LV12889B - Kristālisks ceftiofūrs brīvas skābes formā - Google Patents

Kristālisks ceftiofūrs brīvas skābes formā Download PDF

Info

Publication number
LV12889B
LV12889B LVP-02-107A LV020107A LV12889B LV 12889 B LV12889 B LV 12889B LV 020107 A LV020107 A LV 020107A LV 12889 B LV12889 B LV 12889B
Authority
LV
Latvia
Prior art keywords
crystalline
free acid
ceftiofur
oil
compound
Prior art date
Application number
LVP-02-107A
Other languages
English (en)
Latvian (lv)
Inventor
Michael J. Dunn
Michael S. Bergren
Gregory E. Hardee
Kenneth Paul Shephard
Robert S. Chao
Jeffrey L. Havens
Original Assignee
Pharmacia & Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company
Publication of LV12889B publication Critical patent/LV12889B/lv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
LVP-02-107A 1993-03-12 2002-06-13 Kristālisks ceftiofūrs brīvas skābes formā LV12889B (lv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3329193A 1993-03-12 1993-03-12

Publications (1)

Publication Number Publication Date
LV12889B true LV12889B (lv) 2002-12-20

Family

ID=21869579

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-02-107A LV12889B (lv) 1993-03-12 2002-06-13 Kristālisks ceftiofūrs brīvas skābes formā

Country Status (31)

Country Link
US (1) US5721359A (hu)
EP (1) EP0690864B1 (hu)
JP (1) JP3852946B2 (hu)
KR (1) KR100296810B1 (hu)
CN (1) CN1055090C (hu)
AT (1) ATE202109T1 (hu)
AU (1) AU694419B2 (hu)
BR (1) BR1101034A (hu)
CA (1) CA2155322C (hu)
CZ (1) CZ289332B6 (hu)
DE (2) DE122005000055I2 (hu)
DK (1) DK0690864T3 (hu)
ES (1) ES2157254T3 (hu)
FI (1) FI120307B (hu)
FR (1) FR05C0045I2 (hu)
GR (1) GR3036514T3 (hu)
HU (1) HU222244B1 (hu)
IL (1) IL108910A (hu)
LU (1) LU91206I2 (hu)
LV (1) LV12889B (hu)
NL (1) NL300208I2 (hu)
NO (2) NO313199B1 (hu)
NZ (1) NZ263002A (hu)
PL (1) PL184611B1 (hu)
PT (1) PT690864E (hu)
RU (1) RU2136685C1 (hu)
SI (1) SI0690864T1 (hu)
SK (1) SK283674B6 (hu)
TW (1) TW267170B (hu)
WO (1) WO1994020505A1 (hu)
ZA (1) ZA941586B (hu)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736151A (en) * 1996-12-09 1998-04-07 Pharmacia & Upjohn Company Antibiotic oil suspensions
US6074657A (en) * 1997-03-20 2000-06-13 Pharmacia & Upjohn Company Administration of an injectable antibiotic in the ear of an animal
JP4738713B2 (ja) * 2000-09-12 2011-08-03 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 修飾された担体を含む医薬組成物
US7829100B2 (en) * 2000-09-12 2010-11-09 Teagarden Dirk L Pharmaceutical composition having modified carrier
KR100423895B1 (ko) * 2001-02-19 2004-03-24 주식회사 엘지생명과학 셉티오퍼 하이드로클로라이드의 현탁제 조성물
EP1406880A1 (en) * 2001-07-10 2004-04-14 PHARMACIA & UPJOHN COMPANY Crystalline thiazine oxazolidinones
EP3168218B1 (en) * 2001-08-15 2018-11-14 Pharmacia & Upjohn Company LLC A crystal comprising an l-malic acid salt of n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide for use as a medicament
KR20040097187A (ko) † 2002-03-21 2004-11-17 파마시아 앤드 업존 캄파니 동물의 귀로의 주사가능한 항생제의 투여 방법
US20040022815A1 (en) * 2002-08-05 2004-02-05 Orchid Health Care Novel pharmaceutical composition of ceftiofur
KR20040015622A (ko) * 2002-08-13 2004-02-19 대한뉴팜(주) 세프티오푸르나트륨을 활성성분으로 함유하는 현탁주사액조성물
US20040115822A1 (en) * 2002-09-12 2004-06-17 Schapaugh Randal Lee Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition
US7659061B2 (en) * 2002-11-19 2010-02-09 Pharmacia & Upjohn Company Pharmaceutical compositions having a modified vehicle
US20040115837A1 (en) * 2002-11-27 2004-06-17 Schapaugh Randal Lee Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
ATE440101T1 (de) * 2003-03-27 2009-09-15 Basilea Pharmaceutica Ag Cephalosporin in kristalliner form
EP1728791A4 (en) 2004-03-25 2008-12-10 Astellas Pharma Inc COMPOSITIONS FOR SOLID PHARMACEUTICAL PREPARATION OF SOLIFENACIN OR BZW. A SALT OF IT
US7815939B2 (en) 2005-07-20 2010-10-19 Astellas Pharma Inc. Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms
EP1934231A4 (en) * 2005-10-12 2011-10-26 Orchid Chemicals & Pharm Ltd CRYSTALLINE SODIUM SALT OF ANTIBIOTICS BASED ON CEPHALOSPORINE
US8470809B2 (en) * 2005-10-12 2013-06-25 Orchid Chemicals & Pharmaceuticals Limited Crystalline sodium salt of cephalosporin antibiotic
PT2195293E (pt) 2007-08-22 2014-01-21 Astrazeneca Ab Derivados da ciclopropilamida
US9943614B2 (en) 2008-06-17 2018-04-17 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
WO2010020871A2 (en) * 2008-08-22 2010-02-25 Orchid Chemicals & Pharmaceuticals Limited Crystalline sodium salt of cephalosporin antibiotic
AU2009316708B2 (en) * 2008-11-19 2014-07-17 Boehringer Ingelheim Animal Health USA Inc. Formulations comprising ceftiofur and ketoprofen or ceftiofur and benzyl alcohol
PE20120003A1 (es) * 2009-01-30 2012-02-12 Glaxosmithkline Llc Hidrocloruro de n-{(1s)-2-amino-1-[(3-fluorofenil)metil)etil}-5-cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino
TW201039825A (en) 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
RU2012136148A (ru) 2010-02-18 2014-03-27 Астразенека Аб Новая кристаллическая форма производного циклопропилбензамида
AU2011218490B9 (en) * 2010-02-18 2014-12-18 Astrazeneca Ab Solid forms comprising a cyclopropyl amide derivative
WO2012150520A1 (en) * 2011-05-02 2012-11-08 Pfizer Inc. Novel cephalosporins useful as antibacterial agents
CN104053458B (zh) 2011-07-20 2016-07-20 布莱阿姆青年大学 包含洗脱塞拉集宁化合物的水凝胶材料
JP6038154B2 (ja) 2011-09-13 2016-12-07 ブリガム・ヤング・ユニバーシティＢｒｉｇｈａｍ Ｙｏｕｎｇ Ｕｎｉｖｅｒｓｉｔｙ 骨疾患および破断骨治療のための組成物
KR101966293B1 (ko) 2011-09-13 2019-04-08 브라이엄 영 유니버시티 손상조직 치유용 제품
US9694019B2 (en) 2011-09-13 2017-07-04 Brigham Young University Compositions and methods for treating bone diseases and broken bones
US9603859B2 (en) 2011-09-13 2017-03-28 Brigham Young University Methods and products for increasing the rate of healing of tissue wounds
MX2014007496A (es) 2011-12-21 2015-02-17 Univ Brigham Young Composiciones para el cuidado oral.
CN102584855B (zh) * 2012-02-16 2014-06-25 青岛科技大学 一种改进的头孢噻呋的制备方法
US9533063B1 (en) 2012-03-01 2017-01-03 Brigham Young University Aerosols incorporating ceragenin compounds and methods of use thereof
CA2872399C (en) 2012-05-02 2021-01-12 Brigham Young University Ceragenin particulate materials and methods for making same
BR112015008804A2 (pt) 2012-10-17 2017-07-04 Univ Brigham Young tratamento e prevenção de mastite
WO2014087972A1 (ja) * 2012-12-03 2014-06-12 株式会社カネカ 還元型補酵素ｑ10誘導体およびその製造方法
CA2897150C (en) 2013-01-07 2021-07-13 Brigham Young University Methods for reducing cellular proliferation and treating certain diseases
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
WO2014151411A1 (en) 2013-03-15 2014-09-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
US10568893B2 (en) 2013-03-15 2020-02-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
RU2546675C2 (ru) * 2013-04-11 2015-04-10 Федеральное казённое предприятие "Государственный научно-исследовательский институт химических продуктов" (ФКП "ГосНИИХП") Способ определения степени кристалличности составов на основе дифениламина
US9387215B2 (en) 2013-04-22 2016-07-12 Brigham Young University Animal feed including cationic cholesterol additive and related methods
KR102177643B1 (ko) * 2013-09-05 2020-11-11 미쓰비시 타나베 파마 코퍼레이션 신규한 결정성 아릴알킬아민 화합물 및 그의 제조 방법
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
CA2844321C (en) 2014-02-27 2021-03-16 Brigham Young University Cationic steroidal antimicrobial compounds
US9867836B2 (en) 2014-03-13 2018-01-16 Brigham Young University Lavage and/or infusion using CSA compounds for increasing fertility in a mammal
US10220045B2 (en) 2014-03-13 2019-03-05 Brigham Young University Compositions and methods for forming stabilized compositions with reduced CSA agglomeration
US9931350B2 (en) 2014-03-14 2018-04-03 Brigham Young University Anti-infective and osteogenic compositions and methods of use
US9686966B2 (en) 2014-04-30 2017-06-27 Brigham Young University Methods and apparatus for cleaning or disinfecting a water delivery system
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
US10441595B2 (en) 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
US10227376B2 (en) 2014-08-22 2019-03-12 Brigham Young University Radiolabeled cationic steroid antimicrobials and diagnostic methods
US10155788B2 (en) 2014-10-07 2018-12-18 Brigham Young University Cationic steroidal antimicrobial prodrug compositions and uses thereof
KR102331856B1 (ko) * 2014-10-21 2021-11-29 다케다 야쿠힌 고교 가부시키가이샤 결정 형태의 5-클로로-n4-[2-(디메틸포스포릴)페닐]-n2-｛2-메톡시-4-[4-(4-메틸피페라진-1-일)피페리딘-1-일]피리미딘-2,4-디아민
US9527883B2 (en) 2015-04-22 2016-12-27 Brigham Young University Methods for the synthesis of ceragenins
WO2016172543A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
KR101753842B1 (ko) * 2015-05-12 2017-07-04 한국화학연구원 불화퀴놀론계 항생제를 담지한 서방형 제제 및 이의 제조방법
US9434759B1 (en) 2015-05-18 2016-09-06 Brigham Young University Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds
CN106543203B (zh) * 2015-09-18 2019-07-02 瑞普（天津）生物药业有限公司 一种长效头孢噻呋自由酸晶体的制备方法
EP3778567A1 (en) * 2016-01-22 2021-02-17 Sandoz Ag Crystalline eravacycline bis-hydrochloride
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
KR101898282B1 (ko) * 2016-05-24 2018-09-13 주식회사 고려비엔피 항생제의 서방형 수의학적 조성물 및 이의 제조방법
US10889577B2 (en) 2016-07-07 2021-01-12 Cyclerion Therapeutics, Inc. Solid forms of an sGC stimulator
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity
US11186556B1 (en) * 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
TW202233625A (zh) * 2020-11-18 2022-09-01 美商傳達治療有限公司 Ｆｇｆｒ抑制劑及其製造及使用方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1207933B (de) * 1962-12-26 1965-12-30 American Home Prod Verfahren zur Herstellung von kristallwasser-freiem D-alpha-Aminobenzylpenicillin
US3489750A (en) * 1967-09-05 1970-01-13 Bristol Myers Co 7-amino-cephalosporanic and decephalosporanic acid derivatives
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
GB1532682A (en) * 1976-04-27 1978-11-22 Bristol Myers Co Process for the preparation of cephadroxil
FR2479229B1 (fr) * 1980-03-26 1986-01-17 Clin Midy Nouveaux derives des cephalosporines, leur procede de preparation et les medicaments utilisables comme antibiotiques qui contiennent lesdits derives
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
US4400503A (en) * 1981-10-30 1983-08-23 Eli Lilly And Company Purification of syn-7-[[(2-amino-4-thiazolyl)(methoxyimino) acetyl]amino]-3-methyl-3-cephem-4-carboxylic acid
DE3313818A1 (de) * 1983-04-16 1984-10-18 Hoechst Ag, 6230 Frankfurt Neue kristallmodifikation von ceftazidim
ES8702440A1 (es) * 1984-10-04 1986-12-16 Monsanto Co Un procedimiento para la preparacion de una composicion de polipeptido inyectable sustancialmente no acuosa.
US4902683A (en) * 1984-10-25 1990-02-20 The Upjohn Company Crystalline cephalosporin hydrohalide salts
IT1181672B (it) * 1984-10-25 1987-09-30 Upjohn Co Cefalosporina alogenidrato cristallino
US4937330A (en) * 1985-08-12 1990-06-26 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
GB8608962D0 (en) * 1986-04-12 1986-05-14 Beecham Group Plc Beta-lactam antibiotics
IT1214587B (it) * 1986-12-23 1990-01-18 Giovanni Bonfanti Metodo per la produzione diprodotti cristallini puri.
EP0278656B1 (en) * 1987-02-02 1992-06-03 Eli Lilly And Company Process for preparing ceftazidime pentahydrate
ATE73333T1 (de) * 1987-07-29 1992-03-15 Upjohn Co Kontrollierte freisetzung von antibiotika-salzen aus einem implantat.
DE3887691T2 (de) * 1987-11-10 1994-06-09 Upjohn Co Cephalosporin-antibiotika.
US4877782A (en) * 1988-02-16 1989-10-31 The Upjohn Company Zinc ceftiofur complexes

Also Published As

Publication number Publication date
FI120307B (fi) 2009-09-15
ES2157254T3 (es) 2001-08-16
FR05C0045I2 (hu) 2007-08-03
SI0690864T1 (en) 2001-10-31
PL310556A1 (en) 1995-12-27
NZ263002A (en) 1996-12-20
SK111495A3 (en) 1995-12-06
CA2155322A1 (en) 1994-09-15
SK283674B6 (sk) 2003-11-04
CZ289332B6 (cs) 2002-01-16
EP0690864A1 (en) 1996-01-10
DE69427469D1 (en) 2001-07-19
FR05C0045I1 (hu) 2006-01-06
HU9501960D0 (en) 1995-09-28
FI954250A0 (fi) 1995-09-11
AU694419B2 (en) 1998-07-23
IL108910A (en) 1999-10-28
JP3852946B2 (ja) 2006-12-06
DE122005000055I1 (de) 2006-02-23
NO953564L (no) 1995-11-07
EP0690864B1 (en) 2001-06-13
CZ9502290A3 (cs) 2001-08-15
NO2005025I2 (no) 2010-11-22
HU222244B1 (hu) 2003-05-28
DE122005000055I2 (de) 2008-06-05
GR3036514T3 (en) 2001-12-31
CN1055090C (zh) 2000-08-02
KR100296810B1 (ko) 2001-10-24
NO953564D0 (no) 1995-09-11
NL300208I1 (nl) 2006-02-01
FI954250A (fi) 1995-09-11
PT690864E (pt) 2001-11-30
ATE202109T1 (de) 2001-06-15
IL108910A0 (en) 1994-06-24
ZA941586B (en) 1995-09-07
PL184611B1 (pl) 2002-11-29
DE69427469T2 (de) 2001-10-31
JPH08507519A (ja) 1996-08-13
BR1101034A (pt) 2002-04-30
CA2155322C (en) 2000-02-29
RU2136685C1 (ru) 1999-09-10
NO2005025I1 (no) 2005-12-05
NL300208I2 (nl) 2006-05-01
CN1119016A (zh) 1996-03-20
AU6351094A (en) 1994-09-26
US5721359A (en) 1998-02-24
LU91206I2 (fr) 2006-05-30
DK0690864T3 (da) 2001-09-17
WO1994020505A1 (en) 1994-09-15
HUT73781A (en) 1996-09-30
NO313199B1 (no) 2002-08-26
TW267170B (hu) 1996-01-01

Similar Documents

Publication Publication Date Title
EP0690864B1 (en) Crystalline ceftiofur free acid
KR0180798B1 (ko) 결정성 페니실린 유도체, 그의 제법 및 용도
PL172830B1 (pl) Preparat farmaceutyczny do zwalczania bakterii PL PL PL PL PL
HU184835B (en) Process for preparing crystallic pentahydrate of cefem-carboxylic acid derivatives
TW200944508A (en) Novel solid forms of bendamustine hydrochloride
JP3726291B2 (ja) 安定な結晶構造を有するベンゾオキサジン化合物およびその製造法
JPS6145626B2 (hu)
EP0189942B1 (en) Cefbuperazone crystalline triethylamine salt
CN112094249A (zh) 磺胺甲噻二唑-糖精共晶及其制备方法与应用
FI62311B (fi) Foerfarande foer framstaellning av kristallint natrium- och kaiumcefalexinmonohydrat
CS195746B2 (en) Process for preparing crystalline methanolate of natrium salt of cephamandole
AU712904B2 (en) Improved process for preparing potassium clavulanate
BG65240B1 (bg) Кристална полиморфна форма на азабицикло (2,2,2) октан-3-амин цитрат и фармацевтичен състав, който я съдържа, метод за получаване и използването
US4791196A (en) Crystalline cephem carboxylic acid addition salt
JPH0692970A (ja) トリアゾリルチオメチルチオセファロスポリン塩酸塩およびその水和物結晶ならびにそれらの製法
KR20070007766A (ko) 3-베타-아미노 17-메틸렌 안드로스테인-6-알파 7-베타-디올하이드로클로라이드의 결정질 형태
MXPA05010083A (es) Cefalosporina en forma cristalina.
CS195747B2 (cs) Způsob výroby krystalické bezvodé sodné soli cefamandolu