MX387463B - Moléculas de unión a antígeno biespecíficas activadoras de células t y antagonistas de unión al eje de pd-1 y usos de los mismos para el tratamiento de cáncer. - Google Patents

Moléculas de unión a antígeno biespecíficas activadoras de células t y antagonistas de unión al eje de pd-1 y usos de los mismos para el tratamiento de cáncer.

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Publication number
MX387463B
MX387463B MX2017006610A MX2017006610A MX387463B MX 387463 B MX387463 B MX 387463B MX 2017006610 A MX2017006610 A MX 2017006610A MX 2017006610 A MX2017006610 A MX 2017006610A MX 387463 B MX387463 B MX 387463B
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MX
Mexico
Prior art keywords
axis
binding
bispecifi
antigen
activate
Prior art date
Application number
MX2017006610A
Other languages
English (en)
Other versions
MX2017006610A (es
Inventor
Alfred Zippelius
Christian Klein
Daniela Thommen
Jens Schreiner
Pablo Umaña
Vaios Karanikas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2017006610A publication Critical patent/MX2017006610A/es
Publication of MX387463B publication Critical patent/MX387463B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/3046—Stomach, Intestines
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Abstract

La presente invención se refiere generalmente a moléculas de unión a antígeno biespecíficas activadoras de células T, a antagonistas del eje de PD-1, y en particular a terapias combinadas que emplean dichas moléculas de unión a antígeno biespecíficas activadoras de células T y antagonistas de unión al eje de PD-1, y al uso de estas terapias combinadas para el tratamiento del cáncer.
MX2017006610A 2014-11-20 2015-11-16 Moléculas de unión a antígeno biespecíficas activadoras de células t y antagonistas de unión al eje de pd-1 y usos de los mismos para el tratamiento de cáncer. MX387463B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP14194136 2014-11-20
EP15152141 2015-01-22
EP15167173 2015-05-11
PCT/EP2015/076682 WO2016079050A1 (en) 2014-11-20 2015-11-16 Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists

Publications (2)

Publication Number Publication Date
MX2017006610A MX2017006610A (es) 2017-09-29
MX387463B true MX387463B (es) 2025-03-18

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MX2017006610A MX387463B (es) 2014-11-20 2015-11-16 Moléculas de unión a antígeno biespecíficas activadoras de células t y antagonistas de unión al eje de pd-1 y usos de los mismos para el tratamiento de cáncer.

Country Status (23)

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US (2) US10781262B2 (es)
EP (3) EP3789402B1 (es)
JP (2) JP6944369B2 (es)
KR (2) KR20240024318A (es)
CN (1) CN107206072B (es)
AU (1) AU2015348657B2 (es)
CA (1) CA2966566C (es)
DK (3) DK4141032T3 (es)
ES (3) ES2835823T3 (es)
FI (1) FI4141032T3 (es)
HR (3) HRP20240959T1 (es)
HU (3) HUE067988T2 (es)
IL (1) IL251961B (es)
LT (3) LT4141032T (es)
MX (1) MX387463B (es)
MY (1) MY192999A (es)
PL (3) PL3789402T3 (es)
RS (3) RS61134B1 (es)
RU (1) RU2753902C2 (es)
SG (1) SG11201704056XA (es)
SI (3) SI4141032T1 (es)
WO (1) WO2016079050A1 (es)
ZA (1) ZA201703121B (es)

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ES2746805T3 (es) 2013-12-12 2020-03-06 Shanghai hengrui pharmaceutical co ltd Anticuerpo de PD-1, fragmento de unión a antígeno del mismo y aplicación médica del mismo
KR102497443B1 (ko) 2014-03-28 2023-02-08 젠코어 인코포레이티드 Cd38 및 cd3에 결합하는 이중특이적 항체
RU2753902C2 (ru) 2014-11-20 2021-08-24 Ф.Хоффманн-Ля Рош Аг Комбинированная терапия на основе активирующих т-клетки биспецифических антигенсвязывающих молекул против cd3 и фолатного рецептора 1 (folr1) и антагонистов, связывающихся с осью pd-1
BR112017011166A2 (pt) 2014-11-26 2018-02-27 Xencor, Inc. anticorpos heterodiméricos que se ligam a cd3 e cd38
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US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
EP3237449A2 (en) 2014-12-22 2017-11-01 Xencor, Inc. Trispecific antibodies
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