LU86047A1 - Derives heterocycliques - Google Patents

Derives heterocycliques Download PDF

Info

Publication number
LU86047A1
LU86047A1 LU86047A LU86047A LU86047A1 LU 86047 A1 LU86047 A1 LU 86047A1 LU 86047 A LU86047 A LU 86047A LU 86047 A LU86047 A LU 86047A LU 86047 A1 LU86047 A1 LU 86047A1
Authority
LU
Luxembourg
Prior art keywords
formula
ester
acid
compounds
compound
Prior art date
Application number
LU86047A
Other languages
English (en)
French (fr)
Inventor
Claudio Semeraro
Dino Micheli
Daniele Pieraccioli
Allan David Borthwick
Giovanni Gavirachi
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT22383/84A external-priority patent/IT1175620B/it
Priority claimed from IT21460/85A external-priority patent/IT1187678B/it
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of LU86047A1 publication Critical patent/LU86047A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B2205/00—Fibre drawing or extruding details
    • C03B2205/44—Monotoring or regulating the preform feed rate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LU86047A 1984-08-22 1985-08-21 Derives heterocycliques LU86047A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT2238384 1984-08-22
IT22383/84A IT1175620B (it) 1984-08-22 1984-08-22 Derivati piridinici
IT2146085 1985-07-05
IT21460/85A IT1187678B (it) 1985-07-05 1985-07-05 Procedimento di preparazione di derivati eterociclici

Publications (1)

Publication Number Publication Date
LU86047A1 true LU86047A1 (fr) 1986-02-28

Family

ID=26327905

Family Applications (2)

Application Number Title Priority Date Filing Date
LU88267C LU88267I2 (de) 1984-08-22 1985-08-21
LU86047A LU86047A1 (fr) 1984-08-22 1985-08-21 Derives heterocycliques

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LU88267C LU88267I2 (de) 1984-08-22 1985-08-21

Country Status (33)

Country Link
US (2) US4801599A (de)
JP (2) JPS6193162A (de)
KR (1) KR920004482B1 (de)
AT (1) AT394042B (de)
AU (1) AU578724B2 (de)
BE (1) BE903103A (de)
BG (1) BG60409B2 (de)
CA (1) CA1268180A (de)
CH (1) CH666684A5 (de)
CS (1) CS403091A3 (de)
CY (1) CY1494A (de)
DE (1) DE3529997C2 (de)
DK (1) DK165949C (de)
ES (5) ES8703839A1 (de)
FI (1) FI81568C (de)
FR (1) FR2569402B1 (de)
GB (1) GB2164336B (de)
GR (1) GR852016B (de)
HK (1) HK52990A (de)
HU (1) HU196754B (de)
IE (1) IE58486B1 (de)
LU (2) LU88267I2 (de)
MX (1) MX159974A (de)
NL (2) NL193065C (de)
NO (2) NO167142C (de)
NZ (1) NZ212895A (de)
PH (1) PH22014A (de)
PT (1) PT81000B (de)
SA (1) SA91120277B1 (de)
SE (1) SE459920B (de)
SG (1) SG40889G (de)
SK (1) SK278327B6 (de)
ZW (1) ZW13185A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
DE3675747D1 (de) * 1985-08-21 1991-01-03 Glaxo Spa 1,4-dihydropyridinverbindungen und ihre herstellung und pharmazeutische formulierung.
IE59632B1 (en) * 1985-08-21 1994-03-09 Glaxo Spa Heterocyclic derivatives
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204461B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204462B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1233370B (it) * 1988-11-21 1992-03-27 Glaxo Spa Procedimento di preparazione di derivati diidropipiridinici utili nel trattamento di disturbi cardiovascolari
US5102709A (en) 1989-04-27 1992-04-07 Canon Kabushiki Kaisha Optical recording medium and process for production thereof
US5196529A (en) * 1990-10-09 1993-03-23 Merck & Co., Inc. 2-phenanthrenyl carbapenem intermediates
US5177202A (en) * 1990-10-09 1993-01-05 Merck & Co., Inc. 2-phenanthrenyl-carbapenems
US5132422A (en) * 1990-10-09 1992-07-21 Merck & Co., Inc. 2-naphthyl-carbapenem intermediates
US5132421A (en) * 1990-10-09 1992-07-21 Merck & Co., Inc. 2-naphthyl-carbapenem intermediates
US5144028A (en) * 1990-10-09 1992-09-01 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem intermediates
US5356889A (en) * 1990-08-01 1994-10-18 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem intermediates
US5208329A (en) * 1990-10-09 1993-05-04 Merck & Co., Inc. 2-biphenyl carbapenem intermediates
IT1244728B (it) * 1991-02-13 1994-08-08 Glaxo Spa Impiego medicamentoso di derivati diidropiridinici
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
WO2000027397A1 (en) * 1998-11-06 2000-05-18 Glaxo Group Limited Antihypertensive medicaments containing lacidipine and telmisartan
CN1681495B (zh) 2002-08-19 2010-05-12 辉瑞产品公司 用于治疗过度增生性疾病的组合物
CA2526730A1 (en) * 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Substituted pyrrole derivatives
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
JP2008507585A (ja) * 2004-07-26 2008-03-13 コセリックス インク 微粒子製剤を用いて吸入したイロプロストによる肺高血圧症の治療
WO2006113309A1 (en) 2005-04-15 2006-10-26 Dr. Reddy's Laboratories Ltd. Lacidipine particles
US20070043088A1 (en) * 2005-08-16 2007-02-22 Eswaraiah Sajja Process for preparing lacidipine
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (de) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Kombinationstherapie mit Fasudil zur Behandlung von pulmonaler Hypertonie
ATE551059T1 (de) 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
SG166829A1 (en) * 2005-11-08 2010-12-29 Ranbaxy Lab Ltd Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
BRPI0714361A2 (pt) * 2006-07-14 2013-03-26 Ranbaxy Lab Ltd polimorfo cristalino, composiÇço farmacÊutica contendo o mesmo, mÉtodo para sua preparaÇço e mÉtodo de tratamento
US20080089947A1 (en) * 2006-08-18 2008-04-17 Knox Clayton D Calcium Influx Inhibitors in the Treatment of Ischemia
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
LT2705839T (lt) 2012-09-10 2018-06-11 Rivopharm Sa Farmacinė kompozicija, apimanti lacidipiną ir jos gavimo būdas
JP2016516804A (ja) 2013-04-17 2016-06-09 ファイザー・インク 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
EP3911648A4 (de) 2019-01-18 2022-10-26 Astrazeneca AB Pcsk9-inhibitoren und verfahren zur verwendung davon

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455945A (en) * 1967-06-07 1969-07-15 Smithkline Corp 4-(carboxy (and carbo-lower alkoxy)phenyl)-1,4-dihydropyridines
DE2228363A1 (de) * 1972-06-10 1974-01-03 Bayer Ag 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
DE3018259A1 (de) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
KR870002073A (ko) 1987-03-28
FI81568B (fi) 1990-07-31
NL8502296A (nl) 1986-03-17
NO167142C (no) 1991-10-09
AU578724B2 (en) 1988-11-03
PT81000B (pt) 1988-03-03
ES8707930A1 (es) 1987-09-01
ES8707932A1 (es) 1987-09-01
FR2569402B1 (fr) 1989-09-22
LU88267I2 (de) 1994-02-03
HK52990A (en) 1990-07-20
JPH0686430B2 (ja) 1994-11-02
KR920004482B1 (ko) 1992-06-05
NO167142B (no) 1991-07-01
AU4657685A (en) 1986-02-27
ES546324A0 (es) 1987-03-01
ES552050A0 (es) 1987-09-01
DE3529997C2 (de) 1996-01-18
PT81000A (en) 1985-09-01
NO1999007I1 (no) 1999-04-23
DK165949B (da) 1993-02-15
PH22014A (en) 1988-05-02
NO853293L (no) 1986-02-24
HUT40625A (en) 1987-01-28
ES552051A0 (es) 1987-09-01
CY1494A (en) 1990-02-16
IE58486B1 (en) 1993-09-22
SE8503888D0 (sv) 1985-08-20
US5011848A (en) 1991-04-30
GR852016B (de) 1985-12-19
GB2164336A (en) 1986-03-19
GB2164336B (en) 1988-06-08
ES8802497A1 (es) 1988-07-01
SG40889G (en) 1989-12-22
JPH0550506B2 (de) 1993-07-29
GB8520924D0 (en) 1985-09-25
ES8707931A1 (es) 1987-09-01
IE852054L (en) 1986-02-22
BG60409B2 (bg) 1995-02-28
ZW13185A1 (en) 1986-03-19
CH666684A5 (de) 1988-08-15
CS403091A3 (en) 1992-06-17
SA91120277B1 (ar) 2006-05-15
SK278327B6 (en) 1996-11-06
NL980037I1 (nl) 1999-02-01
NL193065B (nl) 1998-05-06
HU196754B (en) 1989-01-30
ES552049A0 (es) 1988-07-01
ES552048A0 (es) 1987-09-01
DK165949C (da) 1993-07-05
NZ212895A (en) 1988-07-28
MX159974A (es) 1989-10-17
CA1268180A (en) 1990-04-24
JPS6479152A (en) 1989-03-24
US4801599A (en) 1989-01-31
FI81568C (fi) 1990-11-12
ES8703839A1 (es) 1987-03-01
DK378085D0 (da) 1985-08-20
BE903103A (fr) 1986-02-24
DK378085A (da) 1986-02-23
FI853206L (fi) 1986-02-23
NL980037I2 (nl) 1999-03-01
FI853206A0 (fi) 1985-08-21
FR2569402A1 (fr) 1986-02-28
AT394042B (de) 1992-01-27
JPS6193162A (ja) 1986-05-12
NL193065C (nl) 1998-09-08
SE459920B (sv) 1989-08-21
SE8503888L (sv) 1986-02-23
DE3529997A1 (de) 1986-03-06
ATA245485A (de) 1991-07-15

Similar Documents

Publication Publication Date Title
LU86047A1 (fr) Derives heterocycliques
EP0656354B1 (de) Substituiertes N-Piperidin 3-Pyrazolcarboxamid
EP0837848B1 (de) 4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridine als neurothophe und neuroprotektive wirkstoffe
EP0101381B1 (de) Trifluoromethylphenyltetrahydropyridine mit appetithemmender Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
JPH05310694A (ja) 新規な光学的活性の１，４−ジヒドロピリジン化合物の製造法
FR2566404A1 (fr) Nouveaux derives de la 1,4-dihydropyridine, leurs sels, procede pour les preparer, et compositions pharmaceutiques les contenant
WO2001049684A1 (fr) Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
EP0240398B1 (de) Dissymmetrische 1,4-Dihydropyridin-3,5-dicarbonsäure-Derivate, Verfahren zur Herstellung und Verwendung in Therapeutik
WO2003033466A1 (fr) Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
US4946851A (en) 1.4-dihydropyridines
EP1651596B1 (de) Neue derivate von 4,4'-dithiobis-(3-aminobutan-1-sulfonaten) und diese enthaltende zusammensetzungen
EP0060176B1 (de) Substituierte Trifluormethylphenyltetrahydropyridine mit Appetitzügler-Wirksamkeit, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US4280998A (en) 1,4-Dihydropyridazine-3-carboxylic acid derivatives, a process for their preparation and their use as antihypertensives
FR2586417A1 (fr) Composes heterocycliques, leur preparation et composition pharmaceutique
CA1262906A (en) 3-(2-furoyl)-5-alkoxycarbonyl-2,6-dimethyl-4- (2-nitrophenyl)-1,4-dihydropyridine calcium antagonists
CZ286192A3 (en) Dihydropyridines substituted by indolesulfonamides, process of their preparation and their use in medicaments
FR2562069A1 (fr) Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation, et leur application comme medicaments
FR2511677A1 (fr) Procede de preparation d'esters des acides alcoxyvincaminiques et alcoxyapovincaminiques
LU86775A1 (fr) Composes heterocycliques,leur preparation et composition pharmaceutique
JPH0670013B2 (ja) ３‐ニトロ‐ジヒドロピリジン類
FR2751652A1 (fr) Derives du thienylcyclohexane, des procedes pour leur preparation et leur utilisation en tant que produits industriels nouveaux pour la synthese de derives thienylcyclohexyles
EP0695747A1 (de) Derivate von substituierten N-oxiden 1-(7-chlorochinolin-4-yl)pyrazol-3-carboxamiden als Ligand des neurotensin Rezeptors
FR2554109A1 (fr) Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation en therapeutique comme medicaments
CH624379A5 (en) Process for the preparation of new 2-hydroxymethyl-2-phenyl-1,3-indanedione esters
CA2107533A1 (en) Dihydropyridine-alkoxy- and -alkylamino-aroyl esters

Legal Events

Date Code Title Description
CCP Supplementary protection certificate

Free format text: 88267, EXPIRES:20051107