ZA879414B - Morpholinoethylester of mycophenolic acid and derivatives thereof - Google Patents

Morpholinoethylester of mycophenolic acid and derivatives thereof

Info

Publication number
ZA879414B
ZA879414B ZA879414A ZA879414A ZA879414B ZA 879414 B ZA879414 B ZA 879414B ZA 879414 A ZA879414 A ZA 879414A ZA 879414 A ZA879414 A ZA 879414A ZA 879414 B ZA879414 B ZA 879414B
Authority
ZA
South Africa
Prior art keywords
agents
morpholinoethylester
derivatives
mycophenolic acid
chem
Prior art date
Application number
ZA879414A
Other languages
English (en)
Inventor
Peter H Nelson
H Nelson Peter
Chee-Liang Leo Gu
Leo Gu Chee-Liang
Anthony C Allison
C Allison Anthony
Elsie M Eugui
M Eugui Elsie
William A Lee
A Lee William
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA879414(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of ZA879414B publication Critical patent/ZA879414B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
ZA879414A 1987-01-30 1987-12-15 Morpholinoethylester of mycophenolic acid and derivatives thereof ZA879414B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ZA879414B true ZA879414B (en) 1989-08-30

Family

ID=21733252

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA879414A ZA879414B (en) 1987-01-30 1987-12-15 Morpholinoethylester of mycophenolic acid and derivatives thereof

Country Status (26)

Country Link
US (7) US4753935A (xx)
EP (1) EP0281713B1 (xx)
JP (1) JPS63188672A (xx)
KR (1) KR940003758B1 (xx)
AT (1) ATE68180T1 (xx)
AU (1) AU599728B2 (xx)
CA (1) CA1333285C (xx)
DE (2) DE19675020I2 (xx)
DK (1) DK166675B1 (xx)
ES (1) ES2038190T3 (xx)
FI (1) FI85141C (xx)
GE (1) GEP20094816B (xx)
GR (1) GR3002866T3 (xx)
HK (1) HK125893A (xx)
HU (2) HU201927B (xx)
IE (1) IE60750B1 (xx)
IL (1) IL84833A (xx)
LU (1) LU88795I2 (xx)
LV (1) LV5748B4 (xx)
MX (1) MX9203163A (xx)
NL (1) NL960019I2 (xx)
NO (2) NO171680C (xx)
NZ (1) NZ222922A (xx)
PH (1) PH23819A (xx)
PT (1) PT86343B (xx)
ZA (1) ZA879414B (xx)

Families Citing this family (82)

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US5177072A (en) * 1987-01-30 1993-01-05 Syntex (U.S.A.) Inc. Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives
WO1990009788A1 (en) * 1989-02-23 1990-09-07 The University Of North Carolina At Chapel Hill Etoposide analogues
US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
DE69421280T2 (de) * 1993-06-25 2000-07-13 Main Camp Marketing Pty Ltd Therapeutisches agens
ATE173475T1 (de) * 1993-09-15 1998-12-15 Syntex Inc Kristallines, wasserfreies mofetilmycophenolat und zubereitungen zu deren intravenösen anwendung
CN1089583C (zh) * 1993-10-01 2002-08-28 辛泰克斯（美国）公司 霉酚酸2－(4－吗啉代)乙酯高剂量口服悬浮剂
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
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ID18663A (id) 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
CA2348267A1 (en) * 1998-10-29 2000-05-11 Henry H. Gu Novel inhibitors of impdh enzyme
AU764479B2 (en) 1998-10-29 2003-08-21 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of IMPDH enzyme
IN188985B (xx) 1998-12-09 2002-11-30 Biocon Ltd
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
EP1276739A2 (en) * 2000-04-24 2003-01-22 Bristol-Myers Squibb Company Heterocycles that are inhibitors of impdh enzyme
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
GB0124953D0 (en) * 2001-10-17 2001-12-05 Novartis Ag Organic Compounds
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
WO2004012746A2 (en) * 2002-08-02 2004-02-12 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
AU2003231924A1 (en) * 2003-04-07 2004-11-01 Biocon Limited Microwave synthesis of mycophenolate
ES2327639T3 (es) * 2003-05-14 2009-11-02 Dsm Ip Assets B.V. Uso de derivados de ftalida para el tratamiento y prevecion de diabetes mellitus.
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EP1667987B1 (en) * 2003-09-11 2008-07-23 Sandoz AG Process for the production of mycophenolate mofetil
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CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US7439373B2 (en) * 2004-07-20 2008-10-21 TEVA Gyógyszergyár Zártkörúen Múködö Részvénytársaság Crystalline mycophenolate sodium
JP2008517584A (ja) * 2004-08-16 2008-05-29 アディポジェン ファーマシューティカルズ ピーティーワイ リミテッド 代謝調節薬剤およびそのための使用
CA2533326C (en) * 2005-01-20 2012-01-03 Apotex Fermentation Inc. An improved process for the preparation of mycophenolate mofetil
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WO2006086498A2 (en) * 2005-02-08 2006-08-17 Aspreva Pharmaceuticals Sa Treatment of vascular, autoimmune and inflammatory diseases using low dosages of impdh inhibitors
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CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
CN101378749A (zh) * 2006-02-13 2009-03-04 诺瓦提斯公司 高剂量的麦考酚酸(mpa)
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US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
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CN100484930C (zh) * 2007-03-16 2009-05-06 重庆大新药业股份有限公司 一种吗替麦考酚酯的制备方法
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KR100975520B1 (ko) * 2008-02-01 2010-08-12 종근당바이오 주식회사 마이코페놀레이트 모페틸의 개선된 제조방법
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CN104017020B (zh) 2010-03-31 2017-04-12 吉利德制药有限责任公司 核苷氨基磷酸酯
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CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
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US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
NZ723459A (en) 2013-03-14 2017-12-22 Alkermes Pharma Ireland Ltd Prodrugs of fumarates and their use in treating various diseases
US10369133B2 (en) 2013-07-23 2019-08-06 The University Of Tennessee Research Foundation Immunosuppressive compounds and therapeutics
RU2672872C2 (ru) * 2014-01-10 2018-11-20 Фуджифилм Корпорэйшн Способ и устройство для прогнозирования эффективной дозы или восприимчивости к 5-гидрокси-1н-имидазол-4-карбоксамиду, способ определения количества ксантозинмонофосфата, а также средство и способ для лечения миелодиспластического синдрома
CA2940845C (en) 2014-02-24 2019-09-24 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
WO2017210262A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
WO2018167628A1 (en) 2017-03-13 2018-09-20 Ftf Pharma Private Limited Pharmaceutical composition of oral suspension of immunosuppressive agents
US10835489B2 (en) * 2018-03-09 2020-11-17 University Of Saskatchewan Modified release formulations of mycophenolate mofetil
CN110526885A (zh) * 2019-08-20 2019-12-03 上海英诺富成生物科技有限公司 麦考酚酸的前体药物及其制备方法
CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
JP2024508327A (ja) 2021-03-03 2024-02-26 サナ バイオテクノロジー，インコーポレイテッド 心筋細胞療法と併用する免疫抑制療法、及び関連する方法ならびに組成物

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Also Published As

Publication number Publication date
MX9203163A (es) 1992-07-31
HU201927B (en) 1991-01-28
DK658787D0 (da) 1987-12-15
GR3002866T3 (en) 1993-01-25
LV5748B4 (lv) 1997-02-20
AU8254087A (en) 1988-08-04
US4786637A (en) 1988-11-22
ATE68180T1 (de) 1991-10-15
CA1333285C (en) 1994-11-29
HU210350A9 (en) 1995-03-28
PH23819A (en) 1989-11-23
NO1997007I1 (no) 1997-07-01
NO875240L (no) 1988-08-01
DE3773660D1 (de) 1991-11-14
GEP20094816B (en) 2009-11-10
PT86343B (pt) 1991-02-08
JPH0571591B2 (xx) 1993-10-07
FI875502A0 (fi) 1987-12-15
AU599728B2 (en) 1990-07-26
DK166675B1 (da) 1993-06-28
IL84833A (en) 1992-03-29
US4952579A (en) 1990-08-28
KR880009016A (ko) 1988-09-13
NZ222922A (en) 1990-09-26
IE60750B1 (en) 1994-08-10
EP0281713B1 (en) 1991-10-09
LU88795I2 (fr) 1996-11-05
HUT47567A (en) 1989-03-28
FI85141B (fi) 1991-11-29
DE19675020I2 (de) 2002-11-07
JPS63188672A (ja) 1988-08-04
US4753935A (en) 1988-06-28
NO171680B (no) 1993-01-11
IE873397L (en) 1988-07-30
US4992467A (en) 1991-02-12
EP0281713A1 (en) 1988-09-14
FI875502A (fi) 1988-07-31
DK658787A (da) 1988-07-31
NL960019I2 (nl) 1997-06-02
US4868153A (en) 1989-09-19
NO875240D0 (no) 1987-12-15
LV5748A4 (lv) 1996-10-20
HK125893A (en) 1993-11-19
FI85141C (fi) 1992-03-10
US4948793A (en) 1990-08-14
IL84833A0 (en) 1988-06-30
KR940003758B1 (ko) 1994-04-30
NO171680C (no) 1993-04-21
ES2038190T3 (es) 1993-07-16
US4808592A (en) 1989-02-28
NL960019I1 (nl) 1996-10-01
PT86343A (en) 1988-01-01

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