MA28565B1 - Proteines hybrides d'albumine - Google Patents

Proteines hybrides d'albumine

Info

Publication number
MA28565B1
MA28565B1 MA29305A MA29305A MA28565B1 MA 28565 B1 MA28565 B1 MA 28565B1 MA 29305 A MA29305 A MA 29305A MA 29305 A MA29305 A MA 29305A MA 28565 B1 MA28565 B1 MA 28565B1
Authority
MA
Morocco
Prior art keywords
albumin
hybrid proteins
proteins
hybrid
Prior art date
Application number
MA29305A
Other languages
English (en)
Inventor
Craig A Rosen
William A Haseltine
Paul A Moore
Jason B Bock
Adam Bell
Yanggu Shi
David Lafleur
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Publication of MA28565B1 publication Critical patent/MA28565B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • C07K14/765Serum albumin, e.g. HSA
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/35Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
MA29305A 2004-02-09 2006-09-08 Proteines hybrides d'albumine MA28565B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US54227404P 2004-02-09 2004-02-09
US54990104P 2004-03-05 2004-03-05
US55690604P 2004-03-29 2004-03-29
US63660304P 2004-12-17 2004-12-17

Publications (1)

Publication Number Publication Date
MA28565B1 true MA28565B1 (fr) 2007-05-02

Family

ID=34865403

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29305A MA28565B1 (fr) 2004-02-09 2006-09-08 Proteines hybrides d'albumine

Country Status (20)

Country Link
US (3) US7569384B2 (fr)
EP (1) EP1729795B1 (fr)
JP (2) JP5010923B2 (fr)
KR (1) KR101184391B1 (fr)
CN (1) CN102816241B (fr)
AU (2) AU2005211725B2 (fr)
BR (1) BRPI0507026A (fr)
CA (1) CA2554089C (fr)
CY (1) CY1117401T1 (fr)
DK (1) DK1729795T3 (fr)
ES (1) ES2567634T3 (fr)
HU (1) HUE027902T2 (fr)
IL (1) IL176894A (fr)
MA (1) MA28565B1 (fr)
MX (1) MXPA06009072A (fr)
NO (1) NO20064059L (fr)
NZ (1) NZ548612A (fr)
PL (1) PL1729795T3 (fr)
SI (1) SI1729795T1 (fr)
WO (1) WO2005077042A2 (fr)

Families Citing this family (206)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
JP2003530838A (ja) 2000-04-12 2003-10-21 ヒューマン ゲノム サイエンシズ インコーポレイテッド アルブミン融合タンパク質
AU2002364587A1 (en) 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
ES2425738T3 (es) * 2001-12-21 2013-10-17 Human Genome Sciences, Inc. Proteínas de fusión de la albúmina
US20080194481A1 (en) 2001-12-21 2008-08-14 Human Genome Sciences, Inc. Albumin Fusion Proteins
US20060002935A1 (en) 2002-06-28 2006-01-05 Domantis Limited Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
EP1594530A4 (fr) 2003-01-22 2006-10-11 Human Genome Sciences Inc Proteines hybrides d'albumine
US7077176B2 (en) * 2003-04-28 2006-07-18 Medical Instill Technologies, Inc. Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
EP1729795B1 (fr) * 2004-02-09 2016-02-03 Human Genome Sciences, Inc. Proteines hybrides d'albumine
CN101724071A (zh) 2004-10-08 2010-06-09 杜门蒂斯有限公司 抗肿瘤坏死因子受体1的单域抗体及其使用方法
AU2006280312A1 (en) * 2005-08-12 2007-02-22 Human Genome Sciences, Inc. Albumin fusion proteins
JP2009509535A (ja) * 2005-09-27 2009-03-12 アムニクス, インコーポレイテッド タンパク様薬剤およびその使用
US7855279B2 (en) * 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
US20090099031A1 (en) * 2005-09-27 2009-04-16 Stemmer Willem P Genetic package and uses thereof
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
JP2009514900A (ja) * 2005-11-04 2009-04-09 スミスクライン・ビーチャム・コーポレイション 血糖降下剤の投与方法
US20080280328A1 (en) * 2005-11-18 2008-11-13 Novozymes A/S Glucoamylase Variants
EP1816201A1 (fr) 2006-02-06 2007-08-08 CSL Behring GmbH Facteur de coagulation VIIa modifié ayant une stabilité 'half-life' améliorée
UA100666C2 (uk) 2006-04-11 2013-01-25 Новартіс Аг Інгібітори нсv/віл та їх застосування
WO2007127286A2 (fr) * 2006-04-24 2007-11-08 Medical Instill Technologies, Inc. dispositif de lyophilisation perméable aux aiguilles et refermable de façon étanche par laser et procédé associé
BRPI0712383A2 (pt) * 2006-06-07 2012-07-10 Human Genome Sciences Inc proteìnas de fusão da albumina
PE20121528A1 (es) * 2006-09-13 2012-12-12 Smithkline Beecham Corp Metodos para administrar agentes hipoglucemiantes de larga duracion
AU2007294805A1 (en) * 2006-09-14 2008-03-20 Human Genome Sciences, Inc. Albumin fusion proteins
WO2008052043A2 (fr) * 2006-10-24 2008-05-02 Cogenesys, Inc. Protéines de fusion agonistes du récepteur opioïde
EP2121743B1 (fr) 2006-11-22 2015-06-03 Bristol-Myers Squibb Company Substances thérapeutiques à base de protéines modifiées ciblées sur des récepteurs de tyrosine kinases, dont l'igf-ir
CA3161849A1 (fr) 2007-01-30 2008-08-07 Epivax, Inc. Epitopes de lymphocytes t regulateurs, compositions et utilisations de ceux-ci
ATE516814T1 (de) 2007-02-02 2011-08-15 Bristol Myers Squibb Co 10fn3 domain zur behandlung von krankheiten begleitet von unerwünschter angiogenese
EA200901494A1 (ru) 2007-06-06 2010-06-30 Домантис Лимитед Способы селекции протеазоустойчивых полипептидов
RU2361607C2 (ru) * 2007-06-09 2009-07-20 Государственное образовательное учреждение высшего профессионального образования "Челябинская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию Российской Федерации" Способ локальной иммунотерапии гнойно-воспалительных заболеваний мягких тканей челюстно-лицевой области
AU2008275911A1 (en) * 2007-07-19 2009-01-22 Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University Self- anchoring MEMS intrafascicular neural electrode
CN103298935A (zh) * 2007-08-15 2013-09-11 阿穆尼克斯公司 用于改善生物活性多肽性能的组合物和方法
BRPI0816406A2 (pt) * 2007-09-05 2017-05-16 Sanofi Aventis uso de urato oxidase para o tratamento ou a profilaxia de distúrbios ou sequelas indiretas do coração ocasionadas por eventos isquêmicos ou de reperfusão.
EP2050764A1 (fr) 2007-10-15 2009-04-22 sanofi-aventis Nouveau format d'anticorps bispécifique polyvalent
GB0723712D0 (en) * 2007-12-04 2008-01-16 Apitope Technology Bristol Ltd Peptides
EP2072527A1 (fr) 2007-12-21 2009-06-24 Altonabiotec AG Procédé et système pour fournir des services de communications sur un terminal mobile, et terminal mobile
WO2009116557A1 (fr) * 2008-03-21 2009-09-24 富士フイルム株式会社 Composition contenant un médicament
CN102099373A (zh) 2008-05-22 2011-06-15 百时美施贵宝公司 基于纤连蛋白的多价支架结构域蛋白
US20110300127A1 (en) * 2008-05-27 2011-12-08 Fujifilm Corporation Drug-containing composition
PL2373681T3 (pl) 2008-12-10 2017-07-31 Glaxosmithkline Llc Kompozycje farmaceutyczne albiglutydu
SI2393828T1 (sl) 2009-02-03 2017-01-31 Amunix Operating Inc. Podaljšani rekombinantni polipetidi in sestavki, ki jih obsegajo
US8680050B2 (en) * 2009-02-03 2014-03-25 Amunix Operating Inc. Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
US20110046060A1 (en) * 2009-08-24 2011-02-24 Amunix Operating, Inc., Coagulation factor IX compositions and methods of making and using same
US8703717B2 (en) 2009-02-03 2014-04-22 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
SG172789A1 (en) 2009-02-11 2011-08-29 Novozymes Biopharma Dk As Albumin variants and conjugates
EP2398827A2 (fr) 2009-02-19 2011-12-28 Glaxo Group Limited Polypeptides, domaines variables d'anticorps, et antagonistes améliorés, tous étant des anti-tnfr1
CN102458442B (zh) * 2009-04-08 2016-06-29 加利福尼亚大学董事会 具有受控血清药代动力学的人蛋白支架
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
KR101286721B1 (ko) * 2009-06-05 2013-07-16 한국과학기술연구원 폴리-시스테인 펩티드 융합 재조합 알부민 및 이의 제조방법
AU2010258898B8 (en) 2009-06-08 2015-02-05 Amunix Operating Inc. Glucose-regulating polypeptides and methods of making and using same
US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
JP2012532619A (ja) 2009-07-16 2012-12-20 グラクソ グループ リミテッド Tnfr1を部分的に阻害するためのアンタゴニスト、用途および方法
BR112012001977A2 (pt) 2009-07-29 2017-01-31 Glaxo Group Ltd domínio variável único de imunoglobulina, polipeptídeo isolado, ligante, proteína de fusão, ácido nucleico isolado, molécula de ácido nucleico isolado, vetor, célula hospedeira, métodos para produzir um polipeptídeo e para tratar e/ou prevenir uma condição, composição farmacêutica, uso de um domínio variável único, e, dispositivo de dispensação pulmonar.
PE20121564A1 (es) 2009-10-27 2012-11-29 Glaxo Group Ltd Polipeptidos anti-tnfr1 estables, dominios variables de anticuerpos y antagonistas
PH12012500827A1 (en) 2009-10-30 2013-01-07 Boehringer Ingelheim Int Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin
BR112012009450A2 (pt) 2009-10-30 2017-05-23 Novozymes Biopharma Dk As variantes de albumina
WO2011098644A2 (fr) 2010-02-09 2011-08-18 Proyecto De Biomedicina Cima, S.L. Composition pour le traitement de maladies infectieuses et tumorales
BR112012019881A2 (pt) 2010-02-18 2017-06-27 Bristol Myers Squibb Co proteínas de domínio estrutural baseadas na fibronectina que ligam-se à il-23
WO2011123830A2 (fr) 2010-04-02 2011-10-06 Amunix Operating Inc. Compositions d'alpha 1-antitrypsine, leurs procédés de préparation et d'utilisation
EP2556087A1 (fr) 2010-04-09 2013-02-13 Novozymes Biopharma DK A/S Dérivés et variants d'albumine
KR20130056871A (ko) 2010-04-13 2013-05-30 브리스톨-마이어스 스큅 컴퍼니 Pcsk9에 결합하는 피브로넥틴 기반 스캐폴드 도메인 단백질
WO2011140176A1 (fr) 2010-05-04 2011-11-10 Glaxosmithkline Llc Méthodes de traitement ou de prévention de troubles cardiovasculaires, et de fourniture d'une protection cardiovasculaire
JP6200806B2 (ja) * 2010-05-21 2017-09-20 メリマック ファーマシューティカルズ インコーポレーティッド 二重特異的融合タンパク質
ES2573108T3 (es) 2010-05-26 2016-06-06 Bristol-Myers Squibb Company Proteínas de armazón a base de fibronectina que tienen estabilidad mejorada
AU2011268498A1 (en) 2010-06-24 2013-01-31 Genoscience Pharma Sas Treatment of hepatitis C virus related diseases using hydroxychloroquine or a combination of hydroxychloroquine and an anti-viral agent
WO2012013597A1 (fr) * 2010-07-28 2012-02-02 Justus-Liebig-Universität Giessen Substances et utilisation desdites substances pour influer sur les récepteurs peptidiques natriurétiques
AU2011311880B2 (en) 2010-10-08 2014-07-24 Novartis Ag Vitamin E formulations of sulfamide NS3 inhibitors
WO2012088006A1 (fr) 2010-12-22 2012-06-28 Bristol-Myers Squibb Company Protéines à domaine échafaudage à base de fibronectine qui se lient à l'il-23
CN103443126B (zh) 2011-01-06 2016-11-23 葛兰素集团有限公司 结合TGFβ受体II的配体
WO2012093704A1 (fr) * 2011-01-07 2012-07-12 中外製薬株式会社 Procédé pour l'amélioration de propriétés physiques d'anticorps
EP2678002A2 (fr) 2011-02-25 2014-01-01 Medtronic, Inc. Thérapie pour néphropathie et/ou insuffisance cardiaque
AU2012222833B2 (en) 2011-03-03 2017-03-16 Zymeworks Inc. Multivalent heteromultimer scaffold design and constructs
AU2012251583B2 (en) 2011-05-05 2017-06-08 Albumedix Ltd. Albumin variants
US20130244937A1 (en) 2011-09-02 2013-09-19 Nile Therapeutics, Inc. Chimeric natriuretic peptide compositions and methods of preparation
US9522951B2 (en) 2011-10-31 2016-12-20 Bristol-Myers Squibb Company Fibronectin binding domains with reduced immunogenicity
EP2780364A2 (fr) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Protéines ayant une demi-vie et d'autres propriétés améliorées
NZ628014A (en) 2012-02-15 2016-09-30 Biogen Ma Inc Recombinant factor viii proteins
CN111548418A (zh) 2012-02-15 2020-08-18 比奥贝拉蒂治疗公司 因子viii组合物及其制备和使用方法
CN104302408B (zh) 2012-02-27 2016-12-14 阿穆尼克斯运营公司 Xten缀合组合物和制造其的方法
WO2013138338A2 (fr) 2012-03-12 2013-09-19 Massachusetts Institute Of Technology Méthodes de traitement de lésions tissulaires, associées à l'ischémie, faisant appel à l'apolipoprotéine d
WO2013137869A1 (fr) 2012-03-14 2013-09-19 Boehringer Ingelheim International Gmbh Polythérapie pour le traitement d'une infection par le hcv dans une population de patients co-infectés hcv-hiv
ES2664328T3 (es) 2012-03-16 2018-04-19 Albumedix A/S Variantes de albúmina
WO2013143581A1 (fr) 2012-03-28 2013-10-03 Boehringer Ingelheim International Gmbh Polythérapie pour le traitement d'une infection par le vhc dans une sous-population de sous-génotype de patients spécifique
WO2013177187A2 (fr) 2012-05-22 2013-11-28 Massachusetts Institute Of Technology Traitement de tumeur synergique avec du pk il-2 étendu et des agents thérapeutiques
JP6498601B2 (ja) 2012-07-13 2019-04-10 ザイムワークス,インコーポレイテッド 多価ヘテロ多量体足場設計および構築物
EP2888279A1 (fr) 2012-08-22 2015-07-01 Glaxo Group Limited Anticorps anti-lrp6
US8853154B2 (en) 2012-09-13 2014-10-07 Bristol-Myers Squibb Company Fibronectin based scaffold domain proteins that bind to myostatin
CA2890766A1 (fr) 2012-11-08 2014-05-15 Novozymes Biopharma Dk A/S Variants d'albumine
US20140205566A1 (en) 2012-11-30 2014-07-24 Novartis Ag Cyclic nucleuoside derivatives and uses thereof
US20150361159A1 (en) 2013-02-01 2015-12-17 Bristol-Myers Squibb Company Fibronectin based scaffold proteins
US9255262B2 (en) * 2013-03-06 2016-02-09 Vision Global Holdings Ltd. Albumin-binding arginine deminase and the use thereof
EP2964666B1 (fr) 2013-03-06 2020-11-18 GlaxoSmithKline LLC Cellules hôtes et procédés d'utilisation
USRE48805E1 (en) * 2013-03-06 2021-11-02 Vision Global Holdings Ltd. Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein
EP2968587A2 (fr) 2013-03-13 2016-01-20 Bristol-Myers Squibb Company Domaines d'échafaudage à base de fibronectine liés à une sérum albumine ou fragment se liant à celle-ci
HRP20201113T1 (hr) 2013-03-15 2020-10-30 Glaxosmithkline Intellectual Property Development Limited Vežući proteini protiv lag-3
US9914770B2 (en) 2013-04-30 2018-03-13 Intas Pharmaceuticals Ltd Cloning, expression and purification method for the preparation of ranibizumab
MX364532B (es) 2013-07-04 2019-04-29 Glykos Finland Oy Celulas de hongos filamentosos deficientes de o-manosiltransferasa y metodos de uso de las mismas.
WO2015023890A1 (fr) * 2013-08-14 2015-02-19 The Arizona Board Of Regents On Behalf Of The University Of Arizona Analogues de pacap/vip glycosylés avec pénétration du snc augmentée pour le traitement de maladies neurodégénératives
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
CN105377882B (zh) * 2014-03-06 2020-05-05 葛兰素史密斯克莱有限责任公司 宿主细胞和使用方法
US20170204149A1 (en) 2014-06-23 2017-07-20 Novartis Ag Hsa-gdf-15 fusion polypeptide and use thereof
CN108064266A (zh) 2014-07-21 2018-05-22 格利科斯芬兰公司 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备
CA2957717C (fr) 2014-08-12 2021-10-19 Massachusetts Institute Of Technology Traitement tumoral synergique a l'aide d'il-2 et d'une proteine de fusion fc liant l'integrine
US20170216403A1 (en) 2014-08-12 2017-08-03 Massachusetts Institute Of Technology Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
EA034516B1 (ru) 2014-11-25 2020-02-14 Бристол-Маерс Сквибб Компани Способы и композиции для мечения радиоактивным изотопомf биологических препаратов
ES2822990T3 (es) 2014-11-25 2021-05-05 Bristol Myers Squibb Co Novedosos polipéptidos de unión a PD-L1 para obtención de imágenes
USRE49529E1 (en) 2014-12-19 2023-05-16 Inozyme Pharma, Inc. Methods of treating tissue calcification
MX2017013687A (es) 2015-04-24 2018-07-06 Viiv Healthcare Uk No 5 Ltd Polipeptidos dirigidos a la fusion de vih.
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
AU2016301303B2 (en) 2015-08-03 2021-10-07 Bioverativ Therapeutics Inc. Factor IX fusion proteins and methods of making and using same
CA2989966C (fr) 2015-08-20 2024-04-30 Albumedix A/S Variants de l'albumine et leurs conjugues
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
RU2021133819A (ru) 2015-09-02 2021-12-10 Иммутеп С.A.С. Анти-lag-3 антитела
HRP20210635T1 (hr) * 2015-09-08 2021-08-20 Jcr Pharmaceuticals Co., Ltd. Novi mutant humanog seruma albumina
KR102152437B1 (ko) * 2015-09-18 2020-09-07 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 장시간 작용형 아드레노메둘린 유도체
ES2809125T3 (es) 2015-09-23 2021-03-03 Bristol Myers Squibb Co Moléculas de armazón a base de fibronectina de unión a glipicano-3
CN110498851B (zh) * 2015-11-10 2022-10-11 孙嘉琳 一种抗肿瘤蛋白内皮抑素的衍生物及应用
WO2017109706A1 (fr) 2015-12-22 2017-06-29 Novartis Ag Méthodes de traitement ou d'amélioration de troubles métaboliques à l'aide du facteur-15 de croissance et de différenciation (gdf-15)
PL3393496T3 (pl) 2015-12-23 2024-04-22 The Johns Hopkins University Długo działający agonista glp-1r jako terapia stanów neurologicznych i neurodegeneracyjnych
WO2017159540A1 (fr) * 2016-03-14 2017-09-21 Jcrファーマ株式会社 Protéine de fusion albumine sérique-hormone de croissance 20k
US10994033B2 (en) 2016-06-01 2021-05-04 Bristol-Myers Squibb Company Imaging methods using 18F-radiolabeled biologics
EP3827835A1 (fr) 2016-06-16 2021-06-02 Inozyme Pharma, Inc. Méthodes de traitement d'une prolifération myo-intimale
WO2018102743A1 (fr) 2016-12-02 2018-06-07 Bioverativ Therapeutics Inc. Méthodes de traitement de l'arthropathie hémophilique à l'aide de facteurs de coagulation chimériques
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2018132516A1 (fr) 2017-01-10 2018-07-19 Nodus Therapeutics Polythérapie pour le traitment de tumeurs avec une protéine de fusion fc de liaison à l'intégrine et un modulateur immunitaire
US10350266B2 (en) 2017-01-10 2019-07-16 Nodus Therapeutics, Inc. Method of treating cancer with a multiple integrin binding Fc fusion protein
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
WO2019067502A1 (fr) 2017-09-27 2019-04-04 Alexion Pharmaceuticals, Inc. Méthodes d'amélioration de la fonction cardio-vasculaire et de traitement d'une maladie cardio-vasculaire à l'aide d'une ecto-nucléotide pyrophosphatase/phosphodiestérase recombinante
CN110090295B (zh) * 2018-01-29 2022-12-23 武汉康理通科技有限公司 Ephrin-B1在制备治疗炎症性肠病的药物中的用途
WO2019152827A1 (fr) * 2018-02-02 2019-08-08 AskGene Pharma, Inc. Nouveaux conjugués anticorps-médicament (adc), procédés de fabrication et procédés d'utilisation de ceux-ci
MX2020008394A (es) 2018-02-12 2020-09-21 Biontech Rna Pharmaceuticals Gmbh Tratamiento que usa arn que codifica citoquinas.
DK3794024T5 (da) 2018-05-14 2024-08-19 Werewolf Therapeutics Inc Aktiverbare interleukin-2 polypeptider og fremgangsmåder til anvendelse heraf
EP3794023A1 (fr) 2018-05-14 2021-03-24 Werewolf Therapeutics, Inc. Polypeptides d'interleukine 12 activables et procédés d'utilisation associés
JP7763589B2 (ja) 2018-05-18 2025-11-04 バイオベラティブ セラピューティクス インコーポレイテッド 血友病aを処置する方法
EP3806889A4 (fr) 2018-06-18 2022-07-13 Anwita Biosciences, Inc. Protéines de fusion à base de cytokine et leurs utilisations
JP7550745B2 (ja) 2018-07-24 2024-09-13 バイオエヌテック エスエー Il2アゴニスト
US20220002370A1 (en) 2018-09-27 2022-01-06 Xilio Development, Inc. Masked cytokine polypeptides
MX2021003435A (es) 2018-09-28 2021-06-15 Massachusetts Inst Technology Moleculas inmunomoduladoras localizadas en el colageno y metodos de las mismas.
WO2020154032A1 (fr) 2019-01-23 2020-07-30 Massachusetts Institute Of Technology Schéma posologique de dosage d'immunothérapie combinée pour un blocage de points de contrôle immunitaires
WO2020152367A1 (fr) 2019-01-25 2020-07-30 Ospedale San Raffaele S.R.L. Inhibiteur de dux4 et ses utilisations
MX2021009506A (es) 2019-02-08 2021-09-08 Biontech Cell & Gene Therapies Gmbh Tratamiento que implica celulas t modificadas con car y citoquinas.
CA3133414A1 (fr) 2019-03-18 2020-09-24 Biontech Cell & Gene Therapies Gmbh Variants du recepteur de l'interleukine-2 (il2r) et de l'interleukine-2 (il2) pour l'activation specifique de cellules effectrices immunitaires
WO2020200481A1 (fr) 2019-04-05 2020-10-08 Biontech Rna Pharmaceuticals Gmbh Traitement à l'interleukine-2 (il2) et à l'interféron (ifn)
EP3955957A1 (fr) 2019-04-15 2022-02-23 Qwixel Therapeutics LLC Compositions de protéines de fusion comprenant des interférons de type i masqués ciblés (ifna et ifnb) et un anticorps contre un antigène tumoral, destinées à être utilisées dans le traitement du cancer
MX2021013766A (es) 2019-05-14 2022-02-21 Werewolf Therapeutics Inc Restos de separacion y metodos de uso de los mismos.
CN111944036B (zh) * 2019-05-14 2024-09-06 上海盖浦生物科技有限公司 一种增殖免疫细胞的突变体蛋白
TW202115105A (zh) 2019-06-24 2021-04-16 德商拜恩迪克Rna製藥有限公司 Il2激動劑
US11642409B2 (en) 2019-06-26 2023-05-09 Massachusetts Insttute of Technology Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
RU2714392C1 (ru) * 2019-07-09 2020-02-14 Екатерина Олеговна Кудасова Способ модификации поверхности метилметакрилата стоматологического протеза низкотемпературной газоразрядной плазмой кислорода низкого давления за счет изменения контактного угла смачивания по воде и свободной поверхностной энергии
AU2020329290A1 (en) 2019-08-13 2022-03-24 Elpis Biopharmaceuticals Engineered interleukin-2 receptor beta agonists
WO2021058091A1 (fr) 2019-09-24 2021-04-01 Biontech Rna Pharmaceuticals Gmbh Traitement impliquant un anticorps thérapeutique et l'interleukine-2 (il2)
AU2020384375A1 (en) 2019-11-14 2022-05-26 Werewolf Therapeutics, Inc. Activatable cytokine polypeptides and methods of use thereof
WO2021129927A1 (fr) 2019-12-23 2021-07-01 Biontech Cell & Gene Therapies Gmbh Traitement avec des cellules effectrices immunitaires modifiées pour exprimer un récepteur d'antigène
WO2021129945A1 (fr) 2019-12-27 2021-07-01 Biontech Cell & Gene Therapies Gmbh Administration in vitro et in vivo de gène pour cellules effectrices immunitaires utilisant des nanoparticules fonctionnalisées avec des protéines de répétition ankyrin conçues (darpin)
EP4110407A1 (fr) 2020-02-28 2023-01-04 Bristol-Myers Squibb Company Échafaudages et anticorps à base de fibronectine radiomarqués et leurs utilisations théranostiques
CA3171370A1 (fr) 2020-03-16 2021-09-23 Ugur Sahin Recepteurs de lymphocytes t specifiques a un antigene et epitopes de lymphocytes t
WO2021197589A1 (fr) 2020-03-31 2021-10-07 BioNTech SE Traitement faisant appel à un arn non immunogène pour la vaccination d'antigènes
PH12022553181A1 (en) 2020-05-26 2024-03-04 Boehringer Ingelheim Int Anti-pd-1 antibodies
WO2022030580A1 (fr) * 2020-08-06 2022-02-10 国立大学法人宮崎大学 Nouveau dérivé d'adrénomédulline à action prolongée, son procédé de production, et son utilisation pharmaceutique
KR102467827B1 (ko) * 2020-08-31 2022-11-16 연세대학교 산학협력단 미생물 에어로졸화 과정 중 발생하는 손상 방지 방법
CN112724259B (zh) * 2020-11-16 2022-12-20 天津林达生物科技有限公司 人血清白蛋白与白介素2的融合蛋白及其用途
TW202235431A (zh) 2020-11-25 2022-09-16 美商艾希利歐發展股份有限公司 腫瘤特異性可裂解連接子
WO2022135666A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Programme de traitement faisant intervenir des protéines cytokines
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性rna
WO2022135667A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Arn thérapeutique pour le traitement du cancer
CN112753846B (zh) * 2021-01-27 2023-08-29 吉林农业大学 一种超持水大豆分离蛋白凝胶及其制备方法
EP4322925A2 (fr) 2021-04-12 2024-02-21 BioNTech SE Compositions d'arn comprenant une substance tampon et procédés de préparation, de stockage et d'utilisation de celles-ci
AU2022260466A1 (en) 2021-04-20 2023-11-02 BioNTech SE Virus vaccine
CN117957237A (zh) * 2021-05-14 2024-04-30 安特利亚生物科学公司 经修饰的b型利钠肽
TW202317620A (zh) 2021-06-04 2023-05-01 德商百靈佳殷格翰國際股份有限公司 抗SIRPα抗體
CN113391067B (zh) * 2021-06-16 2023-07-25 军事科学院军事医学研究院军事兽医研究所 抗尼帕病毒g蛋白抗体的间接elisa检测方法
WO2023051926A1 (fr) 2021-09-30 2023-04-06 BioNTech SE Traitement impliquant un arn non immunogène pour vaccination antigénique et antagonistes liant l'axe pd-1
US20250222096A1 (en) 2021-10-21 2025-07-10 BioNTech SE Coronavirus vaccine
JP2024540948A (ja) 2021-10-22 2024-11-06 ビオンテック・ソシエタス・エウロパエア 異なる投与のrnaを投与するための組成物
WO2023083434A1 (fr) 2021-11-09 2023-05-19 BioNTech SE Arn codant pour la peptidoglycane hydrolase et son utilisation pour le traitement d'une infection bactérienne
WO2023126053A1 (fr) 2021-12-28 2023-07-06 BioNTech SE Formulations à base de lipides pour administration d'arn
US20250114337A1 (en) * 2022-01-21 2025-04-10 The Methodist Hospital Methods for vascular regeneration and wound treatment
WO2023165681A1 (fr) 2022-03-01 2023-09-07 BioNTech SE Nanoparticules lipidiques (npl) d'arn comprenant un polymère de polyoxazoline et/ou de polyoxazine
WO2023193892A1 (fr) 2022-04-05 2023-10-12 BioNTech SE Compositions d'acide nucléique comprenant un polyphosphate inorganique et procédés de préparation, de stockage et d'utilisation de celles-ci
CN119731199A (zh) 2022-05-10 2025-03-28 艾佩斯瑞生物制药公司 工程化的白细胞介素-2受体β降低结合的激动剂
US11878055B1 (en) 2022-06-26 2024-01-23 BioNTech SE Coronavirus vaccine
WO2024017479A1 (fr) 2022-07-21 2024-01-25 BioNTech SE Cellules multifonctionnelles exprimant de manière transitoire un récepteur immunitaire et une ou plusieurs cytokines, leur utilisation et leurs procédés de production
WO2024028325A1 (fr) 2022-08-01 2024-02-08 BioNTech SE Compositions d'acide nucléique contenant des composés conjugués-oligo éthylène glycol (oeg) amphiphiles et procédés d'utilisation de tels composés et compositions
WO2024027910A1 (fr) 2022-08-03 2024-02-08 BioNTech SE Arn pour la prévention ou le traitement de la tuberculose
EP4565266A1 (fr) 2022-08-03 2025-06-11 Nanoramic, Inc. Arn pour la prévention ou le traitement de la tuberculose
CN115960175A (zh) * 2022-08-08 2023-04-14 江南大学 一种强化乳铁蛋白表达的毕赤酵母及其构建方法与应用
EP4603587A1 (fr) * 2022-10-11 2025-08-20 JCR Pharmaceuticals Co., Ltd. Protéine de fusion d'albumine sérique et de protéine physiologiquement active
WO2024080304A1 (fr) * 2022-10-11 2024-04-18 Jcrファーマ株式会社 Protéine de fusion d'albumine sérique et de protéine physiologiquement active
EP4389762A1 (fr) 2022-12-23 2024-06-26 Ospedale San Raffaele S.r.l. Inhibiteurs de l'activité de dux4 et leur utilisation en thérapie.
WO2024153324A1 (fr) 2023-01-18 2024-07-25 BioNTech SE Formulations d'arn à usage pharmaceutique
EP4694919A1 (fr) 2023-04-14 2026-02-18 BioNTech SE Arn pour la prévention ou le traitement de la tuberculose
WO2024213776A1 (fr) 2023-04-14 2024-10-17 BioNTech SE Arn pour prévenir ou traiter la tuberculose
WO2024216214A1 (fr) 2023-04-14 2024-10-17 BioNTech SE Arn pour la prévention ou le traitement de la tuberculose
WO2025006676A2 (fr) 2023-06-27 2025-01-02 Firecyte Therapeutics, Inc. Compositions à base de protéines de liaison des facteurs de croissance de type insuline de type 1 (igfbpl1) et leurs procédés d'utilisation
WO2025021277A1 (fr) 2023-07-21 2025-01-30 BioNTech SE Agents et procédés d'administration ciblée de cytokines à des cellules immunitaires
WO2025026866A1 (fr) 2023-07-28 2025-02-06 BioNTech SE Agents thérapeutiques à base d'arn à toxicité réduite
WO2025074337A1 (fr) 2023-10-06 2025-04-10 Boehringer Ingelheim International Gmbh Utilisation d'anticorps anti-sirp-alpha pour traiter une maladie ou un trouble hépatique
TW202535460A (zh) 2023-10-06 2025-09-16 德商百靈佳殷格翰國際股份有限公司 抗SIRP-α抗體用於治療癌症之用途
CN117511986A (zh) * 2023-10-17 2024-02-06 广州立白企业集团有限公司 一种高效构建多基因改造酵母菌的方法及其应用
TW202539697A (zh) 2023-11-15 2025-10-16 德商拜恩技術股份公司 冠狀病毒疫苗
US20250277020A1 (en) 2024-03-01 2025-09-04 Boehringer Ingelheim International Gmbh Antibodies to connective tissue growth factor (ctgf) and uses thereof
WO2026042012A1 (fr) 2024-08-19 2026-02-26 Institute Of Molecular And Clinical Ophthalmology Basel (Iob) Anticorps à domaine unique et polypeptides les contenant
CN120591344A (zh) * 2025-06-13 2025-09-05 广州景旸生物科技有限公司 Col3a1蛋白的制备方法及其应用

Family Cites Families (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4002531A (en) 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US4714681A (en) 1981-07-01 1987-12-22 The Board Of Reagents, The University Of Texas System Cancer Center Quadroma cells and trioma cells and methods for the production of same
US4474893A (en) 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4716111A (en) 1982-08-11 1987-12-29 Trustees Of Boston University Process for producing human antibodies
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
DE3668186D1 (de) 1985-04-01 1990-02-15 Celltech Ltd Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert.
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB2210621B (en) 1987-04-09 1990-11-21 Delta Biotechnology Ltd Two micron yeast plasmid vector
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US4994560A (en) 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
US5489425A (en) 1987-06-24 1996-02-06 The Dow Chemical Company Functionalized polyamine chelants
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
PT88641B (pt) 1987-10-02 1993-04-30 Genentech Inc Metodo para a preparacao de uma variante de adesao
GB8725529D0 (en) 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides
JPH01215289A (ja) 1988-02-22 1989-08-29 Toa Nenryo Kogyo Kk 遺伝子組換えによる正常ヒト血清アルブミンaの製造方法
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
ZA894792B (en) 1988-06-24 1991-04-24 Dow Chemical Co Macrocyclic bifunctional chelants,complexes thereof and their antibody conjugates
US5756065A (en) 1988-06-24 1998-05-26 The Dow Chemical Company Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
ATE120457T1 (de) 1988-06-24 1995-04-15 Dow Chemical Co Macrocyclische bifunktionelle chelatbildner, komplexe davon und ihre konjugierten antikörper.
US5274119A (en) 1988-07-01 1993-12-28 The Dow Chemical Company Vicinal diols
US4925648A (en) 1988-07-29 1990-05-15 Immunomedics, Inc. Detection and treatment of infectious and inflammatory lesions
FR2649991B2 (fr) 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
AU4216689A (en) 1988-08-11 1990-03-05 California Biotechnology, Inc. Method for stabilizing heterologous protein expression and vectors for use therein
US5601819A (en) 1988-08-11 1997-02-11 The General Hospital Corporation Bispecific antibodies for selective immune regulation and for selective immune cell binding
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP1541682A3 (fr) 1988-09-02 2005-07-06 Dyax Corp. Production et sélection de protéines de liaison diversifiées recombinantes
US5349052A (en) 1988-10-20 1994-09-20 Royal Free Hospital School Of Medicine Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor
US5342604A (en) 1988-10-31 1994-08-30 The Dow Chemical Company Complexes possessing ortho ligating functionality
US5696239A (en) 1988-10-31 1997-12-09 The Dow Chemical Company Conjugates possessing ortho ligating functionality and complexes thereof
JP2989002B2 (ja) 1988-12-22 1999-12-13 キリン―アムジエン・インコーポレーテツド 化学修飾顆粒球コロニー刺激因子
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5705363A (en) * 1989-03-02 1998-01-06 The Women's Research Institute Recombinant production of human interferon τ polypeptides and nucleic acids
US5231020A (en) 1989-03-30 1993-07-27 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
US5324844A (en) 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5766883A (en) 1989-04-29 1998-06-16 Delta Biotechnology Limited Polypeptides
US5808003A (en) 1989-05-26 1998-09-15 Perimmune Holdings, Inc. Polyaminocarboxylate chelators
ES2096590T3 (es) 1989-06-29 1997-03-16 Medarex Inc Reactivos biespecificos para la terapia del sida.
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
FR2650598B1 (fr) 1989-08-03 1994-06-03 Rhone Poulenc Sante Derives de l'albumine a fonction therapeutique
US5073627A (en) 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
WO1991005867A1 (fr) 1989-10-13 1991-05-02 Amgen Inc. Isoformes d'erythropoietine
US5667986A (en) * 1989-10-18 1997-09-16 Delta Biotechnology Limited Yeast promoter for expressing heterologous polypeptides
GB8924021D0 (en) 1989-10-25 1989-12-13 Celltech Ltd Recombinant dna method and vectors for the use therein
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
WO1991010737A1 (fr) 1990-01-11 1991-07-25 Molecular Affinities Corporation Production d'anticorps utilisant des librairies de genes
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
ES2087997T3 (es) 1990-01-12 1996-08-01 Cell Genesys Inc Generacion de anticuerpos xenogenicos.
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5545618A (en) 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
US5747334A (en) 1990-02-15 1998-05-05 The University Of North Carolina At Chapel Hill Random peptide library
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9013017D0 (en) 1990-06-11 1990-08-01 Mars Uk Ltd Compounds
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5225341A (en) 1990-07-19 1993-07-06 The Regents Of The University Of California Biologically safe plant transformation system using a ds transposon
US5202239A (en) 1990-08-07 1993-04-13 Scios Nova Inc. Expression of recombinant polypeptides with improved purification
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
DE69130709T3 (de) 1990-10-05 2005-12-22 Celldex Therapeutics, Inc. Gezielte immunostimulierung mit bispezifischen stoffen
JPH07108232B2 (ja) 1990-10-09 1995-11-22 エム・ディ・リサーチ株式会社 ペプチド又は蛋白質の製造方法
EP0557300B1 (fr) 1990-10-29 1997-11-19 Chiron Corporation Anticorps bispecifiques, methodes de production et utilisation desdits anticorps
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
ATE414768T1 (de) 1991-04-10 2008-12-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
DE69214709T2 (de) 1991-04-26 1997-02-20 Surface Active Ltd Neue Antikörper und Verfahren zu ihrer Verwendung
US5646012A (en) 1991-04-30 1997-07-08 Rhone-Poulenc Rorer S.A. Yeast promoter and use thereof
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
CA2110799A1 (fr) 1991-06-14 1992-12-23 Arnold H. Horwitz Fragments d'anticorps d'origine microbienne, et conjugues
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
ATE463573T1 (de) 1991-12-02 2010-04-15 Medimmune Ltd Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
US5428139A (en) 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
FR2686620B1 (fr) 1992-01-27 1995-06-23 Rhone Poulenc Rorer Sa Serum-albumine humaine, preparation et utilisation.
FR2686900B1 (fr) 1992-01-31 1995-07-21 Rhone Poulenc Rorer Sa Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant.
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
EP0627940B1 (fr) 1992-03-05 2003-05-07 Board of Regents, The University of Texas System Utilisation d'immunoconjugués pour le diagnostic et/ou le traitement de tumeurs vascularisées.
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
ES2136664T3 (es) 1992-06-09 1999-12-01 Hoppe Ag Sistema de cierre y conjunto de cerradura.
US5505931A (en) 1993-03-04 1996-04-09 The Dow Chemical Company Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents
EP0652766B2 (fr) 1992-07-31 2008-03-19 Genentech, Inc. Composition aqueuse a base d'hormone de croissance humaine
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US5441050A (en) 1992-12-18 1995-08-15 Neoprobe Corporation Radiation responsive surgical instrument
DK82893D0 (da) 1993-07-08 1993-07-08 Novo Nordisk As Peptid
US5512459A (en) 1993-07-20 1996-04-30 Bionebraska, Inc. Enzymatic method for modification or recombinant polypeptides
GB9317618D0 (en) 1993-08-24 1993-10-06 Royal Free Hosp School Med Polymer modifications
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
WO1995015982A2 (fr) 1993-12-08 1995-06-15 Genzyme Corporation Procede de generation d'anticorps specifiques
US5705483A (en) * 1993-12-09 1998-01-06 Eli Lilly And Company Glucagon-like insulinotropic peptides, compositions and methods
DK144093D0 (fr) * 1993-12-23 1993-12-23 Novo Nordisk As
DE69531148T2 (de) 1994-01-31 2004-04-29 Trustees Of Boston University, Boston Bibliotheken aus polyklonalen antikörpern
US5516637A (en) 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
US5985660A (en) 1994-06-15 1999-11-16 Systemix, Inc. Method of identifying biological response modifiers involved in dendritic and/or lymphoid progenitor cell proliferation and/or differentiation
US5639642A (en) 1994-06-16 1997-06-17 Novo Nordisk A/S Synthetic leader peptide sequences
US5623054A (en) 1994-06-23 1997-04-22 The General Hospital Corporation Crucifer AFT proteins and uses thereof
US5574008A (en) * 1994-08-30 1996-11-12 Eli Lilly And Company Biologically active fragments of glucagon-like insulinotropic peptide
US5512549A (en) * 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
EP0822830B1 (fr) 1995-04-27 2008-04-02 Amgen Fremont Inc. Anticorps anti-IL-8 dérivés de xenosouris immunisées
CA2219486A1 (fr) 1995-04-28 1996-10-31 Abgenix, Inc. Anticorps humains derives de xeno-souris immunisees
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
GB9526733D0 (en) * 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US6087129A (en) 1996-01-19 2000-07-11 Betagene, Inc. Recombinant expression of proteins from secretory cell lines
CA2246431A1 (fr) 1996-01-19 1997-07-24 Board Of Regents, The University Of Texas System Expression recombinee de proteines a partir de lignees cellulaires secretoires
US6110707A (en) 1996-01-19 2000-08-29 Board Of Regents, The University Of Texas System Recombinant expression of proteins from secretory cell lines
JP2978435B2 (ja) 1996-01-24 1999-11-15 チッソ株式会社 アクリロキシプロピルシランの製造方法
CZ297338B6 (cs) 1996-03-01 2006-11-15 Novo Nordisk A/S Peptid potlacující chut k jídlu, farmaceutický prostredek jej obsahující a jeho pouzití
US5912229A (en) 1996-03-01 1999-06-15 Novo Nordisk Als Use of a pharmaceutical composition comprising an appetite-suppressing peptide
AU5711196A (en) 1996-03-14 1997-10-01 Human Genome Sciences, Inc. Apoptosis inducing molecule i
EP0904278A4 (fr) 1996-03-22 1999-09-15 Human Genome Sciences Inc Molecule ii inductrice d'apoptose
US6300065B1 (en) 1996-05-31 2001-10-09 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6110703A (en) 1996-07-05 2000-08-29 Novo Nordisk A/S Method for the production of polypeptides
EP0918859A1 (fr) 1996-08-02 1999-06-02 ZymoGenetics, Inc. Polypeptides homologues de l'insuline, specifiques des testicules
US6277819B1 (en) 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6006753A (en) * 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
AU4199597A (en) 1996-09-09 1998-04-02 Novo Nordisk A/S A cdna and peptide with relation to cancer and weight loss
AU7364696A (en) 1996-09-18 1998-04-14 Human Genome Sciences, Inc. Human tumor necrosis factor receptor-like genes
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
UA65549C2 (uk) * 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
EP1306092A3 (fr) 1996-11-05 2003-05-07 Eli Lilly & Company Utilisation d'analogues et de derivés de GLP-1 administrés de facon périphérique aux fins de la régulation de l'obésité
DE69732572T2 (de) 1996-11-12 2005-12-29 Novo Nordisk A/S Verwendung von glp-1 peptiden
EP2305027B1 (fr) 1996-12-03 2014-07-02 Amgen Fremont Inc. Mammifères trangèniques obtenus par génie génétique contenant des loci des immunoglobulines humaines qui comprennent plusieurs régions de VH et de Vkappa, et anticorps aussi obtenus.
EP0954589A1 (fr) 1997-01-24 1999-11-10 Novo Nordisk A/S Nouvelles sequences-guides synthetiques de peptides
AU5773798A (en) 1997-01-29 1998-08-18 Polymasc Pharmaceuticals Plc Pegylation process
US20060084082A1 (en) * 1997-03-07 2006-04-20 Human Genome Sciences, Inc. 186 human secreted proteins
US20030049618A1 (en) * 1997-03-07 2003-03-13 Ruben Steven M. 186 human secreted proteins
US20030065139A1 (en) * 1998-03-19 2003-04-03 Craig A. Rosen Secreted protein hmmbd35
US6420526B1 (en) * 1997-03-07 2002-07-16 Human Genome Sciences, Inc. 186 human secreted proteins
US20030175858A1 (en) * 1997-03-07 2003-09-18 Ruben Steven M. 186 human secreted proteins
CA2283834A1 (fr) * 1997-03-31 1998-10-08 James Arthur Hoffmann Analogues de peptide 1 assimile au glucagon (glp-1)
SI0970126T1 (en) 1997-04-14 2001-08-31 Micromet Ag Novel method for the production of antihuman antigen receptors and uses thereof
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
GB9713412D0 (en) 1997-06-26 1997-08-27 Delta Biotechnology Ltd Improved protein expression strains
JP2001516580A (ja) 1997-09-17 2001-10-02 ジェネンテック・インコーポレーテッド 分泌性の、および膜貫通性のポリぺプチド、およびそれをコードする核酸
DE69839060T2 (de) 1997-11-03 2009-01-15 Human Genome Sciences, Inc. Vegi, ein inhibitor der angiogenese und des tumorwachstums
WO1999043706A1 (fr) 1998-02-27 1999-09-02 Novo Nordisk A/S Derives d'analogues de glp-1
US7205280B2 (en) * 1998-03-11 2007-04-17 Cognosci, Inc. Methods of suppressing microglial activation
CA2330527A1 (fr) * 1998-06-15 1999-12-23 Genzyme Transgenics Corporation Fusion analogue d'erythropoietine-albumine serique humaine
MY155270A (en) 1998-09-24 2015-09-30 Lilly Co Eli Use of glp-1 or analogs in treatment of stroke
US7259136B2 (en) 1999-04-30 2007-08-21 Amylin Pharmaceuticals, Inc. Compositions and methods for treating peripheral vascular disease
US6514500B1 (en) 1999-10-15 2003-02-04 Conjuchem, Inc. Long lasting synthetic glucagon like peptide {GLP-!}
EP1180121B9 (fr) 1999-05-17 2004-09-08 Conjuchem, Inc. Peptides insulinotropes a longue duree d'action
CA2376641A1 (fr) 1999-07-19 2001-01-25 Aaron Morris Polypeptides chimeres d'albumine serique et utilisations associees
US20020048571A1 (en) 1999-07-19 2002-04-25 Jeno Gyuris Chimeric polypeptides of serum albumin and uses related thereto
JP2003530838A (ja) * 2000-04-12 2003-10-21 ヒューマン ゲノム サイエンシズ インコーポレイテッド アルブミン融合タンパク質
WO2001089554A2 (fr) 2000-05-19 2001-11-29 Bionebraska, Inc. Traitement du syndrome coronarien aigu par glp-1
WO2002034285A2 (fr) 2000-10-20 2002-05-02 Coolidge Thomas R Traitement du myocarde hibernant et de la cardiomiopathie diabétique par un peptide glp-1
US7101561B2 (en) * 2000-12-01 2006-09-05 Innogenetics N.V. Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
UA93662C2 (uk) 2000-12-07 2011-03-10 Эли Лилли Энд Компани Гетерологічний пептидильований глюкагон-подібний білок та його застосування для виготовлення лікарського засобу для лікування пацієнтів, що страждають на ожиріння або інсулінонезалежний цукровий діабет
CA2446739A1 (fr) 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Proteines hybrides beta-1 de chimiokine
CA2458371A1 (fr) 2001-08-23 2003-03-06 Eli Lilly And Company Analogues de glp-1 (glucagon-like peptide 1)
WO2003042354A2 (fr) * 2001-09-04 2003-05-22 Aventis Pharmaceuticals Inc. Polypeptides appeles abrogenes, acides nucleiques codant ces derniers et procedes d'utilisation desdits polypeptides abrogenes pour inhiber l'angiogenese
WO2003030821A2 (fr) * 2001-10-05 2003-04-17 Human Genome Sciences, Inc. Proteines de fusion d'albumine
EP2305312B1 (fr) * 2001-10-10 2015-03-04 ratiopharm GmbH Remodelage et glycoconjugation de l'hormone folliculo-stimulante (FSH)
ES2425738T3 (es) * 2001-12-21 2013-10-17 Human Genome Sciences, Inc. Proteínas de fusión de la albúmina
AU2002364587A1 (en) * 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
US20080167238A1 (en) * 2001-12-21 2008-07-10 Human Genome Sciences, Inc. Albumin Fusion Proteins
KR101271635B1 (ko) * 2001-12-21 2013-06-12 휴먼 게놈 사이언시즈, 인코포레이티드 알부민 융합 단백질
WO2003054182A2 (fr) * 2001-12-21 2003-07-03 Nexia Biotechnologies, Inc. Production de butyrylcholinesterases par des mammiferes transgeniques
JP2005535569A (ja) 2002-04-04 2005-11-24 ノボ・ノルデイスク・エー/エス Glp−1アゴニスト及び心臓血管合併症
CN1241946C (zh) * 2002-07-01 2006-02-15 美国福源集团 对多种细胞具刺激增生作用的人血清白蛋白重组融合蛋白
EP1594530A4 (fr) * 2003-01-22 2006-10-11 Human Genome Sciences Inc Proteines hybrides d'albumine
EA008831B1 (ru) 2003-06-12 2007-08-31 Эли Лилли Энд Компани Слитые белки аналогов glp-1
EP1729795B1 (fr) 2004-02-09 2016-02-03 Human Genome Sciences, Inc. Proteines hybrides d'albumine
US20070270339A1 (en) * 2004-04-23 2007-11-22 Serono, Inc. Use of GPCR54 Ligands for the Treatment of Infertility
AU2005323063B2 (en) 2004-12-24 2011-01-27 Amylin Pharmaceuticals, Llc Use of GLP-1 and agonists thereof to prevent cardiac myocyte apoptosis
US8946149B2 (en) 2005-04-11 2015-02-03 Amylin Pharmaceuticals, Llc Use of exendin and analogs thereof to delay or prevent cardiac remodeling
AU2006280312A1 (en) 2005-08-12 2007-02-22 Human Genome Sciences, Inc. Albumin fusion proteins
KR20090031368A (ko) 2006-05-26 2009-03-25 아밀린 파마슈티칼스, 인크. 울혈성 심부전 치료용 조성물 및 방법
BRPI0712383A2 (pt) 2006-06-07 2012-07-10 Human Genome Sciences Inc proteìnas de fusão da albumina
WO2008019143A2 (fr) 2006-08-04 2008-02-14 Amylin Pharmaceuticals, Inc Utilisation d'exendines et d'agonistes d'exendines et d'agonistes du récepteur glp-1 pour modifier la dimension de particule et la composition de sous-classe de lipoprotéines
JP5005450B2 (ja) * 2007-07-13 2012-08-22 本田技研工業株式会社 燃料給油管の口元内部構造

Also Published As

Publication number Publication date
IL176894A (en) 2012-08-30
KR101184391B1 (ko) 2013-03-14
WO2005077042A3 (fr) 2006-11-30
JP2012140448A (ja) 2012-07-26
PL1729795T3 (pl) 2016-08-31
AU2005211725A1 (en) 2005-08-25
EP1729795A4 (fr) 2008-05-21
US20100093627A1 (en) 2010-04-15
AU2010227035A1 (en) 2010-11-04
BRPI0507026A (pt) 2007-04-17
IL176894A0 (en) 2006-12-10
KR20070016119A (ko) 2007-02-07
CN102816241A (zh) 2012-12-12
US20070048282A1 (en) 2007-03-01
US8143026B2 (en) 2012-03-27
AU2005211725B2 (en) 2010-07-15
CA2554089C (fr) 2013-10-22
JP5568582B2 (ja) 2014-08-06
JP2007522806A (ja) 2007-08-16
ES2567634T3 (es) 2016-04-25
NZ548612A (en) 2009-11-27
NO20064059L (no) 2006-11-02
CY1117401T1 (el) 2017-04-26
CN102816241B (zh) 2015-07-22
HK1095087A1 (zh) 2007-04-27
EP1729795B1 (fr) 2016-02-03
US7569384B2 (en) 2009-08-04
DK1729795T3 (en) 2016-04-11
US20070027306A1 (en) 2007-02-01
SI1729795T1 (sl) 2016-04-29
MXPA06009072A (es) 2007-03-29
JP5010923B2 (ja) 2012-08-29
WO2005077042A2 (fr) 2005-08-25
CA2554089A1 (fr) 2005-08-25
EP1729795A2 (fr) 2006-12-13
HUE027902T2 (en) 2016-11-28

Similar Documents

Publication Publication Date Title
EP1729795A4 (fr) Proteines hybrides d'albumine
EP1463751A4 (fr) Proteines hybrides d'albumine
SMT202000607T1 (it) Proteine leganti l'interleuchina-13
EP1711165A4 (fr) Proteines d'echafaudage membranaires
EP1688439A4 (fr) Composition proteique hybride
EP1915177A4 (fr) Anticorps d'alpha-synucléine et techniques associées
BRPI0815368A2 (pt) "proteinas c-fms humanas a antigeno"
ATE465180T1 (de) Therapeutische anti-igfr1-antikörper- kombinationen
ZA200703445B (en) Nanoparticulated whey proteins
EP1828251A4 (fr) Procedes et compositions permettant d'ameliorer la fabrication de proteines recombinantes
CY2015030I2 (el) Ανταγωνιστικα αντισωματα il-17
EP1736711A4 (fr) Contrôleur d'humidité
MA29014B1 (fr) Formulations d'anticorps
EP1810979A4 (fr) ANTICORPS IgGG4 HUMAINS STABILISES
EP1950309A4 (fr) Agent de denaturation de l'albumine
EP2154148A4 (fr) Proteine l1 tronquee du papillomavirus 11 humain
DE602004019159D1 (de) Drosselklappenstutzen
FR2875398B1 (fr) Implant articulaire d'interposition
DK1809660T3 (da) Thymus-specifikt protein
EP1980801A4 (fr) Unite interieure pour conditionneur d'air
EP1741218A4 (fr) Mobilite d'extension amelioree
EP1682572A4 (fr) Expression de proteines
EP1765386A4 (fr) Domaine ns5 du virus de l'hepatite c tronque et proteines hybrides comprenant ce dernier
DE602004017295D1 (de) Drosselkörper
EP1646401A4 (fr) Anticorps humains specifiques