FI875502A - Morfolinoetylester av mykofenolsyra och dess derivat - Google Patents

Morfolinoetylester av mykofenolsyra och dess derivat Download PDF

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Publication number
FI875502A
FI875502A FI875502A FI875502A FI875502A FI 875502 A FI875502 A FI 875502A FI 875502 A FI875502 A FI 875502A FI 875502 A FI875502 A FI 875502A FI 875502 A FI875502 A FI 875502A
Authority
FI
Finland
Prior art keywords
mykophenolsyra
morpholinoethylester
agents
och dess
derivat
Prior art date
Application number
FI875502A
Other languages
English (en)
Other versions
FI85141C (fi
FI85141B (fi
FI875502A0 (fi
Inventor
Peter H Nelson
Chee-Liang Leo Gu
Anthony C Allison
Elsie M Eugui
William A Lee
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI875502(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of FI875502A0 publication Critical patent/FI875502A0/fi
Publication of FI875502A publication Critical patent/FI875502A/fi
Application granted granted Critical
Publication of FI85141B publication Critical patent/FI85141B/fi
Publication of FI85141C publication Critical patent/FI85141C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
FI875502A 1987-01-30 1987-12-15 Foerfarande foer framstaellning av terapeutiskt aktiv morfolinoetylester av mykofenolsyra och dess derivat. FI85141C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
US871787 1987-01-30

Publications (4)

Publication Number Publication Date
FI875502A0 FI875502A0 (fi) 1987-12-15
FI875502A true FI875502A (fi) 1988-07-31
FI85141B FI85141B (fi) 1991-11-29
FI85141C FI85141C (fi) 1992-03-10

Family

ID=21733252

Family Applications (1)

Application Number Title Priority Date Filing Date
FI875502A FI85141C (fi) 1987-01-30 1987-12-15 Foerfarande foer framstaellning av terapeutiskt aktiv morfolinoetylester av mykofenolsyra och dess derivat.

Country Status (26)

Country Link
US (7) US4753935A (fi)
EP (1) EP0281713B1 (fi)
JP (1) JPS63188672A (fi)
KR (1) KR940003758B1 (fi)
AT (1) ATE68180T1 (fi)
AU (1) AU599728B2 (fi)
CA (1) CA1333285C (fi)
DE (2) DE3773660D1 (fi)
DK (1) DK166675B1 (fi)
ES (1) ES2038190T3 (fi)
FI (1) FI85141C (fi)
GE (1) GEP20094816B (fi)
GR (1) GR3002866T3 (fi)
HK (1) HK125893A (fi)
HU (2) HU201927B (fi)
IE (1) IE60750B1 (fi)
IL (1) IL84833A (fi)
LU (1) LU88795I2 (fi)
LV (1) LV5748B4 (fi)
MX (1) MX9203163A (fi)
NL (1) NL960019I2 (fi)
NO (2) NO171680C (fi)
NZ (1) NZ222922A (fi)
PH (1) PH23819A (fi)
PT (1) PT86343B (fi)
ZA (1) ZA879414B (fi)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
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US5177072A (en) * 1987-01-30 1993-01-05 Syntex (U.S.A.) Inc. Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives
JP3043802B2 (ja) * 1989-02-23 2000-05-22 ザ・ユニバーシティ・オブ・ノース・カロライナ・アット・チャペル・ヒル エトポシド同族体類
US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
ES2140541T3 (es) * 1993-06-25 2000-03-01 Main Camp Marketing Pty Ltd Agente terapeutico.
CZ292423B6 (cs) * 1993-09-15 2003-09-17 Syntex (U.S.A.) Inc. Krystalický, bezvodý mykofenolát mofetilu a intravenózní prostředek, ve kterém je obsažen
EP0721335B1 (en) * 1993-10-01 2005-08-31 Roche Palo Alto LLC Mycophenolate mofetil high dose oral suspensions
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
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US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
CA2348234A1 (en) 1998-10-29 2000-05-11 Chunjian Liu Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
EP1127054A4 (en) * 1998-10-29 2006-11-02 Bristol Myers Squibb Co INHIBITORS OF IMPDH ENZYME
IN188985B (fi) 1998-12-09 2002-11-30 Biocon Ltd
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
JP2003531205A (ja) * 2000-04-24 2003-10-21 ブリストル−マイヤーズ スクイブ カンパニー Ｉｍｐｄｈ酵素の阻害剤である複素環化合物
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
GB0124953D0 (en) * 2001-10-17 2001-12-05 Novartis Ag Organic Compounds
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
AU2003231924A1 (en) * 2003-04-07 2004-11-01 Biocon Limited Microwave synthesis of mycophenolate
US20070082947A1 (en) * 2003-05-14 2007-04-12 D Orazio Daniel Use of phthalide derivatives for the treatment and prevention of diabetes mellitus
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
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JP2008517584A (ja) * 2004-08-16 2008-05-29 アディポジェン ファーマシューティカルズ ピーティーワイ リミテッド 代謝調節薬剤およびそのための使用
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US20060235009A1 (en) * 2005-02-08 2006-10-19 Richard Glickman Treatment of vascular, autoimmune and inflammatory diseases using low dosages of IMPDH inhibitors
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CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
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CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
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US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10369133B2 (en) 2013-07-23 2019-08-06 The University Of Tennessee Research Foundation Immunosuppressive compounds and therapeutics
CN105899951B (zh) * 2014-01-10 2019-07-12 富士胶片株式会社 5-羟基-1h-咪唑-4-甲酰胺的有效给予量的预测装置、黄苷一磷酸的量的测定方法
CA2940845C (en) 2014-02-24 2019-09-24 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
CA3026241A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
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US10835489B2 (en) * 2018-03-09 2020-11-17 University Of Saskatchewan Modified release formulations of mycophenolate mofetil
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CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
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Also Published As

Publication number Publication date
GR3002866T3 (en) 1993-01-25
EP0281713A1 (en) 1988-09-14
US4786637A (en) 1988-11-22
HK125893A (en) 1993-11-19
DK658787A (da) 1988-07-31
NO875240D0 (no) 1987-12-15
HU210350A9 (en) 1995-03-28
DK658787D0 (da) 1987-12-15
LV5748B4 (lv) 1997-02-20
US4952579A (en) 1990-08-28
KR880009016A (ko) 1988-09-13
GEP20094816B (en) 2009-11-10
US4753935A (en) 1988-06-28
US4992467A (en) 1991-02-12
HUT47567A (en) 1989-03-28
NO171680B (no) 1993-01-11
NL960019I1 (nl) 1996-10-01
FI85141C (fi) 1992-03-10
MX9203163A (es) 1992-07-31
NO1997007I1 (no) 1997-07-01
EP0281713B1 (en) 1991-10-09
LV5748A4 (lv) 1996-10-20
PH23819A (en) 1989-11-23
DE3773660D1 (de) 1991-11-14
NO875240L (no) 1988-08-01
IE873397L (en) 1988-07-30
KR940003758B1 (ko) 1994-04-30
US4868153A (en) 1989-09-19
PT86343B (pt) 1991-02-08
ES2038190T3 (es) 1993-07-16
NL960019I2 (nl) 1997-06-02
IL84833A (en) 1992-03-29
NZ222922A (en) 1990-09-26
FI85141B (fi) 1991-11-29
ATE68180T1 (de) 1991-10-15
AU8254087A (en) 1988-08-04
US4948793A (en) 1990-08-14
ZA879414B (en) 1989-08-30
NO171680C (no) 1993-04-21
LU88795I2 (fr) 1996-11-05
JPS63188672A (ja) 1988-08-04
US4808592A (en) 1989-02-28
AU599728B2 (en) 1990-07-26
HU201927B (en) 1991-01-28
DE19675020I2 (de) 2002-11-07
JPH0571591B2 (fi) 1993-10-07
IE60750B1 (en) 1994-08-10
DK166675B1 (da) 1993-06-28
CA1333285C (en) 1994-11-29
FI875502A0 (fi) 1987-12-15
IL84833A0 (en) 1988-06-30
PT86343A (en) 1988-01-01

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