MA42146A - Compositions et procédés d'activation de la signalisation dépendante de « stimulateur de gènes d'interféron » - Google Patents
Compositions et procédés d'activation de la signalisation dépendante de « stimulateur de gènes d'interféron »Info
- Publication number
- MA42146A MA42146A MA042146A MA42146A MA42146A MA 42146 A MA42146 A MA 42146A MA 042146 A MA042146 A MA 042146A MA 42146 A MA42146 A MA 42146A MA 42146 A MA42146 A MA 42146A
- Authority
- MA
- Morocco
- Prior art keywords
- activation
- compositions
- processes
- dependent signaling
- interferon gene
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562131235P | 2015-03-10 | 2015-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA42146A true MA42146A (fr) | 2021-04-21 |
Family
ID=56879700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA042146A MA42146A (fr) | 2015-03-10 | 2016-03-09 | Compositions et procédés d'activation de la signalisation dépendante de « stimulateur de gènes d'interféron » |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US10449211B2 (fr) |
| EP (1) | EP3268035A4 (fr) |
| JP (1) | JP6692826B2 (fr) |
| KR (1) | KR20170129802A (fr) |
| CN (1) | CN107530415A (fr) |
| AR (1) | AR103894A1 (fr) |
| AU (1) | AU2016229146A1 (fr) |
| BR (1) | BR112017018908A2 (fr) |
| CA (1) | CA2979215A1 (fr) |
| CL (1) | CL2017002272A1 (fr) |
| CO (1) | CO2017009104A2 (fr) |
| CR (1) | CR20170410A (fr) |
| DO (1) | DOP2017000205A (fr) |
| EA (1) | EA035817B1 (fr) |
| EC (1) | ECSP17064523A (fr) |
| GT (1) | GT201700200A (fr) |
| HK (2) | HK1247089A1 (fr) |
| IL (1) | IL254047A0 (fr) |
| JO (1) | JO3746B1 (fr) |
| MA (1) | MA42146A (fr) |
| MX (1) | MX2017011597A (fr) |
| MY (1) | MY190404A (fr) |
| PE (1) | PE20171448A1 (fr) |
| PH (1) | PH12017501506A1 (fr) |
| SG (1) | SG11201706756VA (fr) |
| SV (1) | SV2017005529A (fr) |
| TN (1) | TN2017000375A1 (fr) |
| TW (1) | TWI706958B (fr) |
| UY (1) | UY36579A (fr) |
| WO (1) | WO2016145102A1 (fr) |
Families Citing this family (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013358892B2 (en) * | 2012-12-13 | 2018-06-21 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| WO2014110591A1 (fr) | 2013-01-14 | 2014-07-17 | Fred Hutchinson Cancer Research Center | Compositions et procédés pour l'administration de cellules immunitaires pour traiter des cellules tumorales non résécables ou non réséquées et une récidive de tumeur |
| WO2015185565A1 (fr) | 2014-06-04 | 2015-12-10 | Glaxosmithkline Intellectual Property Development Limited | Di-nucléotides cycliques utilisés comme modulateurs de sting |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CR20170410A (es) | 2015-03-10 | 2017-11-08 | Aduro Biotech Inc | Composiciones y métodos para activar la señalización dependiente del "estimulador del gen interferon" |
| US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| GEP20207182B (en) | 2015-08-13 | 2020-11-25 | Merck Sharp & Dohme | Cyclic di-nucleotide compounds as sting agonists |
| BR112018008339A2 (pt) | 2015-10-28 | 2018-10-30 | Aduro Biotech Inc | composições e métodos para ativar estimulador de sinalização dependente do gene de interferon |
| PE20181297A1 (es) * | 2015-12-03 | 2018-08-07 | Glaxosmithkline Ip Dev Ltd | Dinucleotidos de purino ciclico como moduladores de sting |
| US20180369268A1 (en) * | 2015-12-16 | 2018-12-27 | Aduro Biotech, Inc. | Methods for identifying inhibitors of "stimulator of interferon gene"- dependent interferon production |
| EP3402801A1 (fr) | 2016-01-11 | 2018-11-21 | Innate Tumor Immunity, Inc. | Dinucléotides cycliques pour traiter des affections associées à l'activité sting comme le cancer |
| CN114230625A (zh) | 2016-03-18 | 2022-03-25 | 免疫传感器公司 | 环二核苷酸化合物及使用方法 |
| US10188749B2 (en) | 2016-04-14 | 2019-01-29 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| US10696985B1 (en) | 2016-06-06 | 2020-06-30 | Vanderbilt University | Reversibly crosslinked endosomolytic polymer vesicles for cytosolic drug delivery |
| JP7235512B2 (ja) * | 2016-06-24 | 2023-03-08 | バイオジェン・エムエイ・インコーポレイテッド | キャッピング工程を有さないチオール化オリゴヌクレオチドの合成 |
| EP3507367A4 (fr) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | Composés dinucléotidiques cycliques d'acide nucléique bloqué et leurs utilisations |
| SG11201811709WA (en) * | 2016-07-06 | 2019-01-30 | Sperovie Biosciences Inc | Compounds, compositions, and methods for the treatment of disease |
| NL2017267B1 (en) | 2016-07-29 | 2018-02-01 | Aduro Biotech Holdings Europe B V | Anti-pd-1 antibodies |
| US10537590B2 (en) | 2016-09-30 | 2020-01-21 | Boehringer Ingelheim International Gmbh | Cyclic dinucleotide compounds |
| CN110036001B (zh) | 2016-10-04 | 2022-03-22 | 默沙东公司 | 作为STING激动剂的苯并[b]噻吩化合物 |
| WO2018065360A1 (fr) | 2016-10-07 | 2018-04-12 | Biolog Life Science Institute Forschungslabor Und Biochemica-Vertrieb Gmbh | Dinucléotides cycliques contenant du benzimidazole, procédé pour leur préparation et leur utilisation pour activer un stimulateur des voies de signalisation dépendantes de gènes régulés par l'interféron (sting) |
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
| JP2018090562A (ja) * | 2016-12-01 | 2018-06-14 | 武田薬品工業株式会社 | 環状ジヌクレオチド |
| US20190336532A1 (en) * | 2016-12-21 | 2019-11-07 | Fred Hutchinson Cancer Research Center | Scaffolds to treat solid tumor cells and escape variants |
| CN110121336A (zh) | 2017-01-05 | 2019-08-13 | 弗莱德哈钦森癌症研究中心 | 改善疫苗功效的系统和方法 |
| US20200055883A1 (en) | 2017-02-17 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Cyclic di-nucleotides derivative for the treatment of cancer |
| EP3585379A4 (fr) | 2017-02-21 | 2020-12-02 | Board of Regents, The University of Texas System | Dinucléotides cycliques utilisés en tant qu'agonistes du stimulateur de la signalisation dépendante du gène de l'interféron |
| JOP20190218A1 (ar) | 2017-03-22 | 2019-09-22 | Boehringer Ingelheim Int | مركبات ثنائية النيوكليوتيدات حلقية معدلة |
| KR20240135066A (ko) | 2017-04-13 | 2024-09-10 | 사이로파 비.브이. | 항-sirp 알파 항체 |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| AR113224A1 (es) * | 2017-04-28 | 2020-02-19 | Novartis Ag | Conjugados de anticuerpo que comprenden un agonista de sting |
| US11116835B2 (en) | 2017-05-10 | 2021-09-14 | Fred Hutchinson Cancer Research Center | Epstein Barr virus antibodies, vaccines, and uses of the same |
| EP3621624B1 (fr) | 2017-05-12 | 2023-08-30 | Merck Sharp & Dohme LLC | Composés dinucléotidiques cycliques en tant qu'agonistes sting |
| KR20200010500A (ko) | 2017-05-30 | 2020-01-30 | 브리스톨-마이어스 스큅 컴퍼니 | 항-lag-3 항체, pd-1 경로 억제제, 및 면역요법제의 조합을 포함하는 조성물 |
| MA49773A (fr) | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme | Combinaisons d'antagonistes de pd-1 et d'agonistes de sting benzo[b |
| US11285131B2 (en) | 2017-08-04 | 2022-03-29 | Merck Sharp & Dohme Corp. | Benzo[b]thiophene STING agonists for cancer treatment |
| CN111263767B (zh) | 2017-08-30 | 2023-07-18 | 北京轩义医药科技有限公司 | 作为干扰素基因调节剂的刺激剂的环状二核苷酸 |
| EP3676279B1 (fr) * | 2017-08-31 | 2021-12-01 | Bristol-Myers Squibb Company | Dinucléotides cycliques utilisés en tant qu'agents anticancéreux |
| JP7209697B2 (ja) * | 2017-08-31 | 2023-01-20 | ブリストル－マイヤーズ スクイブ カンパニー | 抗癌剤としての環状ジヌクレオチド |
| CA3074232A1 (fr) | 2017-08-31 | 2019-03-07 | Sperovie Biosciences, Inc. | Composes, compositions et methodes pour le traitement d'une maladie |
| US11707531B2 (en) | 2017-09-11 | 2023-07-25 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| WO2019051488A1 (fr) | 2017-09-11 | 2019-03-14 | Sperovie Biosciences, Inc. | Composés, compositions et méthodes de traitement de maladie |
| JP7195317B2 (ja) | 2017-11-10 | 2022-12-23 | 武田薬品工業株式会社 | Ｓｔｉｎｇ調節剤化合物、ならびに製造及び使用する方法 |
| EP3727401A4 (fr) | 2017-12-20 | 2022-04-06 | Merck Sharp & Dohme Corp. | Composés dinucléotidiques cycliques utilisés comme agonistes sting |
| CN111566120B (zh) | 2017-12-20 | 2023-09-29 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸 |
| EP3728282B1 (fr) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | Dinucléotides 2'3' cycliques ayant une liaison phosphonate activant la protéine adaptatrice de sting |
| EP3763724A4 (fr) | 2018-03-09 | 2022-01-12 | Japan Science and Technology Agency | COMPOSÉ PRÉCURSEUR D'ACIDE PHOSPHORIQUE ß-MODIFIÉ, COMPOSÉ D'ACIDE PHOSPHORIQUE ß-MODIFIÉ, INHIBITEUR DE RÉACTION, MÉDICAMENT LES COMPRENANT, ET PROCÉDÉ D'INHIBITION DE RÉACTION |
| WO2019180683A1 (fr) | 2018-03-23 | 2019-09-26 | Takeda Pharmaceutical Company Limited | Composés modulateurs de sting incorporant des liaisons de sulfamate, et procédés de fabrication et d'utilisation |
| SG11202008636YA (en) | 2018-03-23 | 2020-10-29 | Codiak Biosciences Inc | Extracellular vesicles comprising sting-agonist |
| CN111971291A (zh) | 2018-03-27 | 2020-11-20 | 勃林格殷格翰国际有限公司 | 用作sting激动剂的含有2-氮杂-次黄嘌呤或6h-吡唑并[1,5-d][1,2,4]三嗪-7-酮的环状二核苷酸化合物 |
| CN111989338A (zh) | 2018-03-27 | 2020-11-24 | 勃林格殷格翰国际有限公司 | 修饰的环二核苷酸化合物 |
| JP7326319B2 (ja) | 2018-04-03 | 2023-08-15 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｓｔｉｎｇアゴニストとしてのベンゾチオフェン類及び関連する化合物 |
| US11702430B2 (en) | 2018-04-03 | 2023-07-18 | Merck Sharp & Dohme Llc | Aza-benzothiophene compounds as STING agonists |
| WO2019195658A1 (fr) | 2018-04-05 | 2019-10-10 | Dana-Farber Cancer Institute, Inc. | Niveaux sting comme biomarqueur pour l'immunothérapie du cancer |
| TWI833744B (zh) * | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| WO2019211799A1 (fr) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | Analogue de dinucléotide 2'3'-cyclique comprenant un nucléotide modifié par cyclopentanyle |
| AU2019277679A1 (en) | 2018-06-01 | 2020-12-24 | Eisai R&D Management Co., Ltd. | Methods for the treatment of bladder cancer |
| EP3837268A4 (fr) | 2018-08-16 | 2022-04-20 | Eisai R&D Management Co., Ltd. | Sels de composés et cristaux de ceux-ci |
| WO2020041720A1 (fr) | 2018-08-24 | 2020-02-27 | Codiak Biosciences, Inc. | Vésicules extracellulaires ciblant des cellules dendritiques et utilisations associées |
| US11883485B2 (en) | 2018-08-29 | 2024-01-30 | Fred Hutchinson Cancer Center | Methods of eliciting antibodies that bind to full-length glycosylated HIV-1 Env using multimerized Env cores |
| KR102567590B1 (ko) | 2018-09-06 | 2023-08-17 | 다이이찌 산쿄 가부시키가이샤 | 신규 고리형 디뉴클레오티드 유도체 및 그 항체 약물 콘쥬게이트 |
| US20220041644A1 (en) | 2018-09-21 | 2022-02-10 | Shanghai De Novo Pharmatech Co., Ltd. | Cyclic dinucleotide analogue, pharmaceutical composition thereof, and application |
| US12011485B2 (en) | 2018-09-27 | 2024-06-18 | Pierre Fabre Medicament | Sulfomaleimide-based linkers and corresponding conjugates |
| CA3115749A1 (fr) | 2018-10-11 | 2020-04-16 | Ono Pharmaceutical Co., Ltd. | Compose agoniste de sting |
| US11110106B2 (en) | 2018-10-29 | 2021-09-07 | Venenum Biodesign, LLC | Sting agonists for treating bladder cancer and solid tumors |
| EP3873484B1 (fr) | 2018-10-29 | 2023-08-23 | Venenum Biodesign, LLC | Nouveaux agonistes de sting |
| WO2020092633A1 (fr) | 2018-10-30 | 2020-05-07 | Vanderbilt University | Copolymères greffés, procédés de formation de copolymères greffés et procédés d'utilisation correspondants |
| EP3873938A1 (fr) | 2018-10-31 | 2021-09-08 | Novartis AG | Conjugués d'anticorps dc-sign comprenant des agonistes de sting |
| US11766447B2 (en) | 2019-03-07 | 2023-09-26 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| JP7350872B2 (ja) | 2019-03-07 | 2023-09-26 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． | ３’３’－環状ジヌクレオチドおよびそのプロドラッグ |
| DK3934757T3 (da) | 2019-03-07 | 2023-04-17 | Inst Of Organic Chemistry And Biochemistry Ascr V V I | 2'3'-cykliske dinukleotider og prodrugs deraf |
| SG11202109587TA (en) | 2019-03-21 | 2021-10-28 | Codiak Biosciences Inc | Extracellular vesicle conjugates and uses thereof |
| US20220168415A1 (en) | 2019-03-21 | 2022-06-02 | Codiak Biosciences, Inc. | Extracellular vesicles for vaccine delivery |
| WO2020227159A2 (fr) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Métodes de modulation de l'activité immunitaire |
| CA3137119A1 (fr) | 2019-05-09 | 2020-11-12 | Aligos Therapeutics, Inc. | Composes di-nucleosidiques cycliques modifies servant de modulateurs sting |
| US20220409734A1 (en) | 2019-05-10 | 2022-12-29 | Yutaka Nishimoto | Antibody drug conjugates |
| US20220251200A1 (en) | 2019-07-03 | 2022-08-11 | Codiak Biosciences, Inc. | Extracellular vesicles targeting t cells and uses thereof |
| JP2022538690A (ja) | 2019-07-05 | 2022-09-05 | タンボ・インコーポレイテッド | トランス－シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用 |
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- 2016-03-09 CA CA2979215A patent/CA2979215A1/fr not_active Abandoned
- 2016-03-09 AU AU2016229146A patent/AU2016229146A1/en not_active Abandoned
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- 2016-03-09 KR KR1020177028534A patent/KR20170129802A/ko not_active Application Discontinuation
- 2016-03-09 MX MX2017011597A patent/MX2017011597A/es unknown
- 2016-03-09 TW TW105107250A patent/TWI706958B/zh not_active IP Right Cessation
- 2016-03-09 BR BR112017018908-9A patent/BR112017018908A2/pt not_active IP Right Cessation
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- 2016-03-09 EP EP16762447.7A patent/EP3268035A4/fr not_active Withdrawn
- 2016-03-09 WO PCT/US2016/021597 patent/WO2016145102A1/fr active Application Filing
- 2016-03-09 TN TNP/2017/000375A patent/TN2017000375A1/en unknown
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- 2016-03-09 JO JOP/2016/0039A patent/JO3746B1/ar active
- 2016-03-09 CN CN201680022466.9A patent/CN107530415A/zh active Pending
- 2016-03-09 EA EA201791999A patent/EA035817B1/ru unknown
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- 2016-03-10 UY UY0001036579A patent/UY36579A/es not_active Application Discontinuation
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2018
- 2018-05-21 HK HK18106549.3A patent/HK1247089A1/zh unknown
- 2018-07-04 HK HK18108617.6A patent/HK1248603A1/zh unknown
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2019
- 2019-10-21 US US16/659,093 patent/US11040053B2/en active Active
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