ME03425B - Cot modulatori i postupci za njihovu upotrebu - Google Patents

Cot modulatori i postupci za njihovu upotrebu

Info

Publication number
ME03425B
ME03425B MEP-2019-117A MEP2019117A ME03425B ME 03425 B ME03425 B ME 03425B ME P2019117 A MEP2019117 A ME P2019117A ME 03425 B ME03425 B ME 03425B
Authority
ME
Montenegro
Prior art keywords
methods
cot
modulators
cot modulators
Prior art date
Application number
MEP-2019-117A
Other languages
German (de)
English (en)
French (fr)
Unknown language (me)
Inventor
Elizabeth M Bacon
Gayatri Balan
Chien-Hung Chou
Christopher T Clark
Jeromy J Cottell
Musong Kim
Thorsten A Kirschberg
John O Link
Gary Phillips
Scott D Schroeder
Neil H Squires
Kirk L Stevens
James G Taylor
William J Watkins
Nathan E Wright
Sheila M Zipfel
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of ME03425B publication Critical patent/ME03425B/me

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    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/42Nitrogen atoms attached in position 4
    • C07D215/44Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
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    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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MEP-2019-117A 2015-07-06 2016-06-30 Cot modulatori i postupci za njihovu upotrebu ME03425B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562189158P 2015-07-06 2015-07-06
US201562269060P 2015-12-17 2015-12-17
PCT/US2016/040520 WO2017007689A1 (en) 2015-07-06 2016-06-30 Cot modulators and methods of use thereof
EP16738976.6A EP3191470B1 (en) 2015-07-06 2016-06-30 Cot modulators and methods of use thereof

Publications (1)

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ME03425B true ME03425B (me) 2020-01-20

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JP (6) JP6430060B2 (enExample)
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CN (4) CN109879859B (enExample)
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Families Citing this family (39)

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ES2553449T3 (es) 2011-07-06 2015-12-09 Gilead Sciences, Inc. Compuestos para el tratamiento de VIH
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
US20170008905A1 (en) 2015-07-06 2017-01-12 Gilead Sciences, Inc. Cot modulators and methods of use thereof
PL3319955T3 (pl) 2015-07-06 2021-05-04 Gilead Sciences, Inc. 6-aminochinolino-3-karbonitryle jako modulatory cot
ES2800339T3 (es) 2016-06-30 2020-12-29 Gilead Sciences Inc 4,6-diaminoquinazolinas como moduladores de cuna y métodos de uso de los mismos
SI3597646T1 (sl) * 2016-08-19 2023-10-30 Gilead Sciences, Inc. Terapevtske spojine, uporabne za profilaktično ali terapevtsko zdravljenje okužbe z virusom hiv
EA036921B1 (ru) * 2017-02-10 2021-01-15 Джилид Сайэнс, Инк. Терапевтические соединения, которые можно применять для профилактического или терапевтического лечения инфекции вирусом вич
CN108794516A (zh) * 2017-04-26 2018-11-13 上海时莱生物技术有限公司 硼酸和硼酸酯类化合物及其制备方法和用途
AR112412A1 (es) 2017-08-17 2019-10-23 Gilead Sciences Inc Formas de sal de colina de un inhibidor de la cápside del vih
TWI687415B (zh) 2017-08-17 2020-03-11 美商基利科學股份有限公司 Hiv蛋白質膜抑制劑之固體形式
JPWO2019065516A1 (ja) * 2017-09-26 2020-09-10 日本曹達株式会社 キノリン化合物および農園芸用殺菌剤
ES2958828T3 (es) 2018-02-15 2024-02-15 Gilead Sciences Inc Derivados de piridina y su uso para tratar una infección por VIH
JP7038843B2 (ja) 2018-02-16 2022-03-18 ギリアード サイエンシーズ, インコーポレイテッド Retroviridaeウイルス感染の処置において有用な治療用化合物を調製するための方法および中間体
US11760701B2 (en) 2018-02-27 2023-09-19 The Research Foundation For The State University Of New Yrok Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
CN110294660B (zh) * 2018-03-23 2021-09-24 中国农业大学 一种含碳碳三键和/或碳氮三键的不饱和有机化合物的还原氘化方法
CN108658996A (zh) * 2018-06-25 2018-10-16 中国药科大学 一种氘代Fiduxosin的制备方法
EP3823621A1 (en) 2018-07-16 2021-05-26 Gilead Sciences, Inc. Capsid inhibitors for the treatment of hiv
TW202235416A (zh) 2019-06-14 2022-09-16 美商基利科學股份有限公司 Cot 調節劑及其使用方法
CN114206893A (zh) 2019-08-09 2022-03-18 爱杜西亚药品有限公司 (杂)芳基-甲基-硫代-β-D-吡喃半乳糖苷衍生物
CA3147078A1 (en) 2019-08-09 2021-02-18 Martin Bolli (2-acetamidyl)thio-beta-d-galactopyranoside derivatives
JP7604457B2 (ja) 2019-08-15 2024-12-23 イドルシア・ファーマシューティカルズ・リミテッド 2-ヒドロキシシクロアルカン-1-カルバモイル誘導体
RS65294B1 (sr) 2019-08-29 2024-04-30 Idorsia Pharmaceuticals Ltd Derivati alfa-d-galaktopiranozida
KR20220106165A (ko) 2019-11-26 2022-07-28 길리애드 사이언시즈, 인코포레이티드 Hiv의 예방을 위한 캡시드 억제제
EP4126231A1 (en) * 2020-03-30 2023-02-08 Gilead Sciences, Inc. Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound
CN115397824B (zh) * 2020-04-02 2024-10-22 吉利德科学公司 用于制备cot抑制剂化合物的方法
CA3181690A1 (en) 2020-06-25 2021-12-30 Chienhung CHOU Capsid inhibitors for the treatment of hiv
IL301815A (en) 2020-10-06 2023-06-01 Idorsia Pharmaceuticals Ltd Spiro derivatives of alpha-d-galactopyranosides
JP2023547241A (ja) 2020-11-02 2023-11-09 イドーシア ファーマシューティカルズ リミテッド ガレクチン-3を阻害する2-ヒドロキシシクロアルカン-1-カルバモイル誘導体
KR20230145111A (ko) 2021-02-09 2023-10-17 이도르시아 파마슈티컬스 리미티드 히드록시헤테로시클로알칸-카르바모일 유도체
IL305581A (en) 2021-03-03 2023-10-01 Idorsia Pharmaceuticals Ltd Triazolyl-methyl-converted alpha-D-galactopyranoside histories
TW202304435A (zh) * 2021-06-04 2023-02-01 美商基利科學股份有限公司 治療nash之方法
AU2022289728A1 (en) * 2021-06-11 2023-11-16 Neuronascent, Inc. Methods and compositions for lipid formulation of lipophilic small molecule therapies of the heterocyclic type
US12404262B2 (en) 2021-12-03 2025-09-02 Gilead Sciences, Inc. Therapeutic compounds for HIV virus infection
CA3237155A1 (en) 2021-12-03 2023-06-08 Zhimin Du Therapeutic compounds for hiv virus infection
HUE072195T2 (hu) 2021-12-03 2025-10-28 Gilead Sciences Inc Terápiás vegyületek HIV-vírusfertõzésre
WO2024245157A1 (zh) * 2023-05-30 2024-12-05 浙江星浩澎博医药有限公司 氮杂喹啉环衍生物
WO2024249983A1 (en) * 2023-06-02 2024-12-05 Westol, Llc 2,8-dihydroxyquinoline glucuronide derivatives with enhanced properties for use as anticancer, antiviral, antimicrobial, and other therapeutic applications
WO2025020886A1 (zh) * 2023-07-27 2025-01-30 浙江星浩澎博医药有限公司 氮杂喹唑啉环衍生物及其用途
KR102732584B1 (ko) 2024-03-28 2024-11-21 (주)신한티이씨 전기 배전반의 화재 위험 감지 및 진압용 소화 장치

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3930837A (en) 1971-12-31 1976-01-06 Ici Australia Limited 3-chloro-5-acetamidaisoquinoline as a herbicide
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
NL7800191A (nl) 1977-01-10 1978-07-12 Ciba Geigy Anthelmintisch preparaat.
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US5364620A (en) 1983-12-22 1994-11-15 Elan Corporation, Plc Controlled absorption diltiazem formulation for once daily administration
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US4902514A (en) 1988-07-21 1990-02-20 Alza Corporation Dosage form for administering nilvadipine for treating cardiovascular symptoms
JP2634438B2 (ja) 1988-07-26 1997-07-23 三井東圧化学株式会社 不斉ビスオキサゾリルピリジン誘導体およびその製造方法
DE4014171A1 (de) 1990-05-03 1991-11-07 Basf Ag Cyanochinolinverbindungen
GB9310700D0 (en) 1993-05-24 1993-07-07 Zeneca Ltd Novel composition
UA73073C2 (uk) * 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
KR20010022781A (ko) 1997-08-28 2001-03-26 도쿠시마 히데이치 시아노아크릴레이트 화합물을 함유하는 공업용 항균·항진균제, 살조제(殺藻劑) 및 생물 부착 방지제
ES2257864T3 (es) 1998-07-10 2006-08-01 Massachusetts Institute Of Technology Ligandos para metales y procesos mejorados catalizados por metales basados en los mismos.
SI2253620T1 (sl) 1998-09-29 2014-06-30 Wyeth Holdings Llc Substituirani 3-cianokinolini kot inhibitorji protein tirozin-kinaz
RS81904A (sr) 2002-03-20 2007-02-05 Bristol-Myers Squibb Company, Fosfatni prolekovi fluorooksindola
ATE381334T1 (de) 2003-03-03 2008-01-15 Hoffmann La Roche 2,5-substituiertetetrahydroisochinoline zur verwendung als 5-ht6 modulatoren
WO2005019201A2 (en) 2003-08-19 2005-03-03 Wyeth Holdings Corporation Process for the preparation of 4-amino-3-quinolinecarbonitriles
US7399865B2 (en) * 2003-09-15 2008-07-15 Wyeth Protein tyrosine kinase enzyme inhibitors
TW200529846A (en) * 2004-02-20 2005-09-16 Wyeth Corp 3-quinolinecarbonitrile protein kinase inhibitors
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
CN101223170A (zh) * 2005-05-18 2008-07-16 惠氏公司 Tpl2激酶的4,6-二氨基-[1,7]萘啶-3-甲腈抑制剂以及其制备和使用方法
JP2008540656A (ja) * 2005-05-18 2008-11-20 ワイス Tpl2キナーゼの3−シアノキノリン阻害物質ならびにそれを製造および使用する方法
CA2626593A1 (en) 2005-10-28 2007-05-03 Abbott Laboratories Indazole derivatives that inhibit trpv1 receptor
WO2007117465A2 (en) 2006-03-31 2007-10-18 Abbott Laboratories Indazole compounds
US7741354B2 (en) 2006-11-09 2010-06-22 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN101583601B (zh) 2007-01-17 2013-06-05 香港科技大学 作为褪黑素受体mt1和mt2的亚型选择性激动剂的异喹诺酮化合物
GB0820856D0 (en) 2008-11-14 2008-12-24 Univ Leuven Kath Novel inhibitors of flavivirus replication
TWI625121B (zh) 2009-07-13 2018-06-01 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
GB0922302D0 (en) * 2009-12-22 2010-02-03 Imp Innovations Ltd Compounds
EP2545187B1 (en) 2010-03-09 2018-09-05 Dana-Farber Cancer Institute, Inc. Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy
AU2011264209B2 (en) * 2010-06-09 2014-08-07 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Cyanoquinoline derivatives
US9453021B2 (en) 2011-05-10 2016-09-27 Kyowa Hakko Kirin Co., Ltd. Pyrimidodiazepinone compound
JP2014520776A (ja) 2011-07-04 2014-08-25 バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー 植物における非生物的ストレスに対する活性薬剤としての置換されているイソキノリノン類、イソキノリンジオン類、イソキノリントリオン類およびジヒドロイソキノリノン類または各場合でのそれらの塩の使用
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
ME02402B (me) 2011-10-27 2016-09-20 Taisho Pharmaceutical Co Ltd Derivati azola
CN106905346B (zh) 2011-11-11 2019-05-28 吉利德阿波罗公司 Acc抑制剂和其用途
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
CN103483363B (zh) 2012-06-13 2016-12-21 上海赛迦化工产品有限公司 多样性的手性氨基硼酸及其制备方法和应用
WO2014064215A1 (en) 2012-10-24 2014-05-01 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL
CN103408572B (zh) 2013-07-12 2015-12-02 上海工程技术大学 手性氨基硼酸衍生物及其制备方法和应用
JP6542794B2 (ja) 2013-12-12 2019-07-10 ゼノ ロイアルティー アンド マイルストーンズ リミテッド ライアビリティー カンパニー 二環式アルキル化合物、および合成
KR102401840B1 (ko) 2014-03-07 2022-05-25 리커리엄 아이피 홀딩스, 엘엘씨 프로펠란 유도체 및 합성
US9701661B2 (en) * 2014-07-11 2017-07-11 Northwestern University 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase
EP3193855B1 (en) 2014-09-17 2021-05-19 Recurium IP Holdings, LLC Bicyclic compounds
AU2015320792B2 (en) 2014-09-24 2018-08-30 Gilead Sciences, Inc. Methods of treating liver disease
JP6439050B2 (ja) 2014-12-23 2018-12-19 ギリアード サイエンシーズ, インコーポレイテッド Ask1阻害剤を調製するプロセス
MA41252A (fr) 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1
KR20170102299A (ko) 2015-01-09 2017-09-08 길리어드 아폴로, 엘엘씨 비-알콜성 지방간 질환의 치료를 위한 acc 억제제 조합 요법
US10193384B2 (en) 2015-01-16 2019-01-29 3M Innovative Properties Company Systems and methods for selecting grid actions to improve grid outcomes
US20170008905A1 (en) * 2015-07-06 2017-01-12 Gilead Sciences, Inc. Cot modulators and methods of use thereof
PL3319955T3 (pl) * 2015-07-06 2021-05-04 Gilead Sciences, Inc. 6-aminochinolino-3-karbonitryle jako modulatory cot
KR102264012B1 (ko) 2015-12-31 2021-06-10 히트젠 주식회사 술폰아마이드 유도체 및 그 제조방법과 응용
CN119977993A (zh) 2016-03-02 2025-05-13 吉利德阿波罗公司 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法
US10702503B2 (en) 2016-06-21 2020-07-07 Phc Holdings Corporation Catalase inhibitor and method for measuring analyte using catalase inhibitor
ES2800339T3 (es) 2016-06-30 2020-12-29 Gilead Sciences Inc 4,6-diaminoquinazolinas como moduladores de cuna y métodos de uso de los mismos
CN106512014A (zh) 2016-10-27 2017-03-22 武汉大学 肿瘤进展位点2在治疗脂肪肝和ⅱ型糖尿病中的功能和应用
KR102424042B1 (ko) 2017-03-03 2022-07-22 길리애드 사이언시즈, 인코포레이티드 Acc 억제제 및 그의 고체 형태를 제조하는 방법
KR102743630B1 (ko) 2017-03-28 2024-12-18 길리애드 사이언시즈, 인코포레이티드 간 질환을 치료하기 위한 치료 조합물
WO2018191393A1 (en) 2017-04-12 2018-10-18 Gilead Sciences, Inc. Methods of treating liver disease
KR20220103807A (ko) 2017-10-06 2022-07-22 길리애드 사이언시즈, 인코포레이티드 Acc 억제제를 포함하는 조합 요법
CA3129949C (en) 2019-02-19 2024-04-30 Gilead Sciences, Inc. Solid forms of fxr agonists
US20220143153A1 (en) 2019-03-08 2022-05-12 The Regents Of The University Of California Compositions and methods for treating acne
TW202235416A (zh) 2019-06-14 2022-09-16 美商基利科學股份有限公司 Cot 調節劑及其使用方法
AR119594A1 (es) 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
EP4126231A1 (en) 2020-03-30 2023-02-08 Gilead Sciences, Inc. Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound
CN115397824B (zh) 2020-04-02 2024-10-22 吉利德科学公司 用于制备cot抑制剂化合物的方法
TW202304435A (zh) 2021-06-04 2023-02-01 美商基利科學股份有限公司 治療nash之方法

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