BG60409B2 - 4-арил-1,4-дихидропиридин-3,5-дикарбоксилни производни - Google Patents

4-арил-1,4-дихидропиридин-3,5-дикарбоксилни производни Download PDF

Info

Publication number
BG60409B2
BG60409B2 BG98061A BG9806193A BG60409B2 BG 60409 B2 BG60409 B2 BG 60409B2 BG 98061 A BG98061 A BG 98061A BG 9806193 A BG9806193 A BG 9806193A BG 60409 B2 BG60409 B2 BG 60409B2
Authority
BG
Bulgaria
Prior art keywords
general formula
group
dimethyl
compound
methyl
Prior art date
Application number
BG98061A
Other languages
Bulgarian (bg)
English (en)
Inventor
Claudio Semeraro
Dino Micheli
Daniele Pieraccioli
Giovanni Gaviraghi
Allan Borthwick
Original Assignee
Glaxo S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT22383/84A external-priority patent/IT1175620B/it
Priority claimed from IT21460/85A external-priority patent/IT1187678B/it
Application filed by Glaxo S.P.A. filed Critical Glaxo S.P.A.
Publication of BG60409B2 publication Critical patent/BG60409B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B2205/00—Fibre drawing or extruding details
    • C03B2205/44—Monotoring or regulating the preform feed rate
BG98061A 1984-08-22 1993-08-20 4-арил-1,4-дихидропиридин-3,5-дикарбоксилни производни BG60409B2 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22383/84A IT1175620B (it) 1984-08-22 1984-08-22 Derivati piridinici
IT21460/85A IT1187678B (it) 1985-07-05 1985-07-05 Procedimento di preparazione di derivati eterociclici

Publications (1)

Publication Number Publication Date
BG60409B2 true BG60409B2 (bg) 1995-02-28

Family

ID=26327905

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98061A BG60409B2 (bg) 1984-08-22 1993-08-20 4-арил-1,4-дихидропиридин-3,5-дикарбоксилни производни

Country Status (33)

Country Link
US (2) US4801599A (de)
JP (2) JPS6193162A (de)
KR (1) KR920004482B1 (de)
AT (1) AT394042B (de)
AU (1) AU578724B2 (de)
BE (1) BE903103A (de)
BG (1) BG60409B2 (de)
CA (1) CA1268180A (de)
CH (1) CH666684A5 (de)
CS (1) CS403091A3 (de)
CY (1) CY1494A (de)
DE (1) DE3529997C2 (de)
DK (1) DK165949C (de)
ES (5) ES8703839A1 (de)
FI (1) FI81568C (de)
FR (1) FR2569402B1 (de)
GB (1) GB2164336B (de)
GR (1) GR852016B (de)
HK (1) HK52990A (de)
HU (1) HU196754B (de)
IE (1) IE58486B1 (de)
LU (2) LU86047A1 (de)
MX (1) MX159974A (de)
NL (2) NL193065C (de)
NO (2) NO167142C (de)
NZ (1) NZ212895A (de)
PH (1) PH22014A (de)
PT (1) PT81000B (de)
SA (1) SA91120277B1 (de)
SE (1) SE459920B (de)
SG (1) SG40889G (de)
SK (1) SK278327B6 (de)
ZW (1) ZW13185A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
EP0226271B1 (de) * 1985-08-21 1990-11-22 GLAXO S.p.A. 1,4-Dihydropyridinverbindungen und ihre Herstellung und pharmazeutische Formulierung
NL192385C (nl) * 1985-08-21 1997-07-04 Glaxo Spa 6-alkyl-4-fenyl-1,4-dihydro-3,5-pyridinecarbonzuuresters, werkwijze voor de bereiding daarvan en farmaceutische preparaten die deze esters bevatten.
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204462B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204461B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1233370B (it) * 1988-11-21 1992-03-27 Glaxo Spa Procedimento di preparazione di derivati diidropipiridinici utili nel trattamento di disturbi cardiovascolari
US5102709A (en) 1989-04-27 1992-04-07 Canon Kabushiki Kaisha Optical recording medium and process for production thereof
US5196529A (en) * 1990-10-09 1993-03-23 Merck & Co., Inc. 2-phenanthrenyl carbapenem intermediates
US5177202A (en) * 1990-10-09 1993-01-05 Merck & Co., Inc. 2-phenanthrenyl-carbapenems
US5132421A (en) * 1990-10-09 1992-07-21 Merck & Co., Inc. 2-naphthyl-carbapenem intermediates
US5132422A (en) * 1990-10-09 1992-07-21 Merck & Co., Inc. 2-naphthyl-carbapenem intermediates
US5144028A (en) * 1990-10-09 1992-09-01 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem intermediates
US5356889A (en) * 1990-08-01 1994-10-18 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem intermediates
US5208329A (en) * 1990-10-09 1993-05-04 Merck & Co., Inc. 2-biphenyl carbapenem intermediates
IT1244728B (it) * 1991-02-13 1994-08-08 Glaxo Spa Impiego medicamentoso di derivati diidropiridinici
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
WO2000027397A1 (en) * 1998-11-06 2000-05-18 Glaxo Group Limited Antihypertensive medicaments containing lacidipine and telmisartan
AP2005003232A0 (en) 2002-08-19 2005-03-31 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
GEP20084406B (en) * 2003-05-30 2008-06-25 Ranbaxy Lab Ltd Substituted pyrrole derivatives and their use as hmg-co inhibitors
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
CN101090714A (zh) * 2004-07-26 2007-12-19 康泽里克斯公司 通过吸入伊洛前列素和微粒制剂治疗肺动脉高血压症
EP1868577A4 (de) 2005-04-15 2009-12-09 Reddys Lab Inc Dr Lacidipin-partikel
US20070043088A1 (en) * 2005-08-16 2007-02-22 Eswaraiah Sajja Process for preparing lacidipine
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7893050B2 (en) * 2005-10-26 2011-02-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2351569B1 (de) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Kombinationstherapie mit Fasudil zur Behandlung von pulmonaler Hypertonie
AU2006313430B2 (en) * 2005-11-08 2012-09-06 Ranbaxy Laboratories Limited Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
WO2008020314A2 (en) * 2006-03-14 2008-02-21 Ranbaxy Laboratories Limited Statin stabilizing dosage formulations
AU2007274724B2 (en) * 2006-07-14 2012-07-26 Ranbaxy Laboratories Limited Polymorphic forms of an HMG-CoA reductase inhibitor and uses thereof
US20080089947A1 (en) * 2006-08-18 2008-04-17 Knox Clayton D Calcium Influx Inhibitors in the Treatment of Ischemia
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
ITMI20131485A1 (it) 2012-09-10 2014-03-11 Rivopharm Sa Composizione farmaceutica comprendente lacipidina e processo di preparazione
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
MX2021008533A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455945A (en) * 1967-06-07 1969-07-15 Smithkline Corp 4-(carboxy (and carbo-lower alkoxy)phenyl)-1,4-dihydropyridines
DE2228363A1 (de) * 1972-06-10 1974-01-03 Bayer Ag 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
DE3018259A1 (de) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
DK378085A (da) 1986-02-23
KR870002073A (ko) 1987-03-28
FI81568B (fi) 1990-07-31
ES8802497A1 (es) 1988-07-01
NO167142C (no) 1991-10-09
NO853293L (no) 1986-02-24
GB2164336A (en) 1986-03-19
KR920004482B1 (ko) 1992-06-05
SE8503888D0 (sv) 1985-08-20
NL193065B (nl) 1998-05-06
NO1999007I1 (no) 1999-04-23
BE903103A (fr) 1986-02-24
DK378085D0 (da) 1985-08-20
IE852054L (en) 1986-02-22
GB8520924D0 (en) 1985-09-25
DK165949C (da) 1993-07-05
DK165949B (da) 1993-02-15
MX159974A (es) 1989-10-17
ES8707930A1 (es) 1987-09-01
LU88267I2 (de) 1994-02-03
SA91120277B1 (ar) 2006-05-15
ZW13185A1 (en) 1986-03-19
NL980037I1 (nl) 1999-02-01
ES552051A0 (es) 1987-09-01
CH666684A5 (de) 1988-08-15
SK278327B6 (en) 1996-11-06
FI81568C (fi) 1990-11-12
DE3529997C2 (de) 1996-01-18
CS403091A3 (en) 1992-06-17
SE459920B (sv) 1989-08-21
GB2164336B (en) 1988-06-08
AT394042B (de) 1992-01-27
JPH0550506B2 (de) 1993-07-29
GR852016B (de) 1985-12-19
ES552049A0 (es) 1988-07-01
LU86047A1 (fr) 1986-02-28
PH22014A (en) 1988-05-02
ATA245485A (de) 1991-07-15
NZ212895A (en) 1988-07-28
FR2569402A1 (fr) 1986-02-28
ES552050A0 (es) 1987-09-01
DE3529997A1 (de) 1986-03-06
JPH0686430B2 (ja) 1994-11-02
CA1268180A (en) 1990-04-24
NL980037I2 (nl) 1999-03-01
AU4657685A (en) 1986-02-27
HU196754B (en) 1989-01-30
JPS6479152A (en) 1989-03-24
FI853206A0 (fi) 1985-08-21
HK52990A (en) 1990-07-20
PT81000B (pt) 1988-03-03
ES8707932A1 (es) 1987-09-01
PT81000A (en) 1985-09-01
AU578724B2 (en) 1988-11-03
ES552048A0 (es) 1987-09-01
ES8707931A1 (es) 1987-09-01
IE58486B1 (en) 1993-09-22
HUT40625A (en) 1987-01-28
FR2569402B1 (fr) 1989-09-22
SE8503888L (sv) 1986-02-23
ES8703839A1 (es) 1987-03-01
US5011848A (en) 1991-04-30
NO167142B (no) 1991-07-01
US4801599A (en) 1989-01-31
CY1494A (en) 1990-02-16
ES546324A0 (es) 1987-03-01
SG40889G (en) 1989-12-22
NL193065C (nl) 1998-09-08
NL8502296A (nl) 1986-03-17
JPS6193162A (ja) 1986-05-12
FI853206L (fi) 1986-02-23

Similar Documents

Publication Publication Date Title
BG60409B2 (bg) 4-арил-1,4-дихидропиридин-3,5-дикарбоксилни производни
US4946851A (en) 1.4-dihydropyridines
US4806533A (en) 1,4-Dihydro pyridine 3,5 dicarboxylic acid derivatives and compositions
EP0215250B1 (de) 2-Substituierte-1,4-dihydropyridine, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
US4839348A (en) 1,4-dihydropyridines
US5162345A (en) Heterocyclic compounds and their preparation and pharmaceutical formulation
EP0242950B1 (de) Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP0238211B1 (de) Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP0226271B1 (de) 1,4-Dihydropyridinverbindungen und ihre Herstellung und pharmazeutische Formulierung
RU1816282C (ru) Способ получени производных 2-аминоалкилтиометил-1,4-дигидропиридина или их энантиомеров
FI94242B (fi) Menetelmä heterosyklisten johdannaisten valmistamiseksi
KR950011410B1 (ko) 헤테로사이클릭 화합물의 제조방법
HU198907B (en) Process for producing dihydropyridine derivatives and pharmaceutical compositions containing them as active components
LU86775A1 (fr) Composes heterocycliques,leur preparation et composition pharmaceutique
JPS6296468A (ja) 複素環式化合物およびそれらの製造ならびに医薬製剤
NO174419B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser