycophenolate Mofetil
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US20060235009A1 (en) * 2005-02-08 2006-10-19 Richard Glickman Treatment of vascular, autoimmune and inflammatory diseases using low dosages of IMPDH inhibitors
US20080281111A1 (en) * 2005-04-26 2008-11-13 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
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WO2008003637A2 (en) * 2006-07-05 2008-01-10 Dsm Ip Assets B.V. Isolation and use of amine salts of mycophenolic acid
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
US20080188653A1 (en) * 2007-02-04 2008-08-07 Formosa Laboratories, Inc. Process for Preparation of Mycophenolate Mofetil
CN100484930C (zh) * 2007-03-16 2009-05-06 重庆大新药业股份有限公司 一种吗替麦考酚酯的制备方法
WO2009000834A1 (en) * 2007-06-27 2008-12-31 Dsm Ip Assets B.V. Method for the purification of mycophenolate mofetil
WO2009010503A1 (en) * 2007-07-18 2009-01-22 Dsm Ip Assets B.V. Mycophenolic acid recycling in a method for the preparation of mycophenolate mofetil
US20090076000A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched mycophenolate mofetil
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WO2009084008A1 (en) * 2007-12-28 2009-07-09 Cadila Healthcare Limited Process for preparing mycophenolate mofetil
KR100975520B1 (ko) * 2008-02-01 2010-08-12 종근당바이오 주식회사 마이코페놀레이트 모페틸의 개선된 제조방법
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
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FI124873B (fi) 2009-10-06 2015-02-27 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
FI20096026L (fi) 2009-10-06 2011-04-07 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
PT3290428T (pt) 2010-03-31 2021-12-27 Gilead Pharmasset Llc Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino
GB201100786D0 (en) 2011-01-18 2011-03-02 Ems Sa Pharmaceutical compositions of immunosuppressants
CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
WO2013041205A1 (de) 2011-09-19 2013-03-28 Pyxirion Pharma Gmbh Neue therapeutische konzepte zur behandlung von gefässerkrankungen
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
ES2683355T3 (es) 2013-03-14 2018-09-26 Alkermes Pharma Ireland Limited Profármacos de fumaratos y su uso en el tratamiento de diversas enfermedades
US10369133B2 (en) 2013-07-23 2019-08-06 The University Of Tennessee Research Foundation Immunosuppressive compounds and therapeutics
EP3093662B1 (en) * 2014-01-10 2019-05-15 Fujifilm Corporation 5-hydroxy-1h-imidazole-4-carboxamide effective-dose/sensitivity prediction method and prediction device, xanthosine-monophosphate-amount measurement method, and myelodysplastic-syndrome treatment agent and treatment method
NZ723269A (en) 2014-02-24 2017-04-28 Alkermes Pharma Ireland Ltd Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
CA3026241A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
WO2018167628A1 (en) 2017-03-13 2018-09-20 Ftf Pharma Private Limited Pharmaceutical composition of oral suspension of immunosuppressive agents
US10835489B2 (en) * 2018-03-09 2020-11-17 University Of Saskatchewan Modified release formulations of mycophenolate mofetil
WO2020039263A2 (en) 2018-08-18 2020-02-27 Ftf Pharma Private Limited Pharmaceutical suspension for oral dosage
CN110526885A (zh) * 2019-08-20 2019-12-03 上海英诺富成生物科技有限公司 麦考酚酸的前体药物及其制备方法
CN113549040B (zh) * 2020-04-23 2024-08-06 鲁南制药集团股份有限公司 一种吗替麦考酚酯杂质d的制备方法
CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
WO2022187379A1 (en) 2021-03-03 2022-09-09 Sana Biotechnology, Inc. Immunosuppressive therapies for use with cardiomyocyte cell therapies, and associated methods and compositions

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GB1261060A (en) * 1969-09-09 1972-01-19 Ici Ltd Phthalen-1-one derivatives
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US3777020A (en) * 1972-08-14 1973-12-04 Lilly Co Eli Psoriasis treatment with mycophenolic acid
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US3880995A (en) * 1973-05-14 1975-04-29 Lilly Co Eli Treatment of arthritis with mycophenolic acid and derivatives
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Also Published As

Publication number Publication date
NO171680B (no) 1993-01-11
EP0281713B1 (en) 1991-10-09
NO875240D0 (no) 1987-12-15
ES2038190T3 (es) 1993-07-16
US4786637A (en) 1988-11-22
US4992467A (en) 1991-02-12
HUT47567A (en) 1989-03-28
US4868153A (en) 1989-09-19
FI875502A (fi) 1988-07-31
KR940003758B1 (ko) 1994-04-30
FI85141C (fi) 1992-03-10
US4948793A (en) 1990-08-14
NZ222922A (en) 1990-09-26
GR3002866T3 (en) 1993-01-25
PT86343B (pt) 1991-02-08
HU201927B (en) 1991-01-28
US4952579A (en) 1990-08-28
JPH0571591B2 (es) 1993-10-07
US4808592A (en) 1989-02-28
NO1997007I1 (no) 1997-07-01
NL960019I2 (nl) 1997-06-02
GEP20094816B (en) 2009-11-10
HK125893A (en) 1993-11-19
PT86343A (en) 1988-01-01
DE3773660D1 (de) 1991-11-14
AU599728B2 (en) 1990-07-26
NO171680C (no) 1993-04-21
CA1333285C (en) 1994-11-29
LU88795I2 (fr) 1996-11-05
EP0281713A1 (en) 1988-09-14
NL960019I1 (nl) 1996-10-01
ATE68180T1 (de) 1991-10-15
IE60750B1 (en) 1994-08-10
JPS63188672A (ja) 1988-08-04
LV5748A4 (lv) 1996-10-20
MX9203163A (es) 1992-07-31
PH23819A (en) 1989-11-23
IL84833A0 (en) 1988-06-30
HU210350A9 (en) 1995-03-28
DE19675020I2 (de) 2002-11-07
FI875502A0 (fi) 1987-12-15
LV5748B4 (lv) 1997-02-20
DK658787D0 (da) 1987-12-15
IE873397L (en) 1988-07-30
US4753935A (en) 1988-06-28
NO875240L (no) 1988-08-01
KR880009016A (ko) 1988-09-13
DK658787A (da) 1988-07-31
DK166675B1 (da) 1993-06-28
AU8254087A (en) 1988-08-04
ZA879414B (en) 1989-08-30
FI85141B (fi) 1991-11-29

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