CN106543203B - 一种长效头孢噻呋自由酸晶体的制备方法 - Google Patents
一种长效头孢噻呋自由酸晶体的制备方法 Download PDFInfo
- Publication number
- CN106543203B CN106543203B CN201510597860.2A CN201510597860A CN106543203B CN 106543203 B CN106543203 B CN 106543203B CN 201510597860 A CN201510597860 A CN 201510597860A CN 106543203 B CN106543203 B CN 106543203B
- Authority
- CN
- China
- Prior art keywords
- ceftiofur
- free acid
- added
- water
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510597860.2A CN106543203B (zh) | 2015-09-18 | 2015-09-18 | 一种长效头孢噻呋自由酸晶体的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510597860.2A CN106543203B (zh) | 2015-09-18 | 2015-09-18 | 一种长效头孢噻呋自由酸晶体的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106543203A CN106543203A (zh) | 2017-03-29 |
CN106543203B true CN106543203B (zh) | 2019-07-02 |
Family
ID=58361909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510597860.2A Active CN106543203B (zh) | 2015-09-18 | 2015-09-18 | 一种长效头孢噻呋自由酸晶体的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106543203B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111053755B (zh) * | 2019-12-31 | 2022-03-29 | 金日制药(中国)有限公司 | 一种高渗透性的头孢克肟胶囊制剂制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1119016A (zh) * | 1993-03-12 | 1996-03-20 | 厄普约翰公司 | 结晶性头孢噻夫游离酸 |
-
2015
- 2015-09-18 CN CN201510597860.2A patent/CN106543203B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1119016A (zh) * | 1993-03-12 | 1996-03-20 | 厄普约翰公司 | 结晶性头孢噻夫游离酸 |
Non-Patent Citations (2)
Title |
---|
早期成药性评价中化合物晶型的生物活性研究策略;方莲花,等;《中国药学杂志》;20130430;第48卷(第7期);497-500 |
药物晶型及其质量控制;陈桂良,等;《药物分析杂志》;20121231;第32卷(第8期);1503-1508 |
Also Published As
Publication number | Publication date |
---|---|
CN106543203A (zh) | 2017-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101723958B (zh) | 头孢地嗪钠药物及制备方法 | |
CN106562971B (zh) | 一种头孢曲松钠粉针制剂的制备方法 | |
CN106543203B (zh) | 一种长效头孢噻呋自由酸晶体的制备方法 | |
CN110204548B (zh) | 一种具有杀菌消毒作用的哒嗪并三氮唑类药物分子及其制备方法和应用 | |
CN104530084B (zh) | 一种头孢呋辛钠的新晶型及其结晶制备方法 | |
CN105503904A (zh) | 一种头孢噻肟酸的制备方法 | |
CN104844625A (zh) | 头孢孟多酯钠的一种新晶型及其结晶制备方法 | |
CN108210464A (zh) | 一种复方氟苯尼考可溶性粉剂及其制备方法 | |
CN106008554A (zh) | 一种头孢曲松钠无菌粉的制备方法及产品 | |
CN102559829A (zh) | 头孢曲松钠粗盐的合成方法 | |
CN109293513A (zh) | 一种西他沙星中间体的制备方法 | |
CN106478669B (zh) | 一种高纯度盐酸头孢噻呋的精制方法 | |
CN108440569A (zh) | 头孢曲松钠球形晶体的制备方法 | |
CN109232610A (zh) | 一种头孢尼西二苄基乙二胺盐的精制方法 | |
CN102993216A (zh) | 盐酸头孢噻呋的一种制备方法 | |
CN104650115A (zh) | 头孢哌酮钠及其复方特种超细粉体制剂与制备方法 | |
CN104529751B (zh) | 一种结晶l‑乳酸钙的制备方法 | |
CN106434797A (zh) | 一种酶法合成泰拉霉素的工艺 | |
CN101108855A (zh) | 一种头孢噻呋的制备方法 | |
CN113025679A (zh) | 一种叔丁氧羰基头孢卡品前体酸的酶法制备工艺 | |
CN107793432B (zh) | 头孢曲松钠粗盐的精制方法 | |
CN103374019B (zh) | 一种头孢呋肟钠的制备方法 | |
CN103880898A (zh) | 一种合成阿奇霉素的方法 | |
CN109369682A (zh) | 一种头孢唑林-3-甲基类似物的制备方法 | |
CN103819487A (zh) | 利福平新晶型及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CB03 | Change of inventor or designer information |
Inventor after: Jing Dingding Inventor after: Li Xudong Inventor after: Li Shoujun Inventor after: Liu Ailing Inventor after: Xia Xuelin Inventor after: Liu Tuo Inventor after: Zhang Xiaopeng Inventor before: Jing Dingding Inventor before: Li Xudong Inventor before: Liu Ailing Inventor before: Xia Xuelin Inventor before: Liu Tuo Inventor before: Zhang Xiaopeng |
|
CB03 | Change of inventor or designer information |