NO875240D0 - Analogifremgangsmaate for fremstilling av terapeutisk aktiv morfolinoethylester av mycofenolsyre og derivater derav. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktiv morfolinoethylester av mycofenolsyre og derivater derav.

Info

Publication number
NO875240D0
NO875240D0 NO875240A NO875240A NO875240D0 NO 875240 D0 NO875240 D0 NO 875240D0 NO 875240 A NO875240 A NO 875240A NO 875240 A NO875240 A NO 875240A NO 875240 D0 NO875240 D0 NO 875240D0
Authority
NO
Norway
Prior art keywords
morpholinoethylesters
derivatives
preparation
mycophenolic acid
therapeutic active
Prior art date
Application number
NO875240A
Other languages
English (en)
Other versions
NO875240L (no
NO171680B (no
NO171680C (no
Inventor
Peter H Nelson
Chee-Liang Leo Gu
Anthony C Allison
Elsie M Eugui
William A Lee
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO875240(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of NO875240D0 publication Critical patent/NO875240D0/no
Publication of NO875240L publication Critical patent/NO875240L/no
Publication of NO171680B publication Critical patent/NO171680B/no
Publication of NO171680C publication Critical patent/NO171680C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO875240A 1987-01-30 1987-12-15 Analogifremgangsmaate for fremstilling av terapeutisk aktiv morfolinoethylester av mycofenolsyre og derivater derav NO171680C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions

Publications (4)

Publication Number Publication Date
NO875240D0 true NO875240D0 (no) 1987-12-15
NO875240L NO875240L (no) 1988-08-01
NO171680B NO171680B (no) 1993-01-11
NO171680C NO171680C (no) 1993-04-21

Family

ID=21733252

Family Applications (2)

Application Number Title Priority Date Filing Date
NO875240A NO171680C (no) 1987-01-30 1987-12-15 Analogifremgangsmaate for fremstilling av terapeutisk aktiv morfolinoethylester av mycofenolsyre og derivater derav
NO1997007C NO1997007I1 (no) 1987-01-30 1997-07-01 Mykofenolatmofetil eller et farmasøytisk akseptabelt salt derav

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1997007C NO1997007I1 (no) 1987-01-30 1997-07-01 Mykofenolatmofetil eller et farmasøytisk akseptabelt salt derav

Country Status (26)

Country Link
US (7) US4753935A (no)
EP (1) EP0281713B1 (no)
JP (1) JPS63188672A (no)
KR (1) KR940003758B1 (no)
AT (1) ATE68180T1 (no)
AU (1) AU599728B2 (no)
CA (1) CA1333285C (no)
DE (2) DE3773660D1 (no)
DK (1) DK166675B1 (no)
ES (1) ES2038190T3 (no)
FI (1) FI85141C (no)
GE (1) GEP20094816B (no)
GR (1) GR3002866T3 (no)
HK (1) HK125893A (no)
HU (2) HU201927B (no)
IE (1) IE60750B1 (no)
IL (1) IL84833A (no)
LU (1) LU88795I2 (no)
LV (1) LV5748B4 (no)
MX (1) MX9203163A (no)
NL (1) NL960019I2 (no)
NO (2) NO171680C (no)
NZ (1) NZ222922A (no)
PH (1) PH23819A (no)
PT (1) PT86343B (no)
ZA (1) ZA879414B (no)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177072A (en) * 1987-01-30 1993-01-05 Syntex (U.S.A.) Inc. Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives
WO1990009788A1 (en) * 1989-02-23 1990-09-07 The University Of North Carolina At Chapel Hill Etoposide analogues
US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
ATE185698T1 (de) * 1993-06-25 1999-11-15 Main Camp Marketing Pty Ltd Therapeutisches agens
JP3411038B2 (ja) * 1993-09-15 2003-05-26 シンテックス(ユー・エス・エイ)・インコーポレイテッド ミコフェノール酸モフェチルの結晶質無水物およびその静注用製剤
RU2150942C1 (ru) * 1993-10-01 2000-06-20 Синтекс (Ю.ЭС.ЭЙ.) Инк. Оральные суспензии, содержащие высокие дозы мофетила микофенолята
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US6225073B1 (en) * 1994-07-07 2001-05-01 Dade Behring Marburg Gmbh Immunoassay for mycophenolic acid
ID18663A (id) * 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
WO2000025780A1 (en) 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
WO2000026197A1 (en) * 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Novel inhibitors of impdh enzyme
IN188985B (no) 1998-12-09 2002-11-30 Biocon Ltd
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
CA2407370A1 (en) * 2000-04-24 2001-11-01 Bristol-Myers Squibb Company Heterocycles that are inhibitors of impdh enzyme
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
GB0124953D0 (en) * 2001-10-17 2001-12-05 Novartis Ag Organic Compounds
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
AU2003261354A1 (en) * 2002-08-02 2004-02-23 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
WO2004089946A1 (en) * 2003-04-07 2004-10-21 Biocon Limited Microwave synthesis of mycophenolate
WO2004100945A1 (en) * 2003-05-14 2004-11-25 Dsm Ip Assets B.V. Use of phthalide derivatives for the treatment and prevention of diabetes mellitus
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
ES2308226T3 (es) * 2003-09-11 2008-12-01 Sandoz Ag Proceso para la produccion de micofenolato mofetil.
KR20060121887A (ko) * 2003-09-23 2006-11-29 디에스엠 아이피 어셋츠 비.브이. 진성 당뇨병의 치료 및 예방용 조성물
WO2005033089A1 (en) * 2003-10-07 2005-04-14 Biocon Limited Salt of 6-(1, 3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid with n, n-dimethyl-imidodicarbonimidic diamide
EP1740564A2 (en) * 2004-04-26 2007-01-10 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Process for preparation of mycophenolic acid and ester derivatives thereof
MXPA06005658A (es) * 2004-04-27 2007-04-10 Teva Gyogyszergyar Zartkoruen Proceso para preparacion de micofenolato mofetil, y otros esteres de acido micofenolico.
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CN101052631A (zh) * 2004-07-20 2007-10-10 特瓦药厂私人有限公司 结晶霉酚酸钠
AU2005274681A1 (en) * 2004-08-16 2006-02-23 Verva Pharmaceuticals Pty Ltd Metabolism-modulating agents and uses therefor
US20080300404A1 (en) * 2005-01-20 2008-12-04 Apotex Fermentation Inc. Process for the Preparation of Mycophenolate Mofetil
US20060235070A1 (en) * 2005-02-08 2006-10-19 Hayden Michael R Compositions and methods for treating vascular, autoimmune, and inflammatory diseases
US20060235009A1 (en) * 2005-02-08 2006-10-19 Richard Glickman Treatment of vascular, autoimmune and inflammatory diseases using low dosages of IMPDH inhibitors
US20080281111A1 (en) * 2005-04-26 2008-11-13 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
WO2007093346A1 (en) * 2006-02-13 2007-08-23 Novartis Ag High dosage of mycophenolic acid (mpa)
WO2008003637A2 (en) * 2006-07-05 2008-01-10 Dsm Ip Assets B.V. Isolation and use of amine salts of mycophenolic acid
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US20080188653A1 (en) * 2007-02-04 2008-08-07 Formosa Laboratories, Inc. Process for Preparation of Mycophenolate Mofetil
CN100484930C (zh) * 2007-03-16 2009-05-06 重庆大新药业股份有限公司 一种吗替麦考酚酯的制备方法
WO2009000834A1 (en) * 2007-06-27 2008-12-31 Dsm Ip Assets B.V. Method for the purification of mycophenolate mofetil
WO2009010503A1 (en) * 2007-07-18 2009-01-22 Dsm Ip Assets B.V. Mycophenolic acid recycling in a method for the preparation of mycophenolate mofetil
US20090076000A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched mycophenolate mofetil
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
WO2009084008A1 (en) * 2007-12-28 2009-07-09 Cadila Healthcare Limited Process for preparing mycophenolate mofetil
KR100975520B1 (ko) * 2008-02-01 2010-08-12 종근당바이오 주식회사 마이코페놀레이트 모페틸의 개선된 제조방법
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
JP2011527339A (ja) * 2008-07-09 2011-10-27 アスプレバ インターナショナル リミテッド 眼障害を処置するためのミコフェノール酸ナトリウムのpH特異的な溶液
MX2011006891A (es) * 2008-12-23 2011-10-06 Pharmasset Inc Fosforamidatos de nucleosidos.
NZ593647A (en) 2008-12-23 2013-08-30 Gilead Pharmasset Llc Synthesis of purine nucleosides
EP2376514A2 (en) * 2008-12-23 2011-10-19 Pharmasset, Inc. Nucleoside analogs
FI124873B (fi) 2009-10-06 2015-02-27 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
FI20096026L (fi) 2009-10-06 2011-04-07 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
AU2011235112B2 (en) 2010-03-31 2015-07-09 Gilead Pharmasset Llc Nucleoside phosphoramidates
GB201100786D0 (en) 2011-01-18 2011-03-02 Ems Sa Pharmaceutical compositions of immunosuppressants
CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
WO2013041205A1 (de) 2011-09-19 2013-03-28 Pyxirion Pharma Gmbh Neue therapeutische konzepte zur behandlung von gefässerkrankungen
PT2970101T (pt) 2013-03-14 2018-10-04 Alkermes Pharma Ireland Ltd Pró-fármacos de fumaratos e seu uso no tratamento de várias doenças
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10369133B2 (en) 2013-07-23 2019-08-06 The University Of Tennessee Research Foundation Immunosuppressive compounds and therapeutics
JP6294357B2 (ja) * 2014-01-10 2018-03-14 富士フイルム株式会社 5−ヒドロキシ−1h−イミダゾール−4−カルボキサミドの有効投与量または感受性の予測方法および予測装置、キサントシン一リン酸の量の測定方法ならびに骨髄異形成症候群の処置剤および処置方法
NZ723269A (en) 2014-02-24 2017-04-28 Alkermes Pharma Ireland Ltd Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
CA3026241A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
US11918684B2 (en) 2017-03-13 2024-03-05 Liqmeds Worldwide Limited Pharmaceutical composition of oral suspension of immunosuppressive agents
US10835489B2 (en) * 2018-03-09 2020-11-17 University Of Saskatchewan Modified release formulations of mycophenolate mofetil
CN110526885A (zh) * 2019-08-20 2019-12-03 上海英诺富成生物科技有限公司 麦考酚酸的前体药物及其制备方法
CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
CA3212370A1 (en) 2021-03-03 2022-09-09 Sana Biotechnology, Inc. Immunosuppressive therapies for use with cardiomyocyte cell therapies, and associated methods and compositions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1157100A (en) * 1966-09-27 1969-07-02 Ici Ltd Pharmaceutical Compositions
GB1173942A (en) * 1967-06-06 1969-12-10 Bellon Labor Sa Roger New 2,3-Dihydro-1,4-Benzoxazines
GB1261060A (en) * 1969-09-09 1972-01-19 Ici Ltd Phthalen-1-one derivatives
JPS5542995B2 (no) * 1972-02-24 1980-11-04
US3825571A (en) * 1971-07-31 1974-07-23 Chugai Pharmaceutical Co Ltd Mycophenolic acid derivatives
JPS563353B2 (no) * 1972-03-02 1981-01-24
JPS5529994B2 (no) * 1972-03-02 1980-08-07
US3868454A (en) * 1972-08-14 1975-02-25 Lilly Co Eli Psoriasis treatment with mycophenolic acid derivatives
US3777020A (en) * 1972-08-14 1973-12-04 Lilly Co Eli Psoriasis treatment with mycophenolic acid
US3880995A (en) * 1973-05-14 1975-04-29 Lilly Co Eli Treatment of arthritis with mycophenolic acid and derivatives
US3903071A (en) * 1973-05-22 1975-09-02 Lilly Co Eli Mycophenolic acid derivatives
US3905894A (en) * 1973-10-02 1975-09-16 Murskauskone Oy Apparatus for wet fine screening
JPS5724380A (en) * 1980-07-22 1982-02-08 Chugai Pharmaceut Co Ltd Preparation of mycophenolic acid derivative
JPS57183776A (en) * 1981-05-01 1982-11-12 Ajinomoto Co Inc Preparation of mycophenolic acid derivative
JPS57183777A (en) * 1981-05-01 1982-11-12 Ajinomoto Co Inc Preparation of mycophenolic acid derivative
IT1150194B (it) * 1982-02-23 1986-12-10 Chiesi Farma Spa Formulazioni farmaceutiche ad attivita'antiinfiammatoria, analgesica,antipiretica e gastroprotettiva

Also Published As

Publication number Publication date
IL84833A (en) 1992-03-29
FI85141C (fi) 1992-03-10
ATE68180T1 (de) 1991-10-15
AU8254087A (en) 1988-08-04
IL84833A0 (en) 1988-06-30
LU88795I2 (fr) 1996-11-05
NO875240L (no) 1988-08-01
EP0281713A1 (en) 1988-09-14
US4952579A (en) 1990-08-28
US4948793A (en) 1990-08-14
NO171680B (no) 1993-01-11
HUT47567A (en) 1989-03-28
HU210350A9 (en) 1995-03-28
HU201927B (en) 1991-01-28
AU599728B2 (en) 1990-07-26
US4992467A (en) 1991-02-12
US4753935A (en) 1988-06-28
GEP20094816B (en) 2009-11-10
NL960019I1 (nl) 1996-10-01
HK125893A (en) 1993-11-19
DK166675B1 (da) 1993-06-28
FI875502A (fi) 1988-07-31
MX9203163A (es) 1992-07-31
LV5748A4 (lv) 1996-10-20
JPS63188672A (ja) 1988-08-04
DE19675020I2 (de) 2002-11-07
DE3773660D1 (de) 1991-11-14
IE873397L (en) 1988-07-30
PT86343B (pt) 1991-02-08
JPH0571591B2 (no) 1993-10-07
KR940003758B1 (ko) 1994-04-30
GR3002866T3 (en) 1993-01-25
ES2038190T3 (es) 1993-07-16
NO1997007I1 (no) 1997-07-01
FI85141B (fi) 1991-11-29
PH23819A (en) 1989-11-23
NO171680C (no) 1993-04-21
FI875502A0 (fi) 1987-12-15
ZA879414B (en) 1989-08-30
PT86343A (en) 1988-01-01
KR880009016A (ko) 1988-09-13
LV5748B4 (lv) 1997-02-20
IE60750B1 (en) 1994-08-10
NL960019I2 (nl) 1997-06-02
US4786637A (en) 1988-11-22
DK658787A (da) 1988-07-31
US4868153A (en) 1989-09-19
NZ222922A (en) 1990-09-26
EP0281713B1 (en) 1991-10-09
US4808592A (en) 1989-02-28
CA1333285C (en) 1994-11-29
DK658787D0 (da) 1987-12-15

Similar Documents

Publication Publication Date Title
NO171680C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktiv morfolinoethylester av mycofenolsyre og derivater derav
NO890723D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive 3-alkenyl-1-azabicyklo(3.2.0)hept2-en-2-karboksylsyrederivater.
NO160076C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzoksazol- og benzotianolaminderivater.
NO881835L (no) Fremgangsmaate for fremstilling av terapeutisk aktive bicykliske forbindelser.
NO168243C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive alkansulfonanilid-derivater.
NO167737C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydroimidazo(1,4)benzodiazepin-2-oner.
NO173991C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,5-ditiazocin-derivater
ATE123487T1 (de) Derivate der kaffeinsäure und sie enthaltende pharmazeutische zusammensetzungen.
NO173783C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive, kondenserte heterodykliske derivater av 1,2,3,4-tetrahydroakridiner
NO176608C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-piperidinylindazol-derivater
ES2042727T3 (es) Acidos 1,3,4,9-tetrahidropirano(3,4-b)indol-1-acetico.

Legal Events

Date Code Title Description
MK1K Patent expired