SE8503888D0 - Heterocykliska derivat - Google Patents

Heterocykliska derivat

Info

Publication number
SE8503888D0
SE8503888D0 SE8503888A SE8503888A SE8503888D0 SE 8503888 D0 SE8503888 D0 SE 8503888D0 SE 8503888 A SE8503888 A SE 8503888A SE 8503888 A SE8503888 A SE 8503888A SE 8503888 D0 SE8503888 D0 SE 8503888D0
Authority
SE
Sweden
Prior art keywords
alkyl
straight
formula
independently represent
calcium ion
Prior art date
Application number
SE8503888A
Other languages
English (en)
Other versions
SE8503888L (sv
SE459920B (sv
Inventor
C Semeraro
D Micheli
D Pieraccioli
G Gaviraghi
A D Borthwick
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT22383/84A external-priority patent/IT1175620B/it
Priority claimed from IT21460/85A external-priority patent/IT1187678B/it
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of SE8503888D0 publication Critical patent/SE8503888D0/sv
Publication of SE8503888L publication Critical patent/SE8503888L/sv
Publication of SE459920B publication Critical patent/SE459920B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B2205/00—Fibre drawing or extruding details
    • C03B2205/44—Monotoring or regulating the preform feed rate
SE8503888A 1984-08-22 1985-08-20 Estrar av 4-(2-(2-karboxietenyl)fenyl)-dihydropyridindikarboxylsyror, foerfarande foer framstaellning av dessa och en farmaceutisk komposition SE459920B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22383/84A IT1175620B (it) 1984-08-22 1984-08-22 Derivati piridinici
IT21460/85A IT1187678B (it) 1985-07-05 1985-07-05 Procedimento di preparazione di derivati eterociclici

Publications (3)

Publication Number Publication Date
SE8503888D0 true SE8503888D0 (sv) 1985-08-20
SE8503888L SE8503888L (sv) 1986-02-23
SE459920B SE459920B (sv) 1989-08-21

Family

ID=26327905

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8503888A SE459920B (sv) 1984-08-22 1985-08-20 Estrar av 4-(2-(2-karboxietenyl)fenyl)-dihydropyridindikarboxylsyror, foerfarande foer framstaellning av dessa och en farmaceutisk komposition

Country Status (33)

Country Link
US (2) US4801599A (sv)
JP (2) JPS6193162A (sv)
KR (1) KR920004482B1 (sv)
AT (1) AT394042B (sv)
AU (1) AU578724B2 (sv)
BE (1) BE903103A (sv)
BG (1) BG60409B2 (sv)
CA (1) CA1268180A (sv)
CH (1) CH666684A5 (sv)
CS (1) CS403091A3 (sv)
CY (1) CY1494A (sv)
DE (1) DE3529997C2 (sv)
DK (1) DK165949C (sv)
ES (5) ES8703839A1 (sv)
FI (1) FI81568C (sv)
FR (1) FR2569402B1 (sv)
GB (1) GB2164336B (sv)
GR (1) GR852016B (sv)
HK (1) HK52990A (sv)
HU (1) HU196754B (sv)
IE (1) IE58486B1 (sv)
LU (2) LU88267I2 (sv)
MX (1) MX159974A (sv)
NL (2) NL193065C (sv)
NO (2) NO167142C (sv)
NZ (1) NZ212895A (sv)
PH (1) PH22014A (sv)
PT (1) PT81000B (sv)
SA (1) SA91120277B1 (sv)
SE (1) SE459920B (sv)
SG (1) SG40889G (sv)
SK (1) SK278327B6 (sv)
ZW (1) ZW13185A1 (sv)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
CH669788A5 (sv) * 1985-08-21 1989-04-14 Glaxo Spa
EP0226271B1 (en) * 1985-08-21 1990-11-22 GLAXO S.p.A. 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204462B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204461B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1233370B (it) * 1988-11-21 1992-03-27 Glaxo Spa Procedimento di preparazione di derivati diidropipiridinici utili nel trattamento di disturbi cardiovascolari
DE69030982T2 (de) 1989-04-27 1997-11-13 Canon Kk Optisches Aufzeichnungsmedium und Verfahren zu seiner Herstellung
US5196529A (en) * 1990-10-09 1993-03-23 Merck & Co., Inc. 2-phenanthrenyl carbapenem intermediates
US5177202A (en) * 1990-10-09 1993-01-05 Merck & Co., Inc. 2-phenanthrenyl-carbapenems
US5132422A (en) * 1990-10-09 1992-07-21 Merck & Co., Inc. 2-naphthyl-carbapenem intermediates
US5132421A (en) * 1990-10-09 1992-07-21 Merck & Co., Inc. 2-naphthyl-carbapenem intermediates
US5356889A (en) * 1990-08-01 1994-10-18 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem intermediates
US5144028A (en) * 1990-10-09 1992-09-01 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem intermediates
US5208329A (en) * 1990-10-09 1993-05-04 Merck & Co., Inc. 2-biphenyl carbapenem intermediates
IT1244728B (it) * 1991-02-13 1994-08-08 Glaxo Spa Impiego medicamentoso di derivati diidropiridinici
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
WO2000027397A1 (en) * 1998-11-06 2000-05-18 Glaxo Group Limited Antihypertensive medicaments containing lacidipine and telmisartan
ATE502635T1 (de) 2002-08-19 2011-04-15 Pfizer Kombinationstherapie gegen hyperproliferative erkrankungen
AP2501A (en) * 2003-05-30 2012-10-22 Ranbaxy Lab Ltd Substituted pyrrole derivatives
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
KR20070054644A (ko) * 2004-07-26 2007-05-29 액테리온 파마슈티칼 리미티드 미립자 제형으로 흡입된 일로프로스트에 의한 폐고혈압의치료
WO2006113309A1 (en) 2005-04-15 2006-10-26 Dr. Reddy's Laboratories Ltd. Lacidipine particles
US20070043088A1 (en) * 2005-08-16 2007-02-22 Eswaraiah Sajja Process for preparing lacidipine
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2111863B1 (en) 2005-10-26 2012-03-28 Asahi Kasei Pharma Corporation Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension
EP1948599A1 (en) * 2005-11-08 2008-07-30 Ranbaxy Laboratories Limited Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
TW200811101A (en) * 2006-07-14 2008-03-01 Ranbaxy Lab Ltd Polymorphic forms of an HMG-CoA reductase inhibitor and uses thereof
US20080089947A1 (en) * 2006-08-18 2008-04-17 Knox Clayton D Calcium Influx Inhibitors in the Treatment of Ischemia
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
PL2705839T3 (pl) 2012-09-10 2018-07-31 Rivopharm Sa Farmaceutyczna kompozycja zawierająca lacydypinę i proces przygotowania
EP2986599A1 (en) 2013-04-17 2016-02-24 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
US11248001B2 (en) 2019-01-18 2022-02-15 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455945A (en) * 1967-06-07 1969-07-15 Smithkline Corp 4-(carboxy (and carbo-lower alkoxy)phenyl)-1,4-dihydropyridines
DE2228363A1 (de) * 1972-06-10 1974-01-03 Bayer Ag 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
DE3018259A1 (de) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
PT81000A (en) 1985-09-01
PH22014A (en) 1988-05-02
SA91120277B1 (ar) 2006-05-15
NO1999007I1 (no) 1999-04-23
GR852016B (sv) 1985-12-19
LU88267I2 (sv) 1994-02-03
ES546324A0 (es) 1987-03-01
DK378085D0 (da) 1985-08-20
SE8503888L (sv) 1986-02-23
NL980037I2 (nl) 1999-03-01
FR2569402B1 (fr) 1989-09-22
ES8707930A1 (es) 1987-09-01
JPS6193162A (ja) 1986-05-12
LU86047A1 (fr) 1986-02-28
SE459920B (sv) 1989-08-21
MX159974A (es) 1989-10-17
BE903103A (fr) 1986-02-24
GB2164336B (en) 1988-06-08
CH666684A5 (de) 1988-08-15
PT81000B (pt) 1988-03-03
AU578724B2 (en) 1988-11-03
CS403091A3 (en) 1992-06-17
FR2569402A1 (fr) 1986-02-28
ES8703839A1 (es) 1987-03-01
KR920004482B1 (ko) 1992-06-05
NL980037I1 (nl) 1999-02-01
JPH0686430B2 (ja) 1994-11-02
IE58486B1 (en) 1993-09-22
FI81568B (fi) 1990-07-31
IE852054L (en) 1986-02-22
NL8502296A (nl) 1986-03-17
KR870002073A (ko) 1987-03-28
JPH0550506B2 (sv) 1993-07-29
FI853206L (fi) 1986-02-23
ES552050A0 (es) 1987-09-01
NZ212895A (en) 1988-07-28
DK165949C (da) 1993-07-05
FI81568C (sv) 1990-11-12
DE3529997C2 (de) 1996-01-18
NO853293L (no) 1986-02-24
NL193065C (nl) 1998-09-08
CY1494A (en) 1990-02-16
ES552051A0 (es) 1987-09-01
ES552048A0 (es) 1987-09-01
ES8707932A1 (es) 1987-09-01
ES552049A0 (es) 1988-07-01
NO167142C (no) 1991-10-09
ATA245485A (de) 1991-07-15
DK378085A (da) 1986-02-23
ES8707931A1 (es) 1987-09-01
SK278327B6 (en) 1996-11-06
HU196754B (en) 1989-01-30
GB8520924D0 (en) 1985-09-25
NO167142B (no) 1991-07-01
ES8802497A1 (es) 1988-07-01
US5011848A (en) 1991-04-30
GB2164336A (en) 1986-03-19
BG60409B2 (bg) 1995-02-28
AU4657685A (en) 1986-02-27
FI853206A0 (fi) 1985-08-21
NL193065B (nl) 1998-05-06
CA1268180A (en) 1990-04-24
US4801599A (en) 1989-01-31
HUT40625A (en) 1987-01-28
DK165949B (da) 1993-02-15
DE3529997A1 (de) 1986-03-06
SG40889G (en) 1989-12-22
HK52990A (en) 1990-07-20
ZW13185A1 (en) 1986-03-19
JPS6479152A (en) 1989-03-24
AT394042B (de) 1992-01-27

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