CN1793155B - 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物 - Google Patents

4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物 Download PDF

Info

Publication number
CN1793155B
CN1793155B CN2006100513455A CN200610051345A CN1793155B CN 1793155 B CN1793155 B CN 1793155B CN 2006100513455 A CN2006100513455 A CN 2006100513455A CN 200610051345 A CN200610051345 A CN 200610051345A CN 1793155 B CN1793155 B CN 1793155B
Authority
CN
China
Prior art keywords
compound
hydroxyl
alkyl
groups
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN2006100513455A
Other languages
English (en)
Chinese (zh)
Other versions
CN1793155A (zh
Inventor
B·S·布罗克
M·A·勒塔威克
金子卓史
秉薇·V·杨
E·A·格拉瑟
程恒淼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoetis LLC
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1793155(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CN1793155A publication Critical patent/CN1793155A/zh
Application granted granted Critical
Publication of CN1793155B publication Critical patent/CN1793155B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2006100513455A 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物 Expired - Lifetime CN1793155B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
US60/049,348 1997-06-11

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
CNB988059223A Division CN1172947C (zh) 1997-06-11 1998-05-29 4"-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CNB2004100491122A Division CN1243766C (zh) 1997-06-11 1998-05-29 4”－取代的－9－脱氧－9a－氮杂－9a－高红霉素a衍生物

Publications (2)

Publication Number Publication Date
CN1793155A CN1793155A (zh) 2006-06-28
CN1793155B true CN1793155B (zh) 2010-05-12

Family

ID=21959336

Family Applications (4)

Application Number Title Priority Date Filing Date
CN2006100513455A Expired - Lifetime CN1793155B (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CNB2004100491122A Expired - Lifetime CN1243766C (zh) 1997-06-11 1998-05-29 4”－取代的－9－脱氧－9a－氮杂－9a－高红霉素a衍生物
CNB988059223A Expired - Lifetime CN1172947C (zh) 1997-06-11 1998-05-29 4"-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN200910145318A Pending CN101691390A (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物

Family Applications After (3)

Application Number Title Priority Date Filing Date
CNB2004100491122A Expired - Lifetime CN1243766C (zh) 1997-06-11 1998-05-29 4”－取代的－9－脱氧－9a－氮杂－9a－高红霉素a衍生物
CNB988059223A Expired - Lifetime CN1172947C (zh) 1997-06-11 1998-05-29 4"-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN200910145318A Pending CN101691390A (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物

Country Status (49)

Country Link
US (4) US6420536B1 (https=)
EP (1) EP0988310B9 (https=)
JP (2) JP3315704B2 (https=)
KR (1) KR100396168B1 (https=)
CN (4) CN1793155B (https=)
AP (1) AP1231A (https=)
AR (1) AR013086A1 (https=)
AT (1) ATE251173T1 (https=)
AU (1) AU749816B2 (https=)
BG (1) BG64391B1 (https=)
BR (1) BRPI9810519B8 (https=)
CA (1) CA2293823C (https=)
CO (1) CO4950611A1 (https=)
CZ (1) CZ298556B6 (https=)
DE (2) DE122004000018I2 (https=)
DK (1) DK0988310T3 (https=)
DZ (1) DZ2514A1 (https=)
EA (1) EA002441B1 (https=)
EG (1) EG24081A (https=)
ES (1) ES2205487T3 (https=)
FR (1) FR04C0013I2 (https=)
GT (1) GT199800077A (https=)
HN (1) HN1998000086A (https=)
HR (1) HRP980314B1 (https=)
HU (2) HU228005B1 (https=)
ID (1) ID22992A (https=)
IL (1) IL132809A0 (https=)
IS (1) IS1998B (https=)
LU (1) LU91076I9 (https=)
MA (1) MA24564A1 (https=)
ME (1) ME00876B (https=)
MY (1) MY123354A (https=)
NL (1) NL300150I2 (https=)
NO (1) NO316911B1 (https=)
NZ (2) NZ500660A (https=)
OA (1) OA11224A (https=)
PA (1) PA8452201A1 (https=)
PE (1) PE79699A1 (https=)
PL (1) PL191601B1 (https=)
PT (1) PT988310E (https=)
RS (1) RS49675B (https=)
SI (1) SI0988310T1 (https=)
SK (1) SK284171B9 (https=)
TN (1) TNSN98082A1 (https=)
TW (1) TW472060B (https=)
UA (1) UA67744C2 (https=)
UY (1) UY25040A1 (https=)
WO (1) WO1998056802A1 (https=)
ZA (1) ZA985017B (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
ES2281136T3 (es) * 1997-09-10 2007-09-16 Merial Ltd. Uso de 9a-azalidos como agentes antimicrobiales veterinarios.
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2411293A1 (en) * 1999-01-28 2000-07-28 Pfizer Products Inc. Novel azalides and methods of making same
DE60038610T2 (de) * 1999-05-18 2009-06-25 Pfizer Products Inc., Groton Neue kristalline formen eines makrolidantibiotikums
HUP0201516A3 (en) * 1999-05-24 2003-03-28 Pfizer Prod Inc 13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
DK1206476T3 (da) * 1999-08-24 2006-05-15 Abbott Lab 9a-azalider med antibakteriel virkning
US6608033B1 (en) 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
BRPI0017013B1 (pt) 2000-01-27 2015-07-14 Zoetis P Llc Composição de antibiótico azalídeo e método para sua obtenção
BR0110382A (pt) * 2000-04-27 2003-06-24 Pfizer Prod Inc Utilização de composições antibióticas azalida para o tratamento ou prevenção de uma infecção causada por bactérias ou protozoários em mamìferos
RU2263117C2 (ru) * 2001-04-27 2005-10-27 Пфайзер Продактс Инк. Способ получения 4"-замещенных производных 9-деоксо-9а-аза-9а-гомоэритромицина а
AU2002317415A1 (en) * 2001-08-01 2003-02-17 Pfizer Products Inc. Azalide antibiotic compositions
EP1638549A4 (en) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
MXPA06005639A (es) * 2003-11-21 2006-08-17 Pfizer Prod Inc Adyuvante antimicrobiano.
CN103030617A (zh) * 2004-03-16 2013-04-10 贝林格尔.英格海姆国际有限公司 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
ATE429921T1 (de) * 2005-01-14 2009-05-15 Glaxosmithkline Zagreb 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
JP5711135B2 (ja) 2008-10-24 2015-04-30 センプラ ファーマシューティカルズ，インコーポレイテッド 胃腸疾患を治療するための方法
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
MX361413B (es) 2010-03-22 2018-12-05 Cempra Pharmaceuticals Inc Star Formas cristalinas de un macrólido y usos para las mismas.
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
WO2012038372A1 (en) 2010-09-20 2012-03-29 Novartis Ag Novel process for the preparation of 9-deoxo-9a-aza- 9a-homoerythromycin a modified in the c-4'' of the cladinose ring by an epoxide group
EP2625185A4 (en) * 2010-10-10 2014-03-26 Synovo Gmbh INFLAMMATORY MAKROLIDE
WO2013004116A1 (zh) * 2011-07-06 2013-01-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
EP2736915A1 (en) 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
NZ700182A (en) 2012-03-27 2017-02-24 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
EP3027634B1 (en) * 2013-07-31 2018-03-21 Farma GRS, d.o.o. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5226958A (en) * 1991-04-11 1993-07-13 Pacemark, Inc. Sealant for pneumatic inner tubes and tubeless tires
EP0549040A1 (en) 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin

Also Published As

Publication number Publication date
CN1793155A (zh) 2006-06-28
RS49675B (sr) 2007-11-15
US20040180842A1 (en) 2004-09-16
CN1566129A (zh) 2005-01-19
CZ442199A3 (cs) 2000-07-12
HUS1200028I1 (hu) 2016-08-29
KR100396168B1 (ko) 2003-08-27
PL337505A1 (en) 2000-08-28
DZ2514A1 (fr) 2003-02-01
DK0988310T3 (da) 2003-12-15
AP1231A (en) 2003-12-11
US6777393B2 (en) 2004-08-17
HK1028048A1 (en) 2001-02-02
TNSN98082A1 (fr) 2005-03-15
CN1243766C (zh) 2006-03-01
HUP0002209A2 (hu) 2000-12-28
PL191601B1 (pl) 2006-06-30
US6420536B1 (en) 2002-07-16
NO996106L (no) 2000-02-10
DE69818665T2 (de) 2004-04-29
HK1068893A1 (en) 2005-07-29
EA199901015A1 (ru) 2000-06-26
EP0988310B1 (en) 2003-10-01
HK1088014A1 (zh) 2006-10-27
PA8452201A1 (es) 2000-05-24
ATE251173T1 (de) 2003-10-15
AU749816B2 (en) 2002-07-04
AR013086A1 (es) 2000-12-13
EP0988310B9 (en) 2006-03-08
BG64391B1 (bg) 2004-12-30
PE79699A1 (es) 1999-08-25
BRPI9810519B1 (pt) 2012-02-22
NZ500660A (en) 2002-03-01
SI0988310T1 (en) 2004-02-29
UA67744C2 (uk) 2004-07-15
BG103945A (bg) 2000-07-31
CZ298556B6 (cs) 2007-11-07
WO1998056802A1 (en) 1998-12-17
JP2000514098A (ja) 2000-10-24
AU7347598A (en) 1998-12-30
DE69818665D1 (de) 2003-11-06
HRP980314A2 (en) 1999-04-30
BRPI9810519B8 (pt) 2022-11-16
IS1998B (is) 2005-03-15
ZA985017B (en) 1999-12-17
CN101691390A (zh) 2010-04-07
LU91076I2 (fr) 2004-07-05
ME00876B (me) 2012-06-20
CN1172947C (zh) 2004-10-27
BRPI9810519A (pt) 2000-09-19
HN1998000086A (es) 1999-03-08
ES2205487T3 (es) 2004-05-01
NL300150I1 (nl) 2004-08-02
EP0988310A1 (en) 2000-03-29
GT199800077A (es) 1999-12-02
ID22992A (id) 1999-12-23
MY123354A (en) 2006-05-31
JP2002316933A (ja) 2002-10-31
CO4950611A1 (es) 2000-09-01
NO316911B1 (no) 2004-06-21
EA002441B1 (ru) 2002-04-25
JP3315704B2 (ja) 2002-08-19
NL300150I2 (nl) 2004-09-01
DE122004000018I1 (de) 2004-09-30
AP9801255A0 (en) 1998-06-30
SK284171B9 (sk) 2005-03-04
NZ514871A (en) 2003-08-29
YU58699A (https=) 2002-08-12
IL132809A0 (en) 2001-03-19
HRP980314B1 (en) 2004-04-30
TW472060B (en) 2002-01-11
KR20010013632A (ko) 2001-02-26
UY25040A1 (es) 2000-09-29
HU228005B1 (en) 2012-08-28
MA24564A1 (fr) 1998-12-31
CA2293823A1 (en) 1998-12-17
US6936592B2 (en) 2005-08-30
US20020061858A1 (en) 2002-05-23
SK168399A3 (en) 2000-11-07
CN1259136A (zh) 2000-07-05
EG24081A (en) 2008-05-11
OA11224A (en) 2003-07-16
IS5252A (is) 1999-11-16
SK284171B6 (sk) 2004-10-05
HUP0002209A3 (en) 2003-05-28
FR04C0013I1 (https=) 2004-06-11
DE122004000018I2 (de) 2011-01-13
NO996106D0 (no) 1999-12-10
US20040023896A1 (en) 2004-02-05
LU91076I9 (en) 2018-07-02
PT988310E (pt) 2003-12-31
CA2293823C (en) 2004-02-17
FR04C0013I2 (https=) 2005-10-21

Similar Documents

Publication Publication Date Title
CN1793155B (zh) 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
EP0988309B1 (en) C-4''-substituted macrolide derivatives
US6576749B2 (en) C-4″-substituted macrolide derivatives
HK1088014B (en) 4"-substituted-9-deoxo-9a-aza-9a-homoerythromy a derivatives
HK1141809A (en) 4"-substituted-9-deoxo-9a-aza-9a-homoeryti-a derivatives
MXPA99011495A (en) 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
MXPA99011496A (en) C-4''-substituted macrolide derivatives
CZ438999A3 (cs) C-4"- substituované makrolidové deriváty

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1088014

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1088014

Country of ref document: HK

ASS Succession or assignment of patent right

Owner name: ZOETIS P CO., LTD.

Free format text: FORMER OWNER: PFIZER PRODUCTS INC.

Effective date: 20130618

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20130618

Address after: American New Jersey

Patentee after: ZOETIS P LLC

Address before: American Connecticut

Patentee before: Pfizer Products Inc.

ASS Succession or assignment of patent right

Owner name: SHUOTENG SERVICE LLC

Free format text: FORMER OWNER: ZOETIS P CO., LTD.

Effective date: 20150806

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20150806

Address after: new jersey

Patentee after: ZOETIS LLC

Address before: American New Jersey

Patentee before: ZOETIS P LLC

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20100512