CR20170410A - Composiciones y métodos para activar la señalización dependiente del "estimulador del gen interferon" - Google Patents

Composiciones y métodos para activar la señalización dependiente del "estimulador del gen interferon"

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Publication number
CR20170410A
CR20170410A CR20170410A CR20170410A CR20170410A CR 20170410 A CR20170410 A CR 20170410A CR 20170410 A CR20170410 A CR 20170410A CR 20170410 A CR20170410 A CR 20170410A CR 20170410 A CR20170410 A CR 20170410A
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CR
Costa Rica
Prior art keywords
interferon
activate
stimulator
cdn
gen
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CR20170410A
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English (en)
Inventor
Laura Hix Glickman
Jr Thomas W Dubensky
George Edwin Katibah
Kelsey Gauthier
David Kanne
Leonard Sung
Sarah M Mcwhirter
Justin Leong
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Aduro Biotech Inc
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Publication of CR20170410A publication Critical patent/CR20170410A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención proporciona estimuladores inmunitarios di-nucleótidos-cíclicos- (CDN) de gran actividad que activan DC a través de un receptor citoplasmático descubierto recientemente conocido como STING (Estimulador de genes de interferón). En particular, los CDN de la presente invención se proporcionan en forma de una composición que comprende uno o más dinucleótidos cíclicos de purina que inducen la producción de interferón de tipo I dependiente de STING humano, donde los dinuclotidas cíclicos de purina presentes en la composición son CDN bis-3',5' 2'-fluoro sustituidos, y más preferiblemente uno o más CDN bis-3¿,5¿ 2¿,2¿¿-diF-Rp,Rp.
CR20170410A 2015-03-10 2016-03-09 Composiciones y métodos para activar la señalización dependiente del "estimulador del gen interferon" CR20170410A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562131235P 2015-03-10 2015-03-10
PCT/US2016/021597 WO2016145102A1 (en) 2015-03-10 2016-03-09 Compositions and methods for activating "stimulator of interferon gene" -dependent signalling

Publications (1)

Publication Number Publication Date
CR20170410A true CR20170410A (es) 2017-11-08

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Family Applications (1)

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CR20170410A CR20170410A (es) 2015-03-10 2016-03-09 Composiciones y métodos para activar la señalización dependiente del "estimulador del gen interferon"

Country Status (30)

Country Link
US (2) US10449211B2 (es)
EP (1) EP3268035A4 (es)
JP (1) JP6692826B2 (es)
KR (1) KR20170129802A (es)
CN (1) CN107530415A (es)
AR (1) AR103894A1 (es)
AU (1) AU2016229146A1 (es)
BR (1) BR112017018908A2 (es)
CA (1) CA2979215A1 (es)
CL (1) CL2017002272A1 (es)
CO (1) CO2017009104A2 (es)
CR (1) CR20170410A (es)
DO (1) DOP2017000205A (es)
EA (1) EA035817B1 (es)
EC (1) ECSP17064523A (es)
GT (1) GT201700200A (es)
HK (2) HK1247089A1 (es)
IL (1) IL254047A0 (es)
JO (1) JO3746B1 (es)
MA (1) MA42146A (es)
MX (1) MX2017011597A (es)
MY (1) MY190404A (es)
PE (1) PE20171448A1 (es)
PH (1) PH12017501506A1 (es)
SG (1) SG11201706756VA (es)
SV (1) SV2017005529A (es)
TN (1) TN2017000375A1 (es)
TW (1) TWI706958B (es)
UY (1) UY36579A (es)
WO (1) WO2016145102A1 (es)

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US10449211B2 (en) 2019-10-22
EA035817B1 (ru) 2020-08-14
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