NL960019I2 - Morfolino-ethylester van mycofenolzuur en derivaten ervan, de bereiding ervan en hun toepassing in farmaceutische samenstellingen. - Google Patents

Morfolino-ethylester van mycofenolzuur en derivaten ervan, de bereiding ervan en hun toepassing in farmaceutische samenstellingen.

Info

Publication number
NL960019I2
NL960019I2 NL960019C NL960019C NL960019I2 NL 960019 I2 NL960019 I2 NL 960019I2 NL 960019 C NL960019 C NL 960019C NL 960019 C NL960019 C NL 960019C NL 960019 I2 NL960019 I2 NL 960019I2
Authority
NL
Netherlands
Prior art keywords
pharmaceutical compositions
morfolinoethyl
derivatives
ester
preparation
Prior art date
Application number
NL960019C
Other languages
English (en)
Other versions
NL960019I1 (nl
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL960019(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of NL960019I1 publication Critical patent/NL960019I1/nl
Publication of NL960019I2 publication Critical patent/NL960019I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NL960019C 1987-01-30 1996-07-12 Morfolino-ethylester van mycofenolzuur en derivaten ervan, de bereiding ervan en hun toepassing in farmaceutische samenstellingen. NL960019I2 (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions

Publications (2)

Publication Number Publication Date
NL960019I1 NL960019I1 (nl) 1996-10-01
NL960019I2 true NL960019I2 (nl) 1997-06-02

Family

ID=21733252

Family Applications (1)

Application Number Title Priority Date Filing Date
NL960019C NL960019I2 (nl) 1987-01-30 1996-07-12 Morfolino-ethylester van mycofenolzuur en derivaten ervan, de bereiding ervan en hun toepassing in farmaceutische samenstellingen.

Country Status (26)

Country Link
US (7) US4753935A (nl)
EP (1) EP0281713B1 (nl)
JP (1) JPS63188672A (nl)
KR (1) KR940003758B1 (nl)
AT (1) ATE68180T1 (nl)
AU (1) AU599728B2 (nl)
CA (1) CA1333285C (nl)
DE (2) DE19675020I2 (nl)
DK (1) DK166675B1 (nl)
ES (1) ES2038190T3 (nl)
FI (1) FI85141C (nl)
GE (1) GEP20094816B (nl)
GR (1) GR3002866T3 (nl)
HK (1) HK125893A (nl)
HU (2) HU201927B (nl)
IE (1) IE60750B1 (nl)
IL (1) IL84833A (nl)
LU (1) LU88795I2 (nl)
LV (1) LV5748B4 (nl)
MX (1) MX9203163A (nl)
NL (1) NL960019I2 (nl)
NO (2) NO171680C (nl)
NZ (1) NZ222922A (nl)
PH (1) PH23819A (nl)
PT (1) PT86343B (nl)
ZA (1) ZA879414B (nl)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
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WO1990009788A1 (en) * 1989-02-23 1990-09-07 The University Of North Carolina At Chapel Hill Etoposide analogues
US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
ES2140541T3 (es) * 1993-06-25 2000-03-01 Main Camp Marketing Pty Ltd Agente terapeutico.
KR100349772B1 (ko) * 1993-09-15 2002-12-28 신텍스(미국) 인크. 결정성무수물미코페놀레이트모페틸및그의정맥제형
RU2150942C1 (ru) * 1993-10-01 2000-06-20 Синтекс (Ю.ЭС.ЭЙ.) Инк. Оральные суспензии, содержащие высокие дозы мофетила микофенолята
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
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US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
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US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
WO2000025780A1 (en) 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
IN188985B (nl) 1998-12-09 2002-11-30 Biocon Ltd
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
CA2407370A1 (en) * 2000-04-24 2001-11-01 Bristol-Myers Squibb Company Heterocycles that are inhibitors of impdh enzyme
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
GB0124953D0 (en) * 2001-10-17 2001-12-05 Novartis Ag Organic Compounds
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
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GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
AU2003231924A1 (en) * 2003-04-07 2004-11-01 Biocon Limited Microwave synthesis of mycophenolate
DE602004022035D1 (de) * 2003-05-14 2009-08-27 Dsm Ip Assets Bv Verwendung von pthalide derivativen zur behandlung
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
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WO2015013422A1 (en) * 2013-07-23 2015-01-29 University Of Tennessee Research Foundation Immunosuppressive compounds and therapeutics
KR101856889B1 (ko) * 2014-01-10 2018-05-10 후지필름 가부시키가이샤 5-하이드록시-1h-이미다졸-4-카복사마이드의 유효 투여량 또는 감수성의 예측 방법 및 예측 장치, 잔토신 1인산의 양의 측정 방법 그리고 골수 이형성 증후군의 처치제 및 처치 방법
CA2940845C (en) 2014-02-24 2019-09-24 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
CA3026241A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
WO2018167628A1 (en) 2017-03-13 2018-09-20 Ftf Pharma Private Limited Pharmaceutical composition of oral suspension of immunosuppressive agents
US10835489B2 (en) * 2018-03-09 2020-11-17 University Of Saskatchewan Modified release formulations of mycophenolate mofetil
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CN110526885A (zh) * 2019-08-20 2019-12-03 上海英诺富成生物科技有限公司 麦考酚酸的前体药物及其制备方法
CN113549040B (zh) * 2020-04-23 2024-08-06 鲁南制药集团股份有限公司 一种吗替麦考酚酯杂质d的制备方法
CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
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GB1261060A (en) * 1969-09-09 1972-01-19 Ici Ltd Phthalen-1-one derivatives
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US3880995A (en) * 1973-05-14 1975-04-29 Lilly Co Eli Treatment of arthritis with mycophenolic acid and derivatives
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Also Published As

Publication number Publication date
IL84833A (en) 1992-03-29
DE3773660D1 (de) 1991-11-14
PH23819A (en) 1989-11-23
AU599728B2 (en) 1990-07-26
JPS63188672A (ja) 1988-08-04
GEP20094816B (en) 2009-11-10
ES2038190T3 (es) 1993-07-16
US4948793A (en) 1990-08-14
IE873397L (en) 1988-07-30
FI875502A (fi) 1988-07-31
ZA879414B (en) 1989-08-30
LV5748B4 (lv) 1997-02-20
GR3002866T3 (en) 1993-01-25
IE60750B1 (en) 1994-08-10
US4952579A (en) 1990-08-28
IL84833A0 (en) 1988-06-30
US4808592A (en) 1989-02-28
KR880009016A (ko) 1988-09-13
NO875240D0 (no) 1987-12-15
AU8254087A (en) 1988-08-04
FI85141C (fi) 1992-03-10
DK658787D0 (da) 1987-12-15
EP0281713B1 (en) 1991-10-09
HUT47567A (en) 1989-03-28
US4992467A (en) 1991-02-12
DK166675B1 (da) 1993-06-28
DK658787A (da) 1988-07-31
US4786637A (en) 1988-11-22
NO171680B (no) 1993-01-11
HU201927B (en) 1991-01-28
MX9203163A (es) 1992-07-31
ATE68180T1 (de) 1991-10-15
LV5748A4 (lv) 1996-10-20
LU88795I2 (fr) 1996-11-05
HU210350A9 (en) 1995-03-28
NL960019I1 (nl) 1996-10-01
NZ222922A (en) 1990-09-26
PT86343A (en) 1988-01-01
KR940003758B1 (ko) 1994-04-30
JPH0571591B2 (nl) 1993-10-07
PT86343B (pt) 1991-02-08
EP0281713A1 (en) 1988-09-14
NO875240L (no) 1988-08-01
US4868153A (en) 1989-09-19
DE19675020I2 (de) 2002-11-07
FI85141B (fi) 1991-11-29
FI875502A0 (fi) 1987-12-15
NO1997007I1 (no) 1997-07-01
NO171680C (no) 1993-04-21
US4753935A (en) 1988-06-28
HK125893A (en) 1993-11-19
CA1333285C (en) 1994-11-29

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