DK0690864T3 - Krystallinsk ceftiofur på fri syreform - Google Patents

Krystallinsk ceftiofur på fri syreform

Info

Publication number
DK0690864T3
DK0690864T3 DK94910721T DK94910721T DK0690864T3 DK 0690864 T3 DK0690864 T3 DK 0690864T3 DK 94910721 T DK94910721 T DK 94910721T DK 94910721 T DK94910721 T DK 94910721T DK 0690864 T3 DK0690864 T3 DK 0690864T3
Authority
DK
Denmark
Prior art keywords
pct
free acid
acid form
crystalline ceftiofur
date sep
Prior art date
Application number
DK94910721T
Other languages
English (en)
Inventor
Kenneth Paul Shephard
Michael J Dunn
Michael S Bergren
Gregory E Hardee
Robert S Chao
Jeffrey L Havens
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK0690864T3 publication Critical patent/DK0690864T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK94910721T 1993-03-12 1994-03-07 Krystallinsk ceftiofur på fri syreform DK0690864T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3329193A 1993-03-12 1993-03-12
PCT/US1994/001862 WO1994020505A1 (en) 1993-03-12 1994-03-07 Crystalline ceftiofur free acid

Publications (1)

Publication Number Publication Date
DK0690864T3 true DK0690864T3 (da) 2001-09-17

Family

ID=21869579

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94910721T DK0690864T3 (da) 1993-03-12 1994-03-07 Krystallinsk ceftiofur på fri syreform

Country Status (31)

Country Link
US (1) US5721359A (da)
EP (1) EP0690864B1 (da)
JP (1) JP3852946B2 (da)
KR (1) KR100296810B1 (da)
CN (1) CN1055090C (da)
AT (1) ATE202109T1 (da)
AU (1) AU694419B2 (da)
BR (1) BR1101034A (da)
CA (1) CA2155322C (da)
CZ (1) CZ289332B6 (da)
DE (2) DE122005000055I2 (da)
DK (1) DK0690864T3 (da)
ES (1) ES2157254T3 (da)
FI (1) FI120307B (da)
FR (1) FR05C0045I2 (da)
GR (1) GR3036514T3 (da)
HU (1) HU222244B1 (da)
IL (1) IL108910A (da)
LU (1) LU91206I2 (da)
LV (1) LV12889B (da)
NL (1) NL300208I2 (da)
NO (2) NO313199B1 (da)
NZ (1) NZ263002A (da)
PL (1) PL184611B1 (da)
PT (1) PT690864E (da)
RU (1) RU2136685C1 (da)
SI (1) SI0690864T1 (da)
SK (1) SK283674B6 (da)
TW (1) TW267170B (da)
WO (1) WO1994020505A1 (da)
ZA (1) ZA941586B (da)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736151A (en) * 1996-12-09 1998-04-07 Pharmacia & Upjohn Company Antibiotic oil suspensions
US6074657A (en) * 1997-03-20 2000-06-13 Pharmacia & Upjohn Company Administration of an injectable antibiotic in the ear of an animal
US7829100B2 (en) * 2000-09-12 2010-11-09 Teagarden Dirk L Pharmaceutical composition having modified carrier
WO2002022107A2 (en) * 2000-09-12 2002-03-21 Pharmacia & Upjohn Company Pharmaceutical composition having modified carrier
KR100423895B1 (ko) * 2001-02-19 2004-03-24 주식회사 엘지생명과학 셉티오퍼 하이드로클로라이드의 현탁제 조성물
MXPA04000294A (es) * 2001-07-10 2004-05-04 Pharmacia & Upjhon Company Tiacin oxazolidinonas cristalinas.
GEP20063777B (en) 2001-08-15 2006-03-27 Upjohn Co Crystals Including Malic Acid Salt of N-[2-(Diethylamino) Ethyl]-5-[(5-Fluoro-2-Oxo-3h-Indole-3-Ylidene) Methyl]-2, 4-Dimethyl-1h-Pyrrole-3-Carboxamide, Processes for Its Preparation and Compositions Thereof
MXPA04009177A (es) † 2002-03-21 2004-12-07 Pharmacia & Upjohn Co Llc Metodo para administrar un antibiotico inyectable a la oreja de un animal.
US20040022815A1 (en) * 2002-08-05 2004-02-05 Orchid Health Care Novel pharmaceutical composition of ceftiofur
KR20040015622A (ko) * 2002-08-13 2004-02-19 대한뉴팜(주) 세프티오푸르나트륨을 활성성분으로 함유하는 현탁주사액조성물
US20040115822A1 (en) * 2002-09-12 2004-06-17 Schapaugh Randal Lee Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition
US7659061B2 (en) * 2002-11-19 2010-02-09 Pharmacia & Upjohn Company Pharmaceutical compositions having a modified vehicle
US20040115837A1 (en) * 2002-11-27 2004-06-17 Schapaugh Randal Lee Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
BRPI0408716B1 (pt) * 2003-03-27 2017-08-29 Basilea Pharmaceutica Ag. Cefalosporin in crystalline form, process for its preparation and its uses, and preparation of cephalosporin
KR20130041346A (ko) 2004-03-25 2013-04-24 아스텔라스세이야쿠 가부시키가이샤 솔리페나신 또는 그의 염의 고형 제제용 조성물
US7815939B2 (en) 2005-07-20 2010-10-19 Astellas Pharma Inc. Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms
NZ566790A (en) * 2005-10-12 2011-03-31 Orchid Chemicals & Pharm Ltd Crystalline sodium salt of cephalosporin antibiotic
US8470809B2 (en) * 2005-10-12 2013-06-25 Orchid Chemicals & Pharmaceuticals Limited Crystalline sodium salt of cephalosporin antibiotic
SA08290520B1 (ar) 2007-08-22 2012-02-22 استرازينيكا ايه بي مشتقات سيكلو بروبيل أميد وتركيبات صيدلية تحتوي عليها لعلاج حالة مرضية سببها مستقبلات هيستامين h3
EP2303026B1 (en) 2008-06-17 2020-09-09 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
US8431562B2 (en) * 2008-08-22 2013-04-30 Orchid Chemicals & Pharmaceuticals Limited Crystalline sodium salt of cephalosporin antibiotic
NZ592984A (en) * 2008-11-19 2012-12-21 Merial Ltd Formulations comprising ceftiofur and ketoprofen or ceftiofur and benzyl alcohol
EP2400964A4 (en) * 2009-01-30 2012-08-01 Glaxosmithkline Llc CRYSTALLINE FORM OF N - {(1-5) -2-AMINO-1 - [(3-FLUOROPHENYL) METHYL] ETHYL} -5-CHLORO-4- (4-CHLORO-1-METHYL-1H-PYRAZOL) CHLOROHYDRATE 5-YL) -2-THIOPHENE CARBOXAMIDE
TW201039825A (en) 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
SG183274A1 (en) * 2010-02-18 2012-09-27 Astrazeneca Ab Processes for making cyclopropyl amide derivatives and intermediates associated therewith
WO2011102793A1 (en) * 2010-02-18 2011-08-25 Astrazeneca Ab Solid forms comprising a cyclopropyl amide derivative
WO2012150520A1 (en) * 2011-05-02 2012-11-08 Pfizer Inc. Novel cephalosporins useful as antibacterial agents
US8975310B2 (en) 2011-07-20 2015-03-10 Brigham Young University Hydrophobic ceragenin compounds and devices incorporating same
US9603859B2 (en) 2011-09-13 2017-03-28 Brigham Young University Methods and products for increasing the rate of healing of tissue wounds
US9694019B2 (en) 2011-09-13 2017-07-04 Brigham Young University Compositions and methods for treating bone diseases and broken bones
CA2852989C (en) 2011-09-13 2021-06-29 Brigham Young University Compositions for treating bone diseases and broken bones
AU2012308526B2 (en) 2011-09-13 2016-04-21 Brigham Young University Compositions for treating bone diseases and broken bones
AU2011385377B2 (en) 2011-12-21 2017-06-01 Brigham Young University Oral care compositions
CN102584855B (zh) * 2012-02-16 2014-06-25 青岛科技大学 一种改进的头孢噻呋的制备方法
US9533063B1 (en) 2012-03-01 2017-01-03 Brigham Young University Aerosols incorporating ceragenin compounds and methods of use thereof
EP2846634A2 (en) 2012-05-02 2015-03-18 Brigham Young University Ceragenin particulate materials and methods for making same
BR112015008804A2 (pt) 2012-10-17 2017-07-04 Univ Brigham Young tratamento e prevenção de mastite
US9518004B2 (en) * 2012-12-03 2016-12-13 Kaneka Corporation Reduced coenzyme Q10 derivative and method for production thereof
CN105451742B (zh) 2013-01-07 2021-04-06 布莱阿姆青年大学 减少细胞增殖和治疗某些疾病的方法
US10568893B2 (en) 2013-03-15 2020-02-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
WO2014151411A1 (en) 2013-03-15 2014-09-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
RU2546675C2 (ru) * 2013-04-11 2015-04-10 Федеральное казённое предприятие "Государственный научно-исследовательский институт химических продуктов" (ФКП "ГосНИИХП") Способ определения степени кристалличности составов на основе дифениламина
US9387215B2 (en) 2013-04-22 2016-07-12 Brigham Young University Animal feed including cationic cholesterol additive and related methods
CN108484469A (zh) * 2013-09-05 2018-09-04 田边三菱制药株式会社 新型结晶性芳烷基胺化合物及其制造方法
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
CA2844321C (en) 2014-02-27 2021-03-16 Brigham Young University Cationic steroidal antimicrobial compounds
US10220045B2 (en) 2014-03-13 2019-03-05 Brigham Young University Compositions and methods for forming stabilized compositions with reduced CSA agglomeration
US9867836B2 (en) 2014-03-13 2018-01-16 Brigham Young University Lavage and/or infusion using CSA compounds for increasing fertility in a mammal
US9931350B2 (en) 2014-03-14 2018-04-03 Brigham Young University Anti-infective and osteogenic compositions and methods of use
US9686966B2 (en) 2014-04-30 2017-06-27 Brigham Young University Methods and apparatus for cleaning or disinfecting a water delivery system
US10441595B2 (en) 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
US10227376B2 (en) 2014-08-22 2019-03-12 Brigham Young University Radiolabeled cationic steroid antimicrobials and diagnostic methods
US10155788B2 (en) 2014-10-07 2018-12-18 Brigham Young University Cationic steroidal antimicrobial prodrug compositions and uses thereof
EP3760618A1 (en) 2014-10-21 2021-01-06 ARIAD Pharmaceuticals, Inc. Crystalline forms of 5-chloro-n4-[-2-(dimethylphosphoryl) phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl]pyrimidine-2,4-diamine
WO2016172543A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
WO2016172553A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
KR101753842B1 (ko) * 2015-05-12 2017-07-04 한국화학연구원 불화퀴놀론계 항생제를 담지한 서방형 제제 및 이의 제조방법
US9434759B1 (en) 2015-05-18 2016-09-06 Brigham Young University Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds
CN106543203B (zh) * 2015-09-18 2019-07-02 瑞普（天津）生物药业有限公司 一种长效头孢噻呋自由酸晶体的制备方法
PT3390358T (pt) * 2016-01-22 2020-11-09 Sandoz Ag Bis-cloridrato de eravaciclina cristalino
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
KR101898282B1 (ko) * 2016-05-24 2018-09-13 주식회사 고려비엔피 항생제의 서방형 수의학적 조성물 및 이의 제조방법
CN109563087A (zh) * 2016-07-07 2019-04-02 铁木医药有限公司 sGC刺激剂的固体形式
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity
US11186556B1 (en) * 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
TW202233625A (zh) * 2020-11-18 2022-09-01 美商傳達治療有限公司 Ｆｇｆｒ抑制劑及其製造及使用方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1207933B (de) * 1962-12-26 1965-12-30 American Home Prod Verfahren zur Herstellung von kristallwasser-freiem D-alpha-Aminobenzylpenicillin
CY773A (en) * 1967-09-05 1975-03-01 Bristol Myers Co Antibacterial agents and a process for the preparation thereof
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
GB1532682A (en) * 1976-04-27 1978-11-22 Bristol Myers Co Process for the preparation of cephadroxil
FR2479229B1 (fr) * 1980-03-26 1986-01-17 Clin Midy Nouveaux derives des cephalosporines, leur procede de preparation et les medicaments utilisables comme antibiotiques qui contiennent lesdits derives
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
US4400503A (en) * 1981-10-30 1983-08-23 Eli Lilly And Company Purification of syn-7-[[(2-amino-4-thiazolyl)(methoxyimino) acetyl]amino]-3-methyl-3-cephem-4-carboxylic acid
DE3313818A1 (de) * 1983-04-16 1984-10-18 Hoechst Ag, 6230 Frankfurt Neue kristallmodifikation von ceftazidim
KR890002631B1 (ko) * 1984-10-04 1989-07-21 몬산토 캄파니 생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물
IT1181672B (it) * 1984-10-25 1987-09-30 Upjohn Co Cefalosporina alogenidrato cristallino
US4902683A (en) * 1984-10-25 1990-02-20 The Upjohn Company Crystalline cephalosporin hydrohalide salts
WO1987001117A2 (en) * 1985-08-12 1987-02-26 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
GB8608962D0 (en) * 1986-04-12 1986-05-14 Beecham Group Plc Beta-lactam antibiotics
IT1214587B (it) * 1986-12-23 1990-01-18 Giovanni Bonfanti Metodo per la produzione diprodotti cristallini puri.
ATE76874T1 (de) * 1987-02-02 1992-06-15 Lilly Co Eli Verfahren zur herstellung von ceftazidimepentahydrat.
US5079007A (en) * 1987-07-29 1992-01-07 The Upjohn Company Controlled release of antibiotic salts from an implant
WO1989004313A1 (en) * 1987-11-10 1989-05-18 The Upjohn Company Cephalosporin antibiotics
US4877782A (en) * 1988-02-16 1989-10-31 The Upjohn Company Zinc ceftiofur complexes

Also Published As

Publication number Publication date
PL184611B1 (pl) 2002-11-29
HUT73781A (en) 1996-09-30
AU694419B2 (en) 1998-07-23
SK111495A3 (en) 1995-12-06
FR05C0045I1 (da) 2006-01-06
CZ289332B6 (cs) 2002-01-16
BR1101034A (pt) 2002-04-30
DE122005000055I1 (de) 2006-02-23
AU6351094A (en) 1994-09-26
IL108910A0 (en) 1994-06-24
NO2005025I2 (no) 2010-11-22
CA2155322C (en) 2000-02-29
FR05C0045I2 (da) 2007-08-03
NL300208I1 (nl) 2006-02-01
SK283674B6 (sk) 2003-11-04
NO953564D0 (no) 1995-09-11
HU9501960D0 (en) 1995-09-28
CN1055090C (zh) 2000-08-02
TW267170B (da) 1996-01-01
FI954250A (fi) 1995-09-11
NZ263002A (en) 1996-12-20
LU91206I2 (fr) 2006-05-30
ZA941586B (en) 1995-09-07
JP3852946B2 (ja) 2006-12-06
ATE202109T1 (de) 2001-06-15
NO953564L (no) 1995-11-07
KR100296810B1 (ko) 2001-10-24
CN1119016A (zh) 1996-03-20
SI0690864T1 (en) 2001-10-31
FI954250A0 (fi) 1995-09-11
GR3036514T3 (en) 2001-12-31
ES2157254T3 (es) 2001-08-16
JPH08507519A (ja) 1996-08-13
US5721359A (en) 1998-02-24
NO313199B1 (no) 2002-08-26
DE69427469T2 (de) 2001-10-31
FI120307B (fi) 2009-09-15
IL108910A (en) 1999-10-28
HU222244B1 (hu) 2003-05-28
LV12889B (lv) 2002-12-20
WO1994020505A1 (en) 1994-09-15
PT690864E (pt) 2001-11-30
DE122005000055I2 (de) 2008-06-05
EP0690864B1 (en) 2001-06-13
CZ9502290A3 (cs) 2001-08-15
PL310556A1 (en) 1995-12-27
CA2155322A1 (en) 1994-09-15
EP0690864A1 (en) 1996-01-10
NO2005025I1 (no) 2005-12-05
NL300208I2 (nl) 2006-05-01
RU2136685C1 (ru) 1999-09-10
DE69427469D1 (en) 2001-07-19

Similar Documents

Publication Publication Date Title
DK0690864T3 (da) Krystallinsk ceftiofur på fri syreform
FI952900A0 (fi) Polypeptidi ja siitä valmistettu anti-HIV-aine
NO308794B1 (no) Farmakologisk aktive pyridin-derivater, preparater inneholdende forbindelsene samt forbindelsenes anvendelse
IL111861A0 (en) N-substituted azabicycloalkane derivatives
FI954579A0 (fi) Uusia pednisolonijohdannaisia
AU6303996A (en) Mono- and disulfo-substituted anthraquinones and their use for the treatment of bone matrix disorders
IL107520A0 (en) Substituted ortho-ethenylphenylacetic acid derivatives and pharmaceutical compositions containing them
AU1067295A (en) Substituted aminoalkylaminopyridines
AU7228094A (en) Substituted arylthioalkylthiopyridines
DK0691846T3 (da) Imidazoquinoxalinoner til behandling af sygdomme i centralnervesystemet