EA199800337A1 - Способ получения гормона роста, усиливающего секрецию - Google Patents
Способ получения гормона роста, усиливающего секрециюInfo
- Publication number
- EA199800337A1 EA199800337A1 EA199800337A EA199800337A EA199800337A1 EA 199800337 A1 EA199800337 A1 EA 199800337A1 EA 199800337 A EA199800337 A EA 199800337A EA 199800337 A EA199800337 A EA 199800337A EA 199800337 A1 EA199800337 A1 EA 199800337A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- growth hormone
- growth
- secretion
- strengthen
- obtaining
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Настоящее изобретение относится к новому способу получения соединения N-[1(R)-[(1,2-дигидро-1-метансульфонилспиро[3Н-индол-3,4'-пиперидин]-1'-ил)карбонил]-2-(фенилметилокси)этил]-2-амино-2-метилпропанамида и его солей, имеющего структуру (1) и обладающего способностью стимулировать выделение природного или эндогенного гормона роста. Это соединение может быть использовано в тех случаях, когда требуется стимуляция выработки или выделения гормона роста, например, у людей с недостатком природного гормона роста или у животных, используемых для получения пищевых продуктов или шерсти, где стимуляция гормона роста приведет к выращиванию более крупных и продуктивных животных.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US589895P | 1995-10-27 | 1995-10-27 | |
GBGB9602949.1A GB9602949D0 (en) | 1996-02-13 | 1996-02-13 | Process for the preparation of a growth hormone secretagogue |
PCT/US1996/016954 WO1997015573A1 (en) | 1995-10-27 | 1996-10-23 | Process for the preparation of a growth hormone secretagogue |
Publications (1)
Publication Number | Publication Date |
---|---|
EA199800337A1 true EA199800337A1 (ru) | 1998-10-29 |
Family
ID=27268123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199800337A EA199800337A1 (ru) | 1995-10-27 | 1996-10-23 | Способ получения гормона роста, усиливающего секрецию |
Country Status (2)
Country | Link |
---|---|
US (1) | US5723616A (ru) |
EA (1) | EA199800337A1 (ru) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6123964A (en) * | 1995-10-27 | 2000-09-26 | Merck & Co., Inc. | Wet granulation formulation of a growth hormone secretagogue |
US6028196A (en) * | 1995-10-27 | 2000-02-22 | Merck & Co., Inc. | Process for the preparation of a growth hormone secretagogue |
WO1997017351A1 (en) * | 1995-11-08 | 1997-05-15 | Smithkline Beecham Plc | Spiro piperidine derivatives as 5mt receptor antagonists |
US6046333A (en) * | 1996-10-25 | 2000-04-04 | Merck & Co., Inc. | Convergent process for the preparation of a growth hormone secretagogue |
US6194402B1 (en) | 1998-09-02 | 2001-02-27 | Merck & Co., Inc. | Enhancement of return to independent living status with a growth hormone secretagogue |
CA2341649A1 (en) * | 1998-09-02 | 2000-03-09 | Merck & Co., Inc. | Enhancement of return to independent living status with a growth hormone secretagogue |
US6696063B1 (en) * | 1998-12-30 | 2004-02-24 | Applied Research Systems Ars Holding N.V. | Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy |
CA2362290A1 (en) | 1999-02-18 | 2000-08-24 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives as growth hormone secretagogues |
US20010020012A1 (en) * | 2000-02-01 | 2001-09-06 | Andersen Maibritt Bansholm | Use of compounds for the regulation of food intake |
CA2420535A1 (en) * | 2000-08-30 | 2002-03-07 | Mary Tanya Am Ende | Sustained release formulations for growth hormone secretagogues |
GB0313772D0 (en) * | 2003-06-13 | 2003-07-23 | Merck Sharp & Dohme | Therapeutic treatment |
US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
WO2005027913A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue |
EP1682136A4 (en) * | 2003-11-04 | 2009-06-03 | Elixir Pharmaceuticals Inc | THERAPEUTIC COMPOUNDS AND CORRESPONDING USES THEREOF |
CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
EP2118080B1 (en) | 2007-02-09 | 2016-08-31 | Ocera Therapeutics, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5578593A (en) * | 1992-12-11 | 1996-11-26 | Merck & Co., Inc. | Spiro piperidines and homologs promote release of growth hormone |
EP0702681A1 (en) * | 1993-06-07 | 1996-03-27 | Merck & Co. Inc. | Spiro-substituted azacycles as neurokinin antagonists |
-
1996
- 1996-10-23 EA EA199800337A patent/EA199800337A1/ru unknown
- 1996-10-23 US US08/736,173 patent/US5723616A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5723616A (en) | 1998-03-03 |
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