MX2022000159A - Metodos para transduccion y procesamiento celular. - Google Patents
Metodos para transduccion y procesamiento celular.Info
- Publication number
- MX2022000159A MX2022000159A MX2022000159A MX2022000159A MX2022000159A MX 2022000159 A MX2022000159 A MX 2022000159A MX 2022000159 A MX2022000159 A MX 2022000159A MX 2022000159 A MX2022000159 A MX 2022000159A MX 2022000159 A MX2022000159 A MX 2022000159A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- transduction
- processing
- cells
- increased
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 230000026683 transduction Effects 0.000 title abstract 3
- 238000010361 transduction Methods 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 abstract 1
- 238000011467 adoptive cell therapy Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000003672 processing method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B7/00—Elements of centrifuges
- B04B7/08—Rotary bowls
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Developmental Biology & Embryology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
Abstract
Se proporcionan métodos, sistemas y kits para procesamiento celular, por ejemplo, para uso terapéutico, tal como para terapia celular adoptiva. Los métodos proporcionados incluyen métodos de transducción, en los cuales las células y virus se incuban bajo condiciones que dan por resultado la transducción de las células con un vector viral. La incubación en algunas modalidades se lleva a cabo en una cavidad interna de una cámara centrífuga generalmente rígida, tal como una cámara cilíndrica hecha de plástico duro, la cavidad de la cual puede tener un volumen variable. Los métodos incluyen otras etapas de procesamiento, que incluyen aquellos llevados a cabo en tal cámara, incluyendo el lavado, selección, aislamiento, cultivo y formulación. En particular, la descripción se relaciona a un método que proporciona ventajas sobre los métodos de procesamiento disponibles, tales como los métodos disponibles para procesamiento a gran escala. Tales ventajas incluyen, por ejemplo, costo reducido, optimización, eficacia incrementada, seguridad incrementada y reproductibilidad incrementada entre diferentes sujetos y condiciones.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462075801P | 2014-11-05 | 2014-11-05 | |
| US201562129023P | 2015-03-05 | 2015-03-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022000159A true MX2022000159A (es) | 2022-02-21 |
Family
ID=54754736
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017005823A MX2017005823A (es) | 2014-11-05 | 2015-11-04 | Metodos para transduccion y procesamiento celular. |
| MX2022000159A MX2022000159A (es) | 2014-11-05 | 2017-05-03 | Metodos para transduccion y procesamiento celular. |
| MX2021001334A MX2021001334A (es) | 2014-11-05 | 2017-05-03 | Metodos para transduccion y procesamiento celular. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017005823A MX2017005823A (es) | 2014-11-05 | 2015-11-04 | Metodos para transduccion y procesamiento celular. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021001334A MX2021001334A (es) | 2014-11-05 | 2017-05-03 | Metodos para transduccion y procesamiento celular. |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10428351B2 (es) |
| EP (3) | EP4407036A3 (es) |
| JP (3) | JP6740234B2 (es) |
| KR (2) | KR102635942B1 (es) |
| CN (2) | CN107109438B (es) |
| AU (3) | AU2015343121B2 (es) |
| BR (2) | BR112017009220B1 (es) |
| CA (1) | CA2966538A1 (es) |
| CY (1) | CY1123254T1 (es) |
| DK (2) | DK3215601T3 (es) |
| ES (1) | ES2805674T3 (es) |
| FI (1) | FI3757206T3 (es) |
| HR (1) | HRP20201128T1 (es) |
| HU (1) | HUE050264T2 (es) |
| IL (2) | IL292450A (es) |
| LT (1) | LT3215601T (es) |
| MA (1) | MA40318A (es) |
| MX (3) | MX2017005823A (es) |
| MY (1) | MY186199A (es) |
| NZ (2) | NZ769598A (es) |
| PH (1) | PH12017500824A1 (es) |
| PL (2) | PL3215601T3 (es) |
| PT (2) | PT3757206T (es) |
| RS (1) | RS60685B1 (es) |
| SG (2) | SG10202002324SA (es) |
| SI (1) | SI3215601T1 (es) |
| TW (3) | TWI787903B (es) |
| WO (1) | WO2016073602A2 (es) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| DK3143134T3 (da) | 2014-05-15 | 2021-01-04 | Nat Univ Singapore | Modificerede, naturlige dræberceller og anvendelser deraf |
| SG11201703203RA (en) | 2014-10-20 | 2017-05-30 | Juno Therapeutics Inc | Methods and compositions for dosing in adoptive cell therapy |
| PT3757206T (pt) | 2014-11-05 | 2024-05-21 | Juno Therapeutics Inc | Métodos de transdução e processamento de células |
| EP3533876B1 (en) * | 2014-12-19 | 2024-05-22 | Biosafe S.A. | Sequential processing of biological fluids |
| MA41346A (fr) | 2015-01-12 | 2017-11-21 | Juno Therapeutics Inc | Eléments régulateurs post-transcriptionnels d'hépatite modifiée |
| CA2986254A1 (en) | 2015-05-18 | 2016-11-24 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| RU2761555C2 (ru) | 2015-10-22 | 2021-12-09 | Джуно Терапьютикс Гмбх | Способы, наборы, средства и устройства для трансдукции |
| WO2017153974A1 (en) * | 2016-03-07 | 2017-09-14 | Caladrius Biosciences, Inc. | A closed system for labelling and selecting live cells |
| EP3430549A1 (en) | 2016-03-16 | 2019-01-23 | Juno Therapeutics, Inc. | Methods for adaptive design of a treatment regimen and related treatments |
| MA45784A (fr) | 2016-07-29 | 2019-06-05 | Juno Therapeutics Inc | Anticorps anti-idiotypes dirigés contre anti-cd19 anticorps |
| WO2018026953A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| WO2018049420A1 (en) | 2016-09-12 | 2018-03-15 | Juno Therapeutics, Inc. | Perfusion bioreactor bag assemblies |
| KR20190058509A (ko) | 2016-10-07 | 2019-05-29 | 티씨알2 테라퓨틱스 인크. | 융합 단백질을 이용하는 t-세포 수용체 리프로그래밍을 위한 조성물 및 방법 |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| US20200095547A1 (en) * | 2016-12-02 | 2020-03-26 | Darya ALIZADEH | Methods for manufacturing t cells expressing of chimeric antigen receptors and other receptors |
| JP2019536461A (ja) * | 2016-12-05 | 2019-12-19 | ジュノー セラピューティクス インコーポレイテッド | 養子細胞療法のための操作細胞の産生 |
| JP7228522B2 (ja) | 2017-02-27 | 2023-02-24 | ジュノー セラピューティクス インコーポレイテッド | 細胞療法における投薬に関する組成物、製造物品、および方法 |
| EA201992155A1 (ru) | 2017-03-14 | 2020-03-16 | Джуно Терапьютикс, Инк. | Способы криогенного хранения |
| EP3427052A4 (en) * | 2017-03-27 | 2019-12-04 | Hitachi Chemical Advanced Therapeutics Solutions, LLC | CLOSED SYSTEM FOR MARKING AND SELECTING LIVING CELLS |
| AU2018245749A1 (en) | 2017-03-27 | 2019-10-03 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| EP3600356A4 (en) | 2017-03-27 | 2020-12-23 | National University of Singapore | ABBREVIATED NKG2D CHIMERIC RECEPTORS AND USES THEREOF IN IMMUNOTHERAPY WITH NATURAL KILLER CELLS |
| BR112019025403A2 (pt) * | 2017-06-02 | 2020-08-18 | Juno Therapeutics Inc | artigos de fabricação e métodos para tratamento usando terapia celular adotiva |
| WO2019027850A1 (en) | 2017-07-29 | 2019-02-07 | Juno Therapeutics, Inc. | CELL EXPANSION REAGENTS EXPRESSING RECOMBINANT RECEPTORS |
| CA3185343A1 (en) * | 2017-09-01 | 2019-03-07 | Lonza Walkersville, Inc. | End-to-end cell therapy automation |
| US20200292526A1 (en) | 2017-09-07 | 2020-09-17 | Juno Therapeutics, Inc. | Methods of identifying cellular attributes related to outcomes associated with cell therapy |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| CN111542596A (zh) | 2017-11-01 | 2020-08-14 | 朱诺治疗学股份有限公司 | 产生工程化细胞的治疗性组合物的方法 |
| MX2020004239A (es) | 2017-11-01 | 2020-09-09 | Juno Therapeutics Inc | Proceso para producir una composicion de celulas t. |
| JP2021502094A (ja) | 2017-11-10 | 2021-01-28 | ジュノー セラピューティクス インコーポレイテッド | 閉鎖系極低温容器 |
| MX2020005907A (es) | 2017-12-08 | 2020-10-19 | Juno Therapeutics Inc | Formulacion de medio libre de suero para cultivar celulas y metodos de uso de la misma. |
| SG11202005217VA (en) | 2017-12-08 | 2020-07-29 | Juno Therapeutics Inc | Phenotypic markers for cell therapy and related methods |
| JP2021505168A (ja) | 2017-12-08 | 2021-02-18 | ジュノー セラピューティクス インコーポレイテッド | 操作されたｔ細胞の組成物を製造するための方法 |
| JP7470640B2 (ja) | 2018-02-09 | 2024-04-18 | イマティクス ユーエス，アイエヌシー． | Ｔ細胞を製造する方法 |
| AU2019318560A1 (en) | 2018-08-09 | 2021-02-25 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| SG11202101130VA (en) | 2018-08-09 | 2021-03-30 | Juno Therapeutics Inc | Methods for assessing integrated nucleic acids |
| BR112021004261A2 (pt) | 2018-09-11 | 2021-05-25 | Juno Therapeutics Inc | métodos para análise por espectrometria de massas de composições de células geneticamente modificadas |
| SG11202104355SA (en) | 2018-10-31 | 2021-05-28 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| AU2019372331A1 (en) | 2018-11-01 | 2021-05-27 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen |
| JP2022008735A (ja) * | 2018-11-06 | 2022-01-14 | テルモ株式会社 | 細胞製造システム、細胞製造方法、医療装置及び医療デバイス |
| EP3877054B1 (en) | 2018-11-06 | 2023-11-01 | Juno Therapeutics, Inc. | Process for producing genetically engineered t cells |
| US20220008465A1 (en) | 2018-11-16 | 2022-01-13 | Juno Therapeutics, Inc. | Methods of dosing engineered t cells for the treatment of b cell malignancies |
| BR112021010120A2 (pt) | 2018-11-30 | 2021-08-31 | Juno Therapeutics, Inc. | Métodos para dosagem e tratamento de malignidades celulares em terapia celular adotiva |
| SG11202105502RA (en) | 2018-11-30 | 2021-06-29 | Juno Therapeutics Inc | Methods for treatment using adoptive cell therapy |
| SG11202106053SA (en) * | 2018-12-07 | 2021-07-29 | Gracell Biotechnologies Shanghai Co Ltd | Compositions and methods for immunotherapy |
| CA3123314A1 (en) | 2018-12-21 | 2020-06-25 | Octane Biotech Inc. | Carousel for modular biologic production units |
| CN113195725A (zh) | 2018-12-21 | 2021-07-30 | 隆萨沃克斯维尔股份有限公司 | 病毒载体的自动化生产 |
| EP3914690A4 (en) | 2019-02-08 | 2022-11-09 | Lonza Walkersville, Inc. | METHODS AND DEVICES FOR DETERMINING CELL CONCENTRATION IN AUTOMATED BIOREACTORS |
| WO2020180882A1 (en) | 2019-03-05 | 2020-09-10 | Nkarta, Inc. | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| JPWO2020196412A1 (es) * | 2019-03-26 | 2020-10-01 | ||
| BR112021024404A2 (pt) | 2019-06-07 | 2022-04-19 | Juno Therapeutics Inc | Cultura de célula t automatizada |
| US20220306993A1 (en) * | 2019-06-10 | 2022-09-29 | I Peace, Inc. | Erythrocyte removal device, mononuclear cell collector, cell culture device, cell culture system, cell culture method, and mononuclear cell collection method |
| SG11202113356XA (en) | 2019-06-12 | 2021-12-30 | Juno Therapeutics Inc | Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival bcl2 family protein |
| JP2022545467A (ja) | 2019-08-22 | 2022-10-27 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞療法とｚｅｓｔｅホモログ２エンハンサー（ＥＺＨ２）阻害剤との併用療法および関連方法 |
| KR20220073738A (ko) | 2019-08-30 | 2022-06-03 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 분류를 위한 기계 학습 방법 |
| AU2020369940A1 (en) | 2019-10-21 | 2022-05-26 | Flaskworks, Llc | Systems and methods for cell culturing |
| AU2020377043A1 (en) | 2019-10-30 | 2022-06-02 | Juno Therapeutics Gmbh | Cell selection and/or stimulation devices and methods of use |
| KR20220131892A (ko) | 2019-11-05 | 2022-09-29 | 주노 쎄러퓨티크스 인코퍼레이티드 | 치료용 ｔ 세포 조성물의 속성 결정 방법 |
| JP2023504736A (ja) | 2019-12-06 | 2023-02-06 | ジュノー セラピューティクス インコーポレイテッド | Ｇｐｒｃ５ｄ標的結合ドメインに対する抗イディオタイプ抗体ならびに関連する組成物および方法 |
| JP2023504740A (ja) | 2019-12-06 | 2023-02-06 | ジュノー セラピューティクス インコーポレイテッド | Ｂｃｍａ標的結合ドメインに対する抗イディオタイプ抗体ならびに関連する組成物および方法 |
| BR112022010310A2 (pt) | 2019-12-06 | 2022-08-16 | Juno Therapeutics Inc | Métodos relacionados com a toxicidade e resposta associada com terapia celular para tratamento de malignidades de célula b |
| US20240182920A1 (en) * | 2020-01-22 | 2024-06-06 | Carsgen Therapeutics Co., Ltd. | Method for transducing cells with viral vector |
| CN115315269A (zh) | 2020-01-24 | 2022-11-08 | 朱诺治疗学股份有限公司 | 在过继细胞疗法中给药和治疗滤泡性淋巴瘤和边缘区淋巴瘤的方法 |
| CN115427550A (zh) | 2020-01-28 | 2022-12-02 | 朱诺治疗学股份有限公司 | T细胞转导方法 |
| IL294956A (en) * | 2020-02-06 | 2022-09-01 | Cutiss Ag | Apparatus and method for isolating cells |
| AU2021219764A1 (en) | 2020-02-12 | 2022-09-01 | Juno Therapeutics, Inc. | BCMA-directed chimeric antigen receptor T cell compositions and methods and uses thereof |
| US20230190798A1 (en) | 2020-02-12 | 2023-06-22 | Juno Therapeutics, Inc. | Cd19-directed chimeric antigen receptor t cell compositions and methods and uses thereof |
| CN115885036A (zh) * | 2020-04-03 | 2023-03-31 | 米伦纽姆医药公司 | 提高的病毒转导效率 |
| WO2021207689A2 (en) | 2020-04-10 | 2021-10-14 | Juno Therapeutics, Inc. | Methods and uses related to cell therapy engineered with a chimeric antigen receptor targeting b-cell maturation antigen |
| CN115803824A (zh) | 2020-05-13 | 2023-03-14 | 朱诺治疗学股份有限公司 | 鉴定与临床反应相关的特征的方法及其用途 |
| EP4150057A2 (en) | 2020-05-13 | 2023-03-22 | Juno Therapeutics, Inc. | Process for producing donor-batched cells expressing a recombinant receptor |
| KR20230095918A (ko) | 2020-08-05 | 2023-06-29 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ror1-표적 결합 도메인에 대한 항이디오타입 항체 및 관련 조성물 및 방법 |
| WO2022133030A1 (en) | 2020-12-16 | 2022-06-23 | Juno Therapeutics, Inc. | Combination therapy of a cell therapy and a bcl2 inhibitor |
| KR20230137402A (ko) | 2021-02-20 | 2023-10-04 | 카이트 파마 인코포레이티드 | 면역요법 선택을 위한 유전자 마커 |
| US20240168012A1 (en) | 2021-03-22 | 2024-05-23 | Juno Therapeutics, Inc. | Methods of determining potency of a therapeutic cell composition |
| CN117321200A (zh) | 2021-03-22 | 2023-12-29 | 朱诺治疗学股份有限公司 | 评估病毒载体颗粒效力的方法 |
| US20240181052A1 (en) | 2021-03-29 | 2024-06-06 | Juno Therapeutics, Inc. | Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy |
| WO2022234009A2 (en) | 2021-05-06 | 2022-11-10 | Juno Therapeutics Gmbh | Methods for stimulating and transducing t cells |
| KR20230173179A (ko) | 2021-05-14 | 2023-12-26 | 카이트 파마 인코포레이티드 | 키메라 항원 수용체 t세포 요법 |
| CN118742810A (zh) | 2022-02-15 | 2024-10-01 | 凯德药业股份有限公司 | 从免疫疗法预测不良事件 |
| WO2023225569A1 (en) | 2022-05-17 | 2023-11-23 | Umoja Biopharma, Inc. | Manufacturing viral particles |
| WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
| WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
| WO2023250400A1 (en) | 2022-06-22 | 2023-12-28 | Juno Therapeutics, Inc. | Treatment methods for second line therapy of cd19-targeted car t cells |
| WO2024097992A2 (en) | 2022-11-04 | 2024-05-10 | Umoja Biopharma, Inc. | Particles displaying adhesion-molecule fusions |
| WO2024098038A2 (en) | 2022-11-04 | 2024-05-10 | Umoja Biopharma, Inc. | Polynucleotide construct and related viral vectors and methods |
| WO2024124132A1 (en) | 2022-12-09 | 2024-06-13 | Juno Therapeutics, Inc. | Machine learning methods for predicting cell phenotype using holographic imaging |
| WO2024145732A1 (zh) * | 2023-01-03 | 2024-07-11 | 深圳华大生命科学研究院 | 分选流体系统及相关设备、流体分选方法及细胞分选方法 |
| US20240285762A1 (en) | 2023-02-28 | 2024-08-29 | Juno Therapeutics, Inc. | Cell therapy for treating systemic autoimmune diseases |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4163519A (en) | 1977-11-01 | 1979-08-07 | Union Carbide Corporation | Compensating rotor |
| US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
| IN165717B (es) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| SE454413B (sv) | 1986-09-12 | 1988-05-02 | Alfa Laval Separation Ab | Centrifugalseparator med en rotor, vari ett bojligt organ strecker sig ett stycke lengs rotorns omkrets |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| WO1990007380A2 (en) | 1988-12-28 | 1990-07-12 | Stefan Miltenyi | Methods and materials for high gradient magnetic separation of biological materials |
| US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
| EP0557459B1 (en) | 1990-11-13 | 1997-10-22 | Immunex Corporation | Bifunctional selectable fusion genes |
| US5911983A (en) * | 1992-06-26 | 1999-06-15 | University Of Pittsburgh | Gene therapy for Gaucher disease using retroviral vectors |
| EP0804590A1 (en) | 1993-05-21 | 1997-11-05 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| US5437998A (en) * | 1993-09-09 | 1995-08-01 | Synthecon, Inc. | Gas permeable bioreactor and method of use |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| CA2238434A1 (en) | 1995-12-15 | 1997-06-19 | Systemix, Inc. | Method for obtaining retroviral vector supernatant having high transduction efficiency |
| DE19608753C1 (de) | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduktionssystem und seine Verwendung |
| US6451995B1 (en) | 1996-03-20 | 2002-09-17 | Sloan-Kettering Institute For Cancer Research | Single chain FV polynucleotide or peptide constructs of anti-ganglioside GD2 antibodies, cells expressing same and related methods |
| ATE186235T1 (de) | 1996-04-24 | 1999-11-15 | Claude Fell | Zelltrennungsvorrichtung für biologische flüssigkeiten wie blut |
| EP0995802B1 (en) * | 1998-07-10 | 2009-12-23 | Universite Pierre Et Marie Curie | Method for the delivery of nucleic acids to cells in vitro or ex vivo |
| EP1109921A4 (en) | 1998-09-04 | 2002-08-28 | Sloan Kettering Inst Cancer | FOR PROSTATE-SPECIFIC MEMBRANE-ANTI-SPECIFIC FUSION RECEPTORS AND THEIR USE |
| AU2472400A (en) | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| AU1675600A (en) | 1998-12-24 | 2000-07-31 | Biosafe S.A. | Blood separation system particularly for concentrating hematopoietic stem cells |
| US20030119185A1 (en) * | 2000-02-24 | 2003-06-26 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| US20020131960A1 (en) | 2000-06-02 | 2002-09-19 | Michel Sadelain | Artificial antigen presenting cells and methods of use thereof |
| AU2001297703B2 (en) | 2000-11-07 | 2006-10-19 | City Of Hope | CD19-specific redirected immune cells |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| DE10136375A1 (de) | 2001-07-26 | 2003-02-13 | Cellgenix Technologie Transfer | Verfahren zur Anreicherung von Zellen |
| US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
| US7001513B2 (en) | 2003-08-06 | 2006-02-21 | Nuvue Technologies, Inc. | Automated processing of a biological component |
| US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| CN101146559B (zh) | 2005-03-23 | 2012-09-05 | 生物安全股份有限公司 | 用于再生医学的收集、处理和移植包括成人干细胞的细胞亚群的集成系统 |
| JP5453629B2 (ja) * | 2006-08-23 | 2014-03-26 | タカラバイオ株式会社 | 遠心用袋状容器を使用した遺伝子導入方法 |
| CA2682527C (en) | 2007-03-30 | 2017-07-11 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes |
| EP3338895B1 (en) | 2007-12-07 | 2022-08-10 | Miltenyi Biotec B.V. & Co. KG | Sample processing systems and methods |
| US8479118B2 (en) | 2007-12-10 | 2013-07-02 | Microsoft Corporation | Switching search providers within a browser search box |
| JP5173594B2 (ja) | 2008-05-27 | 2013-04-03 | キヤノン株式会社 | 管理装置、画像形成装置及びそれらの処理方法 |
| JP5746025B2 (ja) * | 2008-07-16 | 2015-07-08 | ケーセップ・システムズ，リミテッド・ライアビリティ・カンパニー | 流動床を使用して粒子を操作するための方法及びシステム |
| SI2496698T1 (sl) | 2009-11-03 | 2019-07-31 | City Of Hope | Skrajšan epiderimalni receptor faktorja rasti (EGFRt) za selekcijo transduciranih T celic |
| WO2011116221A1 (en) | 2010-03-18 | 2011-09-22 | Synergenesis, Inc. | System for purifying certain cell populations in blood or bone marrow by depleting others |
| SE535275C2 (sv) | 2010-03-31 | 2012-06-12 | Alfa Laval Corp Ab | Centrifugalseparator och rotor |
| CN103002932B (zh) * | 2010-07-15 | 2015-04-22 | 泰尔茂比司特公司 | 在用于生物流体的离心装置中优化旋转时间的方法 |
| SG190997A1 (en) | 2010-12-09 | 2013-07-31 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| SG192010A1 (en) * | 2011-01-18 | 2013-08-30 | Univ Pennsylvania | Compositions and methods for treating cancer |
| CN106074601A (zh) | 2011-03-23 | 2016-11-09 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| US8398282B2 (en) | 2011-05-12 | 2013-03-19 | Delphi Technologies, Inc. | Vehicle front lighting assembly and systems having a variable tint electrowetting element |
| EP2714886B1 (en) * | 2011-05-30 | 2020-01-22 | Atech Partners Ltd. | Bioreactor system for continuous cell cultivation |
| CN102329776B (zh) * | 2011-07-20 | 2013-02-27 | 华中农业大学 | 一种表达Nectin-1基因胞外区片段的PK-15细胞系及其构建方法 |
| WO2013051718A1 (ja) * | 2011-10-07 | 2013-04-11 | 国立大学法人三重大学 | キメラ抗原受容体 |
| US10208086B2 (en) | 2011-11-11 | 2019-02-19 | Fred Hutchinson Cancer Research Center | Cyclin A1-targeted T-cell immunotherapy for cancer |
| EP2594632A1 (en) * | 2011-11-18 | 2013-05-22 | Miltenyi Biotec GmbH | Method and device for cell modification |
| JP6850528B2 (ja) | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
| EP2817625A2 (en) * | 2012-02-23 | 2014-12-31 | Stage Cell Therapeutics GmbH | Chromatographic isolation of cells and other complex biological materials |
| EP2820138B1 (en) | 2012-02-29 | 2020-10-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Retroviral transduction using poloxamers |
| SG11201405185PA (en) | 2012-03-13 | 2014-10-30 | Emd Millipore Corp | Use of centrifugation-aided infection to increase virus titer |
| US9751928B2 (en) | 2012-05-03 | 2017-09-05 | Fred Hutchinson Cancer Research Center | Enhanced affinity T cell receptors and methods for making the same |
| EP2855666B1 (en) * | 2012-05-25 | 2019-12-04 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| EP2698208A1 (de) | 2012-08-14 | 2014-02-19 | Fresenius Kabi Deutschland GmbH | Zentrifugenvorrichtung und Verfahren zum Betreiben einer Zentrifugenvorrichtung |
| RU2700765C2 (ru) | 2012-08-20 | 2019-09-19 | Фред Хатчинсон Кансэр Рисёч Сентер | Способ и композиции для клеточной иммунотерапии |
| WO2014055668A1 (en) | 2012-10-02 | 2014-04-10 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
| WO2014097442A1 (ja) | 2012-12-20 | 2014-06-26 | 三菱電機株式会社 | 車載装置及びプログラム |
| EP3241897B1 (en) * | 2013-03-07 | 2018-10-03 | Baylor College of Medicine | Targeting cd138 in cancer |
| TWI654206B (zh) * | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
| ES2831315T3 (es) * | 2013-04-03 | 2021-06-08 | Memorial Sloan Kettering Cancer Center | Generación efectiva de células T dirigidas al tumor derivadas de células madre pluripotentes |
| US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
| BR112016009898A2 (pt) | 2013-10-31 | 2017-12-05 | Hutchinson Fred Cancer Res | células-tronco/progenitoras hematopoiéticas e efetoras não-t modificadas e usos das mesmas |
| KR20220136455A (ko) | 2014-04-23 | 2022-10-07 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 치료용 면역 세포 집단의 단리, 배양 및 유전자 조작 방법 |
| US10131876B2 (en) | 2014-04-24 | 2018-11-20 | Miltenyi Biotec Gmbh | Method for automated generation of genetically modified T cells |
| PT3757206T (pt) | 2014-11-05 | 2024-05-21 | Juno Therapeutics Inc | Métodos de transdução e processamento de células |
| MA41346A (fr) | 2015-01-12 | 2017-11-21 | Juno Therapeutics Inc | Eléments régulateurs post-transcriptionnels d'hépatite modifiée |
-
2015
- 2015-11-04 PT PT201760477T patent/PT3757206T/pt unknown
- 2015-11-04 EP EP24168832.4A patent/EP4407036A3/en active Pending
- 2015-11-04 CN CN201580072404.4A patent/CN107109438B/zh active Active
- 2015-11-04 PT PT158022319T patent/PT3215601T/pt unknown
- 2015-11-04 ES ES15802231T patent/ES2805674T3/es active Active
- 2015-11-04 WO PCT/US2015/059030 patent/WO2016073602A2/en active Application Filing
- 2015-11-04 RS RS20200887A patent/RS60685B1/sr unknown
- 2015-11-04 LT LTEP15802231.9T patent/LT3215601T/lt unknown
- 2015-11-04 KR KR1020177015404A patent/KR102635942B1/ko active IP Right Grant
- 2015-11-04 IL IL292450A patent/IL292450A/en unknown
- 2015-11-04 TW TW110125506A patent/TWI787903B/zh active
- 2015-11-04 KR KR1020247004412A patent/KR20240023204A/ko active Application Filing
- 2015-11-04 AU AU2015343121A patent/AU2015343121B2/en active Active
- 2015-11-04 TW TW104136385A patent/TWI735418B/zh active
- 2015-11-04 SI SI201531268T patent/SI3215601T1/sl unknown
- 2015-11-04 PL PL15802231T patent/PL3215601T3/pl unknown
- 2015-11-04 SG SG10202002324SA patent/SG10202002324SA/en unknown
- 2015-11-04 MA MA040318A patent/MA40318A/fr unknown
- 2015-11-04 SG SG11201703656PA patent/SG11201703656PA/en unknown
- 2015-11-04 TW TW111132488A patent/TW202315948A/zh unknown
- 2015-11-04 EP EP15802231.9A patent/EP3215601B1/en active Active
- 2015-11-04 PL PL20176047.7T patent/PL3757206T3/pl unknown
- 2015-11-04 MY MYPI2017000656A patent/MY186199A/en unknown
- 2015-11-04 NZ NZ769598A patent/NZ769598A/en unknown
- 2015-11-04 IL IL252126A patent/IL252126B/en unknown
- 2015-11-04 HU HUE15802231A patent/HUE050264T2/hu unknown
- 2015-11-04 NZ NZ769595A patent/NZ769595A/en unknown
- 2015-11-04 BR BR112017009220-4A patent/BR112017009220B1/pt active IP Right Grant
- 2015-11-04 CN CN202111026157.8A patent/CN113736828A/zh active Pending
- 2015-11-04 DK DK15802231.9T patent/DK3215601T3/da active
- 2015-11-04 EP EP20176047.7A patent/EP3757206B1/en active Active
- 2015-11-04 DK DK20176047.7T patent/DK3757206T3/da active
- 2015-11-04 CA CA2966538A patent/CA2966538A1/en not_active Abandoned
- 2015-11-04 FI FIEP20176047.7T patent/FI3757206T3/fi not_active Application Discontinuation
- 2015-11-04 BR BR122020002722-3A patent/BR122020002722B1/pt not_active IP Right Cessation
- 2015-11-04 MX MX2017005823A patent/MX2017005823A/es unknown
- 2015-11-04 JP JP2017543300A patent/JP6740234B2/ja active Active
- 2015-11-04 US US14/932,660 patent/US10428351B2/en active Active
-
2017
- 2017-05-03 MX MX2022000159A patent/MX2022000159A/es unknown
- 2017-05-03 MX MX2021001334A patent/MX2021001334A/es unknown
- 2017-05-04 PH PH12017500824A patent/PH12017500824A1/en unknown
-
2019
- 2019-08-14 US US16/541,083 patent/US11802295B2/en active Active
-
2020
- 2020-07-17 HR HRP20201128TT patent/HRP20201128T1/hr unknown
- 2020-07-22 JP JP2020124934A patent/JP7202332B2/ja active Active
- 2020-08-13 CY CY20201100763T patent/CY1123254T1/el unknown
- 2020-09-14 AU AU2020233623A patent/AU2020233623B2/en active Active
-
2022
- 2022-11-03 AU AU2022263539A patent/AU2022263539A1/en active Pending
- 2022-12-23 JP JP2022206247A patent/JP2023024691A/ja active Pending
-
2023
- 2023-09-21 US US18/371,302 patent/US20240011051A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12017500824A1 (en) | Methods for transduction and cell processing | |
| MX2021013486A (es) | Viriones de virus adenoasociados con capside variante y metodos para su uso. | |
| BR112020003925A2 (pt) | Produtos alimentícios comestíveis e projetos de biorreator | |
| MA39867A (fr) | Procédés d'isolement, de culture et de manipulation génétique de populations de cellules immunitaires pour une thérapie adoptive | |
| MX2019010735A (es) | Sistemas y metodos para la produccion dirigida de una proteina terapeutica dentro de una celula objetivo. | |
| MX2018012880A (es) | Metodos para proporcionar arn de hebra sencilla. | |
| WO2017044857A3 (en) | Methods and compositions for the treatment of glaucoma | |
| WO2016090178A3 (en) | Processes for producing exosomes in reduced oxygen culture conditions | |
| SG10201902574RA (en) | Adeno-associated virus vector variants for high efficiency genome editing and methods thereof | |
| SG10201900323SA (en) | Method for inducing t cells for cell-based immunotherapy from pluripotent stem cells | |
| MX370018B (es) | Metodos mejorados para la elaboracion de terapias celulares adoptivas. | |
| GB2548740A (en) | Methods for generation of podocytes from pluripotent stem cells and cells produced by the same | |
| EP4374863A3 (en) | Methods for generating stem cell-derived beta cells and uses thereof | |
| MX2015012709A (es) | Moleculas biespecificas que son inmunorreactivas con celulas efectoras inmunes que expresan un receptor activador y un antigeno expresado por una celula infectada por un virus y usos de las mismas. | |
| AU2017241807A1 (en) | Medium, methods, cells and secreted factors for stem cell culture and therapy | |
| MX2017009937A (es) | Cepas fungicas y metodos de uso. | |
| SG10201901559SA (en) | Retinal ganglion cells and progenitors thereof | |
| EP4234032A3 (en) | Induction medium and methods for stem cell culture and therapy | |
| EP3489351A4 (en) | CELL CULTIVATION METHOD, SUSPENDED CELL ELIMINATION METHOD AND METHOD FOR KILLING SUSPENDED CELLS | |
| MX2020011254A (es) | Celulas t car anti-bcma para agotamiento de celulas de plasma. | |
| MX2018011980A (es) | 3-epimerasa y polinucleotido que la codifica. | |
| EP4275746A3 (en) | Extracellular vesicles derived from osteoblastic lineage cells for therapeutic and diagnostic use | |
| AU2018337668A1 (en) | Improved supraparticles | |
| AU2016250096A8 (en) | Method and system for microbiome-derived characterization, diagnostics and therapeutics for conditions associated with functional features | |
| EA202190474A1 (ru) | Терапия на основе микро-рнк, направленная против lcp-1-позитивных раковых опухолей |