ME00876B - 4"supstituisani-9-deokso-9a-aza-9a-homoeritromicin a derivati - Google Patents

4"supstituisani-9-deokso-9a-aza-9a-homoeritromicin a derivati

Info

Publication number
ME00876B
ME00876B MEP-1999-586A MEP1999586A ME00876B ME 00876 B ME00876 B ME 00876B ME P1999586 A MEP1999586 A ME P1999586A ME 00876 B ME00876 B ME 00876B
Authority
ME
Montenegro
Prior art keywords
hydroxy
compound according
groups
integer
optionally substituted
Prior art date
Application number
MEP-1999-586A
Other languages
English (en)
Unknown language (me)
Inventor
Brian Scott Bronk
Michael A Letavic
Takushi Kaneko
Bingwei Vera Yang
Edward Alan Glazer
Hengmiao Cheng
Original Assignee
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME00876(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of ME00876B publication Critical patent/ME00876B/me

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MEP-1999-586A 1997-06-11 1998-05-29 4"supstituisani-9-deokso-9a-aza-9a-homoeritromicin a derivati ME00876B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
PCT/IB1998/000839 WO1998056802A1 (en) 1997-06-11 1998-05-29 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Publications (1)

Publication Number Publication Date
ME00876B true ME00876B (me) 2012-06-20

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-1999-586A ME00876B (me) 1997-06-11 1998-05-29 4"supstituisani-9-deokso-9a-aza-9a-homoeritromicin a derivati

Country Status (49)

Country Link
US (4) US6420536B1 (https=)
EP (1) EP0988310B9 (https=)
JP (2) JP3315704B2 (https=)
KR (1) KR100396168B1 (https=)
CN (4) CN1793155B (https=)
AP (1) AP1231A (https=)
AR (1) AR013086A1 (https=)
AT (1) ATE251173T1 (https=)
AU (1) AU749816B2 (https=)
BG (1) BG64391B1 (https=)
BR (1) BRPI9810519B8 (https=)
CA (1) CA2293823C (https=)
CO (1) CO4950611A1 (https=)
CZ (1) CZ298556B6 (https=)
DE (2) DE122004000018I2 (https=)
DK (1) DK0988310T3 (https=)
DZ (1) DZ2514A1 (https=)
EA (1) EA002441B1 (https=)
EG (1) EG24081A (https=)
ES (1) ES2205487T3 (https=)
FR (1) FR04C0013I2 (https=)
GT (1) GT199800077A (https=)
HN (1) HN1998000086A (https=)
HR (1) HRP980314B1 (https=)
HU (2) HU228005B1 (https=)
ID (1) ID22992A (https=)
IL (1) IL132809A0 (https=)
IS (1) IS1998B (https=)
LU (1) LU91076I9 (https=)
MA (1) MA24564A1 (https=)
ME (1) ME00876B (https=)
MY (1) MY123354A (https=)
NL (1) NL300150I2 (https=)
NO (1) NO316911B1 (https=)
NZ (2) NZ500660A (https=)
OA (1) OA11224A (https=)
PA (1) PA8452201A1 (https=)
PE (1) PE79699A1 (https=)
PL (1) PL191601B1 (https=)
PT (1) PT988310E (https=)
RS (1) RS49675B (https=)
SI (1) SI0988310T1 (https=)
SK (1) SK284171B9 (https=)
TN (1) TNSN98082A1 (https=)
TW (1) TW472060B (https=)
UA (1) UA67744C2 (https=)
UY (1) UY25040A1 (https=)
WO (1) WO1998056802A1 (https=)
ZA (1) ZA985017B (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
ES2281136T3 (es) * 1997-09-10 2007-09-16 Merial Ltd. Uso de 9a-azalidos como agentes antimicrobiales veterinarios.
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2411293A1 (en) * 1999-01-28 2000-07-28 Pfizer Products Inc. Novel azalides and methods of making same
DE60038610T2 (de) * 1999-05-18 2009-06-25 Pfizer Products Inc., Groton Neue kristalline formen eines makrolidantibiotikums
HUP0201516A3 (en) * 1999-05-24 2003-03-28 Pfizer Prod Inc 13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
DK1206476T3 (da) * 1999-08-24 2006-05-15 Abbott Lab 9a-azalider med antibakteriel virkning
US6608033B1 (en) 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
BRPI0017013B1 (pt) 2000-01-27 2015-07-14 Zoetis P Llc Composição de antibiótico azalídeo e método para sua obtenção
BR0110382A (pt) * 2000-04-27 2003-06-24 Pfizer Prod Inc Utilização de composições antibióticas azalida para o tratamento ou prevenção de uma infecção causada por bactérias ou protozoários em mamìferos
RU2263117C2 (ru) * 2001-04-27 2005-10-27 Пфайзер Продактс Инк. Способ получения 4"-замещенных производных 9-деоксо-9а-аза-9а-гомоэритромицина а
AU2002317415A1 (en) * 2001-08-01 2003-02-17 Pfizer Products Inc. Azalide antibiotic compositions
EP1638549A4 (en) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
MXPA06005639A (es) * 2003-11-21 2006-08-17 Pfizer Prod Inc Adyuvante antimicrobiano.
CN103030617A (zh) * 2004-03-16 2013-04-10 贝林格尔.英格海姆国际有限公司 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
ATE429921T1 (de) * 2005-01-14 2009-05-15 Glaxosmithkline Zagreb 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
JP5711135B2 (ja) 2008-10-24 2015-04-30 センプラ ファーマシューティカルズ,インコーポレイテッド 胃腸疾患を治療するための方法
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
MX361413B (es) 2010-03-22 2018-12-05 Cempra Pharmaceuticals Inc Star Formas cristalinas de un macrólido y usos para las mismas.
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
WO2012038372A1 (en) 2010-09-20 2012-03-29 Novartis Ag Novel process for the preparation of 9-deoxo-9a-aza- 9a-homoerythromycin a modified in the c-4'' of the cladinose ring by an epoxide group
EP2625185A4 (en) * 2010-10-10 2014-03-26 Synovo Gmbh INFLAMMATORY MAKROLIDE
WO2013004116A1 (zh) * 2011-07-06 2013-01-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
EP2736915A1 (en) 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
NZ700182A (en) 2012-03-27 2017-02-24 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
EP3027634B1 (en) * 2013-07-31 2018-03-21 Farma GRS, d.o.o. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普(天津)生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5226958A (en) * 1991-04-11 1993-07-13 Pacemark, Inc. Sealant for pneumatic inner tubes and tubeless tires
EP0549040A1 (en) 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Also Published As

Publication number Publication date
CN1793155A (zh) 2006-06-28
RS49675B (sr) 2007-11-15
US20040180842A1 (en) 2004-09-16
CN1566129A (zh) 2005-01-19
CZ442199A3 (cs) 2000-07-12
HUS1200028I1 (hu) 2016-08-29
KR100396168B1 (ko) 2003-08-27
PL337505A1 (en) 2000-08-28
DZ2514A1 (fr) 2003-02-01
DK0988310T3 (da) 2003-12-15
AP1231A (en) 2003-12-11
US6777393B2 (en) 2004-08-17
HK1028048A1 (en) 2001-02-02
TNSN98082A1 (fr) 2005-03-15
CN1243766C (zh) 2006-03-01
HUP0002209A2 (hu) 2000-12-28
PL191601B1 (pl) 2006-06-30
US6420536B1 (en) 2002-07-16
NO996106L (no) 2000-02-10
DE69818665T2 (de) 2004-04-29
HK1068893A1 (en) 2005-07-29
EA199901015A1 (ru) 2000-06-26
EP0988310B1 (en) 2003-10-01
HK1088014A1 (zh) 2006-10-27
PA8452201A1 (es) 2000-05-24
ATE251173T1 (de) 2003-10-15
AU749816B2 (en) 2002-07-04
AR013086A1 (es) 2000-12-13
EP0988310B9 (en) 2006-03-08
BG64391B1 (bg) 2004-12-30
PE79699A1 (es) 1999-08-25
BRPI9810519B1 (pt) 2012-02-22
NZ500660A (en) 2002-03-01
SI0988310T1 (en) 2004-02-29
UA67744C2 (uk) 2004-07-15
BG103945A (bg) 2000-07-31
CZ298556B6 (cs) 2007-11-07
WO1998056802A1 (en) 1998-12-17
JP2000514098A (ja) 2000-10-24
AU7347598A (en) 1998-12-30
DE69818665D1 (de) 2003-11-06
HRP980314A2 (en) 1999-04-30
BRPI9810519B8 (pt) 2022-11-16
IS1998B (is) 2005-03-15
ZA985017B (en) 1999-12-17
CN101691390A (zh) 2010-04-07
LU91076I2 (fr) 2004-07-05
CN1172947C (zh) 2004-10-27
BRPI9810519A (pt) 2000-09-19
HN1998000086A (es) 1999-03-08
ES2205487T3 (es) 2004-05-01
NL300150I1 (nl) 2004-08-02
EP0988310A1 (en) 2000-03-29
GT199800077A (es) 1999-12-02
ID22992A (id) 1999-12-23
MY123354A (en) 2006-05-31
JP2002316933A (ja) 2002-10-31
CO4950611A1 (es) 2000-09-01
NO316911B1 (no) 2004-06-21
EA002441B1 (ru) 2002-04-25
JP3315704B2 (ja) 2002-08-19
NL300150I2 (nl) 2004-09-01
DE122004000018I1 (de) 2004-09-30
CN1793155B (zh) 2010-05-12
AP9801255A0 (en) 1998-06-30
SK284171B9 (sk) 2005-03-04
NZ514871A (en) 2003-08-29
YU58699A (https=) 2002-08-12
IL132809A0 (en) 2001-03-19
HRP980314B1 (en) 2004-04-30
TW472060B (en) 2002-01-11
KR20010013632A (ko) 2001-02-26
UY25040A1 (es) 2000-09-29
HU228005B1 (en) 2012-08-28
MA24564A1 (fr) 1998-12-31
CA2293823A1 (en) 1998-12-17
US6936592B2 (en) 2005-08-30
US20020061858A1 (en) 2002-05-23
SK168399A3 (en) 2000-11-07
CN1259136A (zh) 2000-07-05
EG24081A (en) 2008-05-11
OA11224A (en) 2003-07-16
IS5252A (is) 1999-11-16
SK284171B6 (sk) 2004-10-05
HUP0002209A3 (en) 2003-05-28
FR04C0013I1 (https=) 2004-06-11
DE122004000018I2 (de) 2011-01-13
NO996106D0 (no) 1999-12-10
US20040023896A1 (en) 2004-02-05
LU91076I9 (en) 2018-07-02
PT988310E (pt) 2003-12-31
CA2293823C (en) 2004-02-17
FR04C0013I2 (https=) 2005-10-21

Similar Documents

Publication Publication Date Title
ME00876B (me) 4"supstituisani-9-deokso-9a-aza-9a-homoeritromicin a derivati
JP2006501181A5 (https=)
DK446279A (da) Fremgangsmaade til fremstilling af substituerede 1-carba-2-penem-3-carboxylsyrer
YU47099B (sh) Postupak za dobijanje makrolidnih jedinjenja
BR9910971A (pt) Composto, processos para a preparação de um composto e para produzir um efeito antibacteriano em um animal de sangue quente, uso de um composto, e, composição farmacêutica
HUP9700777A2 (hu) Ösztrogén hatású 2-fenil-1[4-(2-amino-etoxi)-benzil]-indol-származékok, előállításuk és alkalmazásuk, valamint ezeket a vegyületeket tartalmazó gyógyszerkészítmények
KR840005448A (ko) 티에노〔3, 2-c〕 피리딘 유도체의 제조방법
SE8106642L (sv) Piperazinylbensoheterocykliska foreningar och forfarande for framstellning derav
ATE14423T1 (de) Hydroxamsaeurederivate vom typ der mannich-basen mit verbesserter biologischer verfuegbarkeit von nicht-steroiden entzuendungshemmern, verfahren zur herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzung.
OA12697A (en) HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis.
AR013085A1 (es) Compuestos derivados de macrolidos c-4'' sustituidos, composicion farmaceutica, metodo de preparacion, compuestos intermediarios para su preparacion
HUP0302526A2 (hu) Makrolid vegyületek, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
AR059523A2 (es) Azalidas de 13 miembros macrolidos, composiciones farmaceuticas, su uso en la preparacion de medicamentos para el tratamiento de infecciones y procedimientos para preparar estos compuestos.
DE69004340D1 (de) Substituierte 2-Alkinylphenole mit entzündungshemmender Wirkung, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen.
SE8603098D0 (sv) Poly-4-aminopyrrole-2-carboxamido derivatives and process for their preparation
FI834800A0 (fi) Foerfarande foer framstaellning av dialkylaminoalkoxibensylalkohol-derivat
ATE18221T1 (de) (1-arylcyclobutyl)(heterocyclyl)methylaminderivate, ihre herstellung und ihre verwendung als arzneimittel.
DE69104416D1 (de) Acylbenzoxazolinone, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen die sie enthalten.
SE8005686L (sv) Nya halogenvinkamonderivat jemte sett for deras framstellning
JPS5283396A (en) Novel compound physiologically acceptable salts thereof process for preparing same and medical composition containing same
ATE445589T1 (de) Neue retinoidderivate und eine pharmazeutische anti-krebs-zusammensetzung, die diese verbindungen enthält
ATE16278T1 (de) Hydroxybenzylamino-aryl verbindungen, verfahren zur deren herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen.
NO150316C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive nitrosoureaderivater
ES8301479A1 (es) Un procedimiento para la preparacion de antibioticos de b-lactama.
NO180475C (no) Fremgangsmåte for fremstilling av et farmasöytisk preparat