MX2009008574A - Moduladores del receptor de grelina macrociclicos y metodos para usar el mismo. - Google Patents
Moduladores del receptor de grelina macrociclicos y metodos para usar el mismo.Info
- Publication number
- MX2009008574A MX2009008574A MX2009008574A MX2009008574A MX2009008574A MX 2009008574 A MX2009008574 A MX 2009008574A MX 2009008574 A MX2009008574 A MX 2009008574A MX 2009008574 A MX2009008574 A MX 2009008574A MX 2009008574 A MX2009008574 A MX 2009008574A
- Authority
- MX
- Mexico
- Prior art keywords
- disorders
- ghrelin receptor
- methods
- compounds
- same
- Prior art date
Links
- 102000000393 Ghrelin Receptors Human genes 0.000 title abstract 4
- 108010016122 Ghrelin Receptors Proteins 0.000 title abstract 4
- 208000008589 Obesity Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000017701 Endocrine disease Diseases 0.000 abstract 1
- -1 GHS-R1a and subtypes Proteins 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 208000026350 Inborn Genetic disease Diseases 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000016361 genetic disease Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 150000002678 macrocyclic compounds Chemical class 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
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- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D498/04—Ortho-condensed systems
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- C07D498/16—Peri-condensed systems
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- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
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- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Child & Adolescent Psychology (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88916307P | 2007-02-09 | 2007-02-09 | |
| PCT/US2008/001754 WO2008130464A1 (en) | 2007-02-09 | 2008-02-08 | Macrocyclic ghrelin receptor modulators and methods of using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009008574A true MX2009008574A (es) | 2009-12-09 |
Family
ID=39497450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009008574A MX2009008574A (es) | 2007-02-09 | 2008-02-08 | Moduladores del receptor de grelina macrociclicos y metodos para usar el mismo. |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US9371297B2 (enExample) |
| EP (2) | EP2118080B1 (enExample) |
| JP (2) | JP2010518090A (enExample) |
| KR (1) | KR20090107088A (enExample) |
| CN (1) | CN101657436A (enExample) |
| AU (1) | AU2008241532A1 (enExample) |
| BR (1) | BRPI0807046A2 (enExample) |
| CA (1) | CA2677399C (enExample) |
| EA (1) | EA200901077A1 (enExample) |
| ES (2) | ES2604943T3 (enExample) |
| MX (1) | MX2009008574A (enExample) |
| WO (1) | WO2008130464A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7476653B2 (en) * | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| US8921521B2 (en) | 2003-06-18 | 2014-12-30 | Ocera Therapeutics, Inc. | Macrocyclic modulators of the Ghrelin receptor |
| US20090198050A1 (en) * | 2003-06-18 | 2009-08-06 | Tranzyme Pharma Inc. | Macrocyclic Modulators of the Ghrelin Receptor |
| US7491695B2 (en) | 2003-06-18 | 2009-02-17 | Tranzyme Pharma Inc. | Methods of using macrocyclic modulators of the ghrelin receptor |
| JP4928261B2 (ja) * | 2003-06-18 | 2012-05-09 | トランザイム・ファーマ・インコーポレイテッド | モチリン受容体の大環状拮抗薬 |
| US8088733B2 (en) * | 2006-07-06 | 2012-01-03 | Tranzyme Pharma Inc. | Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders |
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-
2008
- 2008-02-08 CN CN200880010587A patent/CN101657436A/zh active Pending
- 2008-02-08 ES ES08799889.4T patent/ES2604943T3/es active Active
- 2008-02-08 EP EP08799889.4A patent/EP2118080B1/en active Active
- 2008-02-08 MX MX2009008574A patent/MX2009008574A/es not_active Application Discontinuation
- 2008-02-08 BR BRPI0807046-6A patent/BRPI0807046A2/pt not_active IP Right Cessation
- 2008-02-08 EA EA200901077A patent/EA200901077A1/ru unknown
- 2008-02-08 WO PCT/US2008/001754 patent/WO2008130464A1/en not_active Ceased
- 2008-02-08 AU AU2008241532A patent/AU2008241532A1/en not_active Abandoned
- 2008-02-08 EP EP12195556.1A patent/EP2644618B1/en not_active Not-in-force
- 2008-02-08 CA CA2677399A patent/CA2677399C/en not_active Expired - Fee Related
- 2008-02-08 ES ES12195556.1T patent/ES2602789T3/es active Active
- 2008-02-08 JP JP2009549129A patent/JP2010518090A/ja active Pending
- 2008-02-08 KR KR1020097018709A patent/KR20090107088A/ko not_active Withdrawn
- 2008-02-08 US US12/028,611 patent/US9371297B2/en not_active Expired - Fee Related
-
2014
- 2014-03-19 JP JP2014056805A patent/JP6047514B2/ja not_active Expired - Fee Related
-
2016
- 2016-06-09 US US15/178,303 patent/US9949949B2/en active Active
-
2018
- 2018-03-28 US US15/938,038 patent/US10258602B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008130464A1 (en) | 2008-10-30 |
| CA2677399C (en) | 2016-09-13 |
| KR20090107088A (ko) | 2009-10-12 |
| AU2008241532A1 (en) | 2008-10-30 |
| CA2677399A1 (en) | 2008-10-30 |
| BRPI0807046A2 (pt) | 2015-05-26 |
| JP6047514B2 (ja) | 2016-12-21 |
| EP2118080A1 (en) | 2009-11-18 |
| US20170042858A1 (en) | 2017-02-16 |
| CN101657436A (zh) | 2010-02-24 |
| EA200901077A1 (ru) | 2010-04-30 |
| US9371297B2 (en) | 2016-06-21 |
| US20080194672A1 (en) | 2008-08-14 |
| ES2602789T3 (es) | 2017-02-22 |
| EP2644618B1 (en) | 2016-08-17 |
| EP2118080B1 (en) | 2016-08-31 |
| US20180228768A1 (en) | 2018-08-16 |
| EP2644618A1 (en) | 2013-10-02 |
| JP2014141507A (ja) | 2014-08-07 |
| US9949949B2 (en) | 2018-04-24 |
| JP2010518090A (ja) | 2010-05-27 |
| ES2604943T3 (es) | 2017-03-10 |
| US10258602B2 (en) | 2019-04-16 |
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